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The map label for this gene is purP [H]

Identifier: 15897186

GI number: 15897186

Start: 207852

End: 208922

Strand: Direct

Name: purP [H]

Synonym: SSO0239

Alternate gene names: 15897186

Gene position: 207852-208922 (Clockwise)

Preceding gene: 15897182

Following gene: 15897187

Centisome position: 6.95

GC content: 33.71

Gene sequence:

>1071_bases
ATGGCTAATTGTAAAGTATGTTCAACATTTATTAACTTATACTGTAATCTCACAACAATGATAATCGCAACAATCGGTAG
TCATTCTGCATTACAGATCTTACATGGAGCCAAGAAGGAAGGTTTTCAAACTATGGTAATAACTGATAATAAAAGAGAAA
ATTTCTACAAAAATTTTAGTTTTATTGATAACATTTATGCATATGCTAGCCTAGATGAAGCAGTATCTATAATTAATGGT
ATTAAGGATTATGGTATATTAATCCCACATGGAAGTTTAGTAGAATACCTAGGCAAGGAAAGAGTAGATAAAATTGAGAC
AAAAATTTTTGGAAACAAGAAAATATTCGAGTGGGAAGCAGATCAGAAAAAGAAAATGGAACTACTTAGAAAGTCAAACA
TAAAGATTCCAGAGATATTTGAAAGACCAGAAGATGTGGATAGATTAGTAATCGTAAAGCTTAACGGAGCTAAAGGGGGT
AAGGGATACTTCCTAGCTAGGAATAAAAGTGAAGTAAAAGAAGGAATTCAAAAGCTCATTGAGAGTAAAATGATAAGAGA
CGAAAATGAAGTAATAATCCAAGAGTATGTCGTAGGAGTTCCGATGTATTTTCAATTTTTCTATAGTGACATTATAAATA
GAACAGAAATCTTCGGAATAGATATAAGATACGAAACTAACATAGATGGACTTAGAAGGCTTCCTTTTGAGTATATGAAA
GAACTTAAGATAAACCCTACGTTTGTAGTTGTTGGCAATATTCCAGCTGTAGCTAGAGAGAGCTTACTACCAGTTGCTTT
AGAGTACGCTAATAACTTCGTTAGAACTACTAAGGAATTAGTACCTCCAGGGATGATAGGACCATTTTGTTTAGAGTCAA
TAATAACTGATAATTCAGATATAGTTGTTTTCGAGTTCTCTGGAAGAATAGTTGCTGGAACTAACTTATACGTAAATGGG
AGTCCATATAGTTGGCTTTACTGGGATGAGCCCATGAGTATAGGAAGAAGGATCGCAAGAGAAATCAGAGTCGCAAACGA
AAAAGATAAGTTAAGCCTCGTGGTGAGCTAA

Upstream 100 bases:

>100_bases
TTCTACTTGAATTCTCCTTTTCAAGATTTCTTCTCTACTGAAAAACTTTCTCATCTCATTACTACCGTATCTCCATTCTA
AAGGACATATACTATCCTCC

Downstream 100 bases:

>100_bases
ATGAATGTTAAGATAGCTGCATTAGCTAGTCATTCTGCACTTGACGTCTTCGATGGAGCTAAAGATGAAGGTTTTCAAAC
AATAGGGCTGTGTAAAAAGG

Product: 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase

Products: NA

Alternate protein names: 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MANCKVCSTFINLYCNLTTMIIATIGSHSALQILHGAKKEGFQTMVITDNKRENFYKNFSFIDNIYAYASLDEAVSIING
IKDYGILIPHGSLVEYLGKERVDKIETKIFGNKKIFEWEADQKKKMELLRKSNIKIPEIFERPEDVDRLVIVKLNGAKGG
KGYFLARNKSEVKEGIQKLIESKMIRDENEVIIQEYVVGVPMYFQFFYSDIINRTEIFGIDIRYETNIDGLRRLPFEYMK
ELKINPTFVVVGNIPAVARESLLPVALEYANNFVRTTKELVPPGMIGPFCLESIITDNSDIVVFEFSGRIVAGTNLYVNG
SPYSWLYWDEPMSIGRRIAREIRVANEKDKLSLVVS

Sequences:

>Translated_356_residues
MANCKVCSTFINLYCNLTTMIIATIGSHSALQILHGAKKEGFQTMVITDNKRENFYKNFSFIDNIYAYASLDEAVSIING
IKDYGILIPHGSLVEYLGKERVDKIETKIFGNKKIFEWEADQKKKMELLRKSNIKIPEIFERPEDVDRLVIVKLNGAKGG
KGYFLARNKSEVKEGIQKLIESKMIRDENEVIIQEYVVGVPMYFQFFYSDIINRTEIFGIDIRYETNIDGLRRLPFEYMK
ELKINPTFVVVGNIPAVARESLLPVALEYANNFVRTTKELVPPGMIGPFCLESIITDNSDIVVFEFSGRIVAGTNLYVNG
SPYSWLYWDEPMSIGRRIAREIRVANEKDKLSLVVS
>Mature_355_residues
ANCKVCSTFINLYCNLTTMIIATIGSHSALQILHGAKKEGFQTMVITDNKRENFYKNFSFIDNIYAYASLDEAVSIINGI
KDYGILIPHGSLVEYLGKERVDKIETKIFGNKKIFEWEADQKKKMELLRKSNIKIPEIFERPEDVDRLVIVKLNGAKGGK
GYFLARNKSEVKEGIQKLIESKMIRDENEVIIQEYVVGVPMYFQFFYSDIINRTEIFGIDIRYETNIDGLRRLPFEYMKE
LKINPTFVVVGNIPAVARESLLPVALEYANNFVRTTKELVPPGMIGPFCLESIITDNSDIVVFEFSGRIVAGTNLYVNGS
PYSWLYWDEPMSIGRRIAREIRVANEKDKLSLVVS

Specific function: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates [H]

COG id: COG1759

COG function: function code R; ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR009720
- InterPro:   IPR010672
- InterPro:   IPR013817 [H]

Pfam domain/function: PF06849 DUF1246; PF06973 DUF1297 [H]

EC number: NA

Molecular weight: Translated: 40696; Mature: 40565

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANCKVCSTFINLYCNLTTMIIATIGSHSALQILHGAKKEGFQTMVITDNKRENFYKNFS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHH
FIDNIYAYASLDEAVSIINGIKDYGILIPHGSLVEYLGKERVDKIETKIFGNKKIFEWEA
HHHHHHHHHHHHHHHHHHHCHHHCCEECCCCHHHHHHCHHHHHHHHHHHCCCCEEEEECC
DQKKKMELLRKSNIKIPEIFERPEDVDRLVIVKLNGAKGGKGYFLARNKSEVKEGIQKLI
CHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEEEEECCCCCCCEEEECCHHHHHHHHHHHH
ESKMIRDENEVIIQEYVVGVPMYFQFFYSDIINRTEIFGIDIRYETNIDGLRRLPFEYMK
HHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEEEEECCCCHHHCCCHHHHH
ELKINPTFVVVGNIPAVARESLLPVALEYANNFVRTTKELVPPGMIGPFCLESIITDNSD
HCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCC
IVVFEFSGRIVAGTNLYVNGSPYSWLYWDEPMSIGRRIAREIRVANEKDKLSLVVS
EEEEEECCEEEECCEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEC
>Mature Secondary Structure 
ANCKVCSTFINLYCNLTTMIIATIGSHSALQILHGAKKEGFQTMVITDNKRENFYKNFS
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHH
FIDNIYAYASLDEAVSIINGIKDYGILIPHGSLVEYLGKERVDKIETKIFGNKKIFEWEA
HHHHHHHHHHHHHHHHHHHCHHHCCEECCCCHHHHHHCHHHHHHHHHHHCCCCEEEEECC
DQKKKMELLRKSNIKIPEIFERPEDVDRLVIVKLNGAKGGKGYFLARNKSEVKEGIQKLI
CHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEEEEECCCCCCCEEEECCHHHHHHHHHHHH
ESKMIRDENEVIIQEYVVGVPMYFQFFYSDIINRTEIFGIDIRYETNIDGLRRLPFEYMK
HHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEEEEECCCCHHHCCCHHHHH
ELKINPTFVVVGNIPAVARESLLPVALEYANNFVRTTKELVPPGMIGPFCLESIITDNSD
HCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCC
IVVFEFSGRIVAGTNLYVNGSPYSWLYWDEPMSIGRRIAREIRVANEKDKLSLVVS
EEEEEECCEEEECCEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]