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The map label for this gene is hemC [H]

Identifier: 15897134

GI number: 15897134

Start: 155103

End: 155984

Strand: Direct

Name: hemC [H]

Synonym: SSO0183

Alternate gene names: 15897134

Gene position: 155103-155984 (Clockwise)

Preceding gene: 15897133

Following gene: 15897135

Centisome position: 5.18

GC content: 32.09

Gene sequence:

>882_bases
TTGAAAATACTAATAGCTGCAAGAGGAAGTAAACTAAGTAGAGTACAAGTAGATATGGTAGGTGAAAAATTAAGAAAAAT
TGGAATAGAATATGATGTAATAGATATAAAAACAAAAGCTGACTTGTTTTCTACTGAACCATTAAGTAAATTAGGTAAAG
GAGTTTTTGAAAAAGAAGTCAATGAGGCTGTATTGGAGGGAAAAGCCGATGTTGCAGTTCACAGCATGAAAGATATCTTA
TCAGAAATAAATCCTGAACTAGAAATATTTGCAGTAATAGAAAGAGATCCTCCATATGATATATTAATTGCAGAGAAAAA
TTTACATAAATTGGACCCAAATACTACAATAGGTACAAGTAGTATAAGGAGGAAAAACTTTATTAAATACATCAGACCAG
AAATAAATACTAAAGATATTAGAGGTAATGTGGACACTAGAATAAGAAAATATTTGTCTAAAGAGTATGATGGTTTAATA
TTAGCTGAGGCCTCAATAAAAAGGCTCAATATTAGTATAAGTTATCACAGGCTTAATGTCTACGATTTCACTCCAGAAGC
TAATCAAGGTATTATAGTAGTCTTAGGAAGAAAAAAAGATGAAAAGGTAAAAGAGGTATTTAAAGAAATTACTCATAAAG
ATACATTAGATGAGGCATTAGCTGAAAGAGCTACAATTAGTGTAGTAGGAGGAGGTTGTCATTCTCCTATTGGTGTGTTA
TTCAGAAAAGAAGGAAAAGAGTTCTATGGGATTGCAAGTTATAGTGATGGGAAGAAAAAAATTACCGTTTCCATTAGCAA
GGCGGGGGATCCGTATACTATAGGATCTGAATTGGGCTTGCTACTAAAAAAGGAGATGAAGAATGAGGGTATTATTCCTT
AG

Upstream 100 bases:

>100_bases
CGCCAAGTCAATATGAGACAATTTTTACTTCAGCTGCCCATAAAGATGATGTAATTGCTGACACTATAGATAAGCTTATG
AAAGTAATAGGCGAACTAAA

Downstream 100 bases:

>100_bases
GCCCGATAATGAAGATAATGAACTCAATGAAAAGCTTATGATACTTCGGAAAAACGGAATTGAAGTTCTAAACATTCCCA
TCTTTAAAATAAAATGCGTC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKILIAARGSKLSRVQVDMVGEKLRKIGIEYDVIDIKTKADLFSTEPLSKLGKGVFEKEVNEAVLEGKADVAVHSMKDIL
SEINPELEIFAVIERDPPYDILIAEKNLHKLDPNTTIGTSSIRRKNFIKYIRPEINTKDIRGNVDTRIRKYLSKEYDGLI
LAEASIKRLNISISYHRLNVYDFTPEANQGIIVVLGRKKDEKVKEVFKEITHKDTLDEALAERATISVVGGGCHSPIGVL
FRKEGKEFYGIASYSDGKKKITVSISKAGDPYTIGSELGLLLKKEMKNEGIIP

Sequences:

>Translated_293_residues
MKILIAARGSKLSRVQVDMVGEKLRKIGIEYDVIDIKTKADLFSTEPLSKLGKGVFEKEVNEAVLEGKADVAVHSMKDIL
SEINPELEIFAVIERDPPYDILIAEKNLHKLDPNTTIGTSSIRRKNFIKYIRPEINTKDIRGNVDTRIRKYLSKEYDGLI
LAEASIKRLNISISYHRLNVYDFTPEANQGIIVVLGRKKDEKVKEVFKEITHKDTLDEALAERATISVVGGGCHSPIGVL
FRKEGKEFYGIASYSDGKKKITVSISKAGDPYTIGSELGLLLKKEMKNEGIIP
>Mature_293_residues
MKILIAARGSKLSRVQVDMVGEKLRKIGIEYDVIDIKTKADLFSTEPLSKLGKGVFEKEVNEAVLEGKADVAVHSMKDIL
SEINPELEIFAVIERDPPYDILIAEKNLHKLDPNTTIGTSSIRRKNFIKYIRPEINTKDIRGNVDTRIRKYLSKEYDGLI
LAEASIKRLNISISYHRLNVYDFTPEANQGIIVVLGRKKDEKVKEVFKEITHKDTLDEALAERATISVVGGGCHSPIGVL
FRKEGKEFYGIASYSDGKKKITVSISKAGDPYTIGSELGLLLKKEMKNEGIIP

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=275, Percent_Identity=30.5454545454545, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI20149500, Length=275, Percent_Identity=30.5454545454545, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI48994974, Length=294, Percent_Identity=32.312925170068, Blast_Score=140, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319996, Length=253, Percent_Identity=30.0395256916996, Blast_Score=99, Evalue=8e-22,
Organism=Drosophila melanogaster, GI20130425, Length=259, Percent_Identity=29.7297297297297, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 32773; Mature: 32773

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIAARGSKLSRVQVDMVGEKLRKIGIEYDVIDIKTKADLFSTEPLSKLGKGVFEKEV
CEEEEEECCCCCEEEHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHCCHHHHHHH
NEAVLEGKADVAVHSMKDILSEINPELEIFAVIERDPPYDILIAEKNLHKLDPNTTIGTS
HHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCH
SIRRKNFIKYIRPEINTKDIRGNVDTRIRKYLSKEYDGLILAEASIKRLNISISYHRLNV
HHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHCCCCEEEEECCEEEEEEEEEEEEEEE
YDFTPEANQGIIVVLGRKKDEKVKEVFKEITHKDTLDEALAERATISVVGGGCHSPIGVL
EECCCCCCCCEEEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHEEEEEECCCCCCCHHHE
FRKEGKEFYGIASYSDGKKKITVSISKAGDPYTIGSELGLLLKKEMKNEGIIP
EEECCCEEEEEEEECCCCEEEEEEEECCCCCEEEHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKILIAARGSKLSRVQVDMVGEKLRKIGIEYDVIDIKTKADLFSTEPLSKLGKGVFEKEV
CEEEEEECCCCCEEEHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHCCHHHHHHH
NEAVLEGKADVAVHSMKDILSEINPELEIFAVIERDPPYDILIAEKNLHKLDPNTTIGTS
HHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCH
SIRRKNFIKYIRPEINTKDIRGNVDTRIRKYLSKEYDGLILAEASIKRLNISISYHRLNV
HHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHCCCCEEEEECCEEEEEEEEEEEEEEE
YDFTPEANQGIIVVLGRKKDEKVKEVFKEITHKDTLDEALAERATISVVGGGCHSPIGVL
EECCCCCCCCEEEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHEEEEEECCCCCCCHHHE
FRKEGKEFYGIASYSDGKKKITVSISKAGDPYTIGSELGLLLKKEMKNEGIIP
EEECCCEEEEEEEECCCCEEEEEEEECCCCCEEEHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA