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The map label for this gene is 15897135

Identifier: 15897135

GI number: 15897135

Start: 155965

End: 156678

Strand: Direct

Name: 15897135

Synonym: SSO0184

Alternate gene names: NA

Gene position: 155965-156678 (Clockwise)

Preceding gene: 15897134

Following gene: 15897136

Centisome position: 5.21

GC content: 31.37

Gene sequence:

>714_bases
ATGAGGGTATTATTCCTTAGGCCCGATAATGAAGATAATGAACTCAATGAAAAGCTTATGATACTTCGGAAAAACGGAAT
TGAAGTTCTAAACATTCCCATCTTTAAAATAAAATGCGTCTCATATTCGTTACCGACCTATGATTATGAGGCACTAGCAT
TTACAAGCAGAAATTCAGTCATTTGTTTCAAAGATCGCACCTTAATTAAAAACGTTCATAAGATATACGCTATCGGAGAA
GAAACTGCTGAGTTATTAATGAAAATGTATAATGTAAATCCGATAACTCCAGAGAGATTTACGAGTATAGAACTAGCTAA
AAGAATTTTGGAAGATAAGGTAAATAGTATACTTAGCATAAGGAGTAGAAAAGCTTCTGAAGATATGAGAAATATTCTTA
ATGGCAAAATTAAATATGATGAGATTTACGTATATGATTCAGAAATAATCAGAGATAATATAAACGAAATATCCAAAATT
CTAACCGAATGTGAAGTTGACGCCATAGCATTTACTAGTTCGTTGATGGCTAAGCTAATTGGTCCTTTTATTAGGGGTAA
GTGTAATATAATAATCTTTAGCATAGGTCCAATGACGACAGAAACTTTGAAACGAGTTAATAATAAGGTAAAAATAATAG
AAAGCAAGACACATTCTATTAAAGGCATTATAGAAACTATTTTAGTGGAGATGAAACGAAATGGACGAGATTAA

Upstream 100 bases:

>100_bases
AGTGATGGGAAGAAAAAAATTACCGTTTCCATTAGCAAGGCGGGGGATCCGTATACTATAGGATCTGAATTGGGCTTGCT
ACTAAAAAAGGAGATGAAGA

Downstream 100 bases:

>100_bases
AGATTTAACGCTTAAAGTTCTTAAAAAGATTGATAATACAGTAATTGATAGTAGTCTTCAGATTAAGTACTATCAAGGCT
TTAAAGATAGATTTGATGTA

Product: uroporphyrinogen III synthase, putative

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MRVLFLRPDNEDNELNEKLMILRKNGIEVLNIPIFKIKCVSYSLPTYDYEALAFTSRNSVICFKDRTLIKNVHKIYAIGE
ETAELLMKMYNVNPITPERFTSIELAKRILEDKVNSILSIRSRKASEDMRNILNGKIKYDEIYVYDSEIIRDNINEISKI
LTECEVDAIAFTSSLMAKLIGPFIRGKCNIIIFSIGPMTTETLKRVNNKVKIIESKTHSIKGIIETILVEMKRNGRD

Sequences:

>Translated_237_residues
MRVLFLRPDNEDNELNEKLMILRKNGIEVLNIPIFKIKCVSYSLPTYDYEALAFTSRNSVICFKDRTLIKNVHKIYAIGE
ETAELLMKMYNVNPITPERFTSIELAKRILEDKVNSILSIRSRKASEDMRNILNGKIKYDEIYVYDSEIIRDNINEISKI
LTECEVDAIAFTSSLMAKLIGPFIRGKCNIIIFSIGPMTTETLKRVNNKVKIIESKTHSIKGIIETILVEMKRNGRD
>Mature_237_residues
MRVLFLRPDNEDNELNEKLMILRKNGIEVLNIPIFKIKCVSYSLPTYDYEALAFTSRNSVICFKDRTLIKNVHKIYAIGE
ETAELLMKMYNVNPITPERFTSIELAKRILEDKVNSILSIRSRKASEDMRNILNGKIKYDEIYVYDSEIIRDNINEISKI
LTECEVDAIAFTSSLMAKLIGPFIRGKCNIIIFSIGPMTTETLKRVNNKVKIIESKTHSIKGIIETILVEMKRNGRD

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 27328; Mature: 27328

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLFLRPDNEDNELNEKLMILRKNGIEVLNIPIFKIKCVSYSLPTYDYEALAFTSRNSV
CEEEEECCCCCCCHHHHHEEEEECCCCEEEECCEEEEEEEEEECCCCCCCEEEEECCCCE
ICFKDRTLIKNVHKIYAIGEETAELLMKMYNVNPITPERFTSIELAKRILEDKVNSILSI
EEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RSRKASEDMRNILNGKIKYDEIYVYDSEIIRDNINEISKILTECEVDAIAFTSSLMAKLI
HHHHHHHHHHHHHCCCEEEEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GPFIRGKCNIIIFSIGPMTTETLKRVNNKVKIIESKTHSIKGIIETILVEMKRNGRD
HHHHCCCEEEEEEECCCCCHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRVLFLRPDNEDNELNEKLMILRKNGIEVLNIPIFKIKCVSYSLPTYDYEALAFTSRNSV
CEEEEECCCCCCCHHHHHEEEEECCCCEEEECCEEEEEEEEEECCCCCCCEEEEECCCCE
ICFKDRTLIKNVHKIYAIGEETAELLMKMYNVNPITPERFTSIELAKRILEDKVNSILSI
EEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RSRKASEDMRNILNGKIKYDEIYVYDSEIIRDNINEISKILTECEVDAIAFTSSLMAKLI
HHHHHHHHHHHHHCCCEEEEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GPFIRGKCNIIIFSIGPMTTETLKRVNNKVKIIESKTHSIKGIIETILVEMKRNGRD
HHHHCCCEEEEEEECCCCCHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]