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The map label for this gene is hemL [H]

Identifier: 15897133

GI number: 15897133

Start: 153826

End: 155106

Strand: Direct

Name: hemL [H]

Synonym: SSO0182

Alternate gene names: 15897133

Gene position: 153826-155106 (Clockwise)

Preceding gene: 15897132

Following gene: 15897134

Centisome position: 5.14

GC content: 37.0

Gene sequence:

>1281_bases
ATGGATAAAGGACGGTGTACCATTTTGAATAGCGAGGAACTATGGGCTCAAGCTAAGCAATTATTTGCTGGAGGAGTAAA
TAGTCCAGTTAGAGCAGCAGTAAAGCCATTCCCCTTTTATGTAGAAAGGGGAAAAGGAGCTTATATTTACACGGTCGATG
GTAAAAAGTTCATTGATTATGTATTAGGTTATGGGCCTCTAATTTTAGGTCACTCCCCAGAATCCGTAAAGAGAAGAATA
GTTGAGCAATTAGAAAGAGGTTGGCTTTTCGGAACTCCTAGTGAATTAGAAATAGAATTAGCTAGAAAAATAAGGTCACA
TATACCATCAGCGCAGAAAATAAGATTTGTAAATAGTGGAACTGAGGCTACAATGGCAGCTATAAGATTAGCTAGAGGCT
ATACAAAAAGAAGCAAAATATTGAAGTTTAGCGGAAATTACCATGGAGCTCACGATTACGCACTTGTGGAAGCAGGAAGC
GCTGCTACAGAATATAACGTTGCAACTTCTGATGGTGTACCAATGGAAATAATGAAGACCGTAGAAATATGCGAATTTAA
CGATCTTGATTGCGTAGATAAAAAATTGAGAAACGAGGATATAGCTACAGTAATCTTAGAACCCGTTATGGGCAATGCTG
GGGTAATCTTACCTGAAAAGGACTTTTTATTTGGATTAAGAGAACTCACAAAAACCTACAACTCTCTATTGATCTTCGAT
GAAGTTATAACTGGTTTTAGAATCAGCATAGGTGGGGCACAATCTTACTATCAAATTTATCCAGACATAACAACACTAGG
TAAAATAATAGGTGGTGGTTTCCCTATCGGTGCAGTAGCAGGAAAAGCAGAGATTATTGATAACTTTACTCCAGCTGGTA
AAGTATTTAATGCTGGCACATTTAACGCTAACCCAATATCTATGATTGCTGGAATTGCTACAATAGAAGAACTTGAAAAA
GAATACCCATATATTATCGCAAACCAAGCCGCCAAGACCCTAGTGGAGGAATTAGAAAGGTTGCTAAAAACAAAACATAC
AATAAACCATGTTGGGAGTATGTTTCAGATATTCTTCGGAATAGATGAGGTTAGAAATTACTCAGATGCTAAAAGAGCTG
ATAAAGAGTACTACATAAAGTTTCATGAAAGACTGTTAAAGGAGGGAGTTTTCATTCCGCCAAGTCAATATGAGACAATT
TTTACTTCAGCTGCCCATAAAGATGATGTAATTGCTGACACTATAGATAAGCTTATGAAAGTAATAGGCGAACTAAATTG
A

Upstream 100 bases:

>100_bases
GATGGATAGACGAAAAGACTGCAGTCTTAGAAATTACTACTGCAATAAAAAGGGCAGGGGCTGATTTAATCATTACTTAT
TATGCTAACGATATTGCTAG

Downstream 100 bases:

>100_bases
AAATACTAATAGCTGCAAGAGGAAGTAAACTAAGTAGAGTACAAGTAGATATGGTAGGTGAAAAATTAAGAAAAATTGGA
ATAGAATATGATGTAATAGA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MDKGRCTILNSEELWAQAKQLFAGGVNSPVRAAVKPFPFYVERGKGAYIYTVDGKKFIDYVLGYGPLILGHSPESVKRRI
VEQLERGWLFGTPSELEIELARKIRSHIPSAQKIRFVNSGTEATMAAIRLARGYTKRSKILKFSGNYHGAHDYALVEAGS
AATEYNVATSDGVPMEIMKTVEICEFNDLDCVDKKLRNEDIATVILEPVMGNAGVILPEKDFLFGLRELTKTYNSLLIFD
EVITGFRISIGGAQSYYQIYPDITTLGKIIGGGFPIGAVAGKAEIIDNFTPAGKVFNAGTFNANPISMIAGIATIEELEK
EYPYIIANQAAKTLVEELERLLKTKHTINHVGSMFQIFFGIDEVRNYSDAKRADKEYYIKFHERLLKEGVFIPPSQYETI
FTSAAHKDDVIADTIDKLMKVIGELN

Sequences:

>Translated_426_residues
MDKGRCTILNSEELWAQAKQLFAGGVNSPVRAAVKPFPFYVERGKGAYIYTVDGKKFIDYVLGYGPLILGHSPESVKRRI
VEQLERGWLFGTPSELEIELARKIRSHIPSAQKIRFVNSGTEATMAAIRLARGYTKRSKILKFSGNYHGAHDYALVEAGS
AATEYNVATSDGVPMEIMKTVEICEFNDLDCVDKKLRNEDIATVILEPVMGNAGVILPEKDFLFGLRELTKTYNSLLIFD
EVITGFRISIGGAQSYYQIYPDITTLGKIIGGGFPIGAVAGKAEIIDNFTPAGKVFNAGTFNANPISMIAGIATIEELEK
EYPYIIANQAAKTLVEELERLLKTKHTINHVGSMFQIFFGIDEVRNYSDAKRADKEYYIKFHERLLKEGVFIPPSQYETI
FTSAAHKDDVIADTIDKLMKVIGELN
>Mature_426_residues
MDKGRCTILNSEELWAQAKQLFAGGVNSPVRAAVKPFPFYVERGKGAYIYTVDGKKFIDYVLGYGPLILGHSPESVKRRI
VEQLERGWLFGTPSELEIELARKIRSHIPSAQKIRFVNSGTEATMAAIRLARGYTKRSKILKFSGNYHGAHDYALVEAGS
AATEYNVATSDGVPMEIMKTVEICEFNDLDCVDKKLRNEDIATVILEPVMGNAGVILPEKDFLFGLRELTKTYNSLLIFD
EVITGFRISIGGAQSYYQIYPDITTLGKIIGGGFPIGAVAGKAEIIDNFTPAGKVFNAGTFNANPISMIAGIATIEELEK
EYPYIIANQAAKTLVEELERLLKTKHTINHVGSMFQIFFGIDEVRNYSDAKRADKEYYIKFHERLLKEGVFIPPSQYETI
FTSAAHKDDVIADTIDKLMKVIGELN

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=322, Percent_Identity=29.8136645962733, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI13994255, Length=405, Percent_Identity=25.9259259259259, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI284507298, Length=235, Percent_Identity=31.9148936170213, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI37574042, Length=368, Percent_Identity=26.0869565217391, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI226442705, Length=368, Percent_Identity=25.5434782608696, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI226442709, Length=337, Percent_Identity=26.7062314540059, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1786349, Length=423, Percent_Identity=43.4988179669031, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1789016, Length=353, Percent_Identity=29.4617563739377, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1788044, Length=335, Percent_Identity=30.1492537313433, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789759, Length=291, Percent_Identity=32.9896907216495, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787560, Length=381, Percent_Identity=26.509186351706, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI145693181, Length=322, Percent_Identity=30.7453416149068, Blast_Score=111, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=303, Percent_Identity=29.3729372937294, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI71992977, Length=361, Percent_Identity=26.8698060941828, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI32564660, Length=323, Percent_Identity=25.6965944272446, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25144274, Length=193, Percent_Identity=32.6424870466321, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323470, Length=344, Percent_Identity=27.0348837209302, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6324432, Length=295, Percent_Identity=27.7966101694915, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357415, Length=299, Percent_Identity=26.7558528428094, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21356575, Length=358, Percent_Identity=26.8156424581006, Blast_Score=98, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 47365; Mature: 47365

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKGRCTILNSEELWAQAKQLFAGGVNSPVRAAVKPFPFYVERGKGAYIYTVDGKKFIDY
CCCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEECCCCEEEEEECCHHHHHH
VLGYGPLILGHSPESVKRRIVEQLERGWLFGTPSELEIELARKIRSHIPSAQKIRFVNSG
HHCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHEEEEECCC
TEATMAAIRLARGYTKRSKILKFSGNYHGAHDYALVEAGSAATEYNVATSDGVPMEIMKT
CHHHHHHHHHHHCCHHHCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHH
VEICEFNDLDCVDKKLRNEDIATVILEPVMGNAGVILPEKDFLFGLRELTKTYNSLLIFD
HHHHCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
EVITGFRISIGGAQSYYQIYPDITTLGKIIGGGFPIGAVAGKAEIIDNFTPAGKVFNAGT
HHHCCEEEEECCCCCCEEECCCHHHHHHHHCCCCCHHHHCCHHHHHHCCCCCCCEEECCC
FNANPISMIAGIATIEELEKEYPYIIANQAAKTLVEELERLLKTKHTINHVGSMFQIFFG
CCCCHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDEVRNYSDAKRADKEYYIKFHERLLKEGVFIPPSQYETIFTSAAHKDDVIADTIDKLMK
HHHHHCCHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHH
VIGELN
HHHCCC
>Mature Secondary Structure
MDKGRCTILNSEELWAQAKQLFAGGVNSPVRAAVKPFPFYVERGKGAYIYTVDGKKFIDY
CCCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEECCCCEEEEEECCHHHHHH
VLGYGPLILGHSPESVKRRIVEQLERGWLFGTPSELEIELARKIRSHIPSAQKIRFVNSG
HHCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHEEEEECCC
TEATMAAIRLARGYTKRSKILKFSGNYHGAHDYALVEAGSAATEYNVATSDGVPMEIMKT
CHHHHHHHHHHHCCHHHCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHH
VEICEFNDLDCVDKKLRNEDIATVILEPVMGNAGVILPEKDFLFGLRELTKTYNSLLIFD
HHHHCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
EVITGFRISIGGAQSYYQIYPDITTLGKIIGGGFPIGAVAGKAEIIDNFTPAGKVFNAGT
HHHCCEEEEECCCCCCEEECCCHHHHHHHHCCCCCHHHHCCHHHHHHCCCCCCCEEECCC
FNANPISMIAGIATIEELEKEYPYIIANQAAKTLVEELERLLKTKHTINHVGSMFQIFFG
CCCCHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDEVRNYSDAKRADKEYYIKFHERLLKEGVFIPPSQYETIFTSAAHKDDVIADTIDKLMK
HHHHHCCHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHH
VIGELN
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA