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The map label for this gene is rnz

Identifier: 15927085

GI number: 15927085

Start: 1541418

End: 1542338

Strand: Reverse

Name: rnz

Synonym: SA1335

Alternate gene names: 15927085

Gene position: 1542338-1541418 (Counterclockwise)

Preceding gene: 15927088

Following gene: 15927083

Centisome position: 54.79

GC content: 33.44

Gene sequence:

>921_bases
ATGGAAGTTACATTTTTTGGAACGAGTGCAGGTTTGCCTACAAAAGAGAGAAATACACAAGCAATCGCCTTAAATTTAGA
ACCATATTCCAATTCCATATGGCTTTTCGACGTTGGTGAAGGTACACAGCACCAAATTTTACATCATGCAATCAAATTAG
GAAAAGTGACACATATATTTATTACTCATATGCATGGCGATCATATTTTTGGTTTGCCAGGATTACTTTCTAGTCGTTCT
TTTCAGGGCGGTGAACAGAAGCCGCTTACATTGGTTGGACCAAAAGGAATTAAAGCATATGTGGAAATGTCTATGAATTT
ATCAGAGTCACATTTAAACTATCCAATTACATATATTGAAATCGATGATCATCTGACATATCATCATGATGGTTTTACTG
TAGAGGCGCATTTACTTAATCATGGTATTCCATCATATGGATATAGAGTAATGGCACCTGAAACTACAGGTACAATCAAT
GTTGAAGCGTTAAAAAACATTGGTCTTGAACCAGGTCCTAAATATCAAGAAGTAAAATCTCATGATACATTTGAACATAA
TGGTCAAGTTTATCAATCAAAAGATTTTAGAGGTGAGTCCAAACAGGGTCCAGTTGTAGCAATTTTTGGTGATACAAAAC
CATGTTCTAATGAACGTGTGATTTCTAGAGATGCTGATGTGATGGTACATGAAGCGACCTATATAGATGGTGAAAAGCAT
TTAGCCAACAATTATCATCATAGCCATATTGAAGACGTATTTGCATTGATAAAAGAAGCCAATGTTAAACGTACGTTGAT
TACACATTTGAGCAATCGCTATAATACAGAAGATATAAATGAAATTTATCAAATATTGATACAAAATGAAGATACACCTA
ATTTTAATTTTGTAAAAGATTTTGATAGTTTTAAAGTCTAA

Upstream 100 bases:

>100_bases
GCAAAGACGAATTTTTAACAGATTTTGATTCAAGTATAAATTAAAACTAAATTGATACAAATTTTATGATAAAATGAATT
GAAGAAAAGGAGGGGCATAT

Downstream 100 bases:

>100_bases
TGACAAAGTAATAAACAATGCTTGCCAAATAGTAATAATTTATAAAAATAACCCGTCCAACTATGTATGTGATGATGCAT
ACATGTGTTGGCGGGTTTGT

Product: hypothetical protein

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MEVTFFGTSAGLPTKERNTQAIALNLEPYSNSIWLFDVGEGTQHQILHHAIKLGKVTHIFITHMHGDHIFGLPGLLSSRS
FQGGEQKPLTLVGPKGIKAYVEMSMNLSESHLNYPITYIEIDDHLTYHHDGFTVEAHLLNHGIPSYGYRVMAPETTGTIN
VEALKNIGLEPGPKYQEVKSHDTFEHNGQVYQSKDFRGESKQGPVVAIFGDTKPCSNERVISRDADVMVHEATYIDGEKH
LANNYHHSHIEDVFALIKEANVKRTLITHLSNRYNTEDINEIYQILIQNEDTPNFNFVKDFDSFKV

Sequences:

>Translated_306_residues
MEVTFFGTSAGLPTKERNTQAIALNLEPYSNSIWLFDVGEGTQHQILHHAIKLGKVTHIFITHMHGDHIFGLPGLLSSRS
FQGGEQKPLTLVGPKGIKAYVEMSMNLSESHLNYPITYIEIDDHLTYHHDGFTVEAHLLNHGIPSYGYRVMAPETTGTIN
VEALKNIGLEPGPKYQEVKSHDTFEHNGQVYQSKDFRGESKQGPVVAIFGDTKPCSNERVISRDADVMVHEATYIDGEKH
LANNYHHSHIEDVFALIKEANVKRTLITHLSNRYNTEDINEIYQILIQNEDTPNFNFVKDFDSFKV
>Mature_306_residues
MEVTFFGTSAGLPTKERNTQAIALNLEPYSNSIWLFDVGEGTQHQILHHAIKLGKVTHIFITHMHGDHIFGLPGLLSSRS
FQGGEQKPLTLVGPKGIKAYVEMSMNLSESHLNYPITYIEIDDHLTYHHDGFTVEAHLLNHGIPSYGYRVMAPETTGTIN
VEALKNIGLEPGPKYQEVKSHDTFEHNGQVYQSKDFRGESKQGPVVAIFGDTKPCSNERVISRDADVMVHEATYIDGEKH
LANNYHHSHIEDVFALIKEANVKRTLITHLSNRYNTEDINEIYQILIQNEDTPNFNFVKDFDSFKV

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=320, Percent_Identity=31.25, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI260166619, Length=283, Percent_Identity=25.7950530035336, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI260166622, Length=283, Percent_Identity=25.7950530035336, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI145553959, Length=283, Percent_Identity=25.7950530035336, Blast_Score=85, Evalue=9e-17,
Organism=Escherichia coli, GI87082078, Length=308, Percent_Identity=41.5584415584416, Blast_Score=239, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_STAA1 (A7X2M2)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442082.1
- ProteinModelPortal:   A7X2M2
- SMR:   A7X2M2
- STRING:   A7X2M2
- EnsemblBacteria:   EBSTAT00000004555
- GeneID:   5559639
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1492
- eggNOG:   COG1234
- GeneTree:   EBGT00050000025134
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- ProtClustDB:   CLSK885396
- BioCyc:   SAUR418127:SAHV_1492-MONOMER
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 34583; Mature: 34583

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVTFFGTSAGLPTKERNTQAIALNLEPYSNSIWLFDVGEGTQHQILHHAIKLGKVTHIF
CEEEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCEEEEE
ITHMHGDHIFGLPGLLSSRSFQGGEQKPLTLVGPKGIKAYVEMSMNLSESHLNYPITYIE
EEEECCCEEECCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCCHHHCCCCEEEEE
IDDHLTYHHDGFTVEAHLLNHGIPSYGYRVMAPETTGTINVEALKNIGLEPGPKYQEVKS
ECCCEEEECCCEEEEEEEHHCCCCCCCEEEECCCCCCEEEHHHHHHCCCCCCCCHHHHCC
HDTFEHNGQVYQSKDFRGESKQGPVVAIFGDTKPCSNERVISRDADVMVHEATYIDGEKH
CCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCEEEEEEEEECCHHH
LANNYHHSHIEDVFALIKEANVKRTLITHLSNRYNTEDINEIYQILIQNEDTPNFNFVKD
HHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEC
FDSFKV
CCCCCC
>Mature Secondary Structure
MEVTFFGTSAGLPTKERNTQAIALNLEPYSNSIWLFDVGEGTQHQILHHAIKLGKVTHIF
CEEEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCEEEEE
ITHMHGDHIFGLPGLLSSRSFQGGEQKPLTLVGPKGIKAYVEMSMNLSESHLNYPITYIE
EEEECCCEEECCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCCHHHCCCCEEEEE
IDDHLTYHHDGFTVEAHLLNHGIPSYGYRVMAPETTGTINVEALKNIGLEPGPKYQEVKS
ECCCEEEECCCEEEEEEEHHCCCCCCCEEEECCCCCCEEEHHHHHHCCCCCCCCHHHHCC
HDTFEHNGQVYQSKDFRGESKQGPVVAIFGDTKPCSNERVISRDADVMVHEATYIDGEKH
CCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCEEEEEEEEECCHHH
LANNYHHSHIEDVFALIKEANVKRTLITHLSNRYNTEDINEIYQILIQNEDTPNFNFVKD
HHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEC
FDSFKV
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA