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The map label for this gene is malA

Identifier: 15927088

GI number: 15927088

Start: 1545313

End: 1546962

Strand: Reverse

Name: malA

Synonym: SA1338

Alternate gene names: 15927088

Gene position: 1546962-1545313 (Counterclockwise)

Preceding gene: 15927089

Following gene: 15927085

Centisome position: 54.96

GC content: 34.3

Gene sequence:

>1650_bases
ATGAATAAGCAATGGTGGAAAGAAGCAGTAGCATATCAAGTATATCCAAGAAGTTTTAATGATAGTAATCACGATGGTAT
TGGGGATTTACCTGGAATGATTGATAAATTGGACTACTTAAAAGATTTAGGTATCGATGTCATTTGGCTCAGTCCAATGT
TTAAATCACCTAATGATGACAATGGTTATGATATTAGTGACTATCAAGAAATTATGGATGAATTTGGAACGATGGAAGAC
TTTGATTGTTTATTAAAAGGTATTCATGATAGAGGCATGAAGCTTATTTTAGATTTAGTTGTAAATCATACATCTGATGA
ACATCCTTGGTTTATAGAATCTAAATCTAGTAAAGACAATCCCAAACGTGATTGGTATATTTGGCAAGATCCAAAGCAAG
ATGGCTCTGAACCTAACAACTGGGAAAGTATCTTTAATGGATCTACATGGGAATATGATGCTAATACTGAGCAATATTAT
TTCCATTTATTCAGTAAAAAACAACCTGATTTGAATTGGGGTAATCCAGAAGTTAGAGATGCTGTATTTGAAATGATGAA
CTGGTGGTTTGATAAAGGCATTGATGGATTTAGAGTAGATGCAATTACGCATATTAAGAAGACGTTTGAAGCGGGTGACT
TACCTGTACCTGAGGGTAAAACATATGCCCCAGCATTTGATGTAGATATGAATCAGCCAGGTATACAAACTTGGTTACAA
GAGATGAAAGATCGCTCATTAAGTAAGTATGACATTATGACTGTCGGTGAAGCGAATGGTGTAAGCCCTGATGATGCTGA
TGACTGGGTCGGGGAAGAAAATGGTAAATTTAATATGATATTCCAATTTGAACATTTGGGACTGTGGAATAGTGGTGATT
CTCACTTTGATGTAAATTCGTATAAATCTGTATTAAATAGATGGCAAAAACAACTTGAAAATAAAGGTTGGAATGCGTTG
TTTATTGAAAATCACGACCAACCACGACGTGTATCGACGTGGGGTGACGATGACAAGTATTGGTATGAATCAGCAACAAG
TCATGCAGCTGTTTATTTCTTGCAACAAGGTACGCCATTCATTTATCAAGGTCAAGAAATTGGTATGACGAATTATCCAT
TTGAAAGTATTGAAACGTTTAACGATGTTGCTGTAAAAAATGACTATCAAATAGTGAAAGCTCAAGGTGGAGATGTAGAC
GCTTTACTTGCGAAATATAAAGATGAGAACCGAGATAATTCTCGCACACCAATGCAATGGGATGATACGTTAAATGGAGG
ATTTACAAATGGTGAACCGTGGTTCCCAGTGAATCTGAATTATAAAACTATCAATGTTGCACAACAATTAGAAGATGAGC
ATTCAGTATTACAATTTTATAAAGATTTAATTCAATTAAGAAAGTCTAATGATGTATACGTATATGGTCAATTTGATTTA
GTAGATGCTGAAAATTCACAAGTTTTTGCGTACACGAGAACATTAAATGAAAAGCAAGTTCTTATTGTAGGTAATCTTAC
TAACCACGAAGCAGAATTAACTGTACCATTTGATTTAAGCCATGGAGAAGTAAAGCTATTTAATTATGATGCCAAAGTTA
ATTTAAAACAGTTACGTCCATATGAAGCATGTGTTATCGAACTAAATTAA

Upstream 100 bases:

>100_bases
TATATTGAAAAACAAAGCACAGGATGTTATTGAACTCGTCATTATAGATACAGAATTAAAAATAAGAAAATCAACACAGC
GATAGCAAAGGAGTTTTAAA

Downstream 100 bases:

>100_bases
CATATTAATATGCCCCCTAATAGAATCTAAGGCCATTTGTAGACCTATAGATATATTAGGGGGCTTCTTTGTTTTTAATT
TTTAATCTTCGTCATAAGGA

Product: alpha-D-1,4-glucosidase

Products: NA

Alternate protein names: Oligosaccharide alpha-1,6-glucosidase 3; Sucrase-isomaltase 3; Isomaltase 3 [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MNKQWWKEAVAYQVYPRSFNDSNHDGIGDLPGMIDKLDYLKDLGIDVIWLSPMFKSPNDDNGYDISDYQEIMDEFGTMED
FDCLLKGIHDRGMKLILDLVVNHTSDEHPWFIESKSSKDNPKRDWYIWQDPKQDGSEPNNWESIFNGSTWEYDANTEQYY
FHLFSKKQPDLNWGNPEVRDAVFEMMNWWFDKGIDGFRVDAITHIKKTFEAGDLPVPEGKTYAPAFDVDMNQPGIQTWLQ
EMKDRSLSKYDIMTVGEANGVSPDDADDWVGEENGKFNMIFQFEHLGLWNSGDSHFDVNSYKSVLNRWQKQLENKGWNAL
FIENHDQPRRVSTWGDDDKYWYESATSHAAVYFLQQGTPFIYQGQEIGMTNYPFESIETFNDVAVKNDYQIVKAQGGDVD
ALLAKYKDENRDNSRTPMQWDDTLNGGFTNGEPWFPVNLNYKTINVAQQLEDEHSVLQFYKDLIQLRKSNDVYVYGQFDL
VDAENSQVFAYTRTLNEKQVLIVGNLTNHEAELTVPFDLSHGEVKLFNYDAKVNLKQLRPYEACVIELN

Sequences:

>Translated_549_residues
MNKQWWKEAVAYQVYPRSFNDSNHDGIGDLPGMIDKLDYLKDLGIDVIWLSPMFKSPNDDNGYDISDYQEIMDEFGTMED
FDCLLKGIHDRGMKLILDLVVNHTSDEHPWFIESKSSKDNPKRDWYIWQDPKQDGSEPNNWESIFNGSTWEYDANTEQYY
FHLFSKKQPDLNWGNPEVRDAVFEMMNWWFDKGIDGFRVDAITHIKKTFEAGDLPVPEGKTYAPAFDVDMNQPGIQTWLQ
EMKDRSLSKYDIMTVGEANGVSPDDADDWVGEENGKFNMIFQFEHLGLWNSGDSHFDVNSYKSVLNRWQKQLENKGWNAL
FIENHDQPRRVSTWGDDDKYWYESATSHAAVYFLQQGTPFIYQGQEIGMTNYPFESIETFNDVAVKNDYQIVKAQGGDVD
ALLAKYKDENRDNSRTPMQWDDTLNGGFTNGEPWFPVNLNYKTINVAQQLEDEHSVLQFYKDLIQLRKSNDVYVYGQFDL
VDAENSQVFAYTRTLNEKQVLIVGNLTNHEAELTVPFDLSHGEVKLFNYDAKVNLKQLRPYEACVIELN
>Mature_549_residues
MNKQWWKEAVAYQVYPRSFNDSNHDGIGDLPGMIDKLDYLKDLGIDVIWLSPMFKSPNDDNGYDISDYQEIMDEFGTMED
FDCLLKGIHDRGMKLILDLVVNHTSDEHPWFIESKSSKDNPKRDWYIWQDPKQDGSEPNNWESIFNGSTWEYDANTEQYY
FHLFSKKQPDLNWGNPEVRDAVFEMMNWWFDKGIDGFRVDAITHIKKTFEAGDLPVPEGKTYAPAFDVDMNQPGIQTWLQ
EMKDRSLSKYDIMTVGEANGVSPDDADDWVGEENGKFNMIFQFEHLGLWNSGDSHFDVNSYKSVLNRWQKQLENKGWNAL
FIENHDQPRRVSTWGDDDKYWYESATSHAAVYFLQQGTPFIYQGQEIGMTNYPFESIETFNDVAVKNDYQIVKAQGGDVD
ALLAKYKDENRDNSRTPMQWDDTLNGGFTNGEPWFPVNLNYKTINVAQQLEDEHSVLQFYKDLIQLRKSNDVYVYGQFDL
VDAENSQVFAYTRTLNEKQVLIVGNLTNHEAELTVPFDLSHGEVKLFNYDAKVNLKQLRPYEACVIELN

Specific function: Unknown

COG id: COG0366

COG function: function code G; Glycosidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 13 family [H]

Homologues:

Organism=Homo sapiens, GI187423904, Length=532, Percent_Identity=32.7067669172932, Blast_Score=257, Evalue=2e-68,
Organism=Escherichia coli, GI1790687, Length=554, Percent_Identity=38.4476534296029, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1786604, Length=132, Percent_Identity=34.8484848484849, Blast_Score=76, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI32565753, Length=203, Percent_Identity=32.512315270936, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25147709, Length=207, Percent_Identity=29.4685990338164, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324416, Length=575, Percent_Identity=36.695652173913, Blast_Score=378, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6321726, Length=575, Percent_Identity=36.3478260869565, Blast_Score=378, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6322241, Length=575, Percent_Identity=36.5217391304348, Blast_Score=375, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6322021, Length=575, Percent_Identity=36.5217391304348, Blast_Score=375, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6322245, Length=570, Percent_Identity=36.6666666666667, Blast_Score=372, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319776, Length=574, Percent_Identity=38.5017421602787, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6321731, Length=574, Percent_Identity=38.3275261324042, Blast_Score=362, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24583745, Length=579, Percent_Identity=34.8877374784111, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24583747, Length=526, Percent_Identity=35.171102661597, Blast_Score=282, Evalue=4e-76,
Organism=Drosophila melanogaster, GI24583749, Length=526, Percent_Identity=35.171102661597, Blast_Score=282, Evalue=4e-76,
Organism=Drosophila melanogaster, GI24586599, Length=531, Percent_Identity=32.5800376647834, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI221330053, Length=585, Percent_Identity=30.4273504273504, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24586593, Length=522, Percent_Identity=33.9080459770115, Blast_Score=262, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24586597, Length=491, Percent_Identity=32.7902240325866, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24586591, Length=491, Percent_Identity=34.4195519348269, Blast_Score=248, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24586589, Length=514, Percent_Identity=33.6575875486381, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24586587, Length=578, Percent_Identity=30.7958477508651, Blast_Score=241, Evalue=8e-64,
Organism=Drosophila melanogaster, GI45549022, Length=546, Percent_Identity=32.0512820512821, Blast_Score=237, Evalue=2e-62,
Organism=Drosophila melanogaster, GI281360393, Length=468, Percent_Identity=31.4102564102564, Blast_Score=189, Evalue=5e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013780
- InterPro:   IPR006047
- InterPro:   IPR006589
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00128 Alpha-amylase [H]

EC number: =3.2.1.10 [H]

Molecular weight: Translated: 63880; Mature: 63880

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQWWKEAVAYQVYPRSFNDSNHDGIGDLPGMIDKLDYLKDLGIDVIWLSPMFKSPNDD
CCHHHHHHHHEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCC
NGYDISDYQEIMDEFGTMEDFDCLLKGIHDRGMKLILDLVVNHTSDEHPWFIESKSSKDN
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
PKRDWYIWQDPKQDGSEPNNWESIFNGSTWEYDANTEQYYFHLFSKKQPDLNWGNPEVRD
CCCCEEEEECCCCCCCCCCCHHHHCCCCCEEECCCCCEEEEEEECCCCCCCCCCCHHHHH
AVFEMMNWWFDKGIDGFRVDAITHIKKTFEAGDLPVPEGKTYAPAFDVDMNQPGIQTWLQ
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCCCCCCEECCEECCCCCCCHHHHHHH
EMKDRSLSKYDIMTVGEANGVSPDDADDWVGEENGKFNMIFQFEHLGLWNSGDSHFDVNS
HHHHCCCCCEEEEEECCCCCCCCCCCHHCCCCCCCCEEEEEEEEECCCCCCCCCCEEHHH
YKSVLNRWQKQLENKGWNALFIENHDQPRRVSTWGDDDKYWYESATSHAAVYFLQQGTPF
HHHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCCCCCCHHHHCCCCCEEEEEEECCCCE
IYQGQEIGMTNYPFESIETFNDVAVKNDYQIVKAQGGDVDALLAKYKDENRDNSRTPMQW
EEECCCCCCCCCCHHHHHHHHHEEECCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCC
DDTLNGGFTNGEPWFPVNLNYKTINVAQQLEDEHSVLQFYKDLIQLRKSNDVYVYGQFDL
CCCCCCCCCCCCCEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEE
VDAENSQVFAYTRTLNEKQVLIVGNLTNHEAELTVPFDLSHGEVKLFNYDAKVNLKQLRP
EECCCCEEEEEEECCCCCEEEEEECCCCCCEEEEEEEECCCCEEEEEECCCEECHHHCCC
YEACVIELN
EEEEEEEEC
>Mature Secondary Structure
MNKQWWKEAVAYQVYPRSFNDSNHDGIGDLPGMIDKLDYLKDLGIDVIWLSPMFKSPNDD
CCHHHHHHHHEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCC
NGYDISDYQEIMDEFGTMEDFDCLLKGIHDRGMKLILDLVVNHTSDEHPWFIESKSSKDN
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
PKRDWYIWQDPKQDGSEPNNWESIFNGSTWEYDANTEQYYFHLFSKKQPDLNWGNPEVRD
CCCCEEEEECCCCCCCCCCCHHHHCCCCCEEECCCCCEEEEEEECCCCCCCCCCCHHHHH
AVFEMMNWWFDKGIDGFRVDAITHIKKTFEAGDLPVPEGKTYAPAFDVDMNQPGIQTWLQ
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCCCCCCEECCEECCCCCCCHHHHHHH
EMKDRSLSKYDIMTVGEANGVSPDDADDWVGEENGKFNMIFQFEHLGLWNSGDSHFDVNS
HHHHCCCCCEEEEEECCCCCCCCCCCHHCCCCCCCCEEEEEEEEECCCCCCCCCCEEHHH
YKSVLNRWQKQLENKGWNALFIENHDQPRRVSTWGDDDKYWYESATSHAAVYFLQQGTPF
HHHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCCCCCCHHHHCCCCCEEEEEEECCCCE
IYQGQEIGMTNYPFESIETFNDVAVKNDYQIVKAQGGDVDALLAKYKDENRDNSRTPMQW
EEECCCCCCCCCCHHHHHHHHHEEECCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCC
DDTLNGGFTNGEPWFPVNLNYKTINVAQQLEDEHSVLQFYKDLIQLRKSNDVYVYGQFDL
CCCCCCCCCCCCCEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEE
VDAENSQVFAYTRTLNEKQVLIVGNLTNHEAELTVPFDLSHGEVKLFNYDAKVNLKQLRP
EECCCCEEEEEEECCCCCEEEEEECCCCCCEEEEEEEECCCCEEEEEECCCEECHHHCCC
YEACVIELN
EEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377 [H]