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The map label for this gene is hisA

Identifier: 16127966

GI number: 16127966

Start: 3991221

End: 3991946

Strand: Direct

Name: hisA

Synonym: CC_3736

Alternate gene names: 16127966

Gene position: 3991221-3991946 (Clockwise)

Preceding gene: 16127965

Following gene: 16127967

Centisome position: 99.36

GC content: 68.6

Gene sequence:

>726_bases
ATGATCCTCTATCCCGCCATCGACCTGAAGGACGGCCAGTGCGTGCGCCTGCTGCATGGCGACATGGACAAGGCCACGGT
CTTCAACACCTCGCCCGCCGACCAGGCCCAGCGCTTCGTCCAGGACGGCTTCTCGTGGCTGCACGTCGTTGACCTGAACG
GCGCCATCGAGGGCAAGTCGGTCAATACGGCCGCTGTCGAACAGATCCTGGAGTCGATCTCGATCCCGGTGCAGCTGGGC
GGCGGCATCCGCACCCTGGAAGGCGTCGAAGCCTGGATCGAGGCGGGCGTGTCGCGCGTGATCCTCGGCACCGTGGCCGT
GCACGATCCCGAACTGGTCAAGAAGGCCGCGCGCCTGTGGCCCGAGCAGATCGCCGTGGCGGTCGACGTGCGCGACGGCA
AGGTCGCGGTCGACGGCTGGACAGGCCTGTCGGACCTGTCGGCGATCGACCTTTCGCGCCGCTTCGAGGACGCCGGCGTC
GCAGCCCTCATTATCACCGACATCAGCCGCGACGGCGCCCTGACGGGCGTCAATGTCGAAGGCGTGGGCGAGCTGGCCGA
CGCCGTCTCGATCCCCGTCATCGCCTCGGGCGGTGTGGCCGCCGTGGCCGATATCGAGCGCCTGAAGGCCCGTCAGGGCG
TCGAGATCGCCGGCGCGATCCTGGGCCGTTCGCTCTATGCCGGCACGATCAAGCCTTCCGAAGCCCTGATCGCGGCGGCC
GCCTGA

Upstream 100 bases:

>100_bases
CCGCTGTGGCCAAGGACAATGTCGCGGGCGTACAGTTCCACCCTGAAAAATCACAAGCATCAGGGCTCGCCCTGCTCGCC
AACTTCCTGGAATGGCGCCC

Downstream 100 bases:

>100_bases
TGCTGAAGACCCGGATCATTCCCTGCCTCGACGTGAAGGACGGGCGGGTGGTCAAGGGGGTCAACTTCGTCTCCCTGCGC
GACGCCGGCGACCCGGTGGA

Product: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MILYPAIDLKDGQCVRLLHGDMDKATVFNTSPADQAQRFVQDGFSWLHVVDLNGAIEGKSVNTAAVEQILESISIPVQLG
GGIRTLEGVEAWIEAGVSRVILGTVAVHDPELVKKAARLWPEQIAVAVDVRDGKVAVDGWTGLSDLSAIDLSRRFEDAGV
AALIITDISRDGALTGVNVEGVGELADAVSIPVIASGGVAAVADIERLKARQGVEIAGAILGRSLYAGTIKPSEALIAAA
A

Sequences:

>Translated_241_residues
MILYPAIDLKDGQCVRLLHGDMDKATVFNTSPADQAQRFVQDGFSWLHVVDLNGAIEGKSVNTAAVEQILESISIPVQLG
GGIRTLEGVEAWIEAGVSRVILGTVAVHDPELVKKAARLWPEQIAVAVDVRDGKVAVDGWTGLSDLSAIDLSRRFEDAGV
AALIITDISRDGALTGVNVEGVGELADAVSIPVIASGGVAAVADIERLKARQGVEIAGAILGRSLYAGTIKPSEALIAAA
A
>Mature_241_residues
MILYPAIDLKDGQCVRLLHGDMDKATVFNTSPADQAQRFVQDGFSWLHVVDLNGAIEGKSVNTAAVEQILESISIPVQLG
GGIRTLEGVEAWIEAGVSRVILGTVAVHDPELVKKAARLWPEQIAVAVDVRDGKVAVDGWTGLSDLSAIDLSRRFEDAGV
AALIITDISRDGALTGVNVEGVGELADAVSIPVIASGGVAAVADIERLKARQGVEIAGAILGRSLYAGTIKPSEALIAAA
A

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=241, Percent_Identity=34.4398340248963, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1788336, Length=241, Percent_Identity=23.6514522821577, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_CAUCR (Q9A230)

Other databases:

- EMBL:   AE005673
- PIR:   F87712
- RefSeq:   NP_422530.1
- ProteinModelPortal:   Q9A230
- SMR:   Q9A230
- GeneID:   940608
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_3736
- NMPDR:   fig|190650.1.peg.3710
- TIGR:   CC_3736
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK00748
- BRENDA:   5.3.1.16
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 25080; Mature: 25080

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILYPAIDLKDGQCVRLLHGDMDKATVFNTSPADQAQRFVQDGFSWLHVVDLNGAIEGKS
CEEECEEECCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
VNTAAVEQILESISIPVQLGGGIRTLEGVEAWIEAGVSRVILGTVAVHDPELVKKAARLW
CCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCHHHEEEEHEEECCHHHHHHHHHCC
PEQIAVAVDVRDGKVAVDGWTGLSDLSAIDLSRRFEDAGVAALIITDISRDGALTGVNVE
HHHEEEEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEECCCC
GVGELADAVSIPVIASGGVAAVADIERLKARQGVEIAGAILGRSLYAGTIKPSEALIAAA
CHHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCHHEEEEC
A
C
>Mature Secondary Structure
MILYPAIDLKDGQCVRLLHGDMDKATVFNTSPADQAQRFVQDGFSWLHVVDLNGAIEGKS
CEEECEEECCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
VNTAAVEQILESISIPVQLGGGIRTLEGVEAWIEAGVSRVILGTVAVHDPELVKKAARLW
CCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCHHHEEEEHEEECCHHHHHHHHHCC
PEQIAVAVDVRDGKVAVDGWTGLSDLSAIDLSRRFEDAGVAALIITDISRDGALTGVNVE
HHHEEEEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEECCCC
GVGELADAVSIPVIASGGVAAVADIERLKARQGVEIAGAILGRSLYAGTIKPSEALIAAA
CHHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCHHEEEEC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647