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The map label for this gene is ubiE

Identifier: 16127938

GI number: 16127938

Start: 3963152

End: 3963910

Strand: Direct

Name: ubiE

Synonym: CC_3708

Alternate gene names: 16127938

Gene position: 3963152-3963910 (Clockwise)

Preceding gene: 16127936

Following gene: 16127939

Centisome position: 98.66

GC content: 66.67

Gene sequence:

>759_bases
ATGAGCAACACCTCCGCCAGCTTCGGTTTCAAGGATGTCGACGCCTCGCTGAAGGCGGGCCTGGTGCGCGGGGTCTTCGA
CCGCGTCGCCAAGAACTACGACATCATGAACGACCTGATGAGCGGCGGCGTCCACCGACTGTGGAAGGACGCGGTGGCTG
CGCGTCTCAATCCTCAGCCCGGCGAGGTGATCATCGACTGCGCCGGCGGCACGGGCGACATGGCGCGGCGCTTCGCCAAG
ATGGCTCGCAAGGCCCAGGAACGCCGGGGCGGCCCCGACGCGACGATCAACATCGTCGACTACAATGCCGAAATGATCAT
GGCCGGCATCGAGCGCGGCGGCGAGCCGGAGATCACCTGGACCGTCGGCGACGCCCAGCGCCTGCCGCTGCCGGACGCCT
ATGCCGACGCCTATGTGATCTCGTTCGGCATCCGCAACGTGACCGACATCAACGCGGCCCTGCGCGAAGCTCGGCGCGTG
CTCAAGCCGGGCGGCCGGTTCCTGTGCCTGGAATTCTCGCGGCCGGTCACCGAGCCTTTGGCCAAGGCCTATGACGCCTA
CAGCTTCAAGGTCATTCCGCAGGTCGGCGAATGGGTCGCCAAGGACCGCGACGCCTACCAGTATCTCGTCGAGAGCATCC
GCCGCTTCCCCGATCAGCGGACCTTCGCGGGCATGATCGAGGCCGCCGGATTCAAGCGCGTGACCTTCACCAACTTTACC
GGCGGCGTCGCGGCCCTGCACCAGGGCTGGGCGATCTAG

Upstream 100 bases:

>100_bases
TTCGGGCAATTCGGGCACAGGGAACCTTCGGCGGATGACGGCGGGCGTGTCGCGGGCTAATAGCGGACTTAAGATATAGA
AAGCCCGGCCCAAAGACGTC

Downstream 100 bases:

>100_bases
GACCGTGGCCACGCTCGAAGCCTTCTGGCGCCTGACCGGCGCGGGCTGGGCCTTGGTCCGGGCCGACGCTCTGATCCCGC
GTGAACTGGAACCCCTGCTT

Product: ubiquinone/menaquinone biosynthesis methlytransferase UbiE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSNTSASFGFKDVDASLKAGLVRGVFDRVAKNYDIMNDLMSGGVHRLWKDAVAARLNPQPGEVIIDCAGGTGDMARRFAK
MARKAQERRGGPDATINIVDYNAEMIMAGIERGGEPEITWTVGDAQRLPLPDAYADAYVISFGIRNVTDINAALREARRV
LKPGGRFLCLEFSRPVTEPLAKAYDAYSFKVIPQVGEWVAKDRDAYQYLVESIRRFPDQRTFAGMIEAAGFKRVTFTNFT
GGVAALHQGWAI

Sequences:

>Translated_252_residues
MSNTSASFGFKDVDASLKAGLVRGVFDRVAKNYDIMNDLMSGGVHRLWKDAVAARLNPQPGEVIIDCAGGTGDMARRFAK
MARKAQERRGGPDATINIVDYNAEMIMAGIERGGEPEITWTVGDAQRLPLPDAYADAYVISFGIRNVTDINAALREARRV
LKPGGRFLCLEFSRPVTEPLAKAYDAYSFKVIPQVGEWVAKDRDAYQYLVESIRRFPDQRTFAGMIEAAGFKRVTFTNFT
GGVAALHQGWAI
>Mature_251_residues
SNTSASFGFKDVDASLKAGLVRGVFDRVAKNYDIMNDLMSGGVHRLWKDAVAARLNPQPGEVIIDCAGGTGDMARRFAKM
ARKAQERRGGPDATINIVDYNAEMIMAGIERGGEPEITWTVGDAQRLPLPDAYADAYVISFGIRNVTDINAALREARRVL
KPGGRFLCLEFSRPVTEPLAKAYDAYSFKVIPQVGEWVAKDRDAYQYLVESIRRFPDQRTFAGMIEAAGFKRVTFTNFTG
GVAALHQGWAI

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=276, Percent_Identity=44.5652173913043, Blast_Score=241, Evalue=4e-64,
Organism=Escherichia coli, GI48994983, Length=253, Percent_Identity=45.8498023715415, Blast_Score=231, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17557039, Length=248, Percent_Identity=45.5645161290323, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6323526, Length=260, Percent_Identity=44.2307692307692, Blast_Score=199, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24641702, Length=258, Percent_Identity=44.9612403100775, Blast_Score=235, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_CAUCN (B8GVY5)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002519196.1
- ProteinModelPortal:   B8GVY5
- SMR:   B8GVY5
- GeneID:   7332021
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_03823
- OMA:   FDVYTIA
- ProtClustDB:   CLSK891661
- HAMAP:   MF_01813
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 27747; Mature: 27616

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTSASFGFKDVDASLKAGLVRGVFDRVAKNYDIMNDLMSGGVHRLWKDAVAARLNPQP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCC
GEVIIDCAGGTGDMARRFAKMARKAQERRGGPDATINIVDYNAEMIMAGIERGGEPEITW
CCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHCCCCCCEEE
TVGDAQRLPLPDAYADAYVISFGIRNVTDINAALREARRVLKPGGRFLCLEFSRPVTEPL
EECCCCCCCCCCHHHHHHHEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
AKAYDAYSFKVIPQVGEWVAKDRDAYQYLVESIRRFPDQRTFAGMIEAAGFKRVTFTNFT
HHHHCCCCEEECCHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCC
GGVAALHQGWAI
CHHHHHHCCCCC
>Mature Secondary Structure 
SNTSASFGFKDVDASLKAGLVRGVFDRVAKNYDIMNDLMSGGVHRLWKDAVAARLNPQP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCC
GEVIIDCAGGTGDMARRFAKMARKAQERRGGPDATINIVDYNAEMIMAGIERGGEPEITW
CCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHCCCCCCEEE
TVGDAQRLPLPDAYADAYVISFGIRNVTDINAALREARRVLKPGGRFLCLEFSRPVTEPL
EECCCCCCCCCCHHHHHHHEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
AKAYDAYSFKVIPQVGEWVAKDRDAYQYLVESIRRFPDQRTFAGMIEAAGFKRVTFTNFT
HHHHCCCCEEECCHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCC
GGVAALHQGWAI
CHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA