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The map label for this gene is ptrB [C]

Identifier: 16127917

GI number: 16127917

Start: 3938317

End: 3940488

Strand: Direct

Name: ptrB [C]

Synonym: CC_3687

Alternate gene names: 16127917

Gene position: 3938317-3940488 (Clockwise)

Preceding gene: 16127912

Following gene: 16127918

Centisome position: 98.04

GC content: 66.9

Gene sequence:

>2172_bases
GTGGGCTGGCGCGCGACGGAATGTTCGATACCGTCCCCAGCCATGATGACGCTCCGCAACGGCTCGGCCGCCGCTCTCGC
CCTTGTCCTCCTGGCCTCCGGCTCCGCGCGAGCCCAGGAGACCGACCCGCACCTGGCCCTCGAGGCCGTCGAAAGCCCTG
AGGCCCTGGCCTGGGTGAAGGCGGAGAACGACAAGACCCTGCCGCTGCTCTCAAGCGATCCGCGCTTTGCGGGCCTGCAG
GCGGAGGCCCTGAAGATCCTGGCCGCCAAGGACCGGATCGCCATGCCCAACTTCGTCGGCAAGACGGTGTTCAACTTCTG
GCAGGACGCCACCCACGTGCGCGGCGTCTGGCGGCGCACCAGCCTTGAGTCCTACAAGTCGGCCGATCCCCAGTGGGAGA
CGGTGATCGACCTGGACGCGCTCTCAGCCGCCGAGGGCAAGAACTGGATCTGGAAGGGCGCCGACTGCCGCCCCAAGACC
CACGACCGCTGCCTGGTAAACCTCTCCAATGGCGGCAAGGACGCGGTGACCGTCCGTGAGTTCGACCTCACCACCAAGAC
CTTCGTCGATCCGGCGGCGGGCGGCTTCGTGCTGCCCGAGAGCAAGCAGTCGATCGAGTGGTTGGACGCCGACACCCTGA
TCCTGACCCGCGACTGGGGTCCAGGCACGACCACCGACAGCGGCTATGGCATGGTGGTCAAGACGCTCAAGCGCGGTCAG
GCGCTGAACGACGCGGTCGAGATCTATCGCGGCCAGAAGGGCGACGTGTCGGTGCGCCCGAACGTCATTCGCGACGCCAA
GGGCGGCCGCGTGGTGCTGATCGAGCAGGCGACCGACTTCTTCAACAGCCTCTATTTCGAGTGGACGCCCAAGGGTCTGG
CGCCACTGCCGCTGCCCAAGAAGGGTGGCATTGTCGGCATGTTGGACGGCTTGCTGGTCGTAAAGACCGAGGAGCCCTGG
ACCTTCGCCGGCGTCGCCATCCCCGCCGGCAGCCTGGCCCTGGTTTCGCCCGAGCGCCTGCGTCCCGGCGCCGAGATCGT
GGCGTCGAACGGCTGTAACCCCTGCGCGATCCTCTCGCCGGGGCCGCGGCAGTCGATCGCCCAGGCCACGGTCACCGACA
ATCGCGTGGTCGCGGTCGTCTATGACAATGTGCGCGGCTCGCTGGTCAGCCTTGAGAACCGGGGCGAACGCGGGGTGGTC
AAGACCAACCTGCCCGTCATCGACAACGCCGCCGTCACCCTGGGCTCGCATTCGGACGAAGGCGATCTTGTCTTCTACAC
CGACGAAGGCTTTGCCACCCCGACCCAGCTGAAGCTGGCCGACGCCACCGGGACCACCGCCCAGACGATCAAGGCCCTGC
CCGCCCAGTTCGACGCCAGCAAGCTGGAAGTCGAGCAGAAGGTCGCCACCTCCAAGGACGGGACCAAGATCCCCTACTTC
CTGATCCATCCCAAGGGTCACAAGCACGACGGCAAGAACCCGCTGCTGCTGCACGCCTATGGCGGCTTCAACCTGTCGAA
GCTGCCCGTCTACGACCCGCTGATCGGCAAACTCTGGCTCGAGCGCGGCGGCAGCTACGCAGTGGCCAATATCCGGGGCG
GCGGCGAGTTTGGCCCAGGCTGGCACCAGGCGGCGCTGAAGGCCAACCGCCAGCGGGCCTATGACGACTATTTCGCCGTG
GCCGAGGACCTGATCGCCAAGAAGATCACCTCGCCCCGCCATCTGGGCGCCTATGGCCGCTCGAACGGCGGCCTCTTGAT
GGGCGTGGCCATGACCCAGCGGCCCGACCTGTGGAACGCCGTGATCGTCGAAAGCCCGCTGCTGGACATGATCCGCTACA
CCCAGCTGCCTGCCGGCGCCTCGTGGATCGGCGAGTACGGCGATCCGGCCATCCCGGCCGAACGCGCCTGGATCGAGGCC
TACAGCCCGTATCAGAAGCTGAAGGCGGGCGTGAAATACCCGCTGGCCTACATCACCACCTCGACCAAGGACGACCGGGT
CCATCCGGGCCACGCGCGCAAGTTCGCCGCCCGTCTGGATGATCTGAAGGTCGACAACCTCTATTTCGAGAACACCGACG
GCGGCCACGCCAACGGAGCCGACCCCAAGGCCAACGCCCGCCGCTGGGCCCTGCACTACACCCACCTGTCGCGCCAGTTG
ATGGATCACTAG

Upstream 100 bases:

>100_bases
GGGCTATATAGTGGAAAAGCCGCGCCAAGTCAGGGGACGCGGCGACGCGGGGCATGATCGCCCACGCTCGGGCCGTTTCC
CGGTTCAAGACATTCGAAAA

Downstream 100 bases:

>100_bases
ATGCGTAAGTCCCTGCTTGCCCTCCTCGCCTCCACGAGTCTGATGACCCTGACCCCCGCCATCGCCGCCGACACCGCAAA
GCCCGCCGGCAAACCCGCCG

Product: prolyl oligopeptidase family protein

Products: Hydrolyzed protein [C]

Alternate protein names: NA

Number of amino acids: Translated: 723; Mature: 722

Protein sequence:

>723_residues
MGWRATECSIPSPAMMTLRNGSAAALALVLLASGSARAQETDPHLALEAVESPEALAWVKAENDKTLPLLSSDPRFAGLQ
AEALKILAAKDRIAMPNFVGKTVFNFWQDATHVRGVWRRTSLESYKSADPQWETVIDLDALSAAEGKNWIWKGADCRPKT
HDRCLVNLSNGGKDAVTVREFDLTTKTFVDPAAGGFVLPESKQSIEWLDADTLILTRDWGPGTTTDSGYGMVVKTLKRGQ
ALNDAVEIYRGQKGDVSVRPNVIRDAKGGRVVLIEQATDFFNSLYFEWTPKGLAPLPLPKKGGIVGMLDGLLVVKTEEPW
TFAGVAIPAGSLALVSPERLRPGAEIVASNGCNPCAILSPGPRQSIAQATVTDNRVVAVVYDNVRGSLVSLENRGERGVV
KTNLPVIDNAAVTLGSHSDEGDLVFYTDEGFATPTQLKLADATGTTAQTIKALPAQFDASKLEVEQKVATSKDGTKIPYF
LIHPKGHKHDGKNPLLLHAYGGFNLSKLPVYDPLIGKLWLERGGSYAVANIRGGGEFGPGWHQAALKANRQRAYDDYFAV
AEDLIAKKITSPRHLGAYGRSNGGLLMGVAMTQRPDLWNAVIVESPLLDMIRYTQLPAGASWIGEYGDPAIPAERAWIEA
YSPYQKLKAGVKYPLAYITTSTKDDRVHPGHARKFAARLDDLKVDNLYFENTDGGHANGADPKANARRWALHYTHLSRQL
MDH

Sequences:

>Translated_723_residues
MGWRATECSIPSPAMMTLRNGSAAALALVLLASGSARAQETDPHLALEAVESPEALAWVKAENDKTLPLLSSDPRFAGLQ
AEALKILAAKDRIAMPNFVGKTVFNFWQDATHVRGVWRRTSLESYKSADPQWETVIDLDALSAAEGKNWIWKGADCRPKT
HDRCLVNLSNGGKDAVTVREFDLTTKTFVDPAAGGFVLPESKQSIEWLDADTLILTRDWGPGTTTDSGYGMVVKTLKRGQ
ALNDAVEIYRGQKGDVSVRPNVIRDAKGGRVVLIEQATDFFNSLYFEWTPKGLAPLPLPKKGGIVGMLDGLLVVKTEEPW
TFAGVAIPAGSLALVSPERLRPGAEIVASNGCNPCAILSPGPRQSIAQATVTDNRVVAVVYDNVRGSLVSLENRGERGVV
KTNLPVIDNAAVTLGSHSDEGDLVFYTDEGFATPTQLKLADATGTTAQTIKALPAQFDASKLEVEQKVATSKDGTKIPYF
LIHPKGHKHDGKNPLLLHAYGGFNLSKLPVYDPLIGKLWLERGGSYAVANIRGGGEFGPGWHQAALKANRQRAYDDYFAV
AEDLIAKKITSPRHLGAYGRSNGGLLMGVAMTQRPDLWNAVIVESPLLDMIRYTQLPAGASWIGEYGDPAIPAERAWIEA
YSPYQKLKAGVKYPLAYITTSTKDDRVHPGHARKFAARLDDLKVDNLYFENTDGGHANGADPKANARRWALHYTHLSRQL
MDH
>Mature_722_residues
GWRATECSIPSPAMMTLRNGSAAALALVLLASGSARAQETDPHLALEAVESPEALAWVKAENDKTLPLLSSDPRFAGLQA
EALKILAAKDRIAMPNFVGKTVFNFWQDATHVRGVWRRTSLESYKSADPQWETVIDLDALSAAEGKNWIWKGADCRPKTH
DRCLVNLSNGGKDAVTVREFDLTTKTFVDPAAGGFVLPESKQSIEWLDADTLILTRDWGPGTTTDSGYGMVVKTLKRGQA
LNDAVEIYRGQKGDVSVRPNVIRDAKGGRVVLIEQATDFFNSLYFEWTPKGLAPLPLPKKGGIVGMLDGLLVVKTEEPWT
FAGVAIPAGSLALVSPERLRPGAEIVASNGCNPCAILSPGPRQSIAQATVTDNRVVAVVYDNVRGSLVSLENRGERGVVK
TNLPVIDNAAVTLGSHSDEGDLVFYTDEGFATPTQLKLADATGTTAQTIKALPAQFDASKLEVEQKVATSKDGTKIPYFL
IHPKGHKHDGKNPLLLHAYGGFNLSKLPVYDPLIGKLWLERGGSYAVANIRGGGEFGPGWHQAALKANRQRAYDDYFAVA
EDLIAKKITSPRHLGAYGRSNGGLLMGVAMTQRPDLWNAVIVESPLLDMIRYTQLPAGASWIGEYGDPAIPAERAWIEAY
SPYQKLKAGVKYPLAYITTSTKDDRVHPGHARKFAARLDDLKVDNLYFENTDGGHANGADPKANARRWALHYTHLSRQLM
DH

Specific function: Cleaves Peptide Bonds On The C-Terminal Side Of Lysyl And Argininyl Residues. [C]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=685, Percent_Identity=27.4452554744526, Blast_Score=192, Evalue=1e-48,
Organism=Homo sapiens, GI284172438, Length=203, Percent_Identity=29.5566502463054, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI284172431, Length=203, Percent_Identity=29.5566502463054, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI284172420, Length=203, Percent_Identity=29.5566502463054, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI284172413, Length=203, Percent_Identity=29.5566502463054, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI70778815, Length=203, Percent_Identity=29.5566502463054, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI108860686, Length=203, Percent_Identity=29.5566502463054, Blast_Score=82, Evalue=3e-15,
Organism=Homo sapiens, GI108860692, Length=204, Percent_Identity=28.921568627451, Blast_Score=80, Evalue=8e-15,
Organism=Escherichia coli, GI1788150, Length=354, Percent_Identity=29.6610169491525, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24583414, Length=278, Percent_Identity=35.6115107913669, Blast_Score=168, Evalue=2e-41,
Organism=Drosophila melanogaster, GI221510989, Length=263, Percent_Identity=33.8403041825095, Blast_Score=150, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: 3.4.21.83 [C]

Molecular weight: Translated: 78548; Mature: 78417

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGWRATECSIPSPAMMTLRNGSAAALALVLLASGSARAQETDPHLALEAVESPEALAWVK
CCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCEEEEEE
AENDKTLPLLSSDPRFAGLQAEALKILAAKDRIAMPNFVGKTVFNFWQDATHVRGVWRRT
CCCCCCCCEECCCCCCCCCHHHHHHEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
SLESYKSADPQWETVIDLDALSAAEGKNWIWKGADCRPKTHDRCLVNLSNGGKDAVTVRE
CHHHHHCCCCCCEEEEEEHHHCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCEEEEEE
FDLTTKTFVDPAAGGFVLPESKQSIEWLDADTLILTRDWGPGTTTDSGYGMVVKTLKRGQ
ECCCHHHHCCCCCCCEECCCCCCCEEEECCCEEEEEECCCCCCCCCCCCHHHHHHHHCCC
ALNDAVEIYRGQKGDVSVRPNVIRDAKGGRVVLIEQATDFFNSLYFEWTPKGLAPLPLPK
HHHHHHHHHCCCCCCEEECCCCEECCCCCEEEEEECHHHHHHCCEEEECCCCCCCCCCCC
KGGIVGMLDGLLVVKTEEPWTFAGVAIPAGSLALVSPERLRPGAEIVASNGCNPCAILSP
CCCEEEEECCEEEEEECCCCEEEEEEECCCCEEEECHHHCCCCCEEEECCCCCEEEEECC
GPRQSIAQATVTDNRVVAVVYDNVRGSLVSLENRGERGVVKTNLPVIDNAAVTLGSHSDE
CCHHHHHEEEECCCEEEEEEEECCCCCEEEECCCCCCCEEEECCCEECCCEEEECCCCCC
GDLVFYTDEGFATPTQLKLADATGTTAQTIKALPAQFDASKLEVEQKVATSKDGTKIPYF
CCEEEEECCCCCCCCEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEE
LIHPKGHKHDGKNPLLLHAYGGFNLSKLPVYDPLIGKLWLERGGSYAVANIRGGGEFGPG
EECCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
WHQAALKANRQRAYDDYFAVAEDLIAKKITSPRHLGAYGRSNGGLLMGVAMTQRPDLWNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEEEECCCCCCCEE
VIVESPLLDMIRYTQLPAGASWIGEYGDPAIPAERAWIEAYSPYQKLKAGVKYPLAYITT
EEECCHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHCCCHHHHHCCCCCCEEEEEE
STKDDRVHPGHARKFAARLDDLKVDNLYFENTDGGHANGADPKANARRWALHYTHLSRQL
CCCCCCCCCCHHHHHHHHHCCEEECCEEEECCCCCCCCCCCCCCCCEEEEEEHHHHHHHH
MDH
HCC
>Mature Secondary Structure 
GWRATECSIPSPAMMTLRNGSAAALALVLLASGSARAQETDPHLALEAVESPEALAWVK
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCEEEEEE
AENDKTLPLLSSDPRFAGLQAEALKILAAKDRIAMPNFVGKTVFNFWQDATHVRGVWRRT
CCCCCCCCEECCCCCCCCCHHHHHHEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
SLESYKSADPQWETVIDLDALSAAEGKNWIWKGADCRPKTHDRCLVNLSNGGKDAVTVRE
CHHHHHCCCCCCEEEEEEHHHCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCEEEEEE
FDLTTKTFVDPAAGGFVLPESKQSIEWLDADTLILTRDWGPGTTTDSGYGMVVKTLKRGQ
ECCCHHHHCCCCCCCEECCCCCCCEEEECCCEEEEEECCCCCCCCCCCCHHHHHHHHCCC
ALNDAVEIYRGQKGDVSVRPNVIRDAKGGRVVLIEQATDFFNSLYFEWTPKGLAPLPLPK
HHHHHHHHHCCCCCCEEECCCCEECCCCCEEEEEECHHHHHHCCEEEECCCCCCCCCCCC
KGGIVGMLDGLLVVKTEEPWTFAGVAIPAGSLALVSPERLRPGAEIVASNGCNPCAILSP
CCCEEEEECCEEEEEECCCCEEEEEEECCCCEEEECHHHCCCCCEEEECCCCCEEEEECC
GPRQSIAQATVTDNRVVAVVYDNVRGSLVSLENRGERGVVKTNLPVIDNAAVTLGSHSDE
CCHHHHHEEEECCCEEEEEEEECCCCCEEEECCCCCCCEEEECCCEECCCEEEECCCCCC
GDLVFYTDEGFATPTQLKLADATGTTAQTIKALPAQFDASKLEVEQKVATSKDGTKIPYF
CCEEEEECCCCCCCCEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEE
LIHPKGHKHDGKNPLLLHAYGGFNLSKLPVYDPLIGKLWLERGGSYAVANIRGGGEFGPG
EECCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
WHQAALKANRQRAYDDYFAVAEDLIAKKITSPRHLGAYGRSNGGLLMGVAMTQRPDLWNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEEEECCCCCCCEE
VIVESPLLDMIRYTQLPAGASWIGEYGDPAIPAERAWIEAYSPYQKLKAGVKYPLAYITT
EEECCHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHCCCHHHHHCCCCCCEEEEEE
STKDDRVHPGHARKFAARLDDLKVDNLYFENTDGGHANGADPKANARRWALHYTHLSRQL
CCCCCCCCCCHHHHHHHHHCCEEECCEEEECCCCCCCCCCCCCCCCEEEEEEHHHHHHHH
MDH
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): 11820 [C]

Specific activity: NA

Km value (mM): 0.23 {tosyl-Arg} 0.92 {benzoyl-Lys} 0.6 {N-benzoyl-Arg} 0.47 {tosyl-Lys-methyl} 0.33 {N-benzyloxycarbonyl-Lys} 0.31 {N-benzyloxycarbonyl-Lys} 0.5 {benzoyl-Arg} 0.48 {benzoyl-Arg} 0.25 {benzoyl-Arg} 80 {acetyl-tyrosine} [C]

Substrates: Protein; H2O [C]

Specific reaction: Protein + H2O = hydrolyzed protein [C]

General reaction: Peptide bond hydrolysis [C]

Inhibitor: Antipain; Aromaticamidines; Benzamidine; Co2+; DFP; Fe2+; Hg2+; L-Arginine; Leupeptin sulfhydryl agents, trypsin inhibitors, 1, 10-phenanthroline; p-Aminobenzamidine; Tosyl -Leuchloromethyl ketone; Zn2+ [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]