Click here to switch to the map view.

The map label for this gene is cobB

Identifier: 16127710

GI number: 16127710

Start: 3721930

End: 3722646

Strand: Direct

Name: cobB

Synonym: CC_3480

Alternate gene names: 16127710

Gene position: 3721930-3722646 (Clockwise)

Preceding gene: 16127709

Following gene: 16127714

Centisome position: 92.66

GC content: 69.04

Gene sequence:

>717_bases
TTGCGAGGGATCATGAAAGTCTTCGTTCTGACGGGCGCCGGCGTCTCGGCCGAGAGCGGTCTGGGCACCTTCCGCGACAA
GGACGGCGTCTGGACGAAGTACGACCTGAACGAGGTGGCCACGCCCCAGGGCTTCGCCCGCAATCCGGCCCTGGTGCGCG
ACTTCTACAACGCCCGCCGCGCCAACCTCGCCGGAGCGCGGCCCAATGCGGCGCACGACGCCCTGGCCCAGCTGGAGGCA
GGCCTGGCGAGGCGCGGCGGCGAGCTTTTCCTCTGCACCCAGAATGTCGACGACCTGCACGAGAAGGCCGGGTGCCGGCG
CGTGATCCACATGCATGGCGAACTGGCCGTCACCCGCTGTCACCATTGCGAGGCGACCTGGCCCGATACGGGGCCGCTGA
AGCCCGACACCGTCTGCGCCGCCTGCGCACGCGACGGCGGAGCCCGGCCCCATGTCGTCTGGTTCGGCGAGATCCCGCTG
TTCATGGACCAGATCGAGGACGCGCTGTCCGCTGCCGACCTCTTCGTCTCGATCGGCACCTCGGGTTCGGTCTATCCCGC
CGCCGGCTTCGTGGCCGAGGCGCGAGCGATGGGGATCGCGACCTGCGAGATCAATCTGGAGCCCTCGGCCAATGCCTATG
TCTTCGACGAGAAGGTCTACGGCCCCGCCACCGAGGTCGTGCCGGCCTGGGTGGAGCGGTTGCTGGCGAGGCTCTAG

Upstream 100 bases:

>100_bases
GTCTTGCGCGCGCCTTCGACTATCTAAACAGTGTCAACTCAAGACTTGATCGCGGTCAAATGAAAAATGACGCCGCCGTC
AGGTTCGCGCCTCAGGGGTA

Downstream 100 bases:

>100_bases
GCCAGCCGCGCCACGCCCCATTCGCACCAGCCCAGAGGCCTTGGGGTCTTGGGCATGTAGCGCTGCTCGACCTCGTCCAG
GGCGAAACCCGCCGCCGCGA

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MRGIMKVFVLTGAGVSAESGLGTFRDKDGVWTKYDLNEVATPQGFARNPALVRDFYNARRANLAGARPNAAHDALAQLEA
GLARRGGELFLCTQNVDDLHEKAGCRRVIHMHGELAVTRCHHCEATWPDTGPLKPDTVCAACARDGGARPHVVWFGEIPL
FMDQIEDALSAADLFVSIGTSGSVYPAAGFVAEARAMGIATCEINLEPSANAYVFDEKVYGPATEVVPAWVERLLARL

Sequences:

>Translated_238_residues
MRGIMKVFVLTGAGVSAESGLGTFRDKDGVWTKYDLNEVATPQGFARNPALVRDFYNARRANLAGARPNAAHDALAQLEA
GLARRGGELFLCTQNVDDLHEKAGCRRVIHMHGELAVTRCHHCEATWPDTGPLKPDTVCAACARDGGARPHVVWFGEIPL
FMDQIEDALSAADLFVSIGTSGSVYPAAGFVAEARAMGIATCEINLEPSANAYVFDEKVYGPATEVVPAWVERLLARL
>Mature_238_residues
MRGIMKVFVLTGAGVSAESGLGTFRDKDGVWTKYDLNEVATPQGFARNPALVRDFYNARRANLAGARPNAAHDALAQLEA
GLARRGGELFLCTQNVDDLHEKAGCRRVIHMHGELAVTRCHHCEATWPDTGPLKPDTVCAACARDGGARPHVVWFGEIPL
FMDQIEDALSAADLFVSIGTSGSVYPAAGFVAEARAMGIATCEINLEPSANAYVFDEKVYGPATEVVPAWVERLLARL

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain

Homologues:

Organism=Homo sapiens, GI300795542, Length=228, Percent_Identity=38.1578947368421, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI6912664, Length=246, Percent_Identity=35.7723577235772, Blast_Score=158, Evalue=5e-39,
Organism=Homo sapiens, GI13787215, Length=233, Percent_Identity=36.9098712446352, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI6912662, Length=262, Percent_Identity=27.8625954198473, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI7657575, Length=254, Percent_Identity=28.740157480315, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI300797577, Length=255, Percent_Identity=29.0196078431373, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI300797597, Length=238, Percent_Identity=28.9915966386555, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI308199517, Length=235, Percent_Identity=54.8936170212766, Blast_Score=248, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17541892, Length=197, Percent_Identity=31.4720812182741, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17567771, Length=123, Percent_Identity=35.7723577235772, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17505510, Length=230, Percent_Identity=27.8260869565217, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17137536, Length=224, Percent_Identity=29.4642857142857, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571445, Length=267, Percent_Identity=27.3408239700375, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NPD_CAUCR (Q9A2S6)

Other databases:

- EMBL:   AE005673
- PIR:   F87680
- RefSeq:   NP_422274.1
- ProteinModelPortal:   Q9A2S6
- SMR:   Q9A2S6
- GeneID:   943270
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_3480
- NMPDR:   fig|190650.1.peg.3454
- TIGR:   CC_3480
- HOGENOM:   HBG641281
- OMA:   FVHEARL
- ProtClustDB:   PRK00481
- GO:   GO:0005737
- HAMAP:   MF_01121
- InterPro:   IPR003000
- PANTHER:   PTHR11085

Pfam domain/function: PF02146 SIR2

EC number: 3.5.1.- [C]

Molecular weight: Translated: 25626; Mature: 25626

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS50305 SIRTUIN

Important sites: ACT_SITE 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGIMKVFVLTGAGVSAESGLGTFRDKDGVWTKYDLNEVATPQGFARNPALVRDFYNARR
CCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEECCHHCCCCCCCCCCCHHHHHHHHHHH
ANLAGARPNAAHDALAQLEAGLARRGGELFLCTQNVDDLHEKAGCRRVIHMHGELAVTRC
CCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEHH
HHCEATWPDTGPLKPDTVCAACARDGGARPHVVWFGEIPLFMDQIEDALSAADLFVSIGT
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHEEEECC
SGSVYPAAGFVAEARAMGIATCEINLEPSANAYVFDEKVYGPATEVVPAWVERLLARL
CCCCCCCHHHHHHHHHCEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MRGIMKVFVLTGAGVSAESGLGTFRDKDGVWTKYDLNEVATPQGFARNPALVRDFYNARR
CCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEECCHHCCCCCCCCCCCHHHHHHHHHHH
ANLAGARPNAAHDALAQLEAGLARRGGELFLCTQNVDDLHEKAGCRRVIHMHGELAVTRC
CCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEHH
HHCEATWPDTGPLKPDTVCAACARDGGARPHVVWFGEIPLFMDQIEDALSAADLFVSIGT
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHEEEECC
SGSVYPAAGFVAEARAMGIATCEINLEPSANAYVFDEKVYGPATEVVPAWVERLLARL
CCCCCCCHHHHHHHHHCEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647