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The map label for this gene is divL

Identifier: 16127714

GI number: 16127714

Start: 3724305

End: 3726614

Strand: Direct

Name: divL

Synonym: CC_3484

Alternate gene names: 16127714

Gene position: 3724305-3726614 (Clockwise)

Preceding gene: 16127710

Following gene: 16127715

Centisome position: 92.71

GC content: 71.52

Gene sequence:

>2310_bases
ATGACTTCGTACGACCTGATCCTCGCGGCGGCGGCCGGCGCGGTATGTCTCGCCATTTCCGTCGCCCTGTGGTCCCACGG
GCAGCGACGGAACCTGGAGGCGCGTATCGTCGCGCTCAAGACGCGCCTGATCCAGCAGGGCGGCTCGGACGACGCCCCGG
CCTGGCTCGACGCCTTCGACACCGCCGTGATCGCCGTCGAGGGCGGCCGCGCAAACCTGGTCGCCGGCGGCGAAGGCCTG
ATCGCCTGCGCCAAGGCGCTGGGGGCGGACGCCGAGGTCTCGGCCGTGGTCGCTGCGCTCAGCGACGCCGATCCGAACTA
CGCCCAGAAGCTGACCGCCCTGTTCGAGCGTGGCGAGCCTTGCGTGTTCGAAGCGCGCGGTCCCCATGGCCTTGTTTCGG
TCGAGGGTCGCGCGGCGGGCGCCCTGGCCTGGCTGCGCCTGGCGCCGATCGACCGCGCCGACTCGGGCCTGCCCACCGCC
GCCCGCTTCGCCGCCTTCGTCGACAGCGTGGTCGAGCCGTGCTGGATCGCCGGCGCCGATGGCCAGGCGATCTGGGGCAA
CGCCGCCTTTGTGCGCGCCGTGGGCGCGGCCTCCGCCCAGGCCCCGGCCCTGGCGGGCAAGAGCTTTGATCGCGGCGCCG
ACGCCGTGGTCGTCGAAGCCGCCGGCAAGGGCGAACGTCGCGAAGCGCTGCGCTGGATCAATGTCGAGGGCCGCCGCCGG
GCGTTCCGACTGTCGGCCCAGCCGCTGGATGGCGGCGGGGTGGGCGTGTTCTGCGCCGACGTCACCGAGATCGAGGATGT
CCGCGACGCCTTCAAGAAGCACGTCGAGGCGCACGACGAGACCCTGAACCACATCGCCGAGGCCGTGGCGATCTTCAGCC
AGACGCGCCGCCTGTCGTACCACAACACCGCCTTCGCCGAGCTGTGGGGCCTGGAGCCGGCCTGGCTGGCCGACCGTCCG
ACGCATGGCGAGGTGCTGGACCGCCTGCGCCAGCGTCGCCGCCTGCCCGAGACCATCGACTACGCCGGCTGGAAGGCCGC
CGAACTGGCCCGTTACGAAGACCTTGGCCCGCAGGCCGACGACCTGTGGGACCTGCCCGACGGCCGCACCCTGAAGGTCG
TCCGTCAGCCGCACCCGCTGGGCGGCATGCTGCTGATCTATTCCGACATCACCGGCGAGCTGCGCCTGAAAGCCCAGTAC
AACGCCCTGATCCAGGTGCAGCAGGCCACGCTGGACAAGCTGAACGACGCCGTCGCCGTGTTCGGCTCGGACGGTCGCCT
GCGGCTGCATAACGAGGCCTTCGAGACGTTCTGGAACGTCACCCCGCACGCCCTGGAGGCGGCCGGAGACTTCGAGGGCG
TGGTCGAGCTGTGCGTGCCGCGTCTGCACGACCTGTCGTTCTGGCGCGAGCTCAAAGGCCGGGTCGCCGATCCGGATCCG
CAGATGCGCGCTCCGACCTCGGGCGAGGTGCGAACCTCCGACAGCCGCATCGTGCTGTACCAGAGCCGGCCGCTGCCGGA
CGGCGCGACCCTGATCGCCTTCGCCGACGTCACCGACACCCGAGACCTGCAGAGCGCCCTGGCCGATCGCTCGGCGGCCC
TGGCCGAAGCCGAGCGCCTGAAGCGCGACTTCGTCGGCAATGTCTCCTACGAGCTGCGCACGCCGCTGACGACGATCATC
GGCTATTCGGAGCTGCTGGAGCGGGCCGACGGCATCTCCGAGCGGGGCCGCAACCACGTGGCCGCCGTCCGCGCCGCCGC
CACCCAGCTGGCGCGCTCGATCGACGACGTGCTGGACATGGCCCAGATCGACGCCGGCGAAATGGCGCTGGAGATCGAGG
ACATCCGCGTCTCAGACCTGCTGCTGAACGCCCAGGAGCGCGCCCTGAAGGACGCACAGCTGGGCGGCGTCACCCTGGCC
GTCGAGTGCGAGGAGGACGTCGGCCTGATCCGGGGTGACGGCAAGCGCCTGGCCCAGACGCTGGACCATCTGGTGGAAAA
CGCCCTGCGCCAGACCCCGCCGGGCGGCCGCGTCACCCTGTCGGCCCGCCGGGCTCTGGGCGAGGTGCGGCTGGACGTCT
CCGACACCGGGCGGGGCGTGCCGTTCCATGTGCAGGCCCACATCTTCGACCGCTTCGTCGGCCGCGATCGCGGCGGCCCG
GGCCTGGGCCTGGCCCTGGTCAAGGCGCTGGTCGAACTGCACGGCGGCTGGGTGGCGCTGGAGAGCGAACCGGGCAACGG
TTCGACCTTCACCTGCCACCTGCCCGAGACCCAACAACCCGGGGCCATGCAGCCCGAACTCGGCTTCTAG

Upstream 100 bases:

>100_bases
ACGCGACGCACGGCCACACCCGCGCTTGATCGCCCTCTGGTCACGGCACGACTAATCTGGGATTCTGATTCGAAGACCCG
CTGGGGTAGCCACGCGCCTG

Downstream 100 bases:

>100_bases
GCGGTCGCGCGGCGCGGAGCGGGGAAGCATTTTTCACCCGCCGCGAGGACCAAACACCCCGCCGCCGCATCATTGTGCCT
CCGAAGGGCTTTACGCGATG

Product: tyrosine kinase DivL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 769; Mature: 768

Protein sequence:

>769_residues
MTSYDLILAAAAGAVCLAISVALWSHGQRRNLEARIVALKTRLIQQGGSDDAPAWLDAFDTAVIAVEGGRANLVAGGEGL
IACAKALGADAEVSAVVAALSDADPNYAQKLTALFERGEPCVFEARGPHGLVSVEGRAAGALAWLRLAPIDRADSGLPTA
ARFAAFVDSVVEPCWIAGADGQAIWGNAAFVRAVGAASAQAPALAGKSFDRGADAVVVEAAGKGERREALRWINVEGRRR
AFRLSAQPLDGGGVGVFCADVTEIEDVRDAFKKHVEAHDETLNHIAEAVAIFSQTRRLSYHNTAFAELWGLEPAWLADRP
THGEVLDRLRQRRRLPETIDYAGWKAAELARYEDLGPQADDLWDLPDGRTLKVVRQPHPLGGMLLIYSDITGELRLKAQY
NALIQVQQATLDKLNDAVAVFGSDGRLRLHNEAFETFWNVTPHALEAAGDFEGVVELCVPRLHDLSFWRELKGRVADPDP
QMRAPTSGEVRTSDSRIVLYQSRPLPDGATLIAFADVTDTRDLQSALADRSAALAEAERLKRDFVGNVSYELRTPLTTII
GYSELLERADGISERGRNHVAAVRAAATQLARSIDDVLDMAQIDAGEMALEIEDIRVSDLLLNAQERALKDAQLGGVTLA
VECEEDVGLIRGDGKRLAQTLDHLVENALRQTPPGGRVTLSARRALGEVRLDVSDTGRGVPFHVQAHIFDRFVGRDRGGP
GLGLALVKALVELHGGWVALESEPGNGSTFTCHLPETQQPGAMQPELGF

Sequences:

>Translated_769_residues
MTSYDLILAAAAGAVCLAISVALWSHGQRRNLEARIVALKTRLIQQGGSDDAPAWLDAFDTAVIAVEGGRANLVAGGEGL
IACAKALGADAEVSAVVAALSDADPNYAQKLTALFERGEPCVFEARGPHGLVSVEGRAAGALAWLRLAPIDRADSGLPTA
ARFAAFVDSVVEPCWIAGADGQAIWGNAAFVRAVGAASAQAPALAGKSFDRGADAVVVEAAGKGERREALRWINVEGRRR
AFRLSAQPLDGGGVGVFCADVTEIEDVRDAFKKHVEAHDETLNHIAEAVAIFSQTRRLSYHNTAFAELWGLEPAWLADRP
THGEVLDRLRQRRRLPETIDYAGWKAAELARYEDLGPQADDLWDLPDGRTLKVVRQPHPLGGMLLIYSDITGELRLKAQY
NALIQVQQATLDKLNDAVAVFGSDGRLRLHNEAFETFWNVTPHALEAAGDFEGVVELCVPRLHDLSFWRELKGRVADPDP
QMRAPTSGEVRTSDSRIVLYQSRPLPDGATLIAFADVTDTRDLQSALADRSAALAEAERLKRDFVGNVSYELRTPLTTII
GYSELLERADGISERGRNHVAAVRAAATQLARSIDDVLDMAQIDAGEMALEIEDIRVSDLLLNAQERALKDAQLGGVTLA
VECEEDVGLIRGDGKRLAQTLDHLVENALRQTPPGGRVTLSARRALGEVRLDVSDTGRGVPFHVQAHIFDRFVGRDRGGP
GLGLALVKALVELHGGWVALESEPGNGSTFTCHLPETQQPGAMQPELGF
>Mature_768_residues
TSYDLILAAAAGAVCLAISVALWSHGQRRNLEARIVALKTRLIQQGGSDDAPAWLDAFDTAVIAVEGGRANLVAGGEGLI
ACAKALGADAEVSAVVAALSDADPNYAQKLTALFERGEPCVFEARGPHGLVSVEGRAAGALAWLRLAPIDRADSGLPTAA
RFAAFVDSVVEPCWIAGADGQAIWGNAAFVRAVGAASAQAPALAGKSFDRGADAVVVEAAGKGERREALRWINVEGRRRA
FRLSAQPLDGGGVGVFCADVTEIEDVRDAFKKHVEAHDETLNHIAEAVAIFSQTRRLSYHNTAFAELWGLEPAWLADRPT
HGEVLDRLRQRRRLPETIDYAGWKAAELARYEDLGPQADDLWDLPDGRTLKVVRQPHPLGGMLLIYSDITGELRLKAQYN
ALIQVQQATLDKLNDAVAVFGSDGRLRLHNEAFETFWNVTPHALEAAGDFEGVVELCVPRLHDLSFWRELKGRVADPDPQ
MRAPTSGEVRTSDSRIVLYQSRPLPDGATLIAFADVTDTRDLQSALADRSAALAEAERLKRDFVGNVSYELRTPLTTIIG
YSELLERADGISERGRNHVAAVRAAATQLARSIDDVLDMAQIDAGEMALEIEDIRVSDLLLNAQERALKDAQLGGVTLAV
ECEEDVGLIRGDGKRLAQTLDHLVENALRQTPPGGRVTLSARRALGEVRLDVSDTGRGVPFHVQAHIFDRFVGRDRGGPG
LGLALVKALVELHGGWVALESEPGNGSTFTCHLPETQQPGAMQPELGF

Specific function: Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1789149, Length=230, Percent_Identity=32.6086956521739, Blast_Score=120, Evalue=5e-28,
Organism=Escherichia coli, GI145693157, Length=271, Percent_Identity=28.4132841328413, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI1788713, Length=269, Percent_Identity=30.4832713754647, Blast_Score=110, Evalue=5e-25,
Organism=Escherichia coli, GI1788393, Length=231, Percent_Identity=30.3030303030303, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI48994928, Length=234, Percent_Identity=29.9145299145299, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1786912, Length=233, Percent_Identity=28.3261802575107, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786600, Length=260, Percent_Identity=28.4615384615385, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI87081816, Length=244, Percent_Identity=30.7377049180328, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1790436, Length=210, Percent_Identity=30.4761904761905, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788549, Length=258, Percent_Identity=26.3565891472868, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790300, Length=286, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790346, Length=221, Percent_Identity=29.8642533936652, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1786783, Length=225, Percent_Identity=27.5555555555556, Blast_Score=73, Evalue=9e-14,
Organism=Escherichia coli, GI1788279, Length=210, Percent_Identity=25.2380952380952, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790567, Length=367, Percent_Identity=25.8855585831063, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=248, Percent_Identity=28.2258064516129, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790861, Length=245, Percent_Identity=26.530612244898, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DIVL_CAUCR (Q9RQQ9)

Other databases:

- EMBL:   AF083422
- EMBL:   AE005673
- PIR:   B87681
- RefSeq:   NP_422278.1
- ProteinModelPortal:   Q9RQQ9
- SMR:   Q9RQQ9
- PhosSite:   Q9RQQ9
- GeneID:   943276
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_3484
- NMPDR:   fig|190650.1.peg.3458
- TIGR:   CC_3484
- HOGENOM:   HBG536150
- OMA:   HHVSYEL
- ProtClustDB:   CLSK2518328
- BRENDA:   2.7.13.3
- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00387
- SMART:   SM00388

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 82797; Mature: 82666

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x122f13d4)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSYDLILAAAAGAVCLAISVALWSHGQRRNLEARIVALKTRLIQQGGSDDAPAWLDAFD
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCC
TAVIAVEGGRANLVAGGEGLIACAKALGADAEVSAVVAALSDADPNYAQKLTALFERGEP
EEEEEEECCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
CVFEARGPHGLVSVEGRAAGALAWLRLAPIDRADSGLPTAARFAAFVDSVVEPCWIAGAD
EEEECCCCCCEEEECCCCCHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCC
GQAIWGNAAFVRAVGAASAQAPALAGKSFDRGADAVVVEAAGKGERREALRWINVEGRRR
CCEEECCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHEECCCCCCE
AFRLSAQPLDGGGVGVFCADVTEIEDVRDAFKKHVEAHDETLNHIAEAVAIFSQTRRLSY
EEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HNTAFAELWGLEPAWLADRPTHGEVLDRLRQRRRLPETIDYAGWKAAELARYEDLGPQAD
CCCHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHCCCCCC
DLWDLPDGRTLKVVRQPHPLGGMLLIYSDITGELRLKAQYNALIQVQQATLDKLNDAVAV
CCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCEEEEEECCHHEEEHHHHHHHCCCEEEE
FGSDGRLRLHNEAFETFWNVTPHALEAAGDFEGVVELCVPRLHDLSFWRELKGRVADPDP
ECCCCEEEECHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
QMRAPTSGEVRTSDSRIVLYQSRPLPDGATLIAFADVTDTRDLQSALADRSAALAEAERL
CCCCCCCCCEEECCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
KRDFVGNVSYELRTPLTTIIGYSELLERADGISERGRNHVAAVRAAATQLARSIDDVLDM
HHHHCCCCCEEHHCCHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
AQIDAGEMALEIEDIRVSDLLLNAQERALKDAQLGGVTLAVECEEDVGLIRGDGKRLAQT
HHCCCCCEEEEEECCCHHHHHHCCHHHHHHHHCCCCEEEEEEECCCCCEEECCHHHHHHH
LDHLVENALRQTPPGGRVTLSARRALGEVRLDVSDTGRGVPFHVQAHIFDRFVGRDRGGP
HHHHHHHHHHCCCCCCEEEEHHHHHHCCEEEEECCCCCCCCEEEHHHHHHHHHCCCCCCC
GLGLALVKALVELHGGWVALESEPGNGSTFTCHLPETQQPGAMQPELGF
CHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCH
>Mature Secondary Structure 
TSYDLILAAAAGAVCLAISVALWSHGQRRNLEARIVALKTRLIQQGGSDDAPAWLDAFD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCC
TAVIAVEGGRANLVAGGEGLIACAKALGADAEVSAVVAALSDADPNYAQKLTALFERGEP
EEEEEEECCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
CVFEARGPHGLVSVEGRAAGALAWLRLAPIDRADSGLPTAARFAAFVDSVVEPCWIAGAD
EEEECCCCCCEEEECCCCCHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCC
GQAIWGNAAFVRAVGAASAQAPALAGKSFDRGADAVVVEAAGKGERREALRWINVEGRRR
CCEEECCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHEECCCCCCE
AFRLSAQPLDGGGVGVFCADVTEIEDVRDAFKKHVEAHDETLNHIAEAVAIFSQTRRLSY
EEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HNTAFAELWGLEPAWLADRPTHGEVLDRLRQRRRLPETIDYAGWKAAELARYEDLGPQAD
CCCHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHCCCCCC
DLWDLPDGRTLKVVRQPHPLGGMLLIYSDITGELRLKAQYNALIQVQQATLDKLNDAVAV
CCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCEEEEEECCHHEEEHHHHHHHCCCEEEE
FGSDGRLRLHNEAFETFWNVTPHALEAAGDFEGVVELCVPRLHDLSFWRELKGRVADPDP
ECCCCEEEECHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
QMRAPTSGEVRTSDSRIVLYQSRPLPDGATLIAFADVTDTRDLQSALADRSAALAEAERL
CCCCCCCCCEEECCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
KRDFVGNVSYELRTPLTTIIGYSELLERADGISERGRNHVAAVRAAATQLARSIDDVLDM
HHHHCCCCCEEHHCCHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
AQIDAGEMALEIEDIRVSDLLLNAQERALKDAQLGGVTLAVECEEDVGLIRGDGKRLAQT
HHCCCCCEEEEEECCCHHHHHHCCHHHHHHHHCCCCEEEEEEECCCCCEEECCHHHHHHH
LDHLVENALRQTPPGGRVTLSARRALGEVRLDVSDTGRGVPFHVQAHIFDRFVGRDRGGP
HHHHHHHHHHCCCCCCEEEEHHHHHHCCEEEEECCCCCCCCEEEHHHHHHHHHCCCCCCC
GLGLALVKALVELHGGWVALESEPGNGSTFTCHLPETQQPGAMQPELGF
CHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10557274; 11259647