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The map label for this gene is fadA [H]

Identifier: 16127692

GI number: 16127692

Start: 3704417

End: 3705604

Strand: Direct

Name: fadA [H]

Synonym: CC_3462

Alternate gene names: 16127692

Gene position: 3704417-3705604 (Clockwise)

Preceding gene: 16127689

Following gene: 16127695

Centisome position: 92.22

GC content: 66.25

Gene sequence:

>1188_bases
ATGCGCGAAGCGGTCATCGTCTCTTACGCCCGCACCGGTCTGGCCAAGTCGGTCCGTGGCGGCTTCAACAACACCCATGG
CGCGGCGATGGCCGGCCACGCCATCCAGCACGCCGTGTCGCGCGCCGGACTGGAAGGGGCTGAGGTCGAGGACGTGGTCC
TGGGCTGCGGCGGTCCTGAAGGCGCCACCGGCATGAACGTCGCGCGCAACGCCGCCATGTGGGCCGGCCTGCCGGTCACC
ACCTCGGGCCAGACCATCAACCGCTTCTGCTCGTCGGGCCTGCAAGCCATCGCCACGGCGGCCAACTATGTGCGCAATGA
CGGGGCCAATGTCGCCATCGGCGGCGGCGTCGAGTCGATCTCGCTGGTCAATGCGGGCGGTCATATGAACCGCTTCCACA
TCACCGAAGAGAAACTGATGCAGACCCATCCGGCGCTGTGGATGGCGATGATCGACACCGCCGACATCGTGGCCAAGCGC
TACAATGTCAGCCGCGAGTACCAGGACGAATACGCCCTGCGCAGCCAGCAGCGCATCGCCGCCGCTCAGGCCGCCGGCCT
GTTCAAGGACGAGATCGTTCCGATGGCCACCAAGATGAAGGTGGTCAACAAGGAAACCAAGGAAGAGTCCTTCGTTGACT
ACGTGGTCGACAAGGACGAATGCAACCGCGCCGACACCACCCTGGAAGGCCTAGCCAGCCTCAAGCCCGTCATGGGCGAG
GGCAAGTTCATCACCGCCGGCAACGCCAGCCAGCTGTCTGACGGCGCCGCCGCCGTGGTGGTGATGGAGGCCAAGGAAGC
CGAAAAGCGCGGCCTGACCCCGCTGGGCGCCTTCCGCGGTTTCGCCGTCGCCGGTTGCGAGCCTGACGAGATGGGCATCG
GCCCGGTCTTCGCCGTGCCGCGCCTGCTGGAACGTCACGGCCTGAAGGTCGACGACATCGACATCTGGGAACTGAACGAA
GCCTTCGCCTCGCAGTGCCTGTACAGCCGCGATCGCCTGGGCATCGACCCGGAGAAGTACAACGTCAACGGCGGCTCGAT
CGCCATCGGTCACCCCTTCGGCATGACCGGCGCCCGCTGCGCCGGCCACCTCTTGCTGGAAGGCAAGCGCCGCAAGGCCA
AGCTGGGCGTGGTGACGATGTGCATCGGCGGTGGCATGGGCGCCGCCGGCCTGTTCGAAATCTTCTGA

Upstream 100 bases:

>100_bases
GGATGGTTTTCCTTTACGCACGCGTGATCTTTCGCACCGCAACGAGACGGTCTAGGGTGGCCGCCAATTCAAACTAACGT
TTAACGGGGAGTGCGCCTCT

Downstream 100 bases:

>100_bases
TTTCGATCAGGACGGATCACGGCGCCCATCCTCCAAAGAGACCTGGATCGCTTCACGCGATCCAGAGCGGCGCCGCCGGC
CTGTTCGAAATCTTCTGATT

Product: thiolase family protein

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MREAVIVSYARTGLAKSVRGGFNNTHGAAMAGHAIQHAVSRAGLEGAEVEDVVLGCGGPEGATGMNVARNAAMWAGLPVT
TSGQTINRFCSSGLQAIATAANYVRNDGANVAIGGGVESISLVNAGGHMNRFHITEEKLMQTHPALWMAMIDTADIVAKR
YNVSREYQDEYALRSQQRIAAAQAAGLFKDEIVPMATKMKVVNKETKEESFVDYVVDKDECNRADTTLEGLASLKPVMGE
GKFITAGNASQLSDGAAAVVVMEAKEAEKRGLTPLGAFRGFAVAGCEPDEMGIGPVFAVPRLLERHGLKVDDIDIWELNE
AFASQCLYSRDRLGIDPEKYNVNGGSIAIGHPFGMTGARCAGHLLLEGKRRKAKLGVVTMCIGGGMGAAGLFEIF

Sequences:

>Translated_395_residues
MREAVIVSYARTGLAKSVRGGFNNTHGAAMAGHAIQHAVSRAGLEGAEVEDVVLGCGGPEGATGMNVARNAAMWAGLPVT
TSGQTINRFCSSGLQAIATAANYVRNDGANVAIGGGVESISLVNAGGHMNRFHITEEKLMQTHPALWMAMIDTADIVAKR
YNVSREYQDEYALRSQQRIAAAQAAGLFKDEIVPMATKMKVVNKETKEESFVDYVVDKDECNRADTTLEGLASLKPVMGE
GKFITAGNASQLSDGAAAVVVMEAKEAEKRGLTPLGAFRGFAVAGCEPDEMGIGPVFAVPRLLERHGLKVDDIDIWELNE
AFASQCLYSRDRLGIDPEKYNVNGGSIAIGHPFGMTGARCAGHLLLEGKRRKAKLGVVTMCIGGGMGAAGLFEIF
>Mature_395_residues
MREAVIVSYARTGLAKSVRGGFNNTHGAAMAGHAIQHAVSRAGLEGAEVEDVVLGCGGPEGATGMNVARNAAMWAGLPVT
TSGQTINRFCSSGLQAIATAANYVRNDGANVAIGGGVESISLVNAGGHMNRFHITEEKLMQTHPALWMAMIDTADIVAKR
YNVSREYQDEYALRSQQRIAAAQAAGLFKDEIVPMATKMKVVNKETKEESFVDYVVDKDECNRADTTLEGLASLKPVMGE
GKFITAGNASQLSDGAAAVVVMEAKEAEKRGLTPLGAFRGFAVAGCEPDEMGIGPVFAVPRLLERHGLKVDDIDIWELNE
AFASQCLYSRDRLGIDPEKYNVNGGSIAIGHPFGMTGARCAGHLLLEGKRRKAKLGVVTMCIGGGMGAAGLFEIF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=394, Percent_Identity=43.6548223350254, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=35.8208955223881, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI4557237, Length=409, Percent_Identity=35.6968215158924, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI148539872, Length=400, Percent_Identity=35.75, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4504327, Length=443, Percent_Identity=30.6997742663657, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI194353979, Length=245, Percent_Identity=31.8367346938775, Blast_Score=105, Evalue=7e-23,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=40.3892944038929, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI87082165, Length=405, Percent_Identity=38.7654320987654, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI1788554, Length=405, Percent_Identity=39.2592592592593, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI48994986, Length=406, Percent_Identity=37.9310344827586, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1788683, Length=420, Percent_Identity=30.2380952380952, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI133906874, Length=369, Percent_Identity=39.8373983739837, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI25147385, Length=401, Percent_Identity=33.6658354114713, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17535921, Length=404, Percent_Identity=35.1485148514851, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=440, Percent_Identity=30, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17535917, Length=398, Percent_Identity=27.6381909547739, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322031, Length=400, Percent_Identity=37, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6325229, Length=404, Percent_Identity=30.9405940594059, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24655093, Length=397, Percent_Identity=40.0503778337531, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI17648125, Length=361, Percent_Identity=39.8891966759003, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24640423, Length=407, Percent_Identity=34.3980343980344, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI17137578, Length=410, Percent_Identity=32.4390243902439, Blast_Score=177, Evalue=9e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41823; Mature: 41823

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAVIVSYARTGLAKSVRGGFNNTHGAAMAGHAIQHAVSRAGLEGAEVEDVVLGCGGPE
CCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
GATGMNVARNAAMWAGLPVTTSGQTINRFCSSGLQAIATAANYVRNDGANVAIGGGVESI
CCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEE
SLVNAGGHMNRFHITEEKLMQTHPALWMAMIDTADIVAKRYNVSREYQDEYALRSQQRIA
EEEECCCCCCEEEECHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AAQAAGLFKDEIVPMATKMKVVNKETKEESFVDYVVDKDECNRADTTLEGLASLKPVMGE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHCCCHHHHHHHHHHHCHHCCC
GKFITAGNASQLSDGAAAVVVMEAKEAEKRGLTPLGAFRGFAVAGCEPDEMGIGPVFAVP
CCEEECCCHHHCCCCCEEEEEEECHHHHHCCCCHHHHHCCEEEECCCCCCCCCCHHHHHH
RLLERHGLKVDDIDIWELNEAFASQCLYSRDRLGIDPEKYNVNGGSIAIGHPFGMTGARC
HHHHHCCCCCCCCCCEECCHHHHHHHHHHCCCCCCCCCCEECCCCEEEECCCCCCCHHHH
AGHLLLEGKRRKAKLGVVTMCIGGGMGAAGLFEIF
HHHHEECCCCCCCCCCEEEEEECCCCCCCHHHHCC
>Mature Secondary Structure
MREAVIVSYARTGLAKSVRGGFNNTHGAAMAGHAIQHAVSRAGLEGAEVEDVVLGCGGPE
CCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
GATGMNVARNAAMWAGLPVTTSGQTINRFCSSGLQAIATAANYVRNDGANVAIGGGVESI
CCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEE
SLVNAGGHMNRFHITEEKLMQTHPALWMAMIDTADIVAKRYNVSREYQDEYALRSQQRIA
EEEECCCCCCEEEECHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AAQAAGLFKDEIVPMATKMKVVNKETKEESFVDYVVDKDECNRADTTLEGLASLKPVMGE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHCCCHHHHHHHHHHHCHHCCC
GKFITAGNASQLSDGAAAVVVMEAKEAEKRGLTPLGAFRGFAVAGCEPDEMGIGPVFAVP
CCEEECCCHHHCCCCCEEEEEEECHHHHHCCCCHHHHHCCEEEECCCCCCCCCCHHHHHH
RLLERHGLKVDDIDIWELNEAFASQCLYSRDRLGIDPEKYNVNGGSIAIGHPFGMTGARC
HHHHHCCCCCCCCCCEECCHHHHHHHHHHCCCCCCCCCCEECCCCEEEECCCCCCCHHHH
AGHLLLEGKRRKAKLGVVTMCIGGGMGAAGLFEIF
HHHHEECCCCCCCCCCEEEEEECCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]