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The map label for this gene is recQ [H]

Identifier: 16127695

GI number: 16127695

Start: 3709014

End: 3710861

Strand: Direct

Name: recQ [H]

Synonym: CC_3465

Alternate gene names: 16127695

Gene position: 3709014-3710861 (Clockwise)

Preceding gene: 16127692

Following gene: 16127696

Centisome position: 92.33

GC content: 71.16

Gene sequence:

>1848_bases
GTGTACGTCCCTCCCGAATCCCCAGAGCTCGACCGCGCGCGCGACGTCCTGCGCCGCACATTTGGTCACGCCGACTTCCG
GGGTCTGCAGGCCGGGGTCATCCACGAGCTGCTGACCGGCCACAGCGCCATGGCGGTGCTGCCCACCGGTGGCGGCAAGA
GCCTGTGCTACCAGATCCCGTCGCTGATCCGGCCGGGCCTGGGTCTGGTCATCTCACCGCTGATCGCCCTGATGGCCGAC
CAGGTGCAGGGCCTGCGCCAGGCCGGCGTCGCCGCCGAGCGGCTGGACAGCAACATCTCGATGGACGAGCGCTCGGACAT
CTGGCGGCGCATCGACGCCGGCGAGGTGGATCTGCTGTATCTGTCGCCCGAGGGCCTGATGCAGCCCTGGATGCTGGACC
GGCTCTCGCGCACGCCGCTGGCCCTGATCGCCGTGGACGAAGCCCACTGTGTCAGCCAGTGGGGCCACGACTTCCGTCCT
GAATACCGGATGCTGGGTCGGCTGGCCGAGCTGTTCCCCGACGCGCCGCGCCTGGCCGTCACCGCCACCGCCGACGCCCG
CACCCGTGACGACATCCGCGCCGAGCTGCGCCTGCAGGGCGCGGCCGAGTTCGTCGACAGCTTCGCGCGTCCGGAGCTGG
CGCTCAGCGCGGAGCGCAAGCGCGGCAAGGGTCACGACCGGGTGGTGGAGCTGGTTCTGGAACGCCCCGGCCGCTCTGGC
GTCATCTATGCCGGCTCGCGCGACGGCACCGAGAAGCTGGCCGAACGGCTGAACGCCGAGGGCGTCCCGGCCCTGGCCTA
TCACGCCGGTCTCGACAAGGCCGTTCGCGCCCGCCGGCTGGAAGACTTCCTCGAGGCCGACGCCGCGGTGATGGTCGCCA
CGATCGCGTTCGGCATGGGCGTCGACAAGCCCGACGTGCGCTATGTGATCCACGCCGATCCGCCGGCCGCCATCGAGGCC
TATTGGCAGGAAGTCGGCCGCGCCGGGCGCGACGGACAGCCGGCCGAGGGCATCACCCTCTATGGCTCGGCCGACATGGC
CTGGGCTGCGCGCCGGATCGAGACCCGCGAGGCGCCCGATGAGGTCAAGCAGGTGCAGTCGCGCAAGCTGCGCCAGTTCT
ACGCCATGCTGGAGGGCGTCACCTGCCGCGCCGCCGCCGTCCGCCGCTATTTCGGCGAAGAGGGCGTCGGCCACTGCGGG
GTCTGCGACATCTGCGTCTCGCCGCCCACCGGGATCGACGCCACGCAAGCGGCTCAGAAGGCGCTGTCGGCCGTCCACCG
GCTGGGCGGGCGTCTTGGTCGCGGCCGCGTGATCGAGCACCTGATGGGCAAGACCAAGGACGTCACGCCCCAGGAGGCGC
AACTGCCGACCTTCGGCATCGGCCGCGAGTTCAGCCAGCCGACCTGGCGCGATCTCTTCGACACCCTGATCTTCGAGGGC
CTGCTGCGCGAGGATCCCAATGACGGGCGACCGCTGATCGGCCTGGGCGATGTCGAGGGCGTGCGGCAGGTCTATCGCAA
CGAGCGCAAGGTCGCGCTGCGCCAGACCACCGACGCGCCCGACAGCGGCGGCCGCGCGGGGGGCGGAATGCGCAAGCGCC
GCGAGGGCCGCGCCCTGACCATCCCGGCCGAAAACCAGCTCCTGTTCGAGGCCCTGCGCTCCTGGCGCAAGGAGCAGGCC
CAGCTGCAGCACGTGCCGCCCTATGTGATCTTCCACGACGCCACCCTGGCCGAGATCGCGGCCGCGCGCCCCGCCACCCT
GGCGGCGCTGGGCAAGGCCGGCGGCGTGGGCCAAGGCAAGCTCGATCGCTATGGCGAGGCGGTCTTGAAAGTGGTTCGCG
AGAACTAA

Upstream 100 bases:

>100_bases
CGGCGCGCGTCGGGAACCCTTCGGCGACCCCGCCCACAGAAACCGCCGTGCCTCAGTTCCTGGCTTGGCGGGGCGCCGAG
CGGCGGCCATAAGAGCCCCC

Downstream 100 bases:

>100_bases
TCGGCGCGCGGCGAGTTCTCTCAGGATCAAGCCGAGGAGCCCCCATGACCCACGTCAACAGCCTGACCCCCTCCGACATC
ACGTCTGCGGTCGACGACAT

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MYVPPESPELDRARDVLRRTFGHADFRGLQAGVIHELLTGHSAMAVLPTGGGKSLCYQIPSLIRPGLGLVISPLIALMAD
QVQGLRQAGVAAERLDSNISMDERSDIWRRIDAGEVDLLYLSPEGLMQPWMLDRLSRTPLALIAVDEAHCVSQWGHDFRP
EYRMLGRLAELFPDAPRLAVTATADARTRDDIRAELRLQGAAEFVDSFARPELALSAERKRGKGHDRVVELVLERPGRSG
VIYAGSRDGTEKLAERLNAEGVPALAYHAGLDKAVRARRLEDFLEADAAVMVATIAFGMGVDKPDVRYVIHADPPAAIEA
YWQEVGRAGRDGQPAEGITLYGSADMAWAARRIETREAPDEVKQVQSRKLRQFYAMLEGVTCRAAAVRRYFGEEGVGHCG
VCDICVSPPTGIDATQAAQKALSAVHRLGGRLGRGRVIEHLMGKTKDVTPQEAQLPTFGIGREFSQPTWRDLFDTLIFEG
LLREDPNDGRPLIGLGDVEGVRQVYRNERKVALRQTTDAPDSGGRAGGGMRKRREGRALTIPAENQLLFEALRSWRKEQA
QLQHVPPYVIFHDATLAEIAAARPATLAALGKAGGVGQGKLDRYGEAVLKVVREN

Sequences:

>Translated_615_residues
MYVPPESPELDRARDVLRRTFGHADFRGLQAGVIHELLTGHSAMAVLPTGGGKSLCYQIPSLIRPGLGLVISPLIALMAD
QVQGLRQAGVAAERLDSNISMDERSDIWRRIDAGEVDLLYLSPEGLMQPWMLDRLSRTPLALIAVDEAHCVSQWGHDFRP
EYRMLGRLAELFPDAPRLAVTATADARTRDDIRAELRLQGAAEFVDSFARPELALSAERKRGKGHDRVVELVLERPGRSG
VIYAGSRDGTEKLAERLNAEGVPALAYHAGLDKAVRARRLEDFLEADAAVMVATIAFGMGVDKPDVRYVIHADPPAAIEA
YWQEVGRAGRDGQPAEGITLYGSADMAWAARRIETREAPDEVKQVQSRKLRQFYAMLEGVTCRAAAVRRYFGEEGVGHCG
VCDICVSPPTGIDATQAAQKALSAVHRLGGRLGRGRVIEHLMGKTKDVTPQEAQLPTFGIGREFSQPTWRDLFDTLIFEG
LLREDPNDGRPLIGLGDVEGVRQVYRNERKVALRQTTDAPDSGGRAGGGMRKRREGRALTIPAENQLLFEALRSWRKEQA
QLQHVPPYVIFHDATLAEIAAARPATLAALGKAGGVGQGKLDRYGEAVLKVVREN
>Mature_615_residues
MYVPPESPELDRARDVLRRTFGHADFRGLQAGVIHELLTGHSAMAVLPTGGGKSLCYQIPSLIRPGLGLVISPLIALMAD
QVQGLRQAGVAAERLDSNISMDERSDIWRRIDAGEVDLLYLSPEGLMQPWMLDRLSRTPLALIAVDEAHCVSQWGHDFRP
EYRMLGRLAELFPDAPRLAVTATADARTRDDIRAELRLQGAAEFVDSFARPELALSAERKRGKGHDRVVELVLERPGRSG
VIYAGSRDGTEKLAERLNAEGVPALAYHAGLDKAVRARRLEDFLEADAAVMVATIAFGMGVDKPDVRYVIHADPPAAIEA
YWQEVGRAGRDGQPAEGITLYGSADMAWAARRIETREAPDEVKQVQSRKLRQFYAMLEGVTCRAAAVRRYFGEEGVGHCG
VCDICVSPPTGIDATQAAQKALSAVHRLGGRLGRGRVIEHLMGKTKDVTPQEAQLPTFGIGREFSQPTWRDLFDTLIFEG
LLREDPNDGRPLIGLGDVEGVRQVYRNERKVALRQTTDAPDSGGRAGGGMRKRREGRALTIPAENQLLFEALRSWRKEQA
QLQHVPPYVIFHDATLAEIAAARPATLAALGKAGGVGQGKLDRYGEAVLKVVREN

Specific function: DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=649, Percent_Identity=31.1248073959938, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI14591902, Length=452, Percent_Identity=35.3982300884956, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI14591904, Length=452, Percent_Identity=35.3982300884956, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI110735439, Length=501, Percent_Identity=33.5329341317365, Blast_Score=245, Evalue=7e-65,
Organism=Homo sapiens, GI169218196, Length=501, Percent_Identity=33.5329341317365, Blast_Score=245, Evalue=8e-65,
Organism=Homo sapiens, GI148612816, Length=435, Percent_Identity=35.8620689655172, Blast_Score=239, Evalue=6e-63,
Organism=Homo sapiens, GI51242947, Length=360, Percent_Identity=38.3333333333333, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI51242943, Length=360, Percent_Identity=38.3333333333333, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI284005309, Length=342, Percent_Identity=38.5964912280702, Blast_Score=196, Evalue=7e-50,
Organism=Homo sapiens, GI55749865, Length=345, Percent_Identity=22.3188405797101, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI21071032, Length=423, Percent_Identity=23.8770685579196, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI148613856, Length=364, Percent_Identity=22.8021978021978, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI38201710, Length=364, Percent_Identity=22.8021978021978, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4758138, Length=350, Percent_Identity=22.8571428571429, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI48994977, Length=607, Percent_Identity=41.3509060955519, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1787016, Length=355, Percent_Identity=23.943661971831, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25145561, Length=647, Percent_Identity=30.757341576507, Blast_Score=281, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI71987997, Length=510, Percent_Identity=34.5098039215686, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71987993, Length=510, Percent_Identity=34.5098039215686, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI32564293, Length=679, Percent_Identity=29.3078055964654, Blast_Score=274, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17552866, Length=449, Percent_Identity=34.5211581291759, Blast_Score=250, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6323844, Length=502, Percent_Identity=33.6653386454183, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6324217, Length=346, Percent_Identity=24.2774566473988, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321856, Length=353, Percent_Identity=23.5127478753541, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323947, Length=351, Percent_Identity=24.7863247863248, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24646066, Length=638, Percent_Identity=33.6990595611285, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24664226, Length=446, Percent_Identity=34.9775784753363, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI62472181, Length=447, Percent_Identity=34.8993288590604, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24664230, Length=448, Percent_Identity=34.8214285714286, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI21358123, Length=352, Percent_Identity=36.6477272727273, Blast_Score=192, Evalue=6e-49,
Organism=Drosophila melanogaster, GI21355075, Length=369, Percent_Identity=23.5772357723577, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 67393; Mature: 67393

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVPPESPELDRARDVLRRTFGHADFRGLQAGVIHELLTGHSAMAVLPTGGGKSLCYQIP
CCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHH
SLIRPGLGLVISPLIALMADQVQGLRQAGVAAERLDSNISMDERSDIWRRIDAGEVDLLY
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEE
LSPEGLMQPWMLDRLSRTPLALIAVDEAHCVSQWGHDFRPEYRMLGRLAELFPDAPRLAV
ECCHHHCCHHHHHHHCCCCEEEEEECHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEE
TATADARTRDDIRAELRLQGAAEFVDSFARPELALSAERKRGKGHDRVVELVLERPGRSG
EECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCC
VIYAGSRDGTEKLAERLNAEGVPALAYHAGLDKAVRARRLEDFLEADAAVMVATIAFGMG
EEEECCCCCHHHHHHHHCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VDKPDVRYVIHADPPAAIEAYWQEVGRAGRDGQPAEGITLYGSADMAWAARRIETREAPD
CCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCHH
EVKQVQSRKLRQFYAMLEGVTCRAAAVRRYFGEEGVGHCGVCDICVSPPTGIDATQAAQK
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHH
ALSAVHRLGGRLGRGRVIEHLMGKTKDVTPQEAQLPTFGIGREFSQPTWRDLFDTLIFEG
HHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LLREDPNDGRPLIGLGDVEGVRQVYRNERKVALRQTTDAPDSGGRAGGGMRKRREGRALT
HHHCCCCCCCCEEECCCHHHHHHHHHCCHHEEEEECCCCCCCCCCCCCCCHHHCCCCEEE
IPAENQLLFEALRSWRKEQAQLQHVPPYVIFHDATLAEIAAARPATLAALGKAGGVGQGK
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCHHHHHHHCCCCCCCCH
LDRYGEAVLKVVREN
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MYVPPESPELDRARDVLRRTFGHADFRGLQAGVIHELLTGHSAMAVLPTGGGKSLCYQIP
CCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHH
SLIRPGLGLVISPLIALMADQVQGLRQAGVAAERLDSNISMDERSDIWRRIDAGEVDLLY
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEE
LSPEGLMQPWMLDRLSRTPLALIAVDEAHCVSQWGHDFRPEYRMLGRLAELFPDAPRLAV
ECCHHHCCHHHHHHHCCCCEEEEEECHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEE
TATADARTRDDIRAELRLQGAAEFVDSFARPELALSAERKRGKGHDRVVELVLERPGRSG
EECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCC
VIYAGSRDGTEKLAERLNAEGVPALAYHAGLDKAVRARRLEDFLEADAAVMVATIAFGMG
EEEECCCCCHHHHHHHHCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VDKPDVRYVIHADPPAAIEAYWQEVGRAGRDGQPAEGITLYGSADMAWAARRIETREAPD
CCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCHH
EVKQVQSRKLRQFYAMLEGVTCRAAAVRRYFGEEGVGHCGVCDICVSPPTGIDATQAAQK
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHH
ALSAVHRLGGRLGRGRVIEHLMGKTKDVTPQEAQLPTFGIGREFSQPTWRDLFDTLIFEG
HHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LLREDPNDGRPLIGLGDVEGVRQVYRNERKVALRQTTDAPDSGGRAGGGMRKRREGRALT
HHHCCCCCCCCEEECCCHHHHHHHHHCCHHEEEEECCCCCCCCCCCCCCCHHHCCCCEEE
IPAENQLLFEALRSWRKEQAQLQHVPPYVIFHDATLAEIAAARPATLAALGKAGGVGQGK
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCHHHHHHHCCCCCCCCH
LDRYGEAVLKVVREN
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]