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The map label for this gene is frmA [H]

Identifier: 16127259

GI number: 16127259

Start: 3243913

End: 3245013

Strand: Direct

Name: frmA [H]

Synonym: CC_3029

Alternate gene names: 16127259

Gene position: 3243913-3245013 (Clockwise)

Preceding gene: 16127255

Following gene: 16127260

Centisome position: 80.76

GC content: 68.12

Gene sequence:

>1101_bases
ATGAAGGCCGCTGTTCTGCGCGAGGTGGGCAAACCCCTCCAGATCGAGACCGTGGCCATCGGCAAGCCCGGCCCGCGCGA
GGTGCTGATCCGCACCAAGGCCGCCGGCGTCTGCCACTCCGACCTGCACTTCGTCGAAGGCTCCTATACCCACGCCCTGC
CCGCCGTGCTGGGCCACGAGAGCGCCGGGATCGTCGAGGCGGTCGGCAGCGAGGTTCGCACCGTCAAGGTCGGCGACCAC
GTCATCACCTGCCTCAACCCCTATTGCGGCCACTGCGAGGTCTGCCTGACCGGGCATATGAACCTCTGCATCAGCCCCGA
GACGCGCCGCAGCAAGAGCGACGCCCCGCGCCTCTTCAAGGAAGACCTGAACGGCGCCACCGGCCCGATGGCCCAGTTCC
TGAACCTGTCGTCCTTCGCCGAGATGATGCTGGTCCACGAGCACGCGTGCGTGGCCATCCGCAAGGACATGCCGTTCGAC
CGCGCCGCCCTGATCGGCTGCTCGGTGATGACCGGCGTGGGCGCGGTGATGCACACCTCCAACGTCCGCCCCGGCGAGAC
CGTGGCCGTGATCGGCTGCGGCGGCGTGGGTCTCGCCACCATCAACGGCGCGGCCATCGCGGGCGCGGGCCGGATCATCG
CCATCGACCGCCTGGCCGGGAAGCTGGAGCTGGCCAAGACCTTCGGCGCCACCGACGTGGTCGACGCCTCGCAGGTCGAC
GACATCGCCAAGGCCGTGGTCGAACTGACCGGCGGCGGGGTGCACCACAGCTTCGAGGCCATCGGCCTGAAGGCCACGGC
GGAGGCCTCGTTCAAGATGCTGCGCCGGGGCGGCACGGCCAATGTCATCGGCATGATCCCGGTCGGCACCAAGATCGAGC
TGCACGGCGTCGACTTCCTGGGCGAGCGCCGCATCCAGGGCAGCTATATGGGCTCCAACCGCTTCCCGGTCGACATGCCG
CGCCTGGTGGACTTCTACATGTCGGGCAAGCTGAAGCTGGACGAACTGATCTCGCGCCGCATCAAGCTGGAGGACGTCAA
CTCGGCCTTCGACGAGCTCAAGCGCGGCGAGCTGGCGCGATCGGTGATCGTGTTTGACTGA

Upstream 100 bases:

>100_bases
TAATTTCAAGTCGCAATGCGCCCCGAACATTTGTTCGAATAGCCCTTCCGTTCGCCCCGAACGGAACGCTAGTCTCCCCT
CAAACAAGAGGGAGACGAGC

Downstream 100 bases:

>100_bases
GGGGAGTGGCGGCGATCCGCGCTGAGCGCGCAAACAGCGGCCAAGGGCCCTTGGGAACCTGGCGCCTGGTGGCCTTTGCG
CTGCCCTGCGTTCCGGTGGC

Product: class II alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MKAAVLREVGKPLQIETVAIGKPGPREVLIRTKAAGVCHSDLHFVEGSYTHALPAVLGHESAGIVEAVGSEVRTVKVGDH
VITCLNPYCGHCEVCLTGHMNLCISPETRRSKSDAPRLFKEDLNGATGPMAQFLNLSSFAEMMLVHEHACVAIRKDMPFD
RAALIGCSVMTGVGAVMHTSNVRPGETVAVIGCGGVGLATINGAAIAGAGRIIAIDRLAGKLELAKTFGATDVVDASQVD
DIAKAVVELTGGGVHHSFEAIGLKATAEASFKMLRRGGTANVIGMIPVGTKIELHGVDFLGERRIQGSYMGSNRFPVDMP
RLVDFYMSGKLKLDELISRRIKLEDVNSAFDELKRGELARSVIVFD

Sequences:

>Translated_366_residues
MKAAVLREVGKPLQIETVAIGKPGPREVLIRTKAAGVCHSDLHFVEGSYTHALPAVLGHESAGIVEAVGSEVRTVKVGDH
VITCLNPYCGHCEVCLTGHMNLCISPETRRSKSDAPRLFKEDLNGATGPMAQFLNLSSFAEMMLVHEHACVAIRKDMPFD
RAALIGCSVMTGVGAVMHTSNVRPGETVAVIGCGGVGLATINGAAIAGAGRIIAIDRLAGKLELAKTFGATDVVDASQVD
DIAKAVVELTGGGVHHSFEAIGLKATAEASFKMLRRGGTANVIGMIPVGTKIELHGVDFLGERRIQGSYMGSNRFPVDMP
RLVDFYMSGKLKLDELISRRIKLEDVNSAFDELKRGELARSVIVFD
>Mature_366_residues
MKAAVLREVGKPLQIETVAIGKPGPREVLIRTKAAGVCHSDLHFVEGSYTHALPAVLGHESAGIVEAVGSEVRTVKVGDH
VITCLNPYCGHCEVCLTGHMNLCISPETRRSKSDAPRLFKEDLNGATGPMAQFLNLSSFAEMMLVHEHACVAIRKDMPFD
RAALIGCSVMTGVGAVMHTSNVRPGETVAVIGCGGVGLATINGAAIAGAGRIIAIDRLAGKLELAKTFGATDVVDASQVD
DIAKAVVELTGGGVHHSFEAIGLKATAEASFKMLRRGGTANVIGMIPVGTKIELHGVDFLGERRIQGSYMGSNRFPVDMP
RLVDFYMSGKLKLDELISRRIKLEDVNSAFDELKRGELARSVIVFD

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=38.2113821138211, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=37.6693766937669, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=36.8563685636856, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=34.9593495934959, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI71565154, Length=366, Percent_Identity=34.9726775956284, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI4501939, Length=362, Percent_Identity=35.3591160220994, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI71743840, Length=368, Percent_Identity=34.5108695652174, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI262073058, Length=368, Percent_Identity=34.5108695652174, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI71565152, Length=370, Percent_Identity=33.2432432432432, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI156627571, Length=352, Percent_Identity=29.2613636363636, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1786552, Length=368, Percent_Identity=35.8695652173913, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1788073, Length=346, Percent_Identity=29.1907514450867, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI87082125, Length=366, Percent_Identity=26.2295081967213, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788075, Length=348, Percent_Identity=24.7126436781609, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87081918, Length=341, Percent_Identity=29.9120234604106, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790045, Length=377, Percent_Identity=25.7294429708223, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788407, Length=348, Percent_Identity=26.1494252873563, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786518, Length=378, Percent_Identity=26.4550264550265, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786825, Length=393, Percent_Identity=23.6641221374046, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1787863, Length=362, Percent_Identity=26.2430939226519, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=35.9249329758713, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=35.7333333333333, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17565904, Length=342, Percent_Identity=36.2573099415205, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17562584, Length=367, Percent_Identity=29.4277929155313, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17562876, Length=372, Percent_Identity=29.0322580645161, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17562878, Length=359, Percent_Identity=28.133704735376, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71988145, Length=368, Percent_Identity=27.1739130434783, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17562582, Length=370, Percent_Identity=28.3783783783784, Blast_Score=111, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6320033, Length=370, Percent_Identity=36.7567567567568, Blast_Score=233, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6323961, Length=369, Percent_Identity=30.0813008130081, Blast_Score=125, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6319621, Length=371, Percent_Identity=30.4582210242588, Blast_Score=123, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6324486, Length=369, Percent_Identity=28.9972899728997, Blast_Score=116, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6323729, Length=371, Percent_Identity=28.8409703504043, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323099, Length=373, Percent_Identity=28.686327077748, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6322619, Length=380, Percent_Identity=30.2631578947368, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=380, Percent_Identity=30.2631578947368, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319257, Length=357, Percent_Identity=26.890756302521, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=295, Percent_Identity=28.4745762711864, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17737895, Length=380, Percent_Identity=38.1578947368421, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI17137530, Length=355, Percent_Identity=26.7605633802817, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17737897, Length=356, Percent_Identity=27.247191011236, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45551930, Length=104, Percent_Identity=37.5, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221457811, Length=104, Percent_Identity=37.5, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45550770, Length=104, Percent_Identity=37.5, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 38911; Mature: 38911

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVLREVGKPLQIETVAIGKPGPREVLIRTKAAGVCHSDLHFVEGSYTHALPAVLGHE
CCCHHHHHCCCCEEEEEEEECCCCCHHEEEEECCCCCCCCCCCEECCCCHHHHHHHHCCC
SAGIVEAVGSEVRTVKVGDHVITCLNPYCGHCEVCLTGHMNLCISPETRRSKSDAPRLFK
CCCHHHHCCCCEEEEEECCEEEEECCCCCCCEEEEEECCCEEEECCCCCCCCCCCHHHHH
EDLNGATGPMAQFLNLSSFAEMMLVHEHACVAIRKDMPFDRAALIGCSVMTGVGAVMHTS
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCHHEECC
NVRPGETVAVIGCGGVGLATINGAAIAGAGRIIAIDRLAGKLELAKTFGATDVVDASQVD
CCCCCCEEEEEEECCCCEEEECCEEEECCCCEEEEEHHCCHHHHHHHCCCCCCCCHHHHH
DIAKAVVELTGGGVHHSFEAIGLKATAEASFKMLRRGGTANVIGMIPVGTKIELHGVDFL
HHHHHHHHHCCCCCCCCHHHCCEEEHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCHH
GERRIQGSYMGSNRFPVDMPRLVDFYMSGKLKLDELISRRIKLEDVNSAFDELKRGELAR
CCCCCCCEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHC
SVIVFD
EEEEEC
>Mature Secondary Structure
MKAAVLREVGKPLQIETVAIGKPGPREVLIRTKAAGVCHSDLHFVEGSYTHALPAVLGHE
CCCHHHHHCCCCEEEEEEEECCCCCHHEEEEECCCCCCCCCCCEECCCCHHHHHHHHCCC
SAGIVEAVGSEVRTVKVGDHVITCLNPYCGHCEVCLTGHMNLCISPETRRSKSDAPRLFK
CCCHHHHCCCCEEEEEECCEEEEECCCCCCCEEEEEECCCEEEECCCCCCCCCCCHHHHH
EDLNGATGPMAQFLNLSSFAEMMLVHEHACVAIRKDMPFDRAALIGCSVMTGVGAVMHTS
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCHHEECC
NVRPGETVAVIGCGGVGLATINGAAIAGAGRIIAIDRLAGKLELAKTFGATDVVDASQVD
CCCCCCEEEEEEECCCCEEEECCEEEECCCCEEEEEHHCCHHHHHHHCCCCCCCCHHHHH
DIAKAVVELTGGGVHHSFEAIGLKATAEASFKMLRRGGTANVIGMIPVGTKIELHGVDFL
HHHHHHHHHCCCCCCCCHHHCCEEEHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCHH
GERRIQGSYMGSNRFPVDMPRLVDFYMSGKLKLDELISRRIKLEDVNSAFDELKRGELAR
CCCCCCCEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHC
SVIVFD
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]