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The map label for this gene is aroK

Identifier: 16127238

GI number: 16127238

Start: 3227943

End: 3228545

Strand: Direct

Name: aroK

Synonym: CC_3008

Alternate gene names: 16127238

Gene position: 3227943-3228545 (Clockwise)

Preceding gene: 16127233

Following gene: 16127239

Centisome position: 80.36

GC content: 71.14

Gene sequence:

>603_bases
ATGACCGAGACCGATCAAACGCCCGACACCGCCCCAGAGGCCGCCCCAGAGGTCGCGCCCATCGTCTCCGACGACCTGGC
GCCGCTGCGCGCCAAGACCATCGTGCTGGTGGGCCTGATGGGCGTGGGCAAGTCCAGCGTCGGGCGGCGGCTGGCCAATG
TGCTGGGCCTGCCGTTCCGCGACGCCGACAATGAGGTCGAGGCCGCCGCCGGACGCTCGATCTCCGAGATCTTCGCCGAG
CTGGGTGAGCCGGCCTTCCGCGACGGCGAGCGCCGGGTGATCGCCCGGCTGCTGGACGAGCCGCCGCACGTGCTGGCCAC
CGGCGGCGGCGCGTTCGTCAACGCCGAGACCCGCGCCCTGATCAACGAGAAGGCCGTGTCGGTCTGGCTGAAGGCCGATG
TCGAGCTCCTGGCCCGCCGCGTCTCGCGCAAGGACAACCGCCCGCTGGTGCGCGGCAAGGACCCGGTGAAGGTGCTGACC
GAGCTCGCCGAAGCCCGCTATCCGGCCTATGCCGAGGCGCAAGTCCATGTCGAGACCGGCGACACCCCCCACATGGTGGC
GGTCGAGGCCATTCTGACGGCGCTGCGTCAGGCCCACGCTTAA

Upstream 100 bases:

>100_bases
AGGCATGGACCGGTTATGACGCATGACAGGGCTCTCGCAAACTTGGGCGCTCGCAAACTTGGCGCTTTGGCCTAGCCTCG
TGTAAACCCGCGACCGCATC

Downstream 100 bases:

>100_bases
GGAGTTCGCATGATCCGCACCGTCCCCGTGGGCCTGGGCGAGCGCGCCTATGACGTCGTCATCGGGCCTGGCCTGCTGGA
TCAGGCCGGCGAGCGTGTCG

Product: shikimate kinase

Products: NA

Alternate protein names: SK

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MTETDQTPDTAPEAAPEVAPIVSDDLAPLRAKTIVLVGLMGVGKSSVGRRLANVLGLPFRDADNEVEAAAGRSISEIFAE
LGEPAFRDGERRVIARLLDEPPHVLATGGGAFVNAETRALINEKAVSVWLKADVELLARRVSRKDNRPLVRGKDPVKVLT
ELAEARYPAYAEAQVHVETGDTPHMVAVEAILTALRQAHA

Sequences:

>Translated_200_residues
MTETDQTPDTAPEAAPEVAPIVSDDLAPLRAKTIVLVGLMGVGKSSVGRRLANVLGLPFRDADNEVEAAAGRSISEIFAE
LGEPAFRDGERRVIARLLDEPPHVLATGGGAFVNAETRALINEKAVSVWLKADVELLARRVSRKDNRPLVRGKDPVKVLT
ELAEARYPAYAEAQVHVETGDTPHMVAVEAILTALRQAHA
>Mature_199_residues
TETDQTPDTAPEAAPEVAPIVSDDLAPLRAKTIVLVGLMGVGKSSVGRRLANVLGLPFRDADNEVEAAAGRSISEIFAEL
GEPAFRDGERRVIARLLDEPPHVLATGGGAFVNAETRALINEKAVSVWLKADVELLARRVSRKDNRPLVRGKDPVKVLTE
LAEARYPAYAEAQVHVETGDTPHMVAVEAILTALRQAHA

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family

Homologues:

Organism=Escherichia coli, GI87082255, Length=166, Percent_Identity=39.1566265060241, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1786587, Length=168, Percent_Identity=29.7619047619048, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): AROK_CAUCN (B8H331)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002518476.1
- ProteinModelPortal:   B8H331
- SMR:   B8H331
- GeneID:   7333557
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_03103
- OMA:   VIYLRAN
- ProtClustDB:   PRK13946
- GO:   GO:0005737
- HAMAP:   MF_00109
- InterPro:   IPR000623
- InterPro:   IPR023000
- PRINTS:   PR01100

Pfam domain/function: PF01202 SKI

EC number: =2.7.1.71

Molecular weight: Translated: 21440; Mature: 21308

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: BINDING 63-63 BINDING 87-87 BINDING 109-109 BINDING 147-147 BINDING 166-166

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETDQTPDTAPEAAPEVAPIVSDDLAPLRAKTIVLVGLMGVGKSSVGRRLANVLGLPFR
CCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
DADNEVEAAAGRSISEIFAELGEPAFRDGERRVIARLLDEPPHVLATGGGAFVNAETRAL
CCCCHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCEEECHHHHHH
INEKAVSVWLKADVELLARRVSRKDNRPLVRGKDPVKVLTELAEARYPAYAEAQVHVETG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECC
DTPHMVAVEAILTALRQAHA
CCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TETDQTPDTAPEAAPEVAPIVSDDLAPLRAKTIVLVGLMGVGKSSVGRRLANVLGLPFR
CCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
DADNEVEAAAGRSISEIFAELGEPAFRDGERRVIARLLDEPPHVLATGGGAFVNAETRAL
CCCCHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCEEECHHHHHH
INEKAVSVWLKADVELLARRVSRKDNRPLVRGKDPVKVLTELAEARYPAYAEAQVHVETG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECC
DTPHMVAVEAILTALRQAHA
CCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA