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The map label for this gene is envZ [H]

Identifier: 16127162

GI number: 16127162

Start: 3155664

End: 3157001

Strand: Direct

Name: envZ [H]

Synonym: CC_2932

Alternate gene names: 16127162

Gene position: 3155664-3157001 (Clockwise)

Preceding gene: 16127161

Following gene: 16127165

Centisome position: 78.56

GC content: 69.73

Gene sequence:

>1338_bases
ATGCCCCTCACCCGCCTCGACATCCCGCCGGCGCTGAAGCGTCTGCTGCCGACCACGCTGTTCGGGCGCAGCCTGCTGAT
CATCATCCTGCCGGTGGCGATCATGCAGATCGCCGTGACCTGGGCGTTCTTTGACGCCCACTGGCAGAGCGTGACCAGCA
AGCTCTCCGAGGGCCTGGCCGGCGACATCGCCTGGGCGGTGCAGTCCTATGAGGACGATCCCAGCCCCGCCGCCGTCGAG
AAGCTGGCCGAGCGGGCCGAAGGCGCGCTGTCGCTGTCGATCGCCTTCCAGAAGGGTCGCAAGCTGCCGACCAGCCATCG
CCCCTCGCTGTTCGCAGCCCTGGACCGGTCGCTGGACAAGGCGCTGGAGGACCGGCTGGACAACCCGTTCTGGTTCGATA
CGACCCGCTACCGCGCCTATATCGACATCCGGGTGCAGGTCGACGGCGGGGTGCTGCAGATCTACGCCCTGCGCGACCGC
GCCTACGCCACCCAGGGCCACATCTTCATCCTGTGGATGGTGGTGGCGACCCTGCTGCTGACGGCGGTGGCCATCCTGTT
CATCCGCAACCAGGTGCGGGCCATCGAGCGCCTGGCCGAGGCCGCCGACGCCTTCGGCCGGGGCGAGGATCCGGAGTTCA
AGCCGCACGGCGCGCGCGAGGTGCGCCAGGCGGCCCTGGCCTTCATCGCCATGAAGCTGCGCATCCAGCGCCATATCGAG
CAGCGCACCGCCCTCCTGGCCAGCGTCAGCCATGACCTGCGCACGCCGCTGACCCGGCTGAAGCTGGAAATGGCCATGGC
CGAGCCCTGCGAGCGCATGGAGGCCATGAAGGGCGATCTGGCCGAAATGGAGCACATGATCGACGAGTACCTGGCCTTCG
CCCGCGGCGAGGGCGGCGAGGCGATCCAGGTCGTGGACCTGTCGGACCTGGTCGAAAGCGTGGTGGCCGACGCCGAGCGC
GGCGGGGCGGCGATCGAGACCGAGATCACGCAAGGGCTGGAAACCCGCCTGCGCCCCCTCACCTTCCGCCGGGCCCTGGC
CAATCTGATCGACAACGGCGTGGCCCACGCCGACCGGGTGCGCGTCACGGTCAGCCCGCGTCAGACCGGCGGCGTCGATG
TGGCCGTCGACGATGACGGTCCCGGCATCCCCGAAGACAAGTACGAGGAGGCCTTCAAGCCCTTCTCGCGGCTCGACGAA
AGCCGGAACCAGAACGAGAAGGGCGTGGGCCTCGGCCTGGCCATCGCCCGCGACATGGCGCGCGGCCTGGGCGGCGATCT
GGTGCTGTCCCGCTCGGCGCTGGGCGGCCTGCGGGCGCTGATCAGGCTGCCGGGGTAA

Upstream 100 bases:

>100_bases
GTGGAGGGGGCGTCGGCCGGCGCACAGCGCGCCCCCTCCGTCGCGCTGCGTATTCGCATCGCGCCACCTCCCCCGCGTTG
CGGGGGAGGAGATTAGCCCC

Downstream 100 bases:

>100_bases
GAGCAAAAACAAGGTGTCATCCCGGAAACGCCGCAGGCGTTATCCGGGACCCAGGGGGTGACGAAACGCCGTGCGCGCCG
CCCCTGGGTCCCGGGTCGGC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MPLTRLDIPPALKRLLPTTLFGRSLLIIILPVAIMQIAVTWAFFDAHWQSVTSKLSEGLAGDIAWAVQSYEDDPSPAAVE
KLAERAEGALSLSIAFQKGRKLPTSHRPSLFAALDRSLDKALEDRLDNPFWFDTTRYRAYIDIRVQVDGGVLQIYALRDR
AYATQGHIFILWMVVATLLLTAVAILFIRNQVRAIERLAEAADAFGRGEDPEFKPHGAREVRQAALAFIAMKLRIQRHIE
QRTALLASVSHDLRTPLTRLKLEMAMAEPCERMEAMKGDLAEMEHMIDEYLAFARGEGGEAIQVVDLSDLVESVVADAER
GGAAIETEITQGLETRLRPLTFRRALANLIDNGVAHADRVRVTVSPRQTGGVDVAVDDDGPGIPEDKYEEAFKPFSRLDE
SRNQNEKGVGLGLAIARDMARGLGGDLVLSRSALGGLRALIRLPG

Sequences:

>Translated_445_residues
MPLTRLDIPPALKRLLPTTLFGRSLLIIILPVAIMQIAVTWAFFDAHWQSVTSKLSEGLAGDIAWAVQSYEDDPSPAAVE
KLAERAEGALSLSIAFQKGRKLPTSHRPSLFAALDRSLDKALEDRLDNPFWFDTTRYRAYIDIRVQVDGGVLQIYALRDR
AYATQGHIFILWMVVATLLLTAVAILFIRNQVRAIERLAEAADAFGRGEDPEFKPHGAREVRQAALAFIAMKLRIQRHIE
QRTALLASVSHDLRTPLTRLKLEMAMAEPCERMEAMKGDLAEMEHMIDEYLAFARGEGGEAIQVVDLSDLVESVVADAER
GGAAIETEITQGLETRLRPLTFRRALANLIDNGVAHADRVRVTVSPRQTGGVDVAVDDDGPGIPEDKYEEAFKPFSRLDE
SRNQNEKGVGLGLAIARDMARGLGGDLVLSRSALGGLRALIRLPG
>Mature_444_residues
PLTRLDIPPALKRLLPTTLFGRSLLIIILPVAIMQIAVTWAFFDAHWQSVTSKLSEGLAGDIAWAVQSYEDDPSPAAVEK
LAERAEGALSLSIAFQKGRKLPTSHRPSLFAALDRSLDKALEDRLDNPFWFDTTRYRAYIDIRVQVDGGVLQIYALRDRA
YATQGHIFILWMVVATLLLTAVAILFIRNQVRAIERLAEAADAFGRGEDPEFKPHGAREVRQAALAFIAMKLRIQRHIEQ
RTALLASVSHDLRTPLTRLKLEMAMAEPCERMEAMKGDLAEMEHMIDEYLAFARGEGGEAIQVVDLSDLVESVVADAERG
GAAIETEITQGLETRLRPLTFRRALANLIDNGVAHADRVRVTVSPRQTGGVDVAVDDDGPGIPEDKYEEAFKPFSRLDES
RNQNEKGVGLGLAIARDMARGLGGDLVLSRSALGGLRALIRLPG

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=288, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790346, Length=287, Percent_Identity=29.616724738676, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1787894, Length=271, Percent_Identity=28.7822878228782, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1786600, Length=192, Percent_Identity=30.2083333333333, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI87082128, Length=294, Percent_Identity=26.530612244898, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786783, Length=253, Percent_Identity=28.0632411067194, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787374, Length=294, Percent_Identity=27.2108843537415, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=23.8095238095238, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI48994928, Length=222, Percent_Identity=27.027027027027, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789149, Length=219, Percent_Identity=25.1141552511416, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790861, Length=298, Percent_Identity=26.510067114094, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=29.3333333333333, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49046; Mature: 48915

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTRLDIPPALKRLLPTTLFGRSLLIIILPVAIMQIAVTWAFFDAHWQSVTSKLSEGLA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GDIAWAVQSYEDDPSPAAVEKLAERAEGALSLSIAFQKGRKLPTSHRPSLFAALDRSLDK
HHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
ALEDRLDNPFWFDTTRYRAYIDIRVQVDGGVLQIYALRDRAYATQGHIFILWMVVATLLL
HHHHHCCCCEEECCCEEEEEEEEEEEECCCEEEEEEECCHHHCCCCCHHHHHHHHHHHHH
TAVAILFIRNQVRAIERLAEAADAFGRGEDPEFKPHGAREVRQAALAFIAMKLRIQRHIE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QRTALLASVSHDLRTPLTRLKLEMAMAEPCERMEAMKGDLAEMEHMIDEYLAFARGEGGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
AIQVVDLSDLVESVVADAERGGAAIETEITQGLETRLRPLTFRRALANLIDNGVAHADRV
EEEEEEHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
RVTVSPRQTGGVDVAVDDDGPGIPEDKYEEAFKPFSRLDESRNQNEKGVGLGLAIARDMA
EEEECCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
RGLGGDLVLSRSALGGLRALIRLPG
HCCCCHHEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PLTRLDIPPALKRLLPTTLFGRSLLIIILPVAIMQIAVTWAFFDAHWQSVTSKLSEGLA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GDIAWAVQSYEDDPSPAAVEKLAERAEGALSLSIAFQKGRKLPTSHRPSLFAALDRSLDK
HHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
ALEDRLDNPFWFDTTRYRAYIDIRVQVDGGVLQIYALRDRAYATQGHIFILWMVVATLLL
HHHHHCCCCEEECCCEEEEEEEEEEEECCCEEEEEEECCHHHCCCCCHHHHHHHHHHHHH
TAVAILFIRNQVRAIERLAEAADAFGRGEDPEFKPHGAREVRQAALAFIAMKLRIQRHIE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QRTALLASVSHDLRTPLTRLKLEMAMAEPCERMEAMKGDLAEMEHMIDEYLAFARGEGGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
AIQVVDLSDLVESVVADAERGGAAIETEITQGLETRLRPLTFRRALANLIDNGVAHADRV
EEEEEEHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
RVTVSPRQTGGVDVAVDDDGPGIPEDKYEEAFKPFSRLDESRNQNEKGVGLGLAIARDMA
EEEECCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
RGLGGDLVLSRSALGGLRALIRLPG
HCCCCHHEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]