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The map label for this gene is nadC [H]

Identifier: 16127145

GI number: 16127145

Start: 3137079

End: 3137927

Strand: Direct

Name: nadC [H]

Synonym: CC_2915

Alternate gene names: 16127145

Gene position: 3137079-3137927 (Clockwise)

Preceding gene: 16127144

Following gene: 16127148

Centisome position: 78.1

GC content: 73.03

Gene sequence:

>849_bases
TTGACGCTTTCCCCGCTCCCCGACCTCCTCGTCCGTCCGATCGTCGACCTGGCCCTCGCCGAAGACCTGGGCCGGGCCGG
CGACATCACCGGCCAGGCCTGTATCGATCCGGACGCCCGGCTGTCGGTGGCCTTCGCCAGCCGGCAGGACGGCCGGGTCT
CAGGGCTGACGTGCGCGCGGCTGGCGCTGGCGGCGATGGACCCGACCGCCCGCTTCGAGATCGTCACGCCCGACGGCGCC
GACGTGACCCCGGGCGCGGTGCTGGCCCGCGCCGAGGGCAACGCCCGCGCCGTGCTGATCGCCGAGCGCACGGGCCTCAA
CCTCCTGGGCCGGATGTCGGGCATCGCCACCCTGACCCGGGCCTATGTCCGCCTGGTCGAGGGCACGAGCGCCACCATCG
TCGACACCCGCAAGACCACGCCCGGCCTGCGGGCCCTGGAGAAGTACGCGGTGCGCTGCGGCGGCGGGGTCAACCACCGC
TTTGGCCTGGATGACGCCATCCTGATCAAGGACAACCATGTCGCGGCCTGCGGCGGGGTCGGCGAGGCGGTCCGCCGGGC
GCGCGCCCATGCCGGCCACCTCGTCAAGGTCGAGGTCGAGGTCGACGGCCTGGACCAGCTGGAAGAAGCCCTCAAGCACG
GGCCGGACGTGGTGATGCTGGACAATTTCAGCCTGGCCGACCTGCGCGCGGCCGTCGCCCTGGCCAAGGGCCGGGCGGTG
CTGGAGGCCTCGGGCGGGGTGAACCTGACCACCGTGCGGGCCATCGCCGAGACGGGCGTGGACGTGATCAGCGTCGGGGC
GCTGACGCACTCGGCGCCGGTGCTGGATATCGGGCTGGACGCCAACTAA

Upstream 100 bases:

>100_bases
AACCGAACGGGACCTGGGCCTCGACCACGGTCCACGATGACGACGACTCCGTCTCGCCGCTGTTCGCCCCACAGATCAGC
CTCTCGCTGTCGGAGTTGTT

Downstream 100 bases:

>100_bases
GCGCAGGGCGAGCTCCCTCTCTCTTAGAGAGAGGGTTGGGGTGAGTGGTTAGGACGCTCGACGGAGTGCCGGCACGCCGT
CAACCGGCGTAACCACTCAC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MTLSPLPDLLVRPIVDLALAEDLGRAGDITGQACIDPDARLSVAFASRQDGRVSGLTCARLALAAMDPTARFEIVTPDGA
DVTPGAVLARAEGNARAVLIAERTGLNLLGRMSGIATLTRAYVRLVEGTSATIVDTRKTTPGLRALEKYAVRCGGGVNHR
FGLDDAILIKDNHVAACGGVGEAVRRARAHAGHLVKVEVEVDGLDQLEEALKHGPDVVMLDNFSLADLRAAVALAKGRAV
LEASGGVNLTTVRAIAETGVDVISVGALTHSAPVLDIGLDAN

Sequences:

>Translated_282_residues
MTLSPLPDLLVRPIVDLALAEDLGRAGDITGQACIDPDARLSVAFASRQDGRVSGLTCARLALAAMDPTARFEIVTPDGA
DVTPGAVLARAEGNARAVLIAERTGLNLLGRMSGIATLTRAYVRLVEGTSATIVDTRKTTPGLRALEKYAVRCGGGVNHR
FGLDDAILIKDNHVAACGGVGEAVRRARAHAGHLVKVEVEVDGLDQLEEALKHGPDVVMLDNFSLADLRAAVALAKGRAV
LEASGGVNLTTVRAIAETGVDVISVGALTHSAPVLDIGLDAN
>Mature_281_residues
TLSPLPDLLVRPIVDLALAEDLGRAGDITGQACIDPDARLSVAFASRQDGRVSGLTCARLALAAMDPTARFEIVTPDGAD
VTPGAVLARAEGNARAVLIAERTGLNLLGRMSGIATLTRAYVRLVEGTSATIVDTRKTTPGLRALEKYAVRCGGGVNHRF
GLDDAILIKDNHVAACGGVGEAVRRARAHAGHLVKVEVEVDGLDQLEEALKHGPDVVMLDNFSLADLRAAVALAKGRAVL
EASGGVNLTTVRAIAETGVDVISVGALTHSAPVLDIGLDAN

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=208, Percent_Identity=41.3461538461538, Blast_Score=144, Evalue=7e-35,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=44.4444444444444, Blast_Score=180, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6321162, Length=246, Percent_Identity=36.9918699186992, Blast_Score=155, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29185; Mature: 29054

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSPLPDLLVRPIVDLALAEDLGRAGDITGQACIDPDARLSVAFASRQDGRVSGLTCAR
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCEEEEEEECCCCCCCCCHHHHH
LALAAMDPTARFEIVTPDGADVTPGAVLARAEGNARAVLIAERTGLNLLGRMSGIATLTR
HHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHH
AYVRLVEGTSATIVDTRKTTPGLRALEKYAVRCGGGVNHRFGLDDAILIKDNHVAACGGV
HHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEECCH
GEAVRRARAHAGHLVKVEVEVDGLDQLEEALKHGPDVVMLDNFSLADLRAAVALAKGRAV
HHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCEE
LEASGGVNLTTVRAIAETGVDVISVGALTHSAPVLDIGLDAN
EEECCCCEEHHHHHHHHCCCCEEEECCCCCCCCEEEECCCCC
>Mature Secondary Structure 
TLSPLPDLLVRPIVDLALAEDLGRAGDITGQACIDPDARLSVAFASRQDGRVSGLTCAR
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCEEEEEEECCCCCCCCCHHHHH
LALAAMDPTARFEIVTPDGADVTPGAVLARAEGNARAVLIAERTGLNLLGRMSGIATLTR
HHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHH
AYVRLVEGTSATIVDTRKTTPGLRALEKYAVRCGGGVNHRFGLDDAILIKDNHVAACGGV
HHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEECCH
GEAVRRARAHAGHLVKVEVEVDGLDQLEEALKHGPDVVMLDNFSLADLRAAVALAKGRAV
HHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCEE
LEASGGVNLTTVRAIAETGVDVISVGALTHSAPVLDIGLDAN
EEECCCCEEHHHHHHHHCCCCEEEECCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]