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The map label for this gene is ahpC [H]

Identifier: 16127148

GI number: 16127148

Start: 3139278

End: 3139841

Strand: Direct

Name: ahpC [H]

Synonym: CC_2918

Alternate gene names: 16127148

Gene position: 3139278-3139841 (Clockwise)

Preceding gene: 16127145

Following gene: 16127149

Centisome position: 78.15

GC content: 62.23

Gene sequence:

>564_bases
ATGTCGCTGATCAACACCGAGATCAAACCCTTTACCGCCCAGGCCTACAAGGACGGCAAGTTCGTCACGGTCAGCGAAGC
GGACGTGAAGGGCAAGTGGTCGGTCTTCTTCTTCTACCCCGCTGACTTCACCTTCGTCTGCCCGACCGAACTGGAAGATC
TCGCTGACAACTACGACGTGTTCACGCGCCTGGGCGTCGAGATCTACGCGGTGTCGACCGACACGCACTTCTCGCACAAG
GCCTGGCACGACAGCTCGCCGGCGATCGGCAAGATCAAGTACACCATGGTCGGCGACCCGTCGGGCCAAGTGACCAACAA
CTTCGAGATCATGCGTCCGGGCGTCGGCCTGGCCGACCGCGGCACCTTCCTGGTCGACCCGCAAGGCGTGATCCAGTTCA
TGGAAGTCACCGCCGAAGGCATCGGCCGCAACGCCATTGAGCTGCTGCGCAAGATCAAGGCCGCCCAGTACGTCGCCGCT
CACCCGGGCGAAGTCTGCCCGGCCAAGTGGGAAGAGGGTGAAAAGACCCTGGCCCCGTCGCTGGACCTGGTCGGCAAGAT
CTAA

Upstream 100 bases:

>100_bases
TTTTCATAGATAAAACCTATTCCATATAGAAGTTTTATCAATTGGATCGATTGTGCGGCGCACTATAGACACCCGCCATT
CTTTCCAACCGGAGCGCCTC

Downstream 100 bases:

>100_bases
GTCTGACGACACTGGCCGCCGCTCCGCCTCCAGCCCGAGGCGGGGCGGCGCGCCCTCTACCCGATCGTTCGTCGCGTTCG
ATCCGCCTCCCCGACAATCG

Product: alkyl hydroperoxide reductase subunit c

Products: NA

Alternate protein names: Alkyl hydroperoxide reductase protein C22; Peroxiredoxin; SCRP-23; Sulfate starvation-induced protein 8; SSI8; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MSLINTEIKPFTAQAYKDGKFVTVSEADVKGKWSVFFFYPADFTFVCPTELEDLADNYDVFTRLGVEIYAVSTDTHFSHK
AWHDSSPAIGKIKYTMVGDPSGQVTNNFEIMRPGVGLADRGTFLVDPQGVIQFMEVTAEGIGRNAIELLRKIKAAQYVAA
HPGEVCPAKWEEGEKTLAPSLDLVGKI

Sequences:

>Translated_187_residues
MSLINTEIKPFTAQAYKDGKFVTVSEADVKGKWSVFFFYPADFTFVCPTELEDLADNYDVFTRLGVEIYAVSTDTHFSHK
AWHDSSPAIGKIKYTMVGDPSGQVTNNFEIMRPGVGLADRGTFLVDPQGVIQFMEVTAEGIGRNAIELLRKIKAAQYVAA
HPGEVCPAKWEEGEKTLAPSLDLVGKI
>Mature_186_residues
SLINTEIKPFTAQAYKDGKFVTVSEADVKGKWSVFFFYPADFTFVCPTELEDLADNYDVFTRLGVEIYAVSTDTHFSHKA
WHDSSPAIGKIKYTMVGDPSGQVTNNFEIMRPGVGLADRGTFLVDPQGVIQFMEVTAEGIGRNAIELLRKIKAAQYVAAH
PGEVCPAKWEEGEKTLAPSLDLVGKI

Specific function: Directly reduces organic hydroperoxides in its reduced dithiol form [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32483377, Length=173, Percent_Identity=42.1965317919075, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI5802974, Length=173, Percent_Identity=42.1965317919075, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI32189392, Length=175, Percent_Identity=38.2857142857143, Blast_Score=136, Evalue=9e-33,
Organism=Homo sapiens, GI4505591, Length=167, Percent_Identity=37.125748502994, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI32455266, Length=167, Percent_Identity=37.125748502994, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI32455264, Length=167, Percent_Identity=37.125748502994, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI5453549, Length=173, Percent_Identity=36.4161849710983, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI33188454, Length=77, Percent_Identity=48.0519480519481, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI1786822, Length=187, Percent_Identity=72.7272727272727, Blast_Score=300, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI17554494, Length=177, Percent_Identity=39.5480225988701, Blast_Score=141, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI193204376, Length=174, Percent_Identity=38.5057471264368, Blast_Score=134, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI32565831, Length=174, Percent_Identity=38.5057471264368, Blast_Score=134, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI25153706, Length=164, Percent_Identity=26.8292682926829, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320661, Length=181, Percent_Identity=30.3867403314917, Blast_Score=105, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6323613, Length=175, Percent_Identity=32.5714285714286, Blast_Score=102, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6319407, Length=158, Percent_Identity=29.1139240506329, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17738015, Length=177, Percent_Identity=36.1581920903955, Blast_Score=133, Evalue=6e-32,
Organism=Drosophila melanogaster, GI21357347, Length=182, Percent_Identity=34.0659340659341, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI17157991, Length=170, Percent_Identity=34.7058823529412, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24641739, Length=170, Percent_Identity=34.7058823529412, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24656348, Length=182, Percent_Identity=32.967032967033, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17864676, Length=182, Percent_Identity=32.967032967033, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24581278, Length=158, Percent_Identity=31.6455696202532, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17975518, Length=158, Percent_Identity=27.8481012658228, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24652436, Length=158, Percent_Identity=27.8481012658228, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24652434, Length=158, Percent_Identity=27.8481012658228, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017559
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20628; Mature: 20496

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLINTEIKPFTAQAYKDGKFVTVSEADVKGKWSVFFFYPADFTFVCPTELEDLADNYDV
CCCCCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEEEECCCEEEECCCCHHHHHCCHHH
FTRLGVEIYAVSTDTHFSHKAWHDSSPAIGKIKYTMVGDPSGQVTNNFEIMRPGVGLADR
HEECCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCCCCCC
GTFLVDPQGVIQFMEVTAEGIGRNAIELLRKIKAAQYVAAHPGEVCPAKWEEGEKTLAPS
CEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCC
LDLVGKI
CHHCCCC
>Mature Secondary Structure 
SLINTEIKPFTAQAYKDGKFVTVSEADVKGKWSVFFFYPADFTFVCPTELEDLADNYDV
CCCCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEEEECCCEEEECCCCHHHHHCCHHH
FTRLGVEIYAVSTDTHFSHKAWHDSSPAIGKIKYTMVGDPSGQVTNNFEIMRPGVGLADR
HEECCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCCCCCC
GTFLVDPQGVIQFMEVTAEGIGRNAIELLRKIKAAQYVAAHPGEVCPAKWEEGEKTLAPS
CEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCC
LDLVGKI
CHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]