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The map label for this gene is nadA

Identifier: 16127142

GI number: 16127142

Start: 3133670

End: 3134803

Strand: Direct

Name: nadA

Synonym: CC_2912

Alternate gene names: 16127142

Gene position: 3133670-3134803 (Clockwise)

Preceding gene: 16127141

Following gene: 16127143

Centisome position: 78.01

GC content: 66.14

Gene sequence:

>1134_bases
ATGCTCACTTTGAGCATAACGGAGGATCAGATGGCCGACGGGTTTGCTACCGCCCCCCAGGACTTCAAGGGGGTCTTCAC
GCCCGAGATCGAGGCGCAGACCGCGCCCGTCTGGGAGAAGGTCAAGCACCACGTCACCCCGATGGAGTGGCGCGTCCAGG
CGCCGCTGATCGTCGAGATCAACCGCCTCAAGCGCGAGAAGAACGCCGCCATCCTGGCCCACAACTACATGACGCCGGAC
ATCTTCCACGGCGTGGGCGACTTCGTGGGCGACAGCCTGGCGCTGGCTAAAGAGGCCGCCAAGAGCGACGCCCAGATCAT
CGTCCAGGCCGGCGTGCACTTCATGGCCGAGACCAGCAAGGTCCTCAGCCCTGAAAAGAAGATCCTGATCCCCGACCTGA
AGGCCGGCTGCAGCCTGGCCTCCTCGATCACCGGCGCGGACGTGCGGCTGATCAAGCAGCGCTATCCGGGCGTGCCGGTG
GTCACCTATGTCAACACCACCGCCGACGTGAAGGCCGAGACCGACATCTGCTGCACCAGCGCCAACGCCGTGCAGGTGGT
CGAATGGGCGGCCAAGGAATGGGGGACCGACAAGGTCATCCTGATCCCGGACGAGTTCCTGGCCCGCAACGTGGCGCGCC
AGACGGACGTCAAGATCATCGCCTGGGCCGGTCACTGCGAAGTCCACAAGCGCTTCACCGCCCAGGACATCGCCGACATG
CGCGCGGCCTGGCCGGGCGCGGAGGTGCTGGCTCACCCCGAATGCCCCGCCGAGATCCTGGAGGCCGCCGACTTTGCGGG
CTCGACGGCGGCGATGAACGACTATGTGGCGGCGAAAAAGCCGGCCCAGGTGGTGCTGATCACCGAGTGCTCGATGGCCA
GCAACGTCCAGGCCGAAAGCCCGGCGACCCAGTTCATCGGCCCCTGCAACATGTGCCCGCACATGAAGCGGATCACGCTG
CAGAACATCTACGACGCCCTCGTGCACGAGCAGTACGAGGTGACGGTCGACGCCGAGGTCCTCGACCGCGCCCGCCTGGC
CGTCCAGCGCATGATCGACCTGCCGCCGCCGGCCGTTCCGGCGCGGTACGACCTAGTGAAGGCCCGCCATCACGTGGATG
TGGAGCTGATCTGA

Upstream 100 bases:

>100_bases
TATGTGAGCCATCAGTTATGCTCACTTTCAGCATAACCCCGACGCCGGAACCCGACTGGAACGATCGCGACGGTCCCGGC
GTTTTTTTGAGGCCCTGGAA

Downstream 100 bases:

>100_bases
CCGCCGCGCGGCCCTCGTCCTTCGACACGCTCAGGATGAGGGAATGAGAGTCACAGTAGGCGTCCTCATGCTGAGCTTGT
CGAAGCACGAGGAAGCCGGC

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MLTLSITEDQMADGFATAPQDFKGVFTPEIEAQTAPVWEKVKHHVTPMEWRVQAPLIVEINRLKREKNAAILAHNYMTPD
IFHGVGDFVGDSLALAKEAAKSDAQIIVQAGVHFMAETSKVLSPEKKILIPDLKAGCSLASSITGADVRLIKQRYPGVPV
VTYVNTTADVKAETDICCTSANAVQVVEWAAKEWGTDKVILIPDEFLARNVARQTDVKIIAWAGHCEVHKRFTAQDIADM
RAAWPGAEVLAHPECPAEILEAADFAGSTAAMNDYVAAKKPAQVVLITECSMASNVQAESPATQFIGPCNMCPHMKRITL
QNIYDALVHEQYEVTVDAEVLDRARLAVQRMIDLPPPAVPARYDLVKARHHVDVELI

Sequences:

>Translated_377_residues
MLTLSITEDQMADGFATAPQDFKGVFTPEIEAQTAPVWEKVKHHVTPMEWRVQAPLIVEINRLKREKNAAILAHNYMTPD
IFHGVGDFVGDSLALAKEAAKSDAQIIVQAGVHFMAETSKVLSPEKKILIPDLKAGCSLASSITGADVRLIKQRYPGVPV
VTYVNTTADVKAETDICCTSANAVQVVEWAAKEWGTDKVILIPDEFLARNVARQTDVKIIAWAGHCEVHKRFTAQDIADM
RAAWPGAEVLAHPECPAEILEAADFAGSTAAMNDYVAAKKPAQVVLITECSMASNVQAESPATQFIGPCNMCPHMKRITL
QNIYDALVHEQYEVTVDAEVLDRARLAVQRMIDLPPPAVPARYDLVKARHHVDVELI
>Mature_377_residues
MLTLSITEDQMADGFATAPQDFKGVFTPEIEAQTAPVWEKVKHHVTPMEWRVQAPLIVEINRLKREKNAAILAHNYMTPD
IFHGVGDFVGDSLALAKEAAKSDAQIIVQAGVHFMAETSKVLSPEKKILIPDLKAGCSLASSITGADVRLIKQRYPGVPV
VTYVNTTADVKAETDICCTSANAVQVVEWAAKEWGTDKVILIPDEFLARNVARQTDVKIIAWAGHCEVHKRFTAQDIADM
RAAWPGAEVLAHPECPAEILEAADFAGSTAAMNDYVAAKKPAQVVLITECSMASNVQAESPATQFIGPCNMCPHMKRITL
QNIYDALVHEQYEVTVDAEVLDRARLAVQRMIDLPPPAVPARYDLVKARHHVDVELI

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily

Homologues:

Organism=Escherichia coli, GI1786964, Length=328, Percent_Identity=35.0609756097561, Blast_Score=170, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADA_CAUCN (B8H2F3)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002518379.1
- ProteinModelPortal:   B8H2F3
- SMR:   B8H2F3
- GeneID:   7333295
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_03006
- OMA:   IAHPECE
- ProtClustDB:   PRK09375
- GO:   GO:0005737
- HAMAP:   MF_00568
- InterPro:   IPR003473
- InterPro:   IPR023066
- TIGRFAMs:   TIGR00550

Pfam domain/function: PF02445 NadA

EC number: =2.5.1.72

Molecular weight: Translated: 41321; Mature: 41321

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: BINDING 74-74 BINDING 92-92 BINDING 163-163 BINDING 180-180 BINDING 252-252 BINDING 269-269

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLSITEDQMADGFATAPQDFKGVFTPEIEAQTAPVWEKVKHHVTPMEWRVQAPLIVEI
CEEEEECHHHHCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCEEEEH
NRLKREKNAAILAHNYMTPDIFHGVGDFVGDSLALAKEAAKSDAQIIVQAGVHFMAETSK
HHHHHCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
VLSPEKKILIPDLKAGCSLASSITGADVRLIKQRYPGVPVVTYVNTTADVKAETDICCTS
HCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEECC
ANAVQVVEWAAKEWGTDKVILIPDEFLARNVARQTDVKIIAWAGHCEVHKRFTAQDIADM
CCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHH
RAAWPGAEVLAHPECPAEILEAADFAGSTAAMNDYVAAKKPAQVVLITECSMASNVQAES
HHCCCCCCEEECCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
PATQFIGPCNMCPHMKRITLQNIYDALVHEQYEVTVDAEVLDRARLAVQRMIDLPPPAVP
CHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCC
ARYDLVKARHHVDVELI
CHHHHHHHHHCCEEEEC
>Mature Secondary Structure
MLTLSITEDQMADGFATAPQDFKGVFTPEIEAQTAPVWEKVKHHVTPMEWRVQAPLIVEI
CEEEEECHHHHCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCEEEEH
NRLKREKNAAILAHNYMTPDIFHGVGDFVGDSLALAKEAAKSDAQIIVQAGVHFMAETSK
HHHHHCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
VLSPEKKILIPDLKAGCSLASSITGADVRLIKQRYPGVPVVTYVNTTADVKAETDICCTS
HCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEECC
ANAVQVVEWAAKEWGTDKVILIPDEFLARNVARQTDVKIIAWAGHCEVHKRFTAQDIADM
CCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHH
RAAWPGAEVLAHPECPAEILEAADFAGSTAAMNDYVAAKKPAQVVLITECSMASNVQAES
HHCCCCCCEEECCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
PATQFIGPCNMCPHMKRITLQNIYDALVHEQYEVTVDAEVLDRARLAVQRMIDLPPPAVP
CHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCC
ARYDLVKARHHVDVELI
CHHHHHHHHHCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA