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The map label for this gene is nadB

Identifier: 16127143

GI number: 16127143

Start: 3134924

End: 3136459

Strand: Direct

Name: nadB

Synonym: CC_2913

Alternate gene names: 16127143

Gene position: 3134924-3136459 (Clockwise)

Preceding gene: 16127142

Following gene: 16127144

Centisome position: 78.04

GC content: 74.54

Gene sequence:

>1536_bases
TTGACCCAGTATCGCATCACCTTCGAAGGCCCCGTCATCCTCGGCGCAGGCTTGGCCGGTCTCACCGCCGCGCTTTCCGC
GACGACGGGGGCCGCCAAGACGGCGCTGGTCTTGTCGCCGACGCCGCTGGCGAGCGGCTGTTCCAGCGCCTGGGCGCAGG
GCGGCATGGCCGCGGCCCTGTCGGGCGACGACTCCCCCGCACTGCACGCCGCCGACACCATCGCCGCCGGCGCGGGCCTG
TGCGATCCGCAGGCCGTCGACCTCCTGACCCGCGAAGGCCCGCAGGCCGTGCGTGACCTCGCAGCCCTCGGCGCGCCGTT
CGATCGCAAGGCGGACGATGGCTTCGTGCTGAGCCTCGAGGCCGCTCACTCGGCCGCCCGTGTCGCCCGGGTCGGCGGCG
ACGGGGCCGGCGCGGCGATCATGGCCGCCGTCATCGCGGCGGTCCGCGCGACGCCGGGCATCGAGGTCCGCGAAAACGCT
CGCGCCCGTCGCCTGCTACAGGACGCGAACGGCCGTGTGGTCGGCGTGCTGGCCGATGTCGACGGCGCCCTGGTCGAGAT
CCGCTCGACCGCCGTGATCCTGGCCACCGGCGGCGTCGGCGGCCTCTACGCCGTGACCACCACGCCCGCCCAGGTGCGCG
GCGAAGGTTTGGGCCTGGCGGCTCTGGCCGGCGCGATGATCGCCGATCCCGAGTTCGTCCAGTTCCACCCCACCGCCATC
GACATCGGTCGCGACCCCGCCCCGCTGGCCACCGAGGCCCTGCGCGGCGAGGGTGCGATCCTGCGCAATGCCGACGGTAA
GGCCTTCATGGCCGACTACCACCCGGCCAAGGAGCTGGCGCCGCGCGACGTGGTCGCCCGCGCCCTTCACGCTGAACGCG
CGGCCGGTCGCGGCGCGTTCCTGGACGCCACGGCTGCCGTCGGCGCCCACTTCCCGCACGAATTCCCGGCCGTGTTCGAG
GCCTGCATGAGCGCGGGGATCGACCCACGTCGGCAGATGATCCCGGTCACGCCCGCCGTGCACTACCACATGGGCGGGGT
CGCCACCGACCTTGACGGCCGCGCCAGCCTGCCGGGCCTCTACGCCGCCGGCGAGTGCGCCTCGACCGGCGTGCAGGGCG
CCAACCGCCTGGCCTCCAACAGCCTGCTGGAAGCCGCCGTGTTCGGCGCCCGCGCCGGCCGCGCGGCGGCGGCCGAGGGC
GCGACGGGCGGCCCGCCGGTCAGCCTCGAGCCCCTGCCCGACCTGCCCGACGCCGCCCTTCAAGGCCTGCGCAAGGCGAT
GAGCCGCGATGCGGGCGTGATCCGCGACGCCGACGGCCTGACCCGACTGCTGGGCGAGATCGAGACGCTGGAAGCCGGCC
ATGGCCAGGGCCCGATCCTGGTCGCCGCCCGACTGATCGTCACCGCCGCCCTGGCTCGCGAGGAAAGCCGAGGAGGCCAC
TGCCGCATCGACTTCCCGGCCACGGATCCCGTCGGCGTCCGGACTTTCGTCACCCTCGACGGACGCGAGCCCGGCTTGCG
ATACGCGGCGGAGTAG

Upstream 100 bases:

>100_bases
TTCGACACGCTCAGGATGAGGGAATGAGAGTCACAGTAGGCGTCCTCATGCTGAGCTTGTCGAAGCACGAGGAAGCCGGC
CCCTCGGAGGAGCCGCTTCG

Downstream 100 bases:

>100_bases
GGGTACGTTTCGGGAACGGAGATGCGATCATGACGACATCAGAGCCCGGCCTTGAAGACGGCTCCGTCAGCGAATTCCTG
TTCGATTTCGACGCCTTCGA

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO; Quinolinate synthase B

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MTQYRITFEGPVILGAGLAGLTAALSATTGAAKTALVLSPTPLASGCSSAWAQGGMAAALSGDDSPALHAADTIAAGAGL
CDPQAVDLLTREGPQAVRDLAALGAPFDRKADDGFVLSLEAAHSAARVARVGGDGAGAAIMAAVIAAVRATPGIEVRENA
RARRLLQDANGRVVGVLADVDGALVEIRSTAVILATGGVGGLYAVTTTPAQVRGEGLGLAALAGAMIADPEFVQFHPTAI
DIGRDPAPLATEALRGEGAILRNADGKAFMADYHPAKELAPRDVVARALHAERAAGRGAFLDATAAVGAHFPHEFPAVFE
ACMSAGIDPRRQMIPVTPAVHYHMGGVATDLDGRASLPGLYAAGECASTGVQGANRLASNSLLEAAVFGARAGRAAAAEG
ATGGPPVSLEPLPDLPDAALQGLRKAMSRDAGVIRDADGLTRLLGEIETLEAGHGQGPILVAARLIVTAALAREESRGGH
CRIDFPATDPVGVRTFVTLDGREPGLRYAAE

Sequences:

>Translated_511_residues
MTQYRITFEGPVILGAGLAGLTAALSATTGAAKTALVLSPTPLASGCSSAWAQGGMAAALSGDDSPALHAADTIAAGAGL
CDPQAVDLLTREGPQAVRDLAALGAPFDRKADDGFVLSLEAAHSAARVARVGGDGAGAAIMAAVIAAVRATPGIEVRENA
RARRLLQDANGRVVGVLADVDGALVEIRSTAVILATGGVGGLYAVTTTPAQVRGEGLGLAALAGAMIADPEFVQFHPTAI
DIGRDPAPLATEALRGEGAILRNADGKAFMADYHPAKELAPRDVVARALHAERAAGRGAFLDATAAVGAHFPHEFPAVFE
ACMSAGIDPRRQMIPVTPAVHYHMGGVATDLDGRASLPGLYAAGECASTGVQGANRLASNSLLEAAVFGARAGRAAAAEG
ATGGPPVSLEPLPDLPDAALQGLRKAMSRDAGVIRDADGLTRLLGEIETLEAGHGQGPILVAARLIVTAALAREESRGGH
CRIDFPATDPVGVRTFVTLDGREPGLRYAAE
>Mature_510_residues
TQYRITFEGPVILGAGLAGLTAALSATTGAAKTALVLSPTPLASGCSSAWAQGGMAAALSGDDSPALHAADTIAAGAGLC
DPQAVDLLTREGPQAVRDLAALGAPFDRKADDGFVLSLEAAHSAARVARVGGDGAGAAIMAAVIAAVRATPGIEVRENAR
ARRLLQDANGRVVGVLADVDGALVEIRSTAVILATGGVGGLYAVTTTPAQVRGEGLGLAALAGAMIADPEFVQFHPTAID
IGRDPAPLATEALRGEGAILRNADGKAFMADYHPAKELAPRDVVARALHAERAAGRGAFLDATAAVGAHFPHEFPAVFEA
CMSAGIDPRRQMIPVTPAVHYHMGGVATDLDGRASLPGLYAAGECASTGVQGANRLASNSLLEAAVFGARAGRAAAAEGA
TGGPPVSLEPLPDLPDAALQGLRKAMSRDAGVIRDADGLTRLLGEIETLEAGHGQGPILVAARLIVTAALAREESRGGHC
RIDFPATDPVGVRTFVTLDGREPGLRYAAE

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily

Homologues:

Organism=Homo sapiens, GI156416003, Length=505, Percent_Identity=32.2772277227723, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1788928, Length=514, Percent_Identity=35.7976653696498, Blast_Score=258, Evalue=7e-70,
Organism=Escherichia coli, GI1790597, Length=534, Percent_Identity=31.2734082397004, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1786942, Length=549, Percent_Identity=31.6939890710383, Blast_Score=182, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17550100, Length=535, Percent_Identity=33.4579439252336, Blast_Score=201, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17505833, Length=527, Percent_Identity=33.2068311195446, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71986328, Length=476, Percent_Identity=27.7310924369748, Blast_Score=103, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322701, Length=535, Percent_Identity=33.0841121495327, Blast_Score=192, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6322416, Length=514, Percent_Identity=32.6848249027237, Blast_Score=190, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6320788, Length=476, Percent_Identity=26.890756302521, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322511, Length=312, Percent_Identity=27.8846153846154, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17137288, Length=523, Percent_Identity=33.4608030592734, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24655642, Length=523, Percent_Identity=33.4608030592734, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24655647, Length=523, Percent_Identity=33.4608030592734, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24663005, Length=525, Percent_Identity=31.4285714285714, Blast_Score=174, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADB_CAUCR (Q9A4C3)

Other databases:

- EMBL:   AE005673
- PIR:   G87609
- RefSeq:   NP_421707.1
- ProteinModelPortal:   Q9A4C3
- GeneID:   942841
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_2913
- NMPDR:   fig|190650.1.peg.2887
- TIGR:   CC_2913
- HOGENOM:   HBG293998
- OMA:   AACTGLH
- ProtClustDB:   PRK07512
- BRENDA:   1.4.3.16
- GO:   GO:0005737
- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- Gene3D:   G3DSA:1.20.58.100
- PRINTS:   PR00368

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C; SSF46977 Succ_DH_flav_C

EC number: =1.4.3.16

Molecular weight: Translated: 51598; Mature: 51467

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: ACT_SITE 236-236 ACT_SITE 255-255

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQYRITFEGPVILGAGLAGLTAALSATTGAAKTALVLSPTPLASGCSSAWAQGGMAAAL
CCEEEEEECCCEEEECCHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHCCCEEEEE
SGDDSPALHAADTIAAGAGLCDPQAVDLLTREGPQAVRDLAALGAPFDRKADDGFVLSLE
CCCCCCCHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEEEH
AAHSAARVARVGGDGAGAAIMAAVIAAVRATPGIEVRENARARRLLQDANGRVVGVLADV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECC
DGALVEIRSTAVILATGGVGGLYAVTTTPAQVRGEGLGLAALAGAMIADPEFVQFHPTAI
CCCEEEEECEEEEEEECCCCCEEEEECCCHHHCCCCCCHHHHHHHHHCCCCEEEEECCEE
DIGRDPAPLATEALRGEGAILRNADGKAFMADYHPAKELAPRDVVARALHAERAAGRGAF
ECCCCCCCHHHHHHCCCCCEEECCCCCEEEECCCCHHHCCHHHHHHHHHHHHHHCCCCCE
LDATAAVGAHFPHEFPAVFEACMSAGIDPRRQMIPVTPAVHYHMGGVATDLDGRASLPGL
EEHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEECCCCCEEECCCEEECCCCCCCCCCC
YAAGECASTGVQGANRLASNSLLEAAVFGARAGRAAAAEGATGGPPVSLEPLPDLPDAAL
EECCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCCHHHH
QGLRKAMSRDAGVIRDADGLTRLLGEIETLEAGHGQGPILVAARLIVTAALAREESRGGH
HHHHHHHHCCCCCEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCE
CRIDFPATDPVGVRTFVTLDGREPGLRYAAE
EEEECCCCCCCCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TQYRITFEGPVILGAGLAGLTAALSATTGAAKTALVLSPTPLASGCSSAWAQGGMAAAL
CEEEEEECCCEEEECCHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHCCCEEEEE
SGDDSPALHAADTIAAGAGLCDPQAVDLLTREGPQAVRDLAALGAPFDRKADDGFVLSLE
CCCCCCCHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEEEH
AAHSAARVARVGGDGAGAAIMAAVIAAVRATPGIEVRENARARRLLQDANGRVVGVLADV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECC
DGALVEIRSTAVILATGGVGGLYAVTTTPAQVRGEGLGLAALAGAMIADPEFVQFHPTAI
CCCEEEEECEEEEEEECCCCCEEEEECCCHHHCCCCCCHHHHHHHHHCCCCEEEEECCEE
DIGRDPAPLATEALRGEGAILRNADGKAFMADYHPAKELAPRDVVARALHAERAAGRGAF
ECCCCCCCHHHHHHCCCCCEEECCCCCEEEECCCCHHHCCHHHHHHHHHHHHHHCCCCCE
LDATAAVGAHFPHEFPAVFEACMSAGIDPRRQMIPVTPAVHYHMGGVATDLDGRASLPGL
EEHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEECCCCCEEECCCEEECCCCCCCCCCC
YAAGECASTGVQGANRLASNSLLEAAVFGARAGRAAAAEGATGGPPVSLEPLPDLPDAAL
EECCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCCHHHH
QGLRKAMSRDAGVIRDADGLTRLLGEIETLEAGHGQGPILVAARLIVTAALAREESRGGH
HHHHHHHHCCCCCEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCE
CRIDFPATDPVGVRTFVTLDGREPGLRYAAE
EEEECCCCCCCCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647