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The map label for this gene is lrp [H]

Identifier: 16127119

GI number: 16127119

Start: 3110424

End: 3110954

Strand: Direct

Name: lrp [H]

Synonym: CC_2887

Alternate gene names: 16127119

Gene position: 3110424-3110954 (Clockwise)

Preceding gene: 16127116

Following gene: 16127120

Centisome position: 77.43

GC content: 67.23

Gene sequence:

>531_bases
TTGTCCTCGTTTGCGCGGCGAGGGTCGAGCGCGCTAGAACAATGTGCTTTTAAATCATCGAAGAGCAGAACGATGGCCGC
CCTCAGCCGTATGGATCTTTCCATCCTCCGCATCCTGGAGGCCGACGCCCGCATCTCGTTCGCCGCCCTGGCCGAGCGGG
TGGGCCTGTCGAAGTCGCCGTGCTGGTCCAGGGTGCAGGCGCTGGAGAAGCAGGGCGTGATCACCGGCTACCACGCCCGC
CTCGACGCCAAGGCGCTGGGCAAGGGGCTGAGCGTCTACGCCCTGGCCACCGTGGAGTTCGCCCGCTACGAGGCCTTCGA
GGCCGCCGTGCTGCGCCATCCGGCGATCACCGACTGCCACTCCACGGCCGGGGCCGGCGACTATCTGCTGCGGATCGTGG
CGGCCGATGTCGAGGACCTCGACCACCTGCTGCGCAAGGAACTGAGCCAGATGCCCGGCGTGCAGCGCTACACCACCACC
GTCTGCATGAAGGCGATCAAGGAAGGCGGCCTGGTGACGGCGGGGCTCTAG

Upstream 100 bases:

>100_bases
CAGCGGCTTCTGGGCCGAGAGCAGTTCATCGAGCGCGAGGTATCGCGCGTAGGTCATGTCTTGCGCCATGGAGCGACCTT
AAGCGGCGTCTTGACGCACA

Downstream 100 bases:

>100_bases
CCGTCCGAATCCGCGTGCTCGCCGAGGCCCGCCCATCGCGCCGGGACGTGCGGCAGCGTGCCGCCCTCACAAGAGCCAAT
GTAAGCACTTGTTAAACCTG

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 176; Mature: 175

Protein sequence:

>176_residues
MSSFARRGSSALEQCAFKSSKSRTMAALSRMDLSILRILEADARISFAALAERVGLSKSPCWSRVQALEKQGVITGYHAR
LDAKALGKGLSVYALATVEFARYEAFEAAVLRHPAITDCHSTAGAGDYLLRIVAADVEDLDHLLRKELSQMPGVQRYTTT
VCMKAIKEGGLVTAGL

Sequences:

>Translated_176_residues
MSSFARRGSSALEQCAFKSSKSRTMAALSRMDLSILRILEADARISFAALAERVGLSKSPCWSRVQALEKQGVITGYHAR
LDAKALGKGLSVYALATVEFARYEAFEAAVLRHPAITDCHSTAGAGDYLLRIVAADVEDLDHLLRKELSQMPGVQRYTTT
VCMKAIKEGGLVTAGL
>Mature_175_residues
SSFARRGSSALEQCAFKSSKSRTMAALSRMDLSILRILEADARISFAALAERVGLSKSPCWSRVQALEKQGVITGYHARL
DAKALGKGLSVYALATVEFARYEAFEAAVLRHPAITDCHSTAGAGDYLLRIVAADVEDLDHLLRKELSQMPGVQRYTTTV
CMKAIKEGGLVTAGL

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=155, Percent_Identity=38.0645161290323, Blast_Score=102, Evalue=1e-23,
Organism=Escherichia coli, GI87081742, Length=143, Percent_Identity=32.1678321678322, Blast_Score=89, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 19023; Mature: 18892

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFARRGSSALEQCAFKSSKSRTMAALSRMDLSILRILEADARISFAALAERVGLSKSP
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
CWSRVQALEKQGVITGYHARLDAKALGKGLSVYALATVEFARYEAFEAAVLRHPAITDCH
HHHHHHHHHHCCCEECHHHHHCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCHH
STAGAGDYLLRIVAADVEDLDHLLRKELSQMPGVQRYTTTVCMKAIKEGGLVTAGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEECCC
>Mature Secondary Structure 
SSFARRGSSALEQCAFKSSKSRTMAALSRMDLSILRILEADARISFAALAERVGLSKSP
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
CWSRVQALEKQGVITGYHARLDAKALGKGLSVYALATVEFARYEAFEAAVLRHPAITDCH
HHHHHHHHHHCCCEECHHHHHCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCHH
STAGAGDYLLRIVAADVEDLDHLLRKELSQMPGVQRYTTTVCMKAIKEGGLVTAGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]