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The map label for this gene is uvrC

Identifier: 16127113

GI number: 16127113

Start: 3103426

End: 3105348

Strand: Direct

Name: uvrC

Synonym: CC_2881

Alternate gene names: 16127113

Gene position: 3103426-3105348 (Clockwise)

Preceding gene: 16127112

Following gene: 16127115

Centisome position: 77.26

GC content: 67.81

Gene sequence:

>1923_bases
GTGACCGACACTCCCTCCGCCTCCGACGCTGAAGCCCCTCTCCGCCAAGCGGCTCCCCTTTGGGGCGCCGCCCTGATCAA
GGACGAGGTCACGCGCCTGCCCGACGCGCCCGGCGTCTATCGCATGATCGGCGAGGCCGATGAGGTGCTGTACGTCGGCA
AGGCGAAAAGCCTGAAGAAGCGCGTCGTCCAGTACGCCCAAGGCCGCTTCCACACCAACCGCATCGCCAACATGGTCGAC
GCCACGCGGGCCATGGAGTTCATCACCACCCGCACCGAAGCCGACGCCCTGCTGCTTGAGATCAACCTGATCAAGCAGCT
CAAGCCCCGCTTCAACGTGCTGCTGCGCGACGACAAGAGCTTTCCCGAGATCGTCATCCGCCGCGACCACGACGCCCCGC
AGCTGCGGAAACACCGCGGCGCCCACACGATCAAGGGCGACTATTTCGGACCCTTCGCCAGCGCCTGGGCGGTGAACCGC
ACGCTGAACACCCTGCAGAAGGCGTTCCTGCTGCGCTCGTGCAGCGACAGCGTCTATGACAGCCGCGACCGGCCTTGCAT
GCTCTACCAGATCAAGCGCTGCGCGGCCCCCTGCACCGGCCTGATCGGCAAGGACGACTACCAGGCCCTCGTCGACCAGG
CCGAGGCGTTCCTGCGAGGCAAGTCCCGCGCGGTCATGGCCACCATGGCCAAGGCGATGGAAGAGGCCGCCGAGGAGCTG
GAGTTCGAGCGCGCCGCCCGCCTGCGCGACCGCATCCGCGCCCTCTCGGCCGTGGCCCAGGAGACCCAGATCAATCCCGA
AACCGTCGAGGAGGCCGATGTCGTGGCCCTGCACGTCGAGGGCGGTCAGGCCTGCGTGCAGGTGTTCTTCTTCCGGGCCG
GCCAGAACTGGGGCAACCGCGCCTACTTCCCCCGCATCACCGGCGCGGCGGATGACCCCGAGGACGAAACCGTCACCGAA
GAGCAGCGGATCATCACCGCGTTCCTGGGCCAGTTCTATGACGACAAACCGATCCCCCGCCTGATCCTGGCCAATGTCCA
GCCGGCCGAGAGCGAGCTGCTGTCCGAAGCCTTCGCCCTGAAGAGCGGCCGCAAGGTCGAGATCGCCGTGCCCAAGCGCG
GCGAGAAGGCCGATCTCGTTCAGCACGTCCTGACCAACGCGCGCGAAGCCCTTGGGCGGAAAATGGCCGAAGGCTCGGCC
CAGACCAAGCTGCTGGCCGGGGTGGCCGAGGCCTTCAAGCTGGACGCCCCGCCCGAGCGGATCGAGGTCTATGACAACAG
CCACATCCAGGGCGCCAACGCCGTCGGCGGCATGATCGTGGCCGGCCCCGAAGGCTTCATGAAGGGCCAGTACCGCAAGT
TCAACATCAAGAGCACCGAGCTCACCCCCGGCGACGACTACGGCATGATGAAGGAGGTGCTGCGCCGCCGCTTCGCGCGC
CTCGTCAAGGAAGAGGAAGAGGGCGACGACGCCAACCGTCCCGACCTCGTCCTCGTCGACGGCGGCCAGGGCCAGCTGGA
CGCGGCGATCGAGATCATGGCCGATCTGGGCGTCGACGACATCGCCGTGGTGGGCGTCGCCAAGGGCCCCGACCGCGACG
CCGGGCTGGAGCGGTTCTTCATCCCCGGCCAGACCCCGTTCATGCTCGAGCCCAAGTCGCCGGTTCTGTATTACCTGCAG
CGGCTGCGCGACGAGGCCCACCGCTTTGCGATCGGCGCCCACCGCACCCGCCGCAGCATGGACCTGAAGAAGAACCCCCT
CGACGAGATCGAAGGCGTGGGTCCGGGCCGCAAGAAGGCCCTGCTGCACGCCTTCGGCTCGGCCAAGGGCGTGGGCCGGG
CCAGCGTCGAGGACCTCGTCAAGGTCGACGGCGTCAGCCAGGCCCTGGCCGAGCGGATCTTCGGGTTTTTCCGGAAGGGC
TGA

Upstream 100 bases:

>100_bases
TCCTGCAGTATCGCGTTTACCCCGACGCGGTCGTGATCGCCCGTATCCGACACAGCCTTGAACGTCGCTGAACGCCCCGG
ACTCGCCTATATCTGCCCCC

Downstream 100 bases:

>100_bases
GGCCTCCCCTCACCCCGTGTCATCCCGGCCGCAGCGCGTAGCGCTGAGAGCCGGGACCCAGGGGGTGAAGGATCGCCGTG
CGCGCCGCCCCTGGGTCCCG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 640; Mature: 639

Protein sequence:

>640_residues
MTDTPSASDAEAPLRQAAPLWGAALIKDEVTRLPDAPGVYRMIGEADEVLYVGKAKSLKKRVVQYAQGRFHTNRIANMVD
ATRAMEFITTRTEADALLLEINLIKQLKPRFNVLLRDDKSFPEIVIRRDHDAPQLRKHRGAHTIKGDYFGPFASAWAVNR
TLNTLQKAFLLRSCSDSVYDSRDRPCMLYQIKRCAAPCTGLIGKDDYQALVDQAEAFLRGKSRAVMATMAKAMEEAAEEL
EFERAARLRDRIRALSAVAQETQINPETVEEADVVALHVEGGQACVQVFFFRAGQNWGNRAYFPRITGAADDPEDETVTE
EQRIITAFLGQFYDDKPIPRLILANVQPAESELLSEAFALKSGRKVEIAVPKRGEKADLVQHVLTNAREALGRKMAEGSA
QTKLLAGVAEAFKLDAPPERIEVYDNSHIQGANAVGGMIVAGPEGFMKGQYRKFNIKSTELTPGDDYGMMKEVLRRRFAR
LVKEEEEGDDANRPDLVLVDGGQGQLDAAIEIMADLGVDDIAVVGVAKGPDRDAGLERFFIPGQTPFMLEPKSPVLYYLQ
RLRDEAHRFAIGAHRTRRSMDLKKNPLDEIEGVGPGRKKALLHAFGSAKGVGRASVEDLVKVDGVSQALAERIFGFFRKG

Sequences:

>Translated_640_residues
MTDTPSASDAEAPLRQAAPLWGAALIKDEVTRLPDAPGVYRMIGEADEVLYVGKAKSLKKRVVQYAQGRFHTNRIANMVD
ATRAMEFITTRTEADALLLEINLIKQLKPRFNVLLRDDKSFPEIVIRRDHDAPQLRKHRGAHTIKGDYFGPFASAWAVNR
TLNTLQKAFLLRSCSDSVYDSRDRPCMLYQIKRCAAPCTGLIGKDDYQALVDQAEAFLRGKSRAVMATMAKAMEEAAEEL
EFERAARLRDRIRALSAVAQETQINPETVEEADVVALHVEGGQACVQVFFFRAGQNWGNRAYFPRITGAADDPEDETVTE
EQRIITAFLGQFYDDKPIPRLILANVQPAESELLSEAFALKSGRKVEIAVPKRGEKADLVQHVLTNAREALGRKMAEGSA
QTKLLAGVAEAFKLDAPPERIEVYDNSHIQGANAVGGMIVAGPEGFMKGQYRKFNIKSTELTPGDDYGMMKEVLRRRFAR
LVKEEEEGDDANRPDLVLVDGGQGQLDAAIEIMADLGVDDIAVVGVAKGPDRDAGLERFFIPGQTPFMLEPKSPVLYYLQ
RLRDEAHRFAIGAHRTRRSMDLKKNPLDEIEGVGPGRKKALLHAFGSAKGVGRASVEDLVKVDGVSQALAERIFGFFRKG
>Mature_639_residues
TDTPSASDAEAPLRQAAPLWGAALIKDEVTRLPDAPGVYRMIGEADEVLYVGKAKSLKKRVVQYAQGRFHTNRIANMVDA
TRAMEFITTRTEADALLLEINLIKQLKPRFNVLLRDDKSFPEIVIRRDHDAPQLRKHRGAHTIKGDYFGPFASAWAVNRT
LNTLQKAFLLRSCSDSVYDSRDRPCMLYQIKRCAAPCTGLIGKDDYQALVDQAEAFLRGKSRAVMATMAKAMEEAAEELE
FERAARLRDRIRALSAVAQETQINPETVEEADVVALHVEGGQACVQVFFFRAGQNWGNRAYFPRITGAADDPEDETVTEE
QRIITAFLGQFYDDKPIPRLILANVQPAESELLSEAFALKSGRKVEIAVPKRGEKADLVQHVLTNAREALGRKMAEGSAQ
TKLLAGVAEAFKLDAPPERIEVYDNSHIQGANAVGGMIVAGPEGFMKGQYRKFNIKSTELTPGDDYGMMKEVLRRRFARL
VKEEEEGDDANRPDLVLVDGGQGQLDAAIEIMADLGVDDIAVVGVAKGPDRDAGLERFFIPGQTPFMLEPKSPVLYYLQR
LRDEAHRFAIGAHRTRRSMDLKKNPLDEIEGVGPGRKKALLHAFGSAKGVGRASVEDLVKVDGVSQALAERIFGFFRKG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=610, Percent_Identity=41.4754098360656, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1788037, Length=210, Percent_Identity=30, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_CAUCR (Q9A4F3)

Other databases:

- EMBL:   AE005673
- PIR:   A87606
- RefSeq:   NP_421677.1
- ProteinModelPortal:   Q9A4F3
- GeneID:   940564
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_2881
- NMPDR:   fig|190650.1.peg.2857
- TIGR:   CC_2881
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 70840; Mature: 70709

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTPSASDAEAPLRQAAPLWGAALIKDEVTRLPDAPGVYRMIGEADEVLYVGKAKSLKK
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECCHHHHHH
RVVQYAQGRFHTNRIANMVDATRAMEFITTRTEADALLLEINLIKQLKPRFNVLLRDDKS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHCCHHHCEEEECCCC
FPEIVIRRDHDAPQLRKHRGAHTIKGDYFGPFASAWAVNRTLNTLQKAFLLRSCSDSVYD
CCCEEEECCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCC
SRDRPCMLYQIKRCAAPCTGLIGKDDYQALVDQAEAFLRGKSRAVMATMAKAMEEAAEEL
CCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
EFERAARLRDRIRALSAVAQETQINPETVEEADVVALHVEGGQACVQVFFFRAGQNWGNR
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCC
AYFPRITGAADDPEDETVTEEQRIITAFLGQFYDDKPIPRLILANVQPAESELLSEAFAL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCHHHHHHHHHHHH
KSGRKVEIAVPKRGEKADLVQHVLTNAREALGRKMAEGSAQTKLLAGVAEAFKLDAPPER
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHH
IEVYDNSHIQGANAVGGMIVAGPEGFMKGQYRKFNIKSTELTPGDDYGMMKEVLRRRFAR
EEECCCCCCCCCCCCCCEEEECCCHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHH
LVKEEEEGDDANRPDLVLVDGGQGQLDAAIEIMADLGVDDIAVVGVAKGPDRDAGLERFF
HHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEE
IPGQTPFMLEPKSPVLYYLQRLRDEAHRFAIGAHRTRRSMDLKKNPLDEIEGVGPGRKKA
CCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHH
LLHAFGSAKGVGRASVEDLVKVDGVSQALAERIFGFFRKG
HHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDTPSASDAEAPLRQAAPLWGAALIKDEVTRLPDAPGVYRMIGEADEVLYVGKAKSLKK
CCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECCHHHHHH
RVVQYAQGRFHTNRIANMVDATRAMEFITTRTEADALLLEINLIKQLKPRFNVLLRDDKS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHCCHHHCEEEECCCC
FPEIVIRRDHDAPQLRKHRGAHTIKGDYFGPFASAWAVNRTLNTLQKAFLLRSCSDSVYD
CCCEEEECCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCC
SRDRPCMLYQIKRCAAPCTGLIGKDDYQALVDQAEAFLRGKSRAVMATMAKAMEEAAEEL
CCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
EFERAARLRDRIRALSAVAQETQINPETVEEADVVALHVEGGQACVQVFFFRAGQNWGNR
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCC
AYFPRITGAADDPEDETVTEEQRIITAFLGQFYDDKPIPRLILANVQPAESELLSEAFAL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCHHHHHHHHHHHH
KSGRKVEIAVPKRGEKADLVQHVLTNAREALGRKMAEGSAQTKLLAGVAEAFKLDAPPER
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHH
IEVYDNSHIQGANAVGGMIVAGPEGFMKGQYRKFNIKSTELTPGDDYGMMKEVLRRRFAR
EEECCCCCCCCCCCCCCEEEECCCHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHH
LVKEEEEGDDANRPDLVLVDGGQGQLDAAIEIMADLGVDDIAVVGVAKGPDRDAGLERFF
HHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEE
IPGQTPFMLEPKSPVLYYLQRLRDEAHRFAIGAHRTRRSMDLKKNPLDEIEGVGPGRKKA
CCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHH
LLHAFGSAKGVGRASVEDLVKVDGVSQALAERIFGFFRKG
HHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647