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The map label for this gene is luxQ [H]

Identifier: 16126867

GI number: 16126867

Start: 2849216

End: 2851297

Strand: Direct

Name: luxQ [H]

Synonym: CC_2632

Alternate gene names: 16126867

Gene position: 2849216-2851297 (Clockwise)

Preceding gene: 16126866

Following gene: 16126868

Centisome position: 70.93

GC content: 68.06

Gene sequence:

>2082_bases
ATGGCGCAGCGTATAGCGTCTCACGAGGAACGGCGGCAGACAGCGCTTCTGTTAGCGCTATCGTTCGCGGTCGCCGCCGC
GATCGTGTTCAGCGAGAACCTCACCCGCACGACGCTGGGCGTCGCCGCCTTCTGGCCCGCCAACGCCTTTCTGGCCGCCG
GCCTGCTCACCCTGACAAGCGTTCGCCGCCTGGTTCTGATCGCGGTGTTCGTCTTCTTCCATGTGGCGGTGTGCCTGCAG
GCAGGCGACGGGCCGCTCAAGGCTCTGGTTTTCGCCACGGTGGACGGACTGGAGGCCGGCGCGGTCTGGGCGGCGTTCCG
CAGGTTCTGGAACGGCGCGCCTCGGGTGCGAACCCTTCGCGCTCTGGCCCAGCTGCCCGCGATCACAACGCCCATCGCGG
CCGGTTCGGCGCTGATCTGCGCGACCGTCCTGCATTTCGGTTACGGCGCGCCCTTCGCCGAGAGCCTGGTGGATTGGCTC
CTGCGCAGCGCCTTGGGCCTGGCTGTCGCGCTTCCGGCCACGCTGGTGCTGATCGACGCCGAACATCGGCGTTCGTTCCA
GCGCCCCTGGTCAGAGAAACTGCTGCTGATGTTCAGCGTCGTGACGGTGGCCCTGCTCTGCGCGCATCCGGCCGCGGGCG
CGCCCCCCGTCTTGATGTTTCCGGTGACCCTGGCCGCCGCCTACAGGCTTGGCGCACGCGGCGCGGCCCTCGCGGCGTTT
CTGACGATCGGGATCATCATGCCGATGGTCATATCGGTGGGCTCTTCCTCCTTCAACTCGACCCAGGACACCGTCATCCA
GGCCCGGACGATCCAGGTGTTCATGGGCGTCCTGTTCTACACCTGCCTCGCCGCCGGGCTGGCGTTCGGCCAGCAGAACC
GGCTCAAGCGCCTGCTGTTGCGCCGCGAGCAGTTGACCCGCGCCGCGCGCGGCCGCGCTCTGGCCGCCACAGAGGCCAAG
ACCGAGTTCCTGGCCACCATGAGCCACGAAATCCGCACGCCGCTGAACAGCGTGCTGGGCTTTGCCCAGTTGCTTGCGGC
GCGCGAGGACTTGCCCCCGGACGCTCGGCGCCAGGTCAATCTGATCGACAGCGCCGGCGCGGCGCTGCTGACCGTGGTCG
ACGACATCCTGGACTTCTCGCGCGTCGAGGCGGGCCAGATCGAGCTATTGCCGGGGCCCACATCGGCCGCCGCGCTGCTG
CGCGACACGGTCGCGATCATGGCCCCCGAGGCGCGCGCCAAGGGCTTGTCGATGGATGTGGAGATCATCGACCCCATCGG
GGTCTTGCACGATCTCGACGCCGACCGCCTGAGGCAGGTTCTGATCAACCTGCTGAACAATGCGGTGAAGTTCACCGAAG
AGGGCCGCATCGACGCGCGGCTGATCATCGAACCGGGCGATATCGAGGACAGGCTGCGCTTCGAGGTTCTCGACACGGGT
GTCGGGATCGAGCTCGACAAGCAGGGTCTGCTGTTTCAGCGCTTCTCGCAGACGGACAGCTCACCCAGCCGCCTGCACGG
CGGCCCGGGCCTTGGACTGGCGATCGCCAAGGCGCTGATCGACGTTATGGGCGGCAAGATCGGCGTGGACAGCGTGCCCG
GTCGCGGGTCGTGCTTCTGGGTGGAGCTCAGCGCCCCGGTCGCCGAGCCGGCCCCGGCGCCTGAGCCCGCGAAACCGCCG
GCCCCGGGCGCGGCGCGGATCCTGATCGTCGACGACCATCCCATCAACCTCGAGATCGGCGCAGCCTTACTCACGCTGGT
CGGATACGAGGTCGATCTGGCGGAGAACGGCAAGCAGGCCGTGGAGAAGGCGGAAGCCGGCGCCTACGACCTGATCCTGA
TGGACATCCACATGCCGTTGATGGACGGGCTGCAGGCGACACGCGCGATCAAGGCCCTGCGCACGTCCACCGGAAAGGCG
CCGATCATCGCCATGAGCGCCGACGCCCTGCCCCGCCAGGTGGAGCGCTGCTACGCCGCCGGCATGGTCGATCACGTCGC
CAAGCCCATCCAACGCGAGGTGCTTTACGCCAAGATCGAGCGTTGGCTGCATCCGCTCCGCGATGGCGACAAGCCCGCCT
AG

Upstream 100 bases:

>100_bases
TGATCACGGCGTGACCGATGCAAGGCCCTGCACAGATCTCGGGCCTGAACTGGATCAACGCCGAGGCGTGAGGCGCGGAT
CGCTTGGGGACAGTTTCAAG

Downstream 100 bases:

>100_bases
GCTCGCCGGACGCGGCCGTTGCGTCTGGGTAGTTTGGGTTGTGGCTTGGAACTGCCCGCCGACACCCCTAACTTGGCCGA
GGATAACGGGAGATGTCCTC

Product: sensor histidine kinase/response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 693; Mature: 692

Protein sequence:

>693_residues
MAQRIASHEERRQTALLLALSFAVAAAIVFSENLTRTTLGVAAFWPANAFLAAGLLTLTSVRRLVLIAVFVFFHVAVCLQ
AGDGPLKALVFATVDGLEAGAVWAAFRRFWNGAPRVRTLRALAQLPAITTPIAAGSALICATVLHFGYGAPFAESLVDWL
LRSALGLAVALPATLVLIDAEHRRSFQRPWSEKLLLMFSVVTVALLCAHPAAGAPPVLMFPVTLAAAYRLGARGAALAAF
LTIGIIMPMVISVGSSSFNSTQDTVIQARTIQVFMGVLFYTCLAAGLAFGQQNRLKRLLLRREQLTRAARGRALAATEAK
TEFLATMSHEIRTPLNSVLGFAQLLAAREDLPPDARRQVNLIDSAGAALLTVVDDILDFSRVEAGQIELLPGPTSAAALL
RDTVAIMAPEARAKGLSMDVEIIDPIGVLHDLDADRLRQVLINLLNNAVKFTEEGRIDARLIIEPGDIEDRLRFEVLDTG
VGIELDKQGLLFQRFSQTDSSPSRLHGGPGLGLAIAKALIDVMGGKIGVDSVPGRGSCFWVELSAPVAEPAPAPEPAKPP
APGAARILIVDDHPINLEIGAALLTLVGYEVDLAENGKQAVEKAEAGAYDLILMDIHMPLMDGLQATRAIKALRTSTGKA
PIIAMSADALPRQVERCYAAGMVDHVAKPIQREVLYAKIERWLHPLRDGDKPA

Sequences:

>Translated_693_residues
MAQRIASHEERRQTALLLALSFAVAAAIVFSENLTRTTLGVAAFWPANAFLAAGLLTLTSVRRLVLIAVFVFFHVAVCLQ
AGDGPLKALVFATVDGLEAGAVWAAFRRFWNGAPRVRTLRALAQLPAITTPIAAGSALICATVLHFGYGAPFAESLVDWL
LRSALGLAVALPATLVLIDAEHRRSFQRPWSEKLLLMFSVVTVALLCAHPAAGAPPVLMFPVTLAAAYRLGARGAALAAF
LTIGIIMPMVISVGSSSFNSTQDTVIQARTIQVFMGVLFYTCLAAGLAFGQQNRLKRLLLRREQLTRAARGRALAATEAK
TEFLATMSHEIRTPLNSVLGFAQLLAAREDLPPDARRQVNLIDSAGAALLTVVDDILDFSRVEAGQIELLPGPTSAAALL
RDTVAIMAPEARAKGLSMDVEIIDPIGVLHDLDADRLRQVLINLLNNAVKFTEEGRIDARLIIEPGDIEDRLRFEVLDTG
VGIELDKQGLLFQRFSQTDSSPSRLHGGPGLGLAIAKALIDVMGGKIGVDSVPGRGSCFWVELSAPVAEPAPAPEPAKPP
APGAARILIVDDHPINLEIGAALLTLVGYEVDLAENGKQAVEKAEAGAYDLILMDIHMPLMDGLQATRAIKALRTSTGKA
PIIAMSADALPRQVERCYAAGMVDHVAKPIQREVLYAKIERWLHPLRDGDKPA
>Mature_692_residues
AQRIASHEERRQTALLLALSFAVAAAIVFSENLTRTTLGVAAFWPANAFLAAGLLTLTSVRRLVLIAVFVFFHVAVCLQA
GDGPLKALVFATVDGLEAGAVWAAFRRFWNGAPRVRTLRALAQLPAITTPIAAGSALICATVLHFGYGAPFAESLVDWLL
RSALGLAVALPATLVLIDAEHRRSFQRPWSEKLLLMFSVVTVALLCAHPAAGAPPVLMFPVTLAAAYRLGARGAALAAFL
TIGIIMPMVISVGSSSFNSTQDTVIQARTIQVFMGVLFYTCLAAGLAFGQQNRLKRLLLRREQLTRAARGRALAATEAKT
EFLATMSHEIRTPLNSVLGFAQLLAAREDLPPDARRQVNLIDSAGAALLTVVDDILDFSRVEAGQIELLPGPTSAAALLR
DTVAIMAPEARAKGLSMDVEIIDPIGVLHDLDADRLRQVLINLLNNAVKFTEEGRIDARLIIEPGDIEDRLRFEVLDTGV
GIELDKQGLLFQRFSQTDSSPSRLHGGPGLGLAIAKALIDVMGGKIGVDSVPGRGSCFWVELSAPVAEPAPAPEPAKPPA
PGAARILIVDDHPINLEIGAALLTLVGYEVDLAENGKQAVEKAEAGAYDLILMDIHMPLMDGLQATRAIKALRTSTGKAP
IIAMSADALPRQVERCYAAGMVDHVAKPIQREVLYAKIERWLHPLRDGDKPA

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=384, Percent_Identity=36.4583333333333, Blast_Score=216, Evalue=4e-57,
Organism=Escherichia coli, GI48994928, Length=370, Percent_Identity=34.8648648648649, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1789149, Length=241, Percent_Identity=41.0788381742739, Blast_Score=179, Evalue=5e-46,
Organism=Escherichia coli, GI87081816, Length=389, Percent_Identity=32.6478149100257, Blast_Score=168, Evalue=1e-42,
Organism=Escherichia coli, GI145693157, Length=231, Percent_Identity=38.961038961039, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1786912, Length=265, Percent_Identity=30.5660377358491, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788393, Length=226, Percent_Identity=29.646017699115, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=31.0043668122271, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=233, Percent_Identity=29.6137339055794, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1788549, Length=246, Percent_Identity=29.6747967479675, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790436, Length=305, Percent_Identity=24.9180327868852, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1790437, Length=130, Percent_Identity=34.6153846153846, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322044, Length=115, Percent_Identity=33.9130434782609, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6322000, Length=118, Percent_Identity=32.2033898305085, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 74123; Mature: 73992

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQRIASHEERRQTALLLALSFAVAAAIVFSENLTRTTLGVAAFWPANAFLAAGLLTLTS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEECCHHHHHHHHHHHHHH
VRRLVLIAVFVFFHVAVCLQAGDGPLKALVFATVDGLEAGAVWAAFRRFWNGAPRVRTLR
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHH
ALAQLPAITTPIAAGSALICATVLHFGYGAPFAESLVDWLLRSALGLAVALPATLVLIDA
HHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHEEEEEC
EHRRSFQRPWSEKLLLMFSVVTVALLCAHPAAGAPPVLMFPVTLAAAYRLGARGAALAAF
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHCCCHHHHHHH
LTIGIIMPMVISVGSSSFNSTQDTVIQARTIQVFMGVLFYTCLAAGLAFGQQNRLKRLLL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
RREQLTRAARGRALAATEAKTEFLATMSHEIRTPLNSVLGFAQLLAAREDLPPDARRQVN
HHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHH
LIDSAGAALLTVVDDILDFSRVEAGQIELLPGPTSAAALLRDTVAIMAPEARAKGLSMDV
HHHHCCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCHHHCCCCCCE
EIIDPIGVLHDLDADRLRQVLINLLNNAVKFTEEGRIDARLIIEPGDIEDRLRFEVLDTG
EEECCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHEEEEEECC
VGIELDKQGLLFQRFSQTDSSPSRLHGGPGLGLAIAKALIDVMGGKIGVDSVPGRGSCFW
CCCEECCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
VELSAPVAEPAPAPEPAKPPAPGAARILIVDDHPINLEIGAALLTLVGYEVDLAENGKQA
EEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCEEEHHCCCHHH
VEKAEAGAYDLILMDIHMPLMDGLQATRAIKALRTSTGKAPIIAMSADALPRQVERCYAA
HHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHH
GMVDHVAKPIQREVLYAKIERWLHPLRDGDKPA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AQRIASHEERRQTALLLALSFAVAAAIVFSENLTRTTLGVAAFWPANAFLAAGLLTLTS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEECCHHHHHHHHHHHHHH
VRRLVLIAVFVFFHVAVCLQAGDGPLKALVFATVDGLEAGAVWAAFRRFWNGAPRVRTLR
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHH
ALAQLPAITTPIAAGSALICATVLHFGYGAPFAESLVDWLLRSALGLAVALPATLVLIDA
HHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHEEEEEC
EHRRSFQRPWSEKLLLMFSVVTVALLCAHPAAGAPPVLMFPVTLAAAYRLGARGAALAAF
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHCCCHHHHHHH
LTIGIIMPMVISVGSSSFNSTQDTVIQARTIQVFMGVLFYTCLAAGLAFGQQNRLKRLLL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
RREQLTRAARGRALAATEAKTEFLATMSHEIRTPLNSVLGFAQLLAAREDLPPDARRQVN
HHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHH
LIDSAGAALLTVVDDILDFSRVEAGQIELLPGPTSAAALLRDTVAIMAPEARAKGLSMDV
HHHHCCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCHHHCCCCCCE
EIIDPIGVLHDLDADRLRQVLINLLNNAVKFTEEGRIDARLIIEPGDIEDRLRFEVLDTG
EEECCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHEEEEEECC
VGIELDKQGLLFQRFSQTDSSPSRLHGGPGLGLAIAKALIDVMGGKIGVDSVPGRGSCFW
CCCEECCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
VELSAPVAEPAPAPEPAKPPAPGAARILIVDDHPINLEIGAALLTLVGYEVDLAENGKQA
EEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCEEEHHCCCHHH
VEKAEAGAYDLILMDIHMPLMDGLQATRAIKALRTSTGKAPIIAMSADALPRQVERCYAA
HHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHH
GMVDHVAKPIQREVLYAKIERWLHPLRDGDKPA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]