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The map label for this gene is rihC [H]

Identifier: 16126852

GI number: 16126852

Start: 2825509

End: 2826480

Strand: Direct

Name: rihC [H]

Synonym: CC_2615

Alternate gene names: 16126852

Gene position: 2825509-2826480 (Clockwise)

Preceding gene: 16126851

Following gene: 16126858

Centisome position: 70.34

GC content: 67.28

Gene sequence:

>972_bases
ATGACGACCCCGACCAAGATCATCTTCGACACCGATCCCGGCATCGACGACGCGATGGCCCTGCTGTTCATCGAGGCGAG
CCCCGCCCTCGACCTGATCGCGGTGACGACCATCTTCGGCAACGCCGATATCGAGACCACCACCCGCAACGCGCTGTACC
TGAAGGACCGCTTCGGCCTGACGGCGCCGGTCTACAAGGGCACGGACAAGCCGCTGACGCGGCCGCGCAACCCCTCGCCC
ACCTTCGTGCATGGCGTGAATGGTCTGGGCGATGTGGAGTTGACGGGTCTGGTCCCAGCCCAGCCGGAAGCCAAGCCCGC
CCATCAGGCGATCATCGACCTGGCCCGCCAGTATCCGGGCGAAGTGGTGCTGTGCGCCGTTGGTCCCCTGACCAACCTGG
CCTTGGCCCTGCAGGCCGATCCTGAGGTCGCCACCCTGCTGAAGTCGGTGGTGATCATGGGCGGCGCGTTCGGCGTGGCC
GGTAAGCCGGGCAATGTCACGCCTGTGGCCGAGGCCAATATCTGGAACGATCCGGAAGCCGCCGATCAGGTCTTCACCGC
CCCCTGGAACCTGACCGCCGTCAGCCTGGACGTGACGACCCAGGTCGTGATGTCGCCCGACTATATGGACGCCCTGGCGG
CCGGCGGCAGCGACGCCTGCGGTTTCCTGAACGCCATCTCCAAGCCCTATGCGGCCTTCTATGGCGAGCGGGACGGCGTG
GTCGGCTGCTGCGTGCACGATGCGGCGGCGGTGGCCTATGTGATCGATCCGAGCTTGTTCACGGTGCGTCGCGGTTCGGT
GCGCGTGGTCACCGAAGGCATCGCGCTTGGCCAGACCTGCCAGAAGGCCGAGGGCGAGCTGTTCGGCCCCAGCGCCTGGG
ACGACCAGCCGATCCAGGCCGCGACCGTGGCCGTCGACGGCGCGCGACTGCTGACGCTGTACGCACAGACGATGGCGGCG
AAGTACGGTTGA

Upstream 100 bases:

>100_bases
CGCCGACGGCTGGAAGGTCGCCTCGGCCCACGTCTCCCTGATGCAGGAGAGCGCCGATCAACGGCTCGCCTCCTCTAACG
AAAAGCGCTAGAGCCCTCGA

Downstream 100 bases:

>100_bases
AATGCGTTGCGTCCTTCGAGGCGCGCTCAGGAGCGCGCACCTCAGGATGAGGATGGCTTACTGATTACCTCATCCTGAGG
CGCCTGCGCAGCAGGCCTCG

Product: inosine-uridine preferring nucleoside hydrolase

Products: cytosine; ribose; uracil [C]

Alternate protein names: Purine/pyrimidine ribonucleoside hydrolase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTTPTKIIFDTDPGIDDAMALLFIEASPALDLIAVTTIFGNADIETTTRNALYLKDRFGLTAPVYKGTDKPLTRPRNPSP
TFVHGVNGLGDVELTGLVPAQPEAKPAHQAIIDLARQYPGEVVLCAVGPLTNLALALQADPEVATLLKSVVIMGGAFGVA
GKPGNVTPVAEANIWNDPEAADQVFTAPWNLTAVSLDVTTQVVMSPDYMDALAAGGSDACGFLNAISKPYAAFYGERDGV
VGCCVHDAAAVAYVIDPSLFTVRRGSVRVVTEGIALGQTCQKAEGELFGPSAWDDQPIQAATVAVDGARLLTLYAQTMAA
KYG

Sequences:

>Translated_323_residues
MTTPTKIIFDTDPGIDDAMALLFIEASPALDLIAVTTIFGNADIETTTRNALYLKDRFGLTAPVYKGTDKPLTRPRNPSP
TFVHGVNGLGDVELTGLVPAQPEAKPAHQAIIDLARQYPGEVVLCAVGPLTNLALALQADPEVATLLKSVVIMGGAFGVA
GKPGNVTPVAEANIWNDPEAADQVFTAPWNLTAVSLDVTTQVVMSPDYMDALAAGGSDACGFLNAISKPYAAFYGERDGV
VGCCVHDAAAVAYVIDPSLFTVRRGSVRVVTEGIALGQTCQKAEGELFGPSAWDDQPIQAATVAVDGARLLTLYAQTMAA
KYG
>Mature_322_residues
TTPTKIIFDTDPGIDDAMALLFIEASPALDLIAVTTIFGNADIETTTRNALYLKDRFGLTAPVYKGTDKPLTRPRNPSPT
FVHGVNGLGDVELTGLVPAQPEAKPAHQAIIDLARQYPGEVVLCAVGPLTNLALALQADPEVATLLKSVVIMGGAFGVAG
KPGNVTPVAEANIWNDPEAADQVFTAPWNLTAVSLDVTTQVVMSPDYMDALAAGGSDACGFLNAISKPYAAFYGERDGVV
GCCVHDAAAVAYVIDPSLFTVRRGSVRVVTEGIALGQTCQKAEGELFGPSAWDDQPIQAATVAVDGARLLTLYAQTMAAK
YG

Specific function: Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity [H]

COG id: COG1957

COG function: function code F; Inosine-uridine nucleoside N-ribohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IUNH family. RihC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788486, Length=287, Percent_Identity=34.8432055749129, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1786213, Length=271, Percent_Identity=40.2214022140221, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1786871, Length=275, Percent_Identity=34.9090909090909, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32565474, Length=298, Percent_Identity=30.8724832214765, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17565698, Length=191, Percent_Identity=31.9371727748691, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320608, Length=197, Percent_Identity=37.0558375634518, Blast_Score=96, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24641839, Length=188, Percent_Identity=36.1702127659575, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641837, Length=194, Percent_Identity=37.6288659793814, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583915, Length=190, Percent_Identity=32.6315789473684, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023186
- InterPro:   IPR001910
- InterPro:   IPR022976 [H]

Pfam domain/function: PF01156 IU_nuc_hydro [H]

EC number: NA

Molecular weight: Translated: 33794; Mature: 33663

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPTKIIFDTDPGIDDAMALLFIEASPALDLIAVTTIFGNADIETTTRNALYLKDRFGL
CCCCCEEEEECCCCCCCEEEEEEEECCCCCEEEEEEEEECCCCCCCCCCCEEEEECCCCC
TAPVYKGTDKPLTRPRNPSPTFVHGVNGLGDVELTGLVPAQPEAKPAHQAIIDLARQYPG
CCCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCC
EVVLCAVGPLTNLALALQADPEVATLLKSVVIMGGAFGVAGKPGNVTPVAEANIWNDPEA
CEEEEECCCHHCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCH
ADQVFTAPWNLTAVSLDVTTQVVMSPDYMDALAAGGSDACGFLNAISKPYAAFYGERDGV
HHHEEECCCCEEEEEEEEEEEEEECCCHHHHHHCCCCCHHHHHHHHCCCHHHHCCCCCCE
VGCCVHDAAAVAYVIDPSLFTVRRGSVRVVTEGIALGQTCQKAEGELFGPSAWDDQPIQA
EEEEECCCCEEEEEECCCEEEEECCCEEEEECCCHHCCHHHHCCCCEECCCCCCCCCCEE
ATVAVDGARLLTLYAQTMAAKYG
EEEEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTPTKIIFDTDPGIDDAMALLFIEASPALDLIAVTTIFGNADIETTTRNALYLKDRFGL
CCCCEEEEECCCCCCCEEEEEEEECCCCCEEEEEEEEECCCCCCCCCCCEEEEECCCCC
TAPVYKGTDKPLTRPRNPSPTFVHGVNGLGDVELTGLVPAQPEAKPAHQAIIDLARQYPG
CCCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCC
EVVLCAVGPLTNLALALQADPEVATLLKSVVIMGGAFGVAGKPGNVTPVAEANIWNDPEA
CEEEEECCCHHCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCH
ADQVFTAPWNLTAVSLDVTTQVVMSPDYMDALAAGGSDACGFLNAISKPYAAFYGERDGV
HHHEEECCCCEEEEEEEEEEEEEECCCHHHHHHCCCCCHHHHHHHHCCCHHHHCCCCCCE
VGCCVHDAAAVAYVIDPSLFTVRRGSVRVVTEGIALGQTCQKAEGELFGPSAWDDQPIQA
EEEEECCCCEEEEEECCCEEEEECCCEEEEECCCHHCCHHHHCCCCEECCCCCCCCCCEE
ATVAVDGARLLTLYAQTMAAKYG
EEEEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: cytidine; H2O; uridine [C]

Specific reaction: cytidine + H2O = cytosine + ribose uridine + H2O = uracil + ribose [C]

General reaction: Pyrimidine-specific nucleoside hydrolase [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA