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The map label for this gene is maeB [H]

Identifier: 16126858

GI number: 16126858

Start: 2833465

End: 2835741

Strand: Direct

Name: maeB [H]

Synonym: CC_2622

Alternate gene names: 16126858

Gene position: 2833465-2835741 (Clockwise)

Preceding gene: 16126852

Following gene: 16126860

Centisome position: 70.54

GC content: 68.38

Gene sequence:

>2277_bases
ATGGACGAGGATTTCCGCAAAGCCGCCTTGGACTATCACCGGCTGCCGCGGCCCGGGAAACTGGCGATCGAGGCCACCAA
GCGGATGGCCACCCAGCGCGACCTCGCCCTCGCCTATTCTCCCGGCGTCGCCGCGCCTTGCATCGCCATCGCCGAGAACC
CTGAGCTGGCGCGCGACTACACCGCGCGCGGCAATCTGGTTGCGGTGATCTCGAACGGCACCGCCGTGCTGGGCCTGGGC
GACATCGGCCCGCTGGCCTCCAAGCCGGTGATGGAAGGCAAGGCCGTCCTCTTCAAGAAGTTCGCCGGCATCGACGTGTT
CGACATCGAGGTCGACGCCAAGGATCCAGACCGCTTCATCGAGGTGGTGGCGGCGCTGGAGCCCACCTTCGGCGGGATCA
ATCTCGAGGACATCAAGGCCCCTGAATGCTTCGTCATCGAGCGCAAGCTGCGCGAGCGGATGAACATCCCGGTCTTCCAC
GACGACCAGCACGGCACCGCCATCGTCTGCGCCGCGGCCGTTCGCAACGCCCTGCTCGTCCAGGGCAAGCAGCTCAAGGA
CGTCAAGCTGGTCACCTCCGGCGCCGGCGCGGCGGCCCTGGCCTGCGTTGATCTCCTGGTCTCGATGGGCCTGCCGGTCG
AGAACGTCACCCTGACCGACATCAAGGGCGTCGTGCACGCCGGCCGCGAGCCGGACATGCCCGACAACATGGCGCGCTAC
GCCCGCCAGACCGACGCCCGCACCCTGCCCGAGGTGCTGCCGGGCGCCGACATCTTCCTGGGCCTGTCGGCCCCGCGCGT
CTTCAAGCCGGAATGGCTGCCACTGCTGGCGCCCAACCCGCTGATCCTGGCCATGGCCAATCCCGAGCCGGAGATCCTGC
CGGAACTGGTCTATGAAAGCCGCCCCGACGCGATCATGGCCACGGGCCGCAGCGACTACGCCAACCAGGTCAACAACGTC
CTCTGCTTCCCCTTCATCTTCCGGGGCGCGCTGGACGTCGGCGCCAGCGAGATCAACGAGGCGATGAAGGTCGCCGCAGT
CGAGGCGATCGCCGAACTGGCGCGCGCCGAGGCCTCAGAAGTGGTGGCCAGCGCCTATGGCGGCGCCGCGCCGGTGTTTG
GCTCGCAGTACATCATCCCCAAGCCCTTCGACCCGCGCCTGATCCTGCAGATCGCCCCGGCCGTGGCCAAGGCGGCGATG
GACAGCGGTGTGGCCACCCGCCCGATCGCCGACTTCGACGCCTATCAGGCCGAGCTGGAGCTGTTCGTCTATCGCTCCGG
CCAGCTGATGCGTCCGGTCTTCGAGCGGGCTCGCAAGCAGCCGGTCAAGGTCGCCTATGCCGAGGCCGAGGACGAGCGCG
TGCTGCGCGCCGTACAGACCGTCGTGGACGAAGGCCTCGCCTACCCGGTGCTGGTGGGCCGGCGCGAGGTCATTACCGGC
AAGATTGAAGAACTGGGACTGCGTCTGGCCGGCAAGGTCGAAATCATCGATCCCCAGGCCGACAAGGATTTGTTCGCGCC
GCTGATCGCCGACTACCAGCGCCTGGTCGGACGTCGGGGCGTGCCGCCGATCGCGGCCGAGCGCCGGGTCACCGGCCGTC
GCACCGTCGCAGCCTCCATGCTCCTGGCGACCGGCTATGTCGAGGCCGCCCTGGTCGGCGGCAGCGGCGACTGGTGGCAG
CACATGAAGTACGCCCTGCCGATCATCCCGCGCCGCGACAATGTCAGCCGGGTCTATGCGATGTCGTCGCTGATCCTGGA
CAAGGGGACGCTGTTCTTCTGCGACACCCACGTCAATGTCGATCCGACCGCAGAGCAGATCGCCGAATGCACCCAGCTGG
CGGCCGAGGCCGTTCGCCGCTTTGGCCTGACGCCCAAGGCGGCCCTGCTGTCGCATTCTTCGTTCGGGGCCAGCGACTCG
CCGACCGCCCGCAAGATGCGCGAAGCCCTGGCCCTGCTCCGCACCCAGGCGCCGGATCTGGAGGTCGACGGCGAAATGCA
TGCCGACGCCGCACTCAGCCAGCACCTGCGCGATCGCATGGTCGCCGACAGCCCGCTGAAGGGCTCGGCCAATCTGCTGG
TCATGCCGACGCTGGATGCGGCCAATATCGGCCTGACCCTGCTCAGCGCCGCGACGGAGTCCCTGCTCGTCGGCCCGGTG
CTGCTGGGCATGGCCAAGCCGCTTCACGTGCTGATCCCCAGCGTGACGGCGCGCGGTATCGTCAACCTGACCGCCCTGGC
GGTGAATCAGGCGGTGTCCGAGCGCGCGGCCAGCTAG

Upstream 100 bases:

>100_bases
TTGGAATTGCCGCGCCAACACCGCTAGCAAGGCTCGTGACGCTTCGCGCTCAGACGAGGCAGGATAACCGCGCCGCGCAG
GCCGCCCAGAGGAACGATCG

Downstream 100 bases:

>100_bases
GCGCGCGAAACAGGCCTGAACGACAAAAGGCCCCGTCCGACACGTCAGCGTCGAACGGGGCCTTCCGAAGATCTCTGGAA
AAGGCCGTCCCTCGGGGCGG

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 758; Mature: 758

Protein sequence:

>758_residues
MDEDFRKAALDYHRLPRPGKLAIEATKRMATQRDLALAYSPGVAAPCIAIAENPELARDYTARGNLVAVISNGTAVLGLG
DIGPLASKPVMEGKAVLFKKFAGIDVFDIEVDAKDPDRFIEVVAALEPTFGGINLEDIKAPECFVIERKLRERMNIPVFH
DDQHGTAIVCAAAVRNALLVQGKQLKDVKLVTSGAGAAALACVDLLVSMGLPVENVTLTDIKGVVHAGREPDMPDNMARY
ARQTDARTLPEVLPGADIFLGLSAPRVFKPEWLPLLAPNPLILAMANPEPEILPELVYESRPDAIMATGRSDYANQVNNV
LCFPFIFRGALDVGASEINEAMKVAAVEAIAELARAEASEVVASAYGGAAPVFGSQYIIPKPFDPRLILQIAPAVAKAAM
DSGVATRPIADFDAYQAELELFVYRSGQLMRPVFERARKQPVKVAYAEAEDERVLRAVQTVVDEGLAYPVLVGRREVITG
KIEELGLRLAGKVEIIDPQADKDLFAPLIADYQRLVGRRGVPPIAAERRVTGRRTVAASMLLATGYVEAALVGGSGDWWQ
HMKYALPIIPRRDNVSRVYAMSSLILDKGTLFFCDTHVNVDPTAEQIAECTQLAAEAVRRFGLTPKAALLSHSSFGASDS
PTARKMREALALLRTQAPDLEVDGEMHADAALSQHLRDRMVADSPLKGSANLLVMPTLDAANIGLTLLSAATESLLVGPV
LLGMAKPLHVLIPSVTARGIVNLTALAVNQAVSERAAS

Sequences:

>Translated_758_residues
MDEDFRKAALDYHRLPRPGKLAIEATKRMATQRDLALAYSPGVAAPCIAIAENPELARDYTARGNLVAVISNGTAVLGLG
DIGPLASKPVMEGKAVLFKKFAGIDVFDIEVDAKDPDRFIEVVAALEPTFGGINLEDIKAPECFVIERKLRERMNIPVFH
DDQHGTAIVCAAAVRNALLVQGKQLKDVKLVTSGAGAAALACVDLLVSMGLPVENVTLTDIKGVVHAGREPDMPDNMARY
ARQTDARTLPEVLPGADIFLGLSAPRVFKPEWLPLLAPNPLILAMANPEPEILPELVYESRPDAIMATGRSDYANQVNNV
LCFPFIFRGALDVGASEINEAMKVAAVEAIAELARAEASEVVASAYGGAAPVFGSQYIIPKPFDPRLILQIAPAVAKAAM
DSGVATRPIADFDAYQAELELFVYRSGQLMRPVFERARKQPVKVAYAEAEDERVLRAVQTVVDEGLAYPVLVGRREVITG
KIEELGLRLAGKVEIIDPQADKDLFAPLIADYQRLVGRRGVPPIAAERRVTGRRTVAASMLLATGYVEAALVGGSGDWWQ
HMKYALPIIPRRDNVSRVYAMSSLILDKGTLFFCDTHVNVDPTAEQIAECTQLAAEAVRRFGLTPKAALLSHSSFGASDS
PTARKMREALALLRTQAPDLEVDGEMHADAALSQHLRDRMVADSPLKGSANLLVMPTLDAANIGLTLLSAATESLLVGPV
LLGMAKPLHVLIPSVTARGIVNLTALAVNQAVSERAAS
>Mature_758_residues
MDEDFRKAALDYHRLPRPGKLAIEATKRMATQRDLALAYSPGVAAPCIAIAENPELARDYTARGNLVAVISNGTAVLGLG
DIGPLASKPVMEGKAVLFKKFAGIDVFDIEVDAKDPDRFIEVVAALEPTFGGINLEDIKAPECFVIERKLRERMNIPVFH
DDQHGTAIVCAAAVRNALLVQGKQLKDVKLVTSGAGAAALACVDLLVSMGLPVENVTLTDIKGVVHAGREPDMPDNMARY
ARQTDARTLPEVLPGADIFLGLSAPRVFKPEWLPLLAPNPLILAMANPEPEILPELVYESRPDAIMATGRSDYANQVNNV
LCFPFIFRGALDVGASEINEAMKVAAVEAIAELARAEASEVVASAYGGAAPVFGSQYIIPKPFDPRLILQIAPAVAKAAM
DSGVATRPIADFDAYQAELELFVYRSGQLMRPVFERARKQPVKVAYAEAEDERVLRAVQTVVDEGLAYPVLVGRREVITG
KIEELGLRLAGKVEIIDPQADKDLFAPLIADYQRLVGRRGVPPIAAERRVTGRRTVAASMLLATGYVEAALVGGSGDWWQ
HMKYALPIIPRRDNVSRVYAMSSLILDKGTLFFCDTHVNVDPTAEQIAECTQLAAEAVRRFGLTPKAALLSHSSFGASDS
PTARKMREALALLRTQAPDLEVDGEMHADAALSQHLRDRMVADSPLKGSANLLVMPTLDAANIGLTLLSAATESLLVGPV
LLGMAKPLHVLIPSVTARGIVNLTALAVNQAVSERAAS

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788806, Length=758, Percent_Identity=58.9709762532982, Blast_Score=880, Evalue=0.0,
Organism=Escherichia coli, GI1788800, Length=329, Percent_Identity=31.6109422492401, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1788635, Length=336, Percent_Identity=25.5952380952381, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI281362674, Length=455, Percent_Identity=26.1538461538462, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356279, Length=455, Percent_Identity=26.1538461538462, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281362672, Length=455, Percent_Identity=26.1538461538462, Blast_Score=84, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24646388, Length=348, Percent_Identity=28.735632183908, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646386, Length=348, Percent_Identity=28.735632183908, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 81400; Mature: 81400

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEDFRKAALDYHRLPRPGKLAIEATKRMATQRDLALAYSPGVAAPCIAIAENPELARDY
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCEEEEECCCCCCCEEEEECCCCHHHHH
TARGNLVAVISNGTAVLGLGDIGPLASKPVMEGKAVLFKKFAGIDVFDIEVDAKDPDRFI
CCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCHHHHH
EVVAALEPTFGGINLEDIKAPECFVIERKLRERMNIPVFHDDQHGTAIVCAAAVRNALLV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHHH
QGKQLKDVKLVTSGAGAAALACVDLLVSMGLPVENVTLTDIKGVVHAGREPDMPDNMARY
CCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCCCCHHHHHH
ARQTDARTLPEVLPGADIFLGLSAPRVFKPEWLPLLAPNPLILAMANPEPEILPELVYES
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEECCCCEEEEECCCCHHHHHHHHHCC
RPDAIMATGRSDYANQVNNVLCFPFIFRGALDVGASEINEAMKVAAVEAIAELARAEASE
CCCEEEECCCHHHHHHHCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VVASAYGGAAPVFGSQYIIPKPFDPRLILQIAPAVAKAAMDSGVATRPIADFDAYQAELE
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEEE
LFVYRSGQLMRPVFERARKQPVKVAYAEAEDERVLRAVQTVVDEGLAYPVLVGRREVITG
EEEECCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCHHHHHC
KIEELGLRLAGKVEIIDPQADKDLFAPLIADYQRLVGRRGVPPIAAERRVTGRRTVAASM
CHHHHCCEEECEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
LLATGYVEAALVGGSGDWWQHMKYALPIIPRRDNVSRVYAMSSLILDKGTLFFCDTHVNV
HHHHCCEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCC
DPTAEQIAECTQLAAEAVRRFGLTPKAALLSHSSFGASDSPTARKMREALALLRTQAPDL
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
EVDGEMHADAALSQHLRDRMVADSPLKGSANLLVMPTLDAANIGLTLLSAATESLLVGPV
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
LLGMAKPLHVLIPSVTARGIVNLTALAVNQAVSERAAS
HHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDEDFRKAALDYHRLPRPGKLAIEATKRMATQRDLALAYSPGVAAPCIAIAENPELARDY
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCEEEEECCCCCCCEEEEECCCCHHHHH
TARGNLVAVISNGTAVLGLGDIGPLASKPVMEGKAVLFKKFAGIDVFDIEVDAKDPDRFI
CCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCHHHHH
EVVAALEPTFGGINLEDIKAPECFVIERKLRERMNIPVFHDDQHGTAIVCAAAVRNALLV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHHH
QGKQLKDVKLVTSGAGAAALACVDLLVSMGLPVENVTLTDIKGVVHAGREPDMPDNMARY
CCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCCCCHHHHHH
ARQTDARTLPEVLPGADIFLGLSAPRVFKPEWLPLLAPNPLILAMANPEPEILPELVYES
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEECCCCEEEEECCCCHHHHHHHHHCC
RPDAIMATGRSDYANQVNNVLCFPFIFRGALDVGASEINEAMKVAAVEAIAELARAEASE
CCCEEEECCCHHHHHHHCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VVASAYGGAAPVFGSQYIIPKPFDPRLILQIAPAVAKAAMDSGVATRPIADFDAYQAELE
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEEE
LFVYRSGQLMRPVFERARKQPVKVAYAEAEDERVLRAVQTVVDEGLAYPVLVGRREVITG
EEEECCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCHHHHHC
KIEELGLRLAGKVEIIDPQADKDLFAPLIADYQRLVGRRGVPPIAAERRVTGRRTVAASM
CHHHHCCEEECEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
LLATGYVEAALVGGSGDWWQHMKYALPIIPRRDNVSRVYAMSSLILDKGTLFFCDTHVNV
HHHHCCEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCC
DPTAEQIAECTQLAAEAVRRFGLTPKAALLSHSSFGASDSPTARKMREALALLRTQAPDL
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
EVDGEMHADAALSQHLRDRMVADSPLKGSANLLVMPTLDAANIGLTLLSAATESLLVGPV
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
LLGMAKPLHVLIPSVTARGIVNLTALAVNQAVSERAAS
HHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]