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The map label for this gene is purL

Identifier: 16126739

GI number: 16126739

Start: 2708112

End: 2710331

Strand: Direct

Name: purL

Synonym: CC_2500

Alternate gene names: 16126739

Gene position: 2708112-2710331 (Clockwise)

Preceding gene: 16126736

Following gene: 16126742

Centisome position: 67.42

GC content: 68.78

Gene sequence:

>2220_bases
ATGAGCACCTCCTCCACGCCCTCCGCGAAGCCCATGGCCGAGATGGCCGCCGAGTTCGGCCTGAAACCCGCCGAATATGA
CGTTGTCCTCAAGCGCCTGGGGCGTGAGCCCAACCTGGTGGAACTGGGCGTCTTTTCGGTGATGTGGTCCGAGCACTGCT
CGTACAAGTCCTCGAAGAACCAGCTGAAGAAGTTCCCGATCGACGGGCCGCGCGTGATCTGCGGTCCTGGCGAGAACGCC
GGCGTCATCGATATCGGCGACGGCGACGCGATCATCTTCAAGATGGAGAGCCACAACCACCCCTCGTACATCGAGCCCTA
TCAGGGCGCGGCGACGGGCGTGGGCGGCATCATGCGCGACGTCTTCACGATGGGCGCGCGGCCGATCGCCCTCTTGAACG
CCCTGCGCTTTGGTGACCCCAGCCATCCGAAGACCAAGCGTCTGGTCGACGGCGTCGTCGCCGGCATCGCCGGCTACGGC
AACTGCGTGGGCGTGCCCACCGTCGCGGGCGAGACCAACTTCCACAAGGGCTACAACGGCAACATCCTGGTCAACGCCAT
GTGCGTGGGCCTGGCCAAGGCCGACAGCATCTTCTACTCGGCCGCCCCGGGCCCGGGCCTGGCGGTCGTCTATTTCGGCT
CCAAGACCGGCCGCGACGGCATCCACGGCGCGACCATGTCCTCGGCCGAGTTCTCAGAGGACTCCGAAGAGAAGCGCCCC
ACCGTCCAGGTCGGCGACCCCTTCGCCGAGAAGCTGCTGATCGAGGCCACGCTGGAGCTGATGGCCACCGGCGCGGTCGC
CGCCATCCAGGACATGGGCGCGGCGGGCCTGACCTCCTCGTCCGTCGAGATGGCCGGCAAGGGCGGCGTCGGCATCGAGC
TGAACATGGACATGGTCCCGCAGCGCGAGACCGGCATGTCGGCCTACGAGATGATGCTGTCGGAAAGCCAGGAGCGCATG
CTGGCGGTCCTCAAGCCCGGCCGCGAGCAGGACGGCCACGCCATCTTCGAAAAGTGGGGCCTGGACGCCGCCGTCATCGG
CTACACCACCGACACCGGCCGTCTGGTGCTGAAGCACCACGGCGAGACCGTCTGCGACGTGCCGCTGGCCCCGCTGTTCG
ACGACGCGCCGCTATATGACCGTCCGTGGGTGCAACCGGCCCTGCAGCCGCGCCTCGACCCGGCCGCCGTCCCCGCTCCG
ACGAACTGGAACGAAGCGGTGCTGAAGATCATCGGCTGCCCGGACATGGCCTCCAAGCGCTGGCTGTGGGAGCAGTACGA
CCGCCACGTCATGGCCGACACGCTGGAAGACAGCGCCACCGGCTGCGACGCCGGCATCGTGCGCATCCACGGCACGGGCA
AGGCCATCGCCGTGACCAGCGACTGCACCCCGCGCTATGTCCAGGCGGACCCCTATGAGGGCGGCAAGCAGGCGGTCGCG
GAAGCCTGGCGCAACCTGACGGCCGCCGGCGCCCTGCCGATCGCCATCACCGACAACCTGAACTTCGGCAGCCCCGAAAA
GCCCGAGACCATGGGCCAGATCGTGCGCGCCACCGACGGCATGGCCGAGGCCTGCCGCGCGCTGGACTTCCCGGTCGTGT
CGGGGAACGTGTCGCTCTACAACGAGACCAACGGCGTCGCCATTCCGCCGACGCCCACCGTCGGCGGCGTGGGCCTGCTG
GAGGACTACGACCTGCGCACGGGCTTTGGCAATGTGGCCGAGGGCGACACCCTGGTGCTGGTCGGCGAGACGCGCGGCGA
ACTGGGCGCCTCGATCTATCTGCGTGAGATTCTGGGTCGCGAAGACGGCGCCCCGCCGCCGGTCGACCTGGCTCTGGAGC
GCAAGACCGGCGACTTCGTGCGCGGCCTGATCAGCTCGGGTCTCGTCGCGGGCGTCCACGACCTGTCGGACGGCGGTCTG
CTGGTCGCGGCGGCCGACGTGGCCCTGGCCAGCAAGATCGGCGTCACCCTGAACGCCACCAGCCAGACGCATGCTCACGC
CTATCTGCTGGGCGAAGACCAAGCCCGCTATCTGATCGCCACGCCCGATCCGGACGCGGTGCTGGAAGCGGCGAAAGAGG
CGGGCGTGCACGCCAACGTCGCGGGCGTCGCGGGCGGGGAAGCGTTCGCGTCGGATGGTCTGTTCAGCGTCTCGCTGGAC
GCCCTGCGCGCCGCGCACGAGGCTTGGCTGCCGGGCTATATGAGCGCGCCGAAGGCCTGA

Upstream 100 bases:

>100_bases
CCCCGTCGGCCAGTCGGGTCGCAAAGGCGGCTGATAATCCCGTCACGACCTGGTCCTCGCCGGTGGCGGAATCCCTGGTA
GCGCGCTAGAACGCGCCCCC

Downstream 100 bases:

>100_bases
GGGTTTACCCTGAGCGCGCGGCCTGTTCAGGCCGCGTGCGACCTTCCTGACCATCGCGCGACCGCCTCCAGCAGCTTGGC
GGGGCTGATCGGCTTGCCCA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 739; Mature: 738

Protein sequence:

>739_residues
MSTSSTPSAKPMAEMAAEFGLKPAEYDVVLKRLGREPNLVELGVFSVMWSEHCSYKSSKNQLKKFPIDGPRVICGPGENA
GVIDIGDGDAIIFKMESHNHPSYIEPYQGAATGVGGIMRDVFTMGARPIALLNALRFGDPSHPKTKRLVDGVVAGIAGYG
NCVGVPTVAGETNFHKGYNGNILVNAMCVGLAKADSIFYSAAPGPGLAVVYFGSKTGRDGIHGATMSSAEFSEDSEEKRP
TVQVGDPFAEKLLIEATLELMATGAVAAIQDMGAAGLTSSSVEMAGKGGVGIELNMDMVPQRETGMSAYEMMLSESQERM
LAVLKPGREQDGHAIFEKWGLDAAVIGYTTDTGRLVLKHHGETVCDVPLAPLFDDAPLYDRPWVQPALQPRLDPAAVPAP
TNWNEAVLKIIGCPDMASKRWLWEQYDRHVMADTLEDSATGCDAGIVRIHGTGKAIAVTSDCTPRYVQADPYEGGKQAVA
EAWRNLTAAGALPIAITDNLNFGSPEKPETMGQIVRATDGMAEACRALDFPVVSGNVSLYNETNGVAIPPTPTVGGVGLL
EDYDLRTGFGNVAEGDTLVLVGETRGELGASIYLREILGREDGAPPPVDLALERKTGDFVRGLISSGLVAGVHDLSDGGL
LVAAADVALASKIGVTLNATSQTHAHAYLLGEDQARYLIATPDPDAVLEAAKEAGVHANVAGVAGGEAFASDGLFSVSLD
ALRAAHEAWLPGYMSAPKA

Sequences:

>Translated_739_residues
MSTSSTPSAKPMAEMAAEFGLKPAEYDVVLKRLGREPNLVELGVFSVMWSEHCSYKSSKNQLKKFPIDGPRVICGPGENA
GVIDIGDGDAIIFKMESHNHPSYIEPYQGAATGVGGIMRDVFTMGARPIALLNALRFGDPSHPKTKRLVDGVVAGIAGYG
NCVGVPTVAGETNFHKGYNGNILVNAMCVGLAKADSIFYSAAPGPGLAVVYFGSKTGRDGIHGATMSSAEFSEDSEEKRP
TVQVGDPFAEKLLIEATLELMATGAVAAIQDMGAAGLTSSSVEMAGKGGVGIELNMDMVPQRETGMSAYEMMLSESQERM
LAVLKPGREQDGHAIFEKWGLDAAVIGYTTDTGRLVLKHHGETVCDVPLAPLFDDAPLYDRPWVQPALQPRLDPAAVPAP
TNWNEAVLKIIGCPDMASKRWLWEQYDRHVMADTLEDSATGCDAGIVRIHGTGKAIAVTSDCTPRYVQADPYEGGKQAVA
EAWRNLTAAGALPIAITDNLNFGSPEKPETMGQIVRATDGMAEACRALDFPVVSGNVSLYNETNGVAIPPTPTVGGVGLL
EDYDLRTGFGNVAEGDTLVLVGETRGELGASIYLREILGREDGAPPPVDLALERKTGDFVRGLISSGLVAGVHDLSDGGL
LVAAADVALASKIGVTLNATSQTHAHAYLLGEDQARYLIATPDPDAVLEAAKEAGVHANVAGVAGGEAFASDGLFSVSLD
ALRAAHEAWLPGYMSAPKA
>Mature_738_residues
STSSTPSAKPMAEMAAEFGLKPAEYDVVLKRLGREPNLVELGVFSVMWSEHCSYKSSKNQLKKFPIDGPRVICGPGENAG
VIDIGDGDAIIFKMESHNHPSYIEPYQGAATGVGGIMRDVFTMGARPIALLNALRFGDPSHPKTKRLVDGVVAGIAGYGN
CVGVPTVAGETNFHKGYNGNILVNAMCVGLAKADSIFYSAAPGPGLAVVYFGSKTGRDGIHGATMSSAEFSEDSEEKRPT
VQVGDPFAEKLLIEATLELMATGAVAAIQDMGAAGLTSSSVEMAGKGGVGIELNMDMVPQRETGMSAYEMMLSESQERML
AVLKPGREQDGHAIFEKWGLDAAVIGYTTDTGRLVLKHHGETVCDVPLAPLFDDAPLYDRPWVQPALQPRLDPAAVPAPT
NWNEAVLKIIGCPDMASKRWLWEQYDRHVMADTLEDSATGCDAGIVRIHGTGKAIAVTSDCTPRYVQADPYEGGKQAVAE
AWRNLTAAGALPIAITDNLNFGSPEKPETMGQIVRATDGMAEACRALDFPVVSGNVSLYNETNGVAIPPTPTVGGVGLLE
DYDLRTGFGNVAEGDTLVLVGETRGELGASIYLREILGREDGAPPPVDLALERKTGDFVRGLISSGLVAGVHDLSDGGLL
VAAADVALASKIGVTLNATSQTHAHAYLLGEDQARYLIATPDPDAVLEAAKEAGVHANVAGVAGGEAFASDGLFSVSLDA
LRAAHEAWLPGYMSAPKA

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Escherichia coli, GI48994899, Length=740, Percent_Identity=25.9459459459459, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321498, Length=793, Percent_Identity=23.5813366960908, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_CAUCR (Q9A5F0)

Other databases:

- EMBL:   AE005673
- PIR:   C87559
- RefSeq:   NP_421303.1
- ProteinModelPortal:   Q9A5F0
- SMR:   Q9A5F0
- GeneID:   944037
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_2500
- NMPDR:   fig|190650.1.peg.2483
- TIGR:   CC_2500
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 77705; Mature: 77574

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSSTPSAKPMAEMAAEFGLKPAEYDVVLKRLGREPNLVELGVFSVMWSEHCSYKSSKN
CCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCHH
QLKKFPIDGPRVICGPGENAGVIDIGDGDAIIFKMESHNHPSYIEPYQGAATGVGGIMRD
HHHCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
VFTMGARPIALLNALRFGDPSHPKTKRLVDGVVAGIAGYGNCVGVPTVAGETNFHKGYNG
HHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCC
NILVNAMCVGLAKADSIFYSAAPGPGLAVVYFGSKTGRDGIHGATMSSAEFSEDSEEKRP
CEEEEEEEHHHHHHCCEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHCCC
TVQVGDPFAEKLLIEATLELMATGAVAAIQDMGAAGLTSSSVEMAGKGGVGIELNMDMVP
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCEEEECCCCCC
QRETGMSAYEMMLSESQERMLAVLKPGREQDGHAIFEKWGLDAAVIGYTTDTGRLVLKHH
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEEECCCCEEEEEEC
GETVCDVPLAPLFDDAPLYDRPWVQPALQPRLDPAAVPAPTNWNEAVLKIIGCPDMASKR
CCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHH
WLWEQYDRHVMADTLEDSATGCDAGIVRIHGTGKAIAVTSDCTPRYVQADPYEGGKQAVA
HHHHHHCCHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCCCCEEECCCCCCHHHHHH
EAWRNLTAAGALPIAITDNLNFGSPEKPETMGQIVRATDGMAEACRALDFPVVSGNVSLY
HHHHCCHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCEEEECCEEEE
NETNGVAIPPTPTVGGVGLLEDYDLRTGFGNVAEGDTLVLVGETRGELGASIYLREILGR
ECCCCEECCCCCCCCCCCCEECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCC
EDGAPPPVDLALERKTGDFVRGLISSGLVAGVHDLSDGGLLVAAADVALASKIGVTLNAT
CCCCCCCCEEEEECCCHHHHHHHHHCCCEECCEECCCCCEEEEEHHHHHHHHCCEEEECC
SQTHAHAYLLGEDQARYLIATPDPDAVLEAAKEAGVHANVAGVAGGEAFASDGLFSVSLD
CCCCEEEEEEECCCCCEEEECCCHHHHHHHHHHCCCCEEEEECCCCCHHHCCCEEEEEHH
ALRAAHEAWLPGYMSAPKA
HHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
STSSTPSAKPMAEMAAEFGLKPAEYDVVLKRLGREPNLVELGVFSVMWSEHCSYKSSKN
CCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCHH
QLKKFPIDGPRVICGPGENAGVIDIGDGDAIIFKMESHNHPSYIEPYQGAATGVGGIMRD
HHHCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
VFTMGARPIALLNALRFGDPSHPKTKRLVDGVVAGIAGYGNCVGVPTVAGETNFHKGYNG
HHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCC
NILVNAMCVGLAKADSIFYSAAPGPGLAVVYFGSKTGRDGIHGATMSSAEFSEDSEEKRP
CEEEEEEEHHHHHHCCEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHCCC
TVQVGDPFAEKLLIEATLELMATGAVAAIQDMGAAGLTSSSVEMAGKGGVGIELNMDMVP
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCEEEECCCCCC
QRETGMSAYEMMLSESQERMLAVLKPGREQDGHAIFEKWGLDAAVIGYTTDTGRLVLKHH
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEEECCCCEEEEEEC
GETVCDVPLAPLFDDAPLYDRPWVQPALQPRLDPAAVPAPTNWNEAVLKIIGCPDMASKR
CCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHH
WLWEQYDRHVMADTLEDSATGCDAGIVRIHGTGKAIAVTSDCTPRYVQADPYEGGKQAVA
HHHHHHCCHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCCCCEEECCCCCCHHHHHH
EAWRNLTAAGALPIAITDNLNFGSPEKPETMGQIVRATDGMAEACRALDFPVVSGNVSLY
HHHHCCHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCEEEECCEEEE
NETNGVAIPPTPTVGGVGLLEDYDLRTGFGNVAEGDTLVLVGETRGELGASIYLREILGR
ECCCCEECCCCCCCCCCCCEECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCC
EDGAPPPVDLALERKTGDFVRGLISSGLVAGVHDLSDGGLLVAAADVALASKIGVTLNAT
CCCCCCCCEEEEECCCHHHHHHHHHCCCEECCEECCCCCEEEEEHHHHHHHHCCEEEECC
SQTHAHAYLLGEDQARYLIATPDPDAVLEAAKEAGVHANVAGVAGGEAFASDGLFSVSLD
CCCCEEEEEEECCCCCEEEECCCHHHHHHHHHHCCCCEEEEECCCCCHHHCCCEEEEEHH
ALRAAHEAWLPGYMSAPKA
HHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647