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The map label for this gene is purQ

Identifier: 16126736

GI number: 16126736

Start: 2706407

End: 2707069

Strand: Direct

Name: purQ

Synonym: CC_2497

Alternate gene names: 16126736

Gene position: 2706407-2707069 (Clockwise)

Preceding gene: 16126735

Following gene: 16126739

Centisome position: 67.37

GC content: 66.82

Gene sequence:

>663_bases
ATGAAAGCCGCCGTCATCGTTTTTCCGGGTTCGAACTGCGATCGTGACTGCAAGGTCGCCATCGAGCGCTCCGCTGGGGC
GCGTGTCGAAATGGTCTGGCACCAGGAGACGGCGCTGCCGGACGACCTGGACCTGATCGTCCTGCCCGGCGGCTTCTCGT
ATGGCGACTACCTGCGCTGCGGCGCCATGGCCGCCCAGAGCCCGGTGATGAAAGAGGTCGTCTCGGCCGCCGGCAAGGGC
GTGGCCGTGGTCGGCATCTGCAACGGCTTCCAGGTGCTGACCGAGGTTGGCCTGCTGCCCGGCGCCCTGCTGCGCAACGC
GGGCCTCAAATATGTCTGCAAGCCGGTCGAGCTGGACATCGTCAACGGCCAGACCCGCTTTACGGCGGGCTATGGCGAGC
AGCGTCAGGCGGTGATGACCGTCGGCAACGGCGAGGGCAACTACTTCGCCGACGAAGAGACGCTGGACCGCCTCGAGGGC
GAAGGCCAGGTGGTGTTCCGCTACAAGGAAAACCCCAACGGCTCGGCCCGCGACATCGCCGGCATCGTCAACAAGGGCGG
CAACGTCCTGGGCCTGATGCCCCACCCCGACCGCGCCTTCGACGCCGATCTGGGCTCCGAAGACGGCGCGGTGCTGTTCC
GCAGCATCTTCCAGAGCGCTTAG

Upstream 100 bases:

>100_bases
GGGGGAGGTGGCGCGGCGCCGATCGGCGACGTGACGGAGGGGGCGCTTTAAAACGCTCGCCCCCTGACATCCCGGCCGAA
CGGTGCTACACGCCCGCGCC

Downstream 100 bases:

>100_bases
TCGCTCCGCCCCTTGATCGCGCGGGCGACACCCCAAGCATCCTCGCACCGCTGGTCGGCGCGATAGACGAAAAGGGCCGG
CGGATTGACCGCCGGCCCCT

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MKAAVIVFPGSNCDRDCKVAIERSAGARVEMVWHQETALPDDLDLIVLPGGFSYGDYLRCGAMAAQSPVMKEVVSAAGKG
VAVVGICNGFQVLTEVGLLPGALLRNAGLKYVCKPVELDIVNGQTRFTAGYGEQRQAVMTVGNGEGNYFADEETLDRLEG
EGQVVFRYKENPNGSARDIAGIVNKGGNVLGLMPHPDRAFDADLGSEDGAVLFRSIFQSA

Sequences:

>Translated_220_residues
MKAAVIVFPGSNCDRDCKVAIERSAGARVEMVWHQETALPDDLDLIVLPGGFSYGDYLRCGAMAAQSPVMKEVVSAAGKG
VAVVGICNGFQVLTEVGLLPGALLRNAGLKYVCKPVELDIVNGQTRFTAGYGEQRQAVMTVGNGEGNYFADEETLDRLEG
EGQVVFRYKENPNGSARDIAGIVNKGGNVLGLMPHPDRAFDADLGSEDGAVLFRSIFQSA
>Mature_220_residues
MKAAVIVFPGSNCDRDCKVAIERSAGARVEMVWHQETALPDDLDLIVLPGGFSYGDYLRCGAMAAQSPVMKEVVSAAGKG
VAVVGICNGFQVLTEVGLLPGALLRNAGLKYVCKPVELDIVNGQTRFTAGYGEQRQAVMTVGNGEGNYFADEETLDRLEG
EGQVVFRYKENPNGSARDIAGIVNKGGNVLGLMPHPDRAFDADLGSEDGAVLFRSIFQSA

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=228, Percent_Identity=27.1929824561404, Blast_Score=64, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321498, Length=231, Percent_Identity=29.4372294372294, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24582111, Length=184, Percent_Identity=31.5217391304348, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24582109, Length=184, Percent_Identity=31.5217391304348, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137292, Length=184, Percent_Identity=31.5217391304348, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_CAUCR (Q9A5F3)

Other databases:

- EMBL:   AE005673
- PIR:   H87558
- RefSeq:   NP_421300.1
- ProteinModelPortal:   Q9A5F3
- SMR:   Q9A5F3
- GeneID:   944041
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_2497
- NMPDR:   fig|190650.1.peg.2480
- TIGR:   CC_2497
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- ProtClustDB:   PRK03619
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF07685 GATase_3

EC number: =6.3.5.3

Molecular weight: Translated: 23388; Mature: 23388

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 87-87 ACT_SITE 195-195

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVIVFPGSNCDRDCKVAIERSAGARVEMVWHQETALPDDLDLIVLPGGFSYGDYLRC
CCEEEEEECCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCHHHHH
GAMAAQSPVMKEVVSAAGKGVAVVGICNGFQVLTEVGLLPGALLRNAGLKYVCKPVELDI
HHHHHCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCHHHHHHCCCEEEECEEEEEE
VNGQTRFTAGYGEQRQAVMTVGNGEGNYFADEETLDRLEGEGQVVFRYKENPNGSARDIA
ECCCEEEEECCCCCCEEEEEEECCCCCEECCHHHHHHHCCCCEEEEEEECCCCCCHHHHH
GIVNKGGNVLGLMPHPDRAFDADLGSEDGAVLFRSIFQSA
HHHCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKAAVIVFPGSNCDRDCKVAIERSAGARVEMVWHQETALPDDLDLIVLPGGFSYGDYLRC
CCEEEEEECCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCHHHHH
GAMAAQSPVMKEVVSAAGKGVAVVGICNGFQVLTEVGLLPGALLRNAGLKYVCKPVELDI
HHHHHCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCHHHHHHCCCEEEECEEEEEE
VNGQTRFTAGYGEQRQAVMTVGNGEGNYFADEETLDRLEGEGQVVFRYKENPNGSARDIA
ECCCEEEEECCCCCCEEEEEEECCCCCEECCHHHHHHHCCCCEEEEEEECCCCCCHHHHH
GIVNKGGNVLGLMPHPDRAFDADLGSEDGAVLFRSIFQSA
HHHCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647