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The map label for this gene is pyrC [H]

Identifier: 16126683

GI number: 16126683

Start: 2648759

End: 2650060

Strand: Direct

Name: pyrC [H]

Synonym: CC_2444

Alternate gene names: 16126683

Gene position: 2648759-2650060 (Clockwise)

Preceding gene: 16126682

Following gene: 16126684

Centisome position: 65.94

GC content: 71.27

Gene sequence:

>1302_bases
ATGAACGCCCCCCAGCCCCTCGCCTTCGTCAACGCCCGTCTGGTCGACCCGGAGAGCGGCTATGACGGTCCCGGCGGTGT
CATCGTCTCCGAAGGCGTCATCACCGACGTCGCCAAGGGCCGCGAGTTCGGCAAGCTGTCCAAGGCTGTGCGGGTCGTCG
ACTGCGGCGGCGCCCTGCTGGCCCCCGGTCTGATCGACCTGCGCGTCCGCACCGGCGAGCCCGGGGCCGAGACCAAGGAA
ACCCTGGCCAGCGCCGCCAAGGCCGCCGCGGCCGGCGGCGTCACCTCGTTCGTCGTCCAGCCCGACACCGCGCCGGCGAT
CGACGATCCCAGCATGGTCGACTTCATCCTGCGCCGCGCCCGCGACGTCGACAGCGCCCGCATCCTGGTGGCCGGCGCGG
CGACCAAGGCCCTCCTGGGCGAGCAGATGGCCGAGATCGGCCTGATGCGCGAGGCCGGCTGCGTCTATGTCACCGACGCT
GGCAAACCCATCGTCGACAGCAAGGTCATGCAGCGCGTCCTGACCTACGCCAAGGGCTTCGACACCCTGCTGGCCCACCG
TCCGATGGACCCGTGGCTGGGCAAGGGCGGTGCGGCGATCGGCGGCGAGTTCGCCGGCCGCATGGGCCTGCCCTCGATCT
CGCCGATGGCCGAGCGCATCATGCTGGAGCGCGACGTCGCCCTCCTGGAAGCCACCGGCGGCCGACTGCTGGTCGACCAG
ATCAGCTCGGCTCAGGCGCTGGAAACCCTGGCCCGCGCCAAGGGCAAGGGCCTGCGGATCAACGCCTCGGTGTCGATCAA
CCATCTGTCGTTCAACGAGCTGGACATCGGCGACTACCGCACCTTCGCCAAGCTGAACCCGCCCCTGCGCGGCGAGGACG
ACCGCCAGGCCCTGATCGAGGCTCTGGCCTCGGGCCTGATCGACATCGTCGTCTCCTCGCACAGCCCGGCCCCGGCCGAG
GACAAGCGCCTGCCGTTCGACGAGGCCGCGCCCGGCGCGGTGGGCCTGGAAACCCTGCTGCCCGCCCTGCTGTCGCTGTA
CCACGAGGAGCGCCTGCCGCTGCTCGACCTGATCCGCGCCGTCACCCTGGCCCCGGCCCAGCTGCTGGGCCTGCGCGGCG
GCCGCCTCGCGCCCGGCGCGCCGGCCGATCTGGTGCTCTGCGACATCGACGCGCCGATCATCGTGGATGCGGCCCGCCTG
CTGTCAAAGTCCAAGAACTCGCCGTTCGACGGACGGCGGCTGCAGGGCCAGGTCTTGATGACCGTGGTCGATGGTCGGGT
GGTGCATCGGGCGGAGGGGTAA

Upstream 100 bases:

>100_bases
TCACACCTCAGGATGAGGTTTTCAGCAGCAACGTTCCTCATCCTGAGGCGCCCGCAAAGCGGGCCTCGAAGGACGCAGGG
CGCCTGCCCGAGATTGAACA

Downstream 100 bases:

>100_bases
ACTCGCAAATGCCGCACCTTTTGGCTGCTCAGCCTATCCCACCTCGTCGAGCAAAGCTGATCGTCGCGGTTTTCTGCGTT
CTGGGCCCGTTGATTGGCTA

Product: aspartate transcarbamoylase subunit PyrC'

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MNAPQPLAFVNARLVDPESGYDGPGGVIVSEGVITDVAKGREFGKLSKAVRVVDCGGALLAPGLIDLRVRTGEPGAETKE
TLASAAKAAAAGGVTSFVVQPDTAPAIDDPSMVDFILRRARDVDSARILVAGAATKALLGEQMAEIGLMREAGCVYVTDA
GKPIVDSKVMQRVLTYAKGFDTLLAHRPMDPWLGKGGAAIGGEFAGRMGLPSISPMAERIMLERDVALLEATGGRLLVDQ
ISSAQALETLARAKGKGLRINASVSINHLSFNELDIGDYRTFAKLNPPLRGEDDRQALIEALASGLIDIVVSSHSPAPAE
DKRLPFDEAAPGAVGLETLLPALLSLYHEERLPLLDLIRAVTLAPAQLLGLRGGRLAPGAPADLVLCDIDAPIIVDAARL
LSKSKNSPFDGRRLQGQVLMTVVDGRVVHRAEG

Sequences:

>Translated_433_residues
MNAPQPLAFVNARLVDPESGYDGPGGVIVSEGVITDVAKGREFGKLSKAVRVVDCGGALLAPGLIDLRVRTGEPGAETKE
TLASAAKAAAAGGVTSFVVQPDTAPAIDDPSMVDFILRRARDVDSARILVAGAATKALLGEQMAEIGLMREAGCVYVTDA
GKPIVDSKVMQRVLTYAKGFDTLLAHRPMDPWLGKGGAAIGGEFAGRMGLPSISPMAERIMLERDVALLEATGGRLLVDQ
ISSAQALETLARAKGKGLRINASVSINHLSFNELDIGDYRTFAKLNPPLRGEDDRQALIEALASGLIDIVVSSHSPAPAE
DKRLPFDEAAPGAVGLETLLPALLSLYHEERLPLLDLIRAVTLAPAQLLGLRGGRLAPGAPADLVLCDIDAPIIVDAARL
LSKSKNSPFDGRRLQGQVLMTVVDGRVVHRAEG
>Mature_433_residues
MNAPQPLAFVNARLVDPESGYDGPGGVIVSEGVITDVAKGREFGKLSKAVRVVDCGGALLAPGLIDLRVRTGEPGAETKE
TLASAAKAAAAGGVTSFVVQPDTAPAIDDPSMVDFILRRARDVDSARILVAGAATKALLGEQMAEIGLMREAGCVYVTDA
GKPIVDSKVMQRVLTYAKGFDTLLAHRPMDPWLGKGGAAIGGEFAGRMGLPSISPMAERIMLERDVALLEATGGRLLVDQ
ISSAQALETLARAKGKGLRINASVSINHLSFNELDIGDYRTFAKLNPPLRGEDDRQALIEALASGLIDIVVSSHSPAPAE
DKRLPFDEAAPGAVGLETLLPALLSLYHEERLPLLDLIRAVTLAPAQLLGLRGGRLAPGAPADLVLCDIDAPIIVDAARL
LSKSKNSPFDGRRLQGQVLMTVVDGRVVHRAEG

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=407, Percent_Identity=27.027027027027, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1786722, Length=423, Percent_Identity=24.3498817966903, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193204318, Length=416, Percent_Identity=24.0384615384615, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322218, Length=195, Percent_Identity=29.2307692307692, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24642586, Length=375, Percent_Identity=26.1333333333333, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI18859883, Length=209, Percent_Identity=28.2296650717703, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45439; Mature: 45439

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPQPLAFVNARLVDPESGYDGPGGVIVSEGVITDVAKGREFGKLSKAVRVVDCGGALL
CCCCCCCCEEEEEEECCCCCCCCCCCEEEECCHHHHHHCCCHHHHHHHHEEEEECCCHHH
APGLIDLRVRTGEPGAETKETLASAAKAAAAGGVTSFVVQPDTAPAIDDPSMVDFILRRA
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
RDVDSARILVAGAATKALLGEQMAEIGLMREAGCVYVTDAGKPIVDSKVMQRVLTYAKGF
CCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCH
DTLLAHRPMDPWLGKGGAAIGGEFAGRMGLPSISPMAERIMLERDVALLEATGGRLLVDQ
HHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHCHHEEECCCCEEEEHH
ISSAQALETLARAKGKGLRINASVSINHLSFNELDIGDYRTFAKLNPPLRGEDDRQALIE
HHHHHHHHHHHHHCCCCEEEEEEEEEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHH
ALASGLIDIVVSSHSPAPAEDKRLPFDEAAPGAVGLETLLPALLSLYHEERLPLLDLIRA
HHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
VTLAPAQLLGLRGGRLAPGAPADLVLCDIDAPIIVDAARLLSKSKNSPFDGRRLQGQVLM
HHHCHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEE
TVVDGRVVHRAEG
EEECCEEEECCCC
>Mature Secondary Structure
MNAPQPLAFVNARLVDPESGYDGPGGVIVSEGVITDVAKGREFGKLSKAVRVVDCGGALL
CCCCCCCCEEEEEEECCCCCCCCCCCEEEECCHHHHHHCCCHHHHHHHHEEEEECCCHHH
APGLIDLRVRTGEPGAETKETLASAAKAAAAGGVTSFVVQPDTAPAIDDPSMVDFILRRA
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
RDVDSARILVAGAATKALLGEQMAEIGLMREAGCVYVTDAGKPIVDSKVMQRVLTYAKGF
CCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCH
DTLLAHRPMDPWLGKGGAAIGGEFAGRMGLPSISPMAERIMLERDVALLEATGGRLLVDQ
HHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHCHHEEECCCCEEEEHH
ISSAQALETLARAKGKGLRINASVSINHLSFNELDIGDYRTFAKLNPPLRGEDDRQALIE
HHHHHHHHHHHHHCCCCEEEEEEEEEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHH
ALASGLIDIVVSSHSPAPAEDKRLPFDEAAPGAVGLETLLPALLSLYHEERLPLLDLIRA
HHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
VTLAPAQLLGLRGGRLAPGAPADLVLCDIDAPIIVDAARLLSKSKNSPFDGRRLQGQVLM
HHHCHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEE
TVVDGRVVHRAEG
EEECCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA