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The map label for this gene is mutB [H]

Identifier: 16126613

GI number: 16126613

Start: 2575086

End: 2577230

Strand: Direct

Name: mutB [H]

Synonym: CC_2374

Alternate gene names: 16126613

Gene position: 2575086-2577230 (Clockwise)

Preceding gene: 16126612

Following gene: 16126615

Centisome position: 64.11

GC content: 68.53

Gene sequence:

>2145_bases
ATGAGCACGTTCCCCGACTTCACCAAGATCGCCTTCGCCGAAGTCCCCGCCCCGGCCGCGCCGAAGGGCGAGGCCTGGAA
CACGCCCGAGGGGGTCGCCGTGGCGCCGGCCTTCGACGCGAGCGACGTCGCTGGCCTCGACTTCACCGGCGGCTTCCCGG
GCGTTGCGCCGTTCGTGCGCGGCCCCTATCCGACCATGTACGTGACCAACCCGTGGACGGTGCGTCAGTACGCGGGCTTC
TCGACGGCCGAAGACTCCAACGCCTTTTATCGCCGCAATCTGGCGGCCGGTCAGATGGGCCTGTCGGTGGCCTTCGACCT
GGCCACTCACCGCGGCTATGACAGCGACCACGAGCGGGTGAAGGGCGACGTCGGCATGGCGGGCGTGGCCATCGACTCGA
TCCTGGACATGCGCACCCTGTTCTCGGGCATCCCGCTCGACAAGATGAGCGTGTCGATGACCATGAACGGCGCGGTGCTG
CCGATCCTGGCGCTCTACATCGTCGCGGCCGAGGAACAGGGCGTCTCGCCCGACAAGCTCTCGGGGACGATCCAGAACGA
CATCCTCAAAGAGTTCATGGTGCGGAACACCTACATCTATCCGCCCGCGCCCTCGATGCGGATCATCTCGGACATCTTCG
CCTTCACCTCGGCGAATATGCCCAAGTTCAACTCGATCTCGATCAGCGGCTACCACATGCAGGAGGCCGGAGCGACGGCC
GACCTGGAGCTGGCCTACACCCTGGCCGACGGCGTCGAGTACGCCCGCGCCGGCGTTGCGGCGGGCATGAGCATCGACCA
GTTCGCGCCGCGCCTGTCGTTCTTCTGGGCGATAGGCATGAACTACTTCATGGAAGTGGCCAAGATGCGGGCCGCGCGCC
TGCTGTGGGCCCGCCTGATGAAGCGCGAGTTCGATCCCAAGGACGACCGCTCGCTCAGCCTTCGCACCCACAGCCAGACC
TCTGGCTGGTCGCTGGCGGCGCAGGACGTGTTCAACAACGTCGCCCGCACCTGCGTCGAGGCCATGGCCGCCGTGAACGG
CCAGACCCAGAGCCTGCACACCAACAGCCTGGACGAGGCCCTGGCCCTGCCGACCGACTTCTCGGCGCGGATCAGCCGCA
ACACCCAGCTCTTCCTGCAGATGGAAAGCGGCACGACCCGCGTCGCCGACCCGTGGGGCGGCAGCTACTATGTCGAGCGC
CTGACCTACGAGCTGGCCCAGAAGGCTCTGGCCCACATCGAGGAGGTCGAGGCGCTGGGCGGCATGGCCAAGGCCATAGA
GCAGGGCCTGCCCAAGCTGCGTATCGAGGAAGCCGCCGCCCGCACCCAGGCCCGCATCGACAGCGGCAAGCAGAGCGTCG
TGGGCGTCAACCGCTACAAGCCTGAGGTCGCCGACGACATCCCGGTGCTGAAGGTCGACAACGGCGCGGTCCGCGCCCAG
CAGTTGGAGAAGCTGGCCCGCCTGAAGGCCGAGCGCGATCCGGCCGCCACCGAAGCCGCCCTAACGGCGCTGGAGGACGG
CGCGCGGGGCGATGGCAACCTGCTGGCTCTGGCCGTCGACGCCGCCCGCGCCAAGGCCACCGTGGGCGAGATCAGCTACG
CCCTGGAGAAGGTGTTCGGCCGTCACCGCGCCGAGATCAAGTCGATCCAGGGGGTCTATATGAAGGAGGCCGGCAACGAT
CCCACCGCCGCGCGCGCCAAGGCCATGGTCGAGGCGTTCGAGCAGGCCGACGGCCGCCGCCCCCGCATCCTGATCGCCAA
GATGGGTCAGGATGGTCATGACCGCGGCCAGAAGGTCATCGCCACGGCCTTCGCCGACCTCGGCTTCGATGTCGACATCG
GCCCGCTGTTCCAGACCCCGGCCGAGGCCGCCCGCCAGGCGGTCGAGAACGACGTCCATGTGGTGGGCGCCAGCTCGCTG
GCCGCCGGCCACCTGACCCTGGCCCCGGAGCTGAAGGCCGAGTTGGCCAAGCAGGGCCGCGACGACATCCTGATGGTCGT
GGGCGGCGTGATCCCGCCCCAGGACTTCCAGGCCCTGCGCGACGCGGGCGCGGCGGCGATCTTCCCGCCGGGGACGGTCA
TCGCCGAGGCGGCCATCGAGCTGCTGGAGCAATTGAACCGGCAGCTGGGCTACACCCAGTCCTAG

Upstream 100 bases:

>100_bases
GCCGTCCAAGGTCCTGACGTCCGCCTGCCCGGACCCGACAGCCATTGCCCGGCCCTGACGCCCGTCCGCTTCGCCGCCGC
CTTCGAGGGAGCCTGAGCTC

Downstream 100 bases:

>100_bases
GCGGCCTTCCGACGAAACAGCCCGCGCTTCTTCTGGGAGCGCTCGGCCGCGATCTCGTCGGGCAGGCCGTGGCGGGCCTC
GATGTCCTTCTGTAGCGCCT

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 714; Mature: 713

Protein sequence:

>714_residues
MSTFPDFTKIAFAEVPAPAAPKGEAWNTPEGVAVAPAFDASDVAGLDFTGGFPGVAPFVRGPYPTMYVTNPWTVRQYAGF
STAEDSNAFYRRNLAAGQMGLSVAFDLATHRGYDSDHERVKGDVGMAGVAIDSILDMRTLFSGIPLDKMSVSMTMNGAVL
PILALYIVAAEEQGVSPDKLSGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFAFTSANMPKFNSISISGYHMQEAGATA
DLELAYTLADGVEYARAGVAAGMSIDQFAPRLSFFWAIGMNYFMEVAKMRAARLLWARLMKREFDPKDDRSLSLRTHSQT
SGWSLAAQDVFNNVARTCVEAMAAVNGQTQSLHTNSLDEALALPTDFSARISRNTQLFLQMESGTTRVADPWGGSYYVER
LTYELAQKALAHIEEVEALGGMAKAIEQGLPKLRIEEAAARTQARIDSGKQSVVGVNRYKPEVADDIPVLKVDNGAVRAQ
QLEKLARLKAERDPAATEAALTALEDGARGDGNLLALAVDAARAKATVGEISYALEKVFGRHRAEIKSIQGVYMKEAGND
PTAARAKAMVEAFEQADGRRPRILIAKMGQDGHDRGQKVIATAFADLGFDVDIGPLFQTPAEAARQAVENDVHVVGASSL
AAGHLTLAPELKAELAKQGRDDILMVVGGVIPPQDFQALRDAGAAAIFPPGTVIAEAAIELLEQLNRQLGYTQS

Sequences:

>Translated_714_residues
MSTFPDFTKIAFAEVPAPAAPKGEAWNTPEGVAVAPAFDASDVAGLDFTGGFPGVAPFVRGPYPTMYVTNPWTVRQYAGF
STAEDSNAFYRRNLAAGQMGLSVAFDLATHRGYDSDHERVKGDVGMAGVAIDSILDMRTLFSGIPLDKMSVSMTMNGAVL
PILALYIVAAEEQGVSPDKLSGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFAFTSANMPKFNSISISGYHMQEAGATA
DLELAYTLADGVEYARAGVAAGMSIDQFAPRLSFFWAIGMNYFMEVAKMRAARLLWARLMKREFDPKDDRSLSLRTHSQT
SGWSLAAQDVFNNVARTCVEAMAAVNGQTQSLHTNSLDEALALPTDFSARISRNTQLFLQMESGTTRVADPWGGSYYVER
LTYELAQKALAHIEEVEALGGMAKAIEQGLPKLRIEEAAARTQARIDSGKQSVVGVNRYKPEVADDIPVLKVDNGAVRAQ
QLEKLARLKAERDPAATEAALTALEDGARGDGNLLALAVDAARAKATVGEISYALEKVFGRHRAEIKSIQGVYMKEAGND
PTAARAKAMVEAFEQADGRRPRILIAKMGQDGHDRGQKVIATAFADLGFDVDIGPLFQTPAEAARQAVENDVHVVGASSL
AAGHLTLAPELKAELAKQGRDDILMVVGGVIPPQDFQALRDAGAAAIFPPGTVIAEAAIELLEQLNRQLGYTQS
>Mature_713_residues
STFPDFTKIAFAEVPAPAAPKGEAWNTPEGVAVAPAFDASDVAGLDFTGGFPGVAPFVRGPYPTMYVTNPWTVRQYAGFS
TAEDSNAFYRRNLAAGQMGLSVAFDLATHRGYDSDHERVKGDVGMAGVAIDSILDMRTLFSGIPLDKMSVSMTMNGAVLP
ILALYIVAAEEQGVSPDKLSGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFAFTSANMPKFNSISISGYHMQEAGATAD
LELAYTLADGVEYARAGVAAGMSIDQFAPRLSFFWAIGMNYFMEVAKMRAARLLWARLMKREFDPKDDRSLSLRTHSQTS
GWSLAAQDVFNNVARTCVEAMAAVNGQTQSLHTNSLDEALALPTDFSARISRNTQLFLQMESGTTRVADPWGGSYYVERL
TYELAQKALAHIEEVEALGGMAKAIEQGLPKLRIEEAAARTQARIDSGKQSVVGVNRYKPEVADDIPVLKVDNGAVRAQQ
LEKLARLKAERDPAATEAALTALEDGARGDGNLLALAVDAARAKATVGEISYALEKVFGRHRAEIKSIQGVYMKEAGNDP
TAARAKAMVEAFEQADGRRPRILIAKMGQDGHDRGQKVIATAFADLGFDVDIGPLFQTPAEAARQAVENDVHVVGASSLA
AGHLTLAPELKAELAKQGRDDILMVVGGVIPPQDFQALRDAGAAAIFPPGTVIAEAAIELLEQLNRQLGYTQS

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=694, Percent_Identity=63.1123919308357, Blast_Score=920, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=685, Percent_Identity=61.1678832116788, Blast_Score=828, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=685, Percent_Identity=64.5255474452555, Blast_Score=923, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 76838; Mature: 76707

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFPDFTKIAFAEVPAPAAPKGEAWNTPEGVAVAPAFDASDVAGLDFTGGFPGVAPFVR
CCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHC
GPYPTMYVTNPWTVRQYAGFSTAEDSNAFYRRNLAAGQMGLSVAFDLATHRGYDSDHERV
CCCCEEEEECCEEEHHHCCCCCCCCCCHHHHHCCCCCCCCHHHHEEHHHHCCCCCHHHHH
KGDVGMAGVAIDSILDMRTLFSGIPLDKMSVSMTMNGAVLPILALYIVAAEEQGVSPDKL
CCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCHHHH
SGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFAFTSANMPKFNSISISGYHMQEAGATA
CCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEECEEECCCCCCC
DLELAYTLADGVEYARAGVAAGMSIDQFAPRLSFFWAIGMNYFMEVAKMRAARLLWARLM
CEEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KREFDPKDDRSLSLRTHSQTSGWSLAAQDVFNNVARTCVEAMAAVNGQTQSLHTNSLDEA
HHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
LALPTDFSARISRNTQLFLQMESGTTRVADPWGGSYYVERLTYELAQKALAHIEEVEALG
HCCCCCCHHHHCCCEEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GMAKAIEQGLPKLRIEEAAARTQARIDSGKQSVVGVNRYKPEVADDIPVLKVDNGAVRAQ
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHCCCCEEEECCCHHHHH
QLEKLARLKAERDPAATEAALTALEDGARGDGNLLALAVDAARAKATVGEISYALEKVFG
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHH
RHRAEIKSIQGVYMKEAGNDPTAARAKAMVEAFEQADGRRPRILIAKMGQDGHDRGQKVI
HHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHH
ATAFADLGFDVDIGPLFQTPAEAARQAVENDVHVVGASSLAAGHLTLAPELKAELAKQGR
HHHHHHCCCCCCCCCHHCCHHHHHHHHHCCCEEEEECCCCCCCCEEECHHHHHHHHHCCC
DDILMVVGGVIPPQDFQALRDAGAAAIFPPGTVIAEAAIELLEQLNRQLGYTQS
CCEEEEECCCCCCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
STFPDFTKIAFAEVPAPAAPKGEAWNTPEGVAVAPAFDASDVAGLDFTGGFPGVAPFVR
CCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHC
GPYPTMYVTNPWTVRQYAGFSTAEDSNAFYRRNLAAGQMGLSVAFDLATHRGYDSDHERV
CCCCEEEEECCEEEHHHCCCCCCCCCCHHHHHCCCCCCCCHHHHEEHHHHCCCCCHHHHH
KGDVGMAGVAIDSILDMRTLFSGIPLDKMSVSMTMNGAVLPILALYIVAAEEQGVSPDKL
CCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCHHHH
SGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFAFTSANMPKFNSISISGYHMQEAGATA
CCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEECEEECCCCCCC
DLELAYTLADGVEYARAGVAAGMSIDQFAPRLSFFWAIGMNYFMEVAKMRAARLLWARLM
CEEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KREFDPKDDRSLSLRTHSQTSGWSLAAQDVFNNVARTCVEAMAAVNGQTQSLHTNSLDEA
HHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
LALPTDFSARISRNTQLFLQMESGTTRVADPWGGSYYVERLTYELAQKALAHIEEVEALG
HCCCCCCHHHHCCCEEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GMAKAIEQGLPKLRIEEAAARTQARIDSGKQSVVGVNRYKPEVADDIPVLKVDNGAVRAQ
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHCCCCEEEECCCHHHHH
QLEKLARLKAERDPAATEAALTALEDGARGDGNLLALAVDAARAKATVGEISYALEKVFG
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHH
RHRAEIKSIQGVYMKEAGNDPTAARAKAMVEAFEQADGRRPRILIAKMGQDGHDRGQKVI
HHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHH
ATAFADLGFDVDIGPLFQTPAEAARQAVENDVHVVGASSLAAGHLTLAPELKAELAKQGR
HHHHHHCCCCCCCCCHHCCHHHHHHHHHCCCEEEEECCCCCCCCEEECHHHHHHHHHCCC
DDILMVVGGVIPPQDFQALRDAGAAAIFPPGTVIAEAAIELLEQLNRQLGYTQS
CCEEEEECCCCCCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]