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The map label for this gene is mutA [H]

Identifier: 16126612

GI number: 16126612

Start: 2573630

End: 2575081

Strand: Direct

Name: mutA [H]

Synonym: CC_2373

Alternate gene names: 16126612

Gene position: 2573630-2575081 (Clockwise)

Preceding gene: 16126606

Following gene: 16126613

Centisome position: 64.07

GC content: 71.9

Gene sequence:

>1452_bases
ATGACGCCCCTGGCCGAGGACTTCGGCGCCCAAGGCGACGCGGCGACCCGCGCGCGCTGGATGGCCCTGGTCGAGAAGAC
CCTGAAGGGTCAAAGCTTCGACGACGCGCTCACCATCACAACGGCGGACGGCCTGACGATCCAGCCGCTCTATACGGCCG
AGGATGGCGTCGCCGTGGCGCGCGACCTGCGCGCCCGGGACACCGACCGCCCCTGGGACCTGCGGATGCGCGCGGCCCAT
CCCGATCCGATACGGGCGGCCAAGGACGTTCTGACCGATCTGGAAGGCGGGGCGGCGTCGGTGCTGCTGCAGATCGATCC
GACCGGCGTGAACGGCGTCGCCATCGGCTCCGCTGACGATCTCGGCAAGGCCTTGTCGGGCGTGTTGCTGGACCTGGCGC
CCGTCGCGCTCGATGCGGGCTTCCTGGGCCCCAAGGCCGCCGACTGGCTGGGCGCGCTGGCCAAGGCCGCGCCGAACGCC
CCCCTCGCCTTTCATCTCGATCCGCTGACCGCCTTCGCCCAGACCGGCGTTAGCCCCGGCCCCATCGAGAGCCATGTCTT
CAACGCCGCGACGGTGGCCACGCGGCTCTCGGCCACCTACGCCAGGGCCAGCCTGTTCCTGGCCACGGGCCGTACGGCGC
ATGAGGCGGGCGGCTCCAATGTCGAGGAACTGGCCCTGATGACGGCCGCCGCCCTGGCCTACGCCAAGGCTCTGGTCCGC
TCTGGCCTGACGATCGAGGAGGCGTTCGGCCGCATTGCTTTGGGCGTCAGCCTGGACGGCGAGTACTTCACCGGCGTCGC
CAAGGTGCGCGCCGCCAAGGCCCTCTGGGCGCGGCTCACAGAATCCTGCGGCGTCACTGTCGCCCCGACCATCGAGGCCC
GCTCCTCGCGGCGCATGCTGGCCAAGGCCGACGCCTGGACGAACCTCTTGCGCCTGACCTCGGCCGGGTTCGCCGGCGCG
GTCGGGGGCGCGGACGCCATCGTGCTGGACGCCTTCACCGACGCCATCGGCCTGCCGACCGCCTTCGCCCGCCGCCAGGC
GCGCAACACCCAGCTCGTTCTGATGGAAGAAAGCCACCTGGGCCGTGTCGCCGATCCGGCCGGCGGGGCCTGGTACCTCG
ACAGCCTGACCGACCAGCTGGCCCGCGCCGCCTGGGCGTCGTTCCAGGCCATCGAAGCCGCCGGCGGCGTCATCAAGGCC
CTGGAGAGCGGCCTCGTCGCTGACGCCGTCGCCAAGAGCCGCACGGCCCAAGAGGCCGCCTACGCCGACAAGAGCCGCAA
GATCCTCGGCGTCACCGTCTTCCCCAACGCCGACGACAAGCCGCCGGAGGTCGAGACGCCCGACTCGTCCGCCTTCGCCG
TCCAAGGTCCTGACGTCCGCCTGCCCGGACCCGACAGCCATTGCCCGGCCCTGACGCCCGTCCGCTTCGCCGCCGCCTTC
GAGGGAGCCTGA

Upstream 100 bases:

>100_bases
AGCCCAGACGCAAGGCTTGACGGCCGTAGCGGCAGGGGCGCATCACGATCAAAAATACAAGAATGCTGCACTGCAGGAGA
GAGACGCTTTGACCGAGGCG

Downstream 100 bases:

>100_bases
GCTCATGAGCACGTTCCCCGACTTCACCAAGATCGCCTTCGCCGAAGTCCCCGCCCCGGCCGCGCCGAAGGGCGAGGCCT
GGAACACGCCCGAGGGGGTC

Product: methylmalonyl-CoA mutase subunit beta

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MTPLAEDFGAQGDAATRARWMALVEKTLKGQSFDDALTITTADGLTIQPLYTAEDGVAVARDLRARDTDRPWDLRMRAAH
PDPIRAAKDVLTDLEGGAASVLLQIDPTGVNGVAIGSADDLGKALSGVLLDLAPVALDAGFLGPKAADWLGALAKAAPNA
PLAFHLDPLTAFAQTGVSPGPIESHVFNAATVATRLSATYARASLFLATGRTAHEAGGSNVEELALMTAAALAYAKALVR
SGLTIEEAFGRIALGVSLDGEYFTGVAKVRAAKALWARLTESCGVTVAPTIEARSSRRMLAKADAWTNLLRLTSAGFAGA
VGGADAIVLDAFTDAIGLPTAFARRQARNTQLVLMEESHLGRVADPAGGAWYLDSLTDQLARAAWASFQAIEAAGGVIKA
LESGLVADAVAKSRTAQEAAYADKSRKILGVTVFPNADDKPPEVETPDSSAFAVQGPDVRLPGPDSHCPALTPVRFAAAF
EGA

Sequences:

>Translated_483_residues
MTPLAEDFGAQGDAATRARWMALVEKTLKGQSFDDALTITTADGLTIQPLYTAEDGVAVARDLRARDTDRPWDLRMRAAH
PDPIRAAKDVLTDLEGGAASVLLQIDPTGVNGVAIGSADDLGKALSGVLLDLAPVALDAGFLGPKAADWLGALAKAAPNA
PLAFHLDPLTAFAQTGVSPGPIESHVFNAATVATRLSATYARASLFLATGRTAHEAGGSNVEELALMTAAALAYAKALVR
SGLTIEEAFGRIALGVSLDGEYFTGVAKVRAAKALWARLTESCGVTVAPTIEARSSRRMLAKADAWTNLLRLTSAGFAGA
VGGADAIVLDAFTDAIGLPTAFARRQARNTQLVLMEESHLGRVADPAGGAWYLDSLTDQLARAAWASFQAIEAAGGVIKA
LESGLVADAVAKSRTAQEAAYADKSRKILGVTVFPNADDKPPEVETPDSSAFAVQGPDVRLPGPDSHCPALTPVRFAAAF
EGA
>Mature_482_residues
TPLAEDFGAQGDAATRARWMALVEKTLKGQSFDDALTITTADGLTIQPLYTAEDGVAVARDLRARDTDRPWDLRMRAAHP
DPIRAAKDVLTDLEGGAASVLLQIDPTGVNGVAIGSADDLGKALSGVLLDLAPVALDAGFLGPKAADWLGALAKAAPNAP
LAFHLDPLTAFAQTGVSPGPIESHVFNAATVATRLSATYARASLFLATGRTAHEAGGSNVEELALMTAAALAYAKALVRS
GLTIEEAFGRIALGVSLDGEYFTGVAKVRAAKALWARLTESCGVTVAPTIEARSSRRMLAKADAWTNLLRLTSAGFAGAV
GGADAIVLDAFTDAIGLPTAFARRQARNTQLVLMEESHLGRVADPAGGAWYLDSLTDQLARAAWASFQAIEAAGGVIKAL
ESGLVADAVAKSRTAQEAAYADKSRKILGVTVFPNADDKPPEVETPDSSAFAVQGPDVRLPGPDSHCPALTPVRFAAAFE
GA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=475, Percent_Identity=25.2631578947368, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1789284, Length=454, Percent_Identity=27.3127753303965, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25144500, Length=511, Percent_Identity=25.2446183953033, Blast_Score=152, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 50033; Mature: 49902

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLAEDFGAQGDAATRARWMALVEKTLKGQSFDDALTITTADGLTIQPLYTAEDGVAVA
CCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCHHHH
RDLRARDTDRPWDLRMRAAHPDPIRAAKDVLTDLEGGAASVLLQIDPTGVNGVAIGSADD
HHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEECCHHH
LGKALSGVLLDLAPVALDAGFLGPKAADWLGALAKAAPNAPLAFHLDPLTAFAQTGVSPG
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHCCCCCC
PIESHVFNAATVATRLSATYARASLFLATGRTAHEAGGSNVEELALMTAAALAYAKALVR
CCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHH
SGLTIEEAFGRIALGVSLDGEYFTGVAKVRAAKALWARLTESCGVTVAPTIEARSSRRML
CCCCHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHH
AKADAWTNLLRLTSAGFAGAVGGADAIVLDAFTDAIGLPTAFARRQARNTQLVLMEESHL
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHCCCHHHHHHHCCCCEEEEEECCCC
GRVADPAGGAWYLDSLTDQLARAAWASFQAIEAAGGVIKALESGLVADAVAKSRTAQEAA
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
YADKSRKILGVTVFPNADDKPPEVETPDSSAFAVQGPDVRLPGPDSHCPALTPVRFAAAF
HHCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCEECCCCCCCCCCCCHHHHHHHC
EGA
CCC
>Mature Secondary Structure 
TPLAEDFGAQGDAATRARWMALVEKTLKGQSFDDALTITTADGLTIQPLYTAEDGVAVA
CCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCHHHH
RDLRARDTDRPWDLRMRAAHPDPIRAAKDVLTDLEGGAASVLLQIDPTGVNGVAIGSADD
HHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEECCHHH
LGKALSGVLLDLAPVALDAGFLGPKAADWLGALAKAAPNAPLAFHLDPLTAFAQTGVSPG
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHCCCCCC
PIESHVFNAATVATRLSATYARASLFLATGRTAHEAGGSNVEELALMTAAALAYAKALVR
CCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHH
SGLTIEEAFGRIALGVSLDGEYFTGVAKVRAAKALWARLTESCGVTVAPTIEARSSRRML
CCCCHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHH
AKADAWTNLLRLTSAGFAGAVGGADAIVLDAFTDAIGLPTAFARRQARNTQLVLMEESHL
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHCCCHHHHHHHCCCCEEEEEECCCC
GRVADPAGGAWYLDSLTDQLARAAWASFQAIEAAGGVIKALESGLVADAVAKSRTAQEAA
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
YADKSRKILGVTVFPNADDKPPEVETPDSSAFAVQGPDVRLPGPDSHCPALTPVRFAAAF
HHCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCEECCCCCCCCCCCCHHHHHHHC
EGA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]