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The map label for this gene is argH

Identifier: 16126450

GI number: 16126450

Start: 2415259

End: 2416587

Strand: Direct

Name: argH

Synonym: CC_2211

Alternate gene names: 16126450

Gene position: 2415259-2416587 (Clockwise)

Preceding gene: 16126444

Following gene: 16126451

Centisome position: 60.13

GC content: 67.49

Gene sequence:

>1329_bases
ATGCAGGCGATCAACGTCTCCATCGGCTTCGACAAGCGCCTGTGGGCGCAAGACCTGGCAGGCTCCCGCGCCCACGCGCG
GATGTTGATGAACCAAGGCGTGATTGCAAGCCATGACGGCGAGGAAATCCTGGAGGGTCTCGCCCGCGTCGAGGACGAGC
TGCTGTCGGGGACCTTCCCGTTCCGCGACGAATACGAAGACATCCACATGAACATCGAAGCGCGGCTGCGCGAGCTGATC
GGCCCGACGGCCGGCCGGCTGCACACCGCCCGCTCGCGCAACGATCAGGTGGCTGTCGACTTCCGCCTGTGGGTCCGCGA
CGCCTGCGACCGCACGGTCGGCCAGCTCGAGGCGCTTCAGAAGGCGCTGCTGACCCAGGCCGAAGCGCACGCCGAGTCGC
TGATGCCGGGCTTCACGCACCTGCAACCGGCCCAGCCGGTGACCTTCGGCCACCACCTGATGGCCTATGTCGAGATGTTC
GGCCGCGACGCCGGCCGCTTCCGCGACGCCCGCGCGCGGATGAACGAATGCCCGCTGGGCGCTGCGGCCCTGGCCGGCTC
GCCCTTCCCGATCGACCGCCAGCAGACGGCGAGCGCGCTGGGCTTTGATCGGCCGACCGCCAACTCTCTCGATAGCGTCT
CGTCGCGCGACTTCGCGCTGGAGGCCCTGTCGGCCGCCTCGATCACCGCCACGCACCTGTCGCGGCTGGCCGAAGAGATC
GTCCTTTGGACGACGCCGATGTTCGGCTTCATCAAGCTGACCGACGCCTTCACCACCGGCAGCTCGATCATGCCGCAGAA
GAAGAACCCCGACGCGGCCGAGCTGATCCGCGCCAAGGTCGGCCGCATCCTGGGCTCGCTGACCACCCTGACGGTGGTCA
TGAAGGGCCTGCCGCTGGCCTATTCAAAGGACATGCAGGAGGACAAGGTCCCGACCTTCGAAGCCTTCGACGCCCTGGAA
CTGAGCCTGCTGGCCATGGCCGGCATGATCGCCGACCTGACGCCCAACACAGAAAACATGGCCAAGGCGGCCGGCGCGGG
CTTCTCCACCGCCACCGATCTGGCCGATTGGCTGGTGCGGACGTTGAACATGCCTTTCCGTGACGCTCACCACGTGACAG
GCTCCGCCGTGAAGACGGCCGAAGGCTTGGGCGTCGATCTGGCGGATCTTTCCCTGGCGCAGTTCCAGGCGATCGAGCCG
CAGATCACGAAAGAGGTCTACGCCGTCCTGACTCCGGCCGCCTCGGCGGCCAGCCGCATGAGCTACGGCGGGACGGCCCC
CGCCCAGGTGCGCGCCCAGATCGCGCGTTGGAAGGAATTGCTGGCATGA

Upstream 100 bases:

>100_bases
CTTCGTTCATATGACCGACAACGCCTCCAACACGCCCAAGGCCAAGGGCCAGGGCCAAGCTATGTGGGGCGGCCGGTTCT
CGGCCAAGCCGGCGGAACTG

Downstream 100 bases:

>100_bases
ACCGTCCCGTGACGATCCTCGCCCTGGCCGCTCTGGCCGTCTCGGTCGCCGCCTGCGGCAAGCAAGGGACGCTAGAGCGC
CCCGCCCCGCTGTGGGACGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MQAINVSIGFDKRLWAQDLAGSRAHARMLMNQGVIASHDGEEILEGLARVEDELLSGTFPFRDEYEDIHMNIEARLRELI
GPTAGRLHTARSRNDQVAVDFRLWVRDACDRTVGQLEALQKALLTQAEAHAESLMPGFTHLQPAQPVTFGHHLMAYVEMF
GRDAGRFRDARARMNECPLGAAALAGSPFPIDRQQTASALGFDRPTANSLDSVSSRDFALEALSAASITATHLSRLAEEI
VLWTTPMFGFIKLTDAFTTGSSIMPQKKNPDAAELIRAKVGRILGSLTTLTVVMKGLPLAYSKDMQEDKVPTFEAFDALE
LSLLAMAGMIADLTPNTENMAKAAGAGFSTATDLADWLVRTLNMPFRDAHHVTGSAVKTAEGLGVDLADLSLAQFQAIEP
QITKEVYAVLTPAASAASRMSYGGTAPAQVRAQIARWKELLA

Sequences:

>Translated_442_residues
MQAINVSIGFDKRLWAQDLAGSRAHARMLMNQGVIASHDGEEILEGLARVEDELLSGTFPFRDEYEDIHMNIEARLRELI
GPTAGRLHTARSRNDQVAVDFRLWVRDACDRTVGQLEALQKALLTQAEAHAESLMPGFTHLQPAQPVTFGHHLMAYVEMF
GRDAGRFRDARARMNECPLGAAALAGSPFPIDRQQTASALGFDRPTANSLDSVSSRDFALEALSAASITATHLSRLAEEI
VLWTTPMFGFIKLTDAFTTGSSIMPQKKNPDAAELIRAKVGRILGSLTTLTVVMKGLPLAYSKDMQEDKVPTFEAFDALE
LSLLAMAGMIADLTPNTENMAKAAGAGFSTATDLADWLVRTLNMPFRDAHHVTGSAVKTAEGLGVDLADLSLAQFQAIEP
QITKEVYAVLTPAASAASRMSYGGTAPAQVRAQIARWKELLA
>Mature_442_residues
MQAINVSIGFDKRLWAQDLAGSRAHARMLMNQGVIASHDGEEILEGLARVEDELLSGTFPFRDEYEDIHMNIEARLRELI
GPTAGRLHTARSRNDQVAVDFRLWVRDACDRTVGQLEALQKALLTQAEAHAESLMPGFTHLQPAQPVTFGHHLMAYVEMF
GRDAGRFRDARARMNECPLGAAALAGSPFPIDRQQTASALGFDRPTANSLDSVSSRDFALEALSAASITATHLSRLAEEI
VLWTTPMFGFIKLTDAFTTGSSIMPQKKNPDAAELIRAKVGRILGSLTTLTVVMKGLPLAYSKDMQEDKVPTFEAFDALE
LSLLAMAGMIADLTPNTENMAKAAGAGFSTATDLADWLVRTLNMPFRDAHHVTGSAVKTAEGLGVDLADLSLAQFQAIEP
QITKEVYAVLTPAASAASRMSYGGTAPAQVRAQIARWKELLA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=441, Percent_Identity=44.4444444444444, Blast_Score=377, Evalue=1e-105,
Organism=Homo sapiens, GI68303542, Length=441, Percent_Identity=44.4444444444444, Blast_Score=377, Evalue=1e-105,
Organism=Homo sapiens, GI68303547, Length=441, Percent_Identity=42.4036281179138, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI68303549, Length=441, Percent_Identity=42.4036281179138, Blast_Score=345, Evalue=5e-95,
Organism=Escherichia coli, GI1790398, Length=437, Percent_Identity=44.8512585812357, Blast_Score=361, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6321806, Length=444, Percent_Identity=42.1171171171171, Blast_Score=347, Evalue=2e-96,
Organism=Drosophila melanogaster, GI221473854, Length=439, Percent_Identity=39.8633257403189, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI78706858, Length=439, Percent_Identity=39.8633257403189, Blast_Score=323, Evalue=1e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_CAUCR (Q9A683)

Other databases:

- EMBL:   AE005673
- PIR:   B87523
- RefSeq:   NP_421014.1
- ProteinModelPortal:   Q9A683
- SMR:   Q9A683
- GeneID:   943132
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_2211
- NMPDR:   fig|190650.1.peg.2194
- TIGR:   CC_2211
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- BRENDA:   4.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 47936; Mature: 47936

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAINVSIGFDKRLWAQDLAGSRAHARMLMNQGVIASHDGEEILEGLARVEDELLSGTFP
CCEEEEEECCCHHHHHHHHCCCHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHCCCCC
FRDEYEDIHMNIEARLRELIGPTAGRLHTARSRNDQVAVDFRLWVRDACDRTVGQLEALQ
CCCCCHHHHCCHHHHHHHHHCCCCHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
KALLTQAEAHAESLMPGFTHLQPAQPVTFGHHLMAYVEMFGRDAGRFRDARARMNECPLG
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
AAALAGSPFPIDRQQTASALGFDRPTANSLDSVSSRDFALEALSAASITATHLSRLAEEI
HHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLWTTPMFGFIKLTDAFTTGSSIMPQKKNPDAAELIRAKVGRILGSLTTLTVVMKGLPLA
HHHCCCCHHHEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
YSKDMQEDKVPTFEAFDALELSLLAMAGMIADLTPNTENMAKAAGAGFSTATDLADWLVR
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHH
TLNMPFRDAHHVTGSAVKTAEGLGVDLADLSLAQFQAIEPQITKEVYAVLTPAASAASRM
HHCCCCCHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHH
SYGGTAPAQVRAQIARWKELLA
CCCCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MQAINVSIGFDKRLWAQDLAGSRAHARMLMNQGVIASHDGEEILEGLARVEDELLSGTFP
CCEEEEEECCCHHHHHHHHCCCHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHCCCCC
FRDEYEDIHMNIEARLRELIGPTAGRLHTARSRNDQVAVDFRLWVRDACDRTVGQLEALQ
CCCCCHHHHCCHHHHHHHHHCCCCHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
KALLTQAEAHAESLMPGFTHLQPAQPVTFGHHLMAYVEMFGRDAGRFRDARARMNECPLG
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
AAALAGSPFPIDRQQTASALGFDRPTANSLDSVSSRDFALEALSAASITATHLSRLAEEI
HHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLWTTPMFGFIKLTDAFTTGSSIMPQKKNPDAAELIRAKVGRILGSLTTLTVVMKGLPLA
HHHCCCCHHHEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
YSKDMQEDKVPTFEAFDALELSLLAMAGMIADLTPNTENMAKAAGAGFSTATDLADWLVR
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHH
TLNMPFRDAHHVTGSAVKTAEGLGVDLADLSLAQFQAIEPQITKEVYAVLTPAASAASRM
HHCCCCCHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHH
SYGGTAPAQVRAQIARWKELLA
CCCCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647