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The map label for this gene is trpE [H]

Identifier: 16126138

GI number: 16126138

Start: 2091405

End: 2092946

Strand: Direct

Name: trpE [H]

Synonym: CC_1895

Alternate gene names: 16126138

Gene position: 2091405-2092946 (Clockwise)

Preceding gene: 16126137

Following gene: 16126140

Centisome position: 52.06

GC content: 68.68

Gene sequence:

>1542_bases
ATGAGTTTGGAGCCCGCGTTCGACGCCTTCTCGGAAGCCTATGACTCCGGGCGGCAGCAAGTCGTTTGGACCCGCCTGAT
CGACGATCTGGAGACGCCGGTTTCGGCCTATCTGAAGATCGCCCAGGCGCGGCCCTACAGCTTCCTGTTCGAAAGCGTCG
AGGGCGGAGCGTGGCGCGGTCGTTATTCGATCGTCACGATGAATCCGGATCTCGTCTGGCGCTGTCGCGGCGACCAGGCC
GAGATCGCCGAGGGCGACGACATCGCCGCCGGCCGGTTTACGCCGCAGCCCGGCGGCGCGCTGGACAGTCTGCGCGATCT
GGTGGCGCGCTCGCGCATGGACCTGCCCAAGGGCTTACCGCCGATGGCCGCCGGCGTGTTCGGCGCCTTGGGCTACGACC
TGGTGCGCCTGGTCGAGCGCCTTCCGGACGTCAATCCGGACGCCTTGAACCTGCCTGACGGCATCATGACCCGCCCGTCG
ATCGTGGCGGTGTTCGACGCCATCGCGCAGGAGATCATCCTGACGACGACCGTACGCCCCCAGGCCGGCGTATCGGCCAA
GGCGGCCCACGACGCCGCCCGCGCGCGGATCGAGGCGGTGATGGCCGACCTGCACCGTCCGCTCGCCCACGACGCGCCCC
GCCCGCCGCGCGGGCCGATGGACTTCACCACCCCGGTCAGCCGCGCGGACTACGCAGAGGTCGTGGCCAAGGCCAAGGAC
TACATCGCCGCCGGCGACATCTTCCAGGTGGTGGCCAGCCACCGCTTCCGCGCGCCCTTCGACCTCCCGCCGTTCGCCCT
CTATCGGTCGCTGCGCCGAACCAATCCCTCGCCCTTCCTGTTCTTCCTGAACCTGGACGGCTTCAATCTGGTCGGCTCCA
GCCCCGAGATTCTGGTTCGCCTGCGCGACGGCAAGATCACCATCCGGCCGATCGCCGGCACCCGTCCGCGCGGCGCGACG
CCCGAGGAAGACGCCGCGCTGGAAGCCGAGCTGCTGGCCGATCCCAAGGAGCGCGCCGAGCATCTGATGCTGCTGGATCT
GGGCCGCAATGACGTCGGCCGCGTGGCGATGCTGAACCATCACGGCCGCAACGCACCGCCGGAACAGGCCCGCCCGAAGG
GCCCGAACGTGCGCGTGACCGAGAGCTTCACGATCGAGCGCTACAGCCACGTGATGCACATCGTCTCGAACGTCGAAGGA
ACCGCGCCTGAAGGCGTTGATCCCGTCGACGTCCTGATGGCCGCCCTGCCCGCCGGCACGCTGTCGGGCGCGCCCAAGGT
TCGCGCCATGGAGATCATCGACGAGCTCGAGGTCGAGAAGCGCGGCATTAGCTATGCTGGCGCGGTCGGCTATTTCGGCG
CCGACGGCGCAGTCGACACCTGCATCGTGCTGCGGACCGCTCTGGTGAAGGACGGCATGATGTACGTCCAGGCCGGCGGC
GGCATCGTCGCCGACAGCGATCCGGACGCCGAGTACGACGAGACCCTGCACAAGTCCCGCGCTCTGAAGCGCGCGGCCGA
AGAGGCCTGGCGATTCAGCTGA

Upstream 100 bases:

>100_bases
AGGCCAAGAGCAACCTGACCCTGGCCCGCCAAGCCATCGGCGTCGACACCGACGCCCTGGCCAAGGCCGAGGCCGCCAAG
GCTGGAAAGAAAGCCGAGTA

Downstream 100 bases:

>100_bases
GCCTGAGGGCTGCTTTGTTCCGCTAAGGACCGCCCAGCCGATCGTCGGGAAGGTGTTGCGTCACCGCCGGCGGCGCCAAC
ACCATCACCGTGGCGAAGCT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MSLEPAFDAFSEAYDSGRQQVVWTRLIDDLETPVSAYLKIAQARPYSFLFESVEGGAWRGRYSIVTMNPDLVWRCRGDQA
EIAEGDDIAAGRFTPQPGGALDSLRDLVARSRMDLPKGLPPMAAGVFGALGYDLVRLVERLPDVNPDALNLPDGIMTRPS
IVAVFDAIAQEIILTTTVRPQAGVSAKAAHDAARARIEAVMADLHRPLAHDAPRPPRGPMDFTTPVSRADYAEVVAKAKD
YIAAGDIFQVVASHRFRAPFDLPPFALYRSLRRTNPSPFLFFLNLDGFNLVGSSPEILVRLRDGKITIRPIAGTRPRGAT
PEEDAALEAELLADPKERAEHLMLLDLGRNDVGRVAMLNHHGRNAPPEQARPKGPNVRVTESFTIERYSHVMHIVSNVEG
TAPEGVDPVDVLMAALPAGTLSGAPKVRAMEIIDELEVEKRGISYAGAVGYFGADGAVDTCIVLRTALVKDGMMYVQAGG
GIVADSDPDAEYDETLHKSRALKRAAEEAWRFS

Sequences:

>Translated_513_residues
MSLEPAFDAFSEAYDSGRQQVVWTRLIDDLETPVSAYLKIAQARPYSFLFESVEGGAWRGRYSIVTMNPDLVWRCRGDQA
EIAEGDDIAAGRFTPQPGGALDSLRDLVARSRMDLPKGLPPMAAGVFGALGYDLVRLVERLPDVNPDALNLPDGIMTRPS
IVAVFDAIAQEIILTTTVRPQAGVSAKAAHDAARARIEAVMADLHRPLAHDAPRPPRGPMDFTTPVSRADYAEVVAKAKD
YIAAGDIFQVVASHRFRAPFDLPPFALYRSLRRTNPSPFLFFLNLDGFNLVGSSPEILVRLRDGKITIRPIAGTRPRGAT
PEEDAALEAELLADPKERAEHLMLLDLGRNDVGRVAMLNHHGRNAPPEQARPKGPNVRVTESFTIERYSHVMHIVSNVEG
TAPEGVDPVDVLMAALPAGTLSGAPKVRAMEIIDELEVEKRGISYAGAVGYFGADGAVDTCIVLRTALVKDGMMYVQAGG
GIVADSDPDAEYDETLHKSRALKRAAEEAWRFS
>Mature_512_residues
SLEPAFDAFSEAYDSGRQQVVWTRLIDDLETPVSAYLKIAQARPYSFLFESVEGGAWRGRYSIVTMNPDLVWRCRGDQAE
IAEGDDIAAGRFTPQPGGALDSLRDLVARSRMDLPKGLPPMAAGVFGALGYDLVRLVERLPDVNPDALNLPDGIMTRPSI
VAVFDAIAQEIILTTTVRPQAGVSAKAAHDAARARIEAVMADLHRPLAHDAPRPPRGPMDFTTPVSRADYAEVVAKAKDY
IAAGDIFQVVASHRFRAPFDLPPFALYRSLRRTNPSPFLFFLNLDGFNLVGSSPEILVRLRDGKITIRPIAGTRPRGATP
EEDAALEAELLADPKERAEHLMLLDLGRNDVGRVAMLNHHGRNAPPEQARPKGPNVRVTESFTIERYSHVMHIVSNVEGT
APEGVDPVDVLMAALPAGTLSGAPKVRAMEIIDELEVEKRGISYAGAVGYFGADGAVDTCIVLRTALVKDGMMYVQAGGG
IVADSDPDAEYDETLHKSRALKRAAEEAWRFS

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=395, Percent_Identity=40, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1788114, Length=467, Percent_Identity=31.2633832976445, Blast_Score=218, Evalue=1e-57,
Organism=Escherichia coli, GI87082077, Length=281, Percent_Identity=25.2669039145907, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786809, Length=273, Percent_Identity=27.1062271062271, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320935, Length=500, Percent_Identity=36.8, Blast_Score=270, Evalue=5e-73,
Organism=Saccharomyces cerevisiae, GI6324361, Length=310, Percent_Identity=26.4516129032258, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 55795; Mature: 55664

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEPAFDAFSEAYDSGRQQVVWTRLIDDLETPVSAYLKIAQARPYSFLFESVEGGAWRG
CCCCHHHHHHHHHHHCCCCEEHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCC
RYSIVTMNPDLVWRCRGDQAEIAEGDDIAAGRFTPQPGGALDSLRDLVARSRMDLPKGLP
EEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
PMAAGVFGALGYDLVRLVERLPDVNPDALNLPDGIMTRPSIVAVFDAIAQEIILTTTVRP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCC
QAGVSAKAAHDAARARIEAVMADLHRPLAHDAPRPPRGPMDFTTPVSRADYAEVVAKAKD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
YIAAGDIFQVVASHRFRAPFDLPPFALYRSLRRTNPSPFLFFLNLDGFNLVGSSPEILVR
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCEEEEE
LRDGKITIRPIAGTRPRGATPEEDAALEAELLADPKERAEHLMLLDLGRNDVGRVAMLNH
EECCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHCEEEEEECCCCCCCCEEEEEC
HGRNAPPEQARPKGPNVRVTESFTIERYSHVMHIVSNVEGTAPEGVDPVDVLMAALPAGT
CCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCC
LSGAPKVRAMEIIDELEVEKRGISYAGAVGYFGADGAVDTCIVLRTALVKDGMMYVQAGG
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEECC
GIVADSDPDAEYDETLHKSRALKRAAEEAWRFS
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLEPAFDAFSEAYDSGRQQVVWTRLIDDLETPVSAYLKIAQARPYSFLFESVEGGAWRG
CCCHHHHHHHHHHHCCCCEEHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCC
RYSIVTMNPDLVWRCRGDQAEIAEGDDIAAGRFTPQPGGALDSLRDLVARSRMDLPKGLP
EEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
PMAAGVFGALGYDLVRLVERLPDVNPDALNLPDGIMTRPSIVAVFDAIAQEIILTTTVRP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCC
QAGVSAKAAHDAARARIEAVMADLHRPLAHDAPRPPRGPMDFTTPVSRADYAEVVAKAKD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
YIAAGDIFQVVASHRFRAPFDLPPFALYRSLRRTNPSPFLFFLNLDGFNLVGSSPEILVR
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCEEEEE
LRDGKITIRPIAGTRPRGATPEEDAALEAELLADPKERAEHLMLLDLGRNDVGRVAMLNH
EECCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHCEEEEEECCCCCCCCEEEEEC
HGRNAPPEQARPKGPNVRVTESFTIERYSHVMHIVSNVEGTAPEGVDPVDVLMAALPAGT
CCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCC
LSGAPKVRAMEIIDELEVEKRGISYAGAVGYFGADGAVDTCIVLRTALVKDGMMYVQAGG
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEECC
GIVADSDPDAEYDETLHKSRALKRAAEEAWRFS
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA