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The map label for this gene is bioA [H]

Identifier: 16125824

GI number: 16125824

Start: 1742489

End: 1743691

Strand: Direct

Name: bioA [H]

Synonym: CC_1577

Alternate gene names: 16125824

Gene position: 1742489-1743691 (Clockwise)

Preceding gene: 16125821

Following gene: 16125825

Centisome position: 43.38

GC content: 68.5

Gene sequence:

>1203_bases
ATGAAGACCGCCAGGCCTCCACTGCCGGTCGTCGCCACGCGCGGCGCCCGCCTGATCCTTGAGGACGGGCGTGAACTGGT
CGACGGTCTGGCGTCCTGGTGGACGGCCTGTCACGGCTACAACCACCCCCATATTGCTGGCGCGCTGCGCAAGCAGATCG
AGACCATGCCGCATGTCATGTTCGGTGGTCTGGCGCATGAACCCGCCTATCGCCTCGCCAAGCGGCTGGCCCGCCTGCTG
CCGGGTGATCTGGACCATGTCTTCTTCGCCGAAAGCGGCTCGGTCGCGGTCGAGATCGCGATGAAGATGGCGCTGCAGTA
CCAGATCAATCGCGGCGTGGGCGGTCGTACACGGTTCCTGGCTTTCCGGGGCGGCTACCACGGCGACACCCTGGCGACGA
TGACGGTCTGCGATCCCGAGGAAGGGATGCACAGCCTGTTCGCCGGCGTGATGCCCGCTCAGGTGATCGCCGACCTGCCC
CGGGACCCTGCGTCCGAAGCGGCGCTCGACGCTCTGCTCGCCGCGCGCGGACACGAGATCGCCGCCATGCTGGTGGAGCC
TCTGATCCAGGGCGCAGGCGGGATGCTTCCGCACCCGCCTGAGGTGCTGCGGACCCTTCGCCGCCTGGCCGACAAGCACG
GCGTGCTGCTGATCTTCGATGAGATCTTCACAGGCTTTGGCCGGACGGGATCCTTGTTCGCCATGCAGGCGGCGGGCGTC
GAGCCGGATATCGTCACCCTGTCCAAGGCGCTGACGGGCGGGACGTTGCCGCTGTCGGCGGCGGTCGCCCGCCGTCATGT
GTTCGAGGCCTTCTGGTCGGATGATCCTGCCGCGGCCCTGATGCACGGCCCCACCTACATGGCCAATCCGCTGGCCTGCG
CCGCCGCCAACGCCTCGCTGGATCTGTTCGAGGATGGCGCCTGGGCGCGCGACGTCGCGCGCGTGTCGGCGGCGTTGGCC
GAAGGGCTTGAGCCCTGTCGCGCCGGCGAGGGCGTGGTCGATGTCCGCACCTTGGGCGCGATCGGCGTCGTCGAGTTCGA
GGCGCCCGTGCCTGTATCGGATCTCTGTGCGCGGTTCGCCGCCCTGGGCGTCTGGATCCGGCCGATGGGCAAGGTGGTCT
ATCTGACGCCGGCCTTCACGACGCCAGACGAGGATCTTTCGCGGCTCACCTCGGCGGTGCGACAGGTTGTCGGCGTCGAT
TGA

Upstream 100 bases:

>100_bases
GGATAGGCAAGGCGCCCCGAGTCCGCAAACGGAAAGCGACATGTCCGATCCTCGCTGGCTAACCGAAGGCGCACCGCACG
TCTGGCGCCCGTACTGCCAG

Downstream 100 bases:

>100_bases
CCGGGCTCGCCGGGTCTGGTCCAAGCGGGGCCATGTCCGGCAAGTCATCCCCGCTCTCGGTCCTGGAGTATCTGGCGATC
TTCGCGATCATCATGACCTG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MKTARPPLPVVATRGARLILEDGRELVDGLASWWTACHGYNHPHIAGALRKQIETMPHVMFGGLAHEPAYRLAKRLARLL
PGDLDHVFFAESGSVAVEIAMKMALQYQINRGVGGRTRFLAFRGGYHGDTLATMTVCDPEEGMHSLFAGVMPAQVIADLP
RDPASEAALDALLAARGHEIAAMLVEPLIQGAGGMLPHPPEVLRTLRRLADKHGVLLIFDEIFTGFGRTGSLFAMQAAGV
EPDIVTLSKALTGGTLPLSAAVARRHVFEAFWSDDPAAALMHGPTYMANPLACAAANASLDLFEDGAWARDVARVSAALA
EGLEPCRAGEGVVDVRTLGAIGVVEFEAPVPVSDLCARFAALGVWIRPMGKVVYLTPAFTTPDEDLSRLTSAVRQVVGVD

Sequences:

>Translated_400_residues
MKTARPPLPVVATRGARLILEDGRELVDGLASWWTACHGYNHPHIAGALRKQIETMPHVMFGGLAHEPAYRLAKRLARLL
PGDLDHVFFAESGSVAVEIAMKMALQYQINRGVGGRTRFLAFRGGYHGDTLATMTVCDPEEGMHSLFAGVMPAQVIADLP
RDPASEAALDALLAARGHEIAAMLVEPLIQGAGGMLPHPPEVLRTLRRLADKHGVLLIFDEIFTGFGRTGSLFAMQAAGV
EPDIVTLSKALTGGTLPLSAAVARRHVFEAFWSDDPAAALMHGPTYMANPLACAAANASLDLFEDGAWARDVARVSAALA
EGLEPCRAGEGVVDVRTLGAIGVVEFEAPVPVSDLCARFAALGVWIRPMGKVVYLTPAFTTPDEDLSRLTSAVRQVVGVD
>Mature_400_residues
MKTARPPLPVVATRGARLILEDGRELVDGLASWWTACHGYNHPHIAGALRKQIETMPHVMFGGLAHEPAYRLAKRLARLL
PGDLDHVFFAESGSVAVEIAMKMALQYQINRGVGGRTRFLAFRGGYHGDTLATMTVCDPEEGMHSLFAGVMPAQVIADLP
RDPASEAALDALLAARGHEIAAMLVEPLIQGAGGMLPHPPEVLRTLRRLADKHGVLLIFDEIFTGFGRTGSLFAMQAAGV
EPDIVTLSKALTGGTLPLSAAVARRHVFEAFWSDDPAAALMHGPTYMANPLACAAANASLDLFEDGAWARDVARVSAALA
EGLEPCRAGEGVVDVRTLGAIGVVEFEAPVPVSDLCARFAALGVWIRPMGKVVYLTPAFTTPDEDLSRLTSAVRQVVGVD

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=402, Percent_Identity=28.1094527363184, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI13994255, Length=359, Percent_Identity=28.6908077994429, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI37574042, Length=358, Percent_Identity=27.0949720670391, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI284507298, Length=311, Percent_Identity=28.6173633440514, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI226442705, Length=358, Percent_Identity=26.536312849162, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI226442709, Length=323, Percent_Identity=27.8637770897833, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1786991, Length=404, Percent_Identity=51.7326732673267, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI145693181, Length=286, Percent_Identity=35.3146853146853, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1789759, Length=396, Percent_Identity=33.0808080808081, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789016, Length=351, Percent_Identity=33.048433048433, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1788044, Length=405, Percent_Identity=32.0987654320988, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1787560, Length=340, Percent_Identity=32.0588235294118, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786349, Length=326, Percent_Identity=31.9018404907975, Blast_Score=112, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI32564660, Length=361, Percent_Identity=29.3628808864266, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=400, Percent_Identity=25.5, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25144274, Length=225, Percent_Identity=28.8888888888889, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=435, Percent_Identity=32.8735632183908, Blast_Score=260, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6324432, Length=394, Percent_Identity=29.1878172588832, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323470, Length=410, Percent_Identity=28.0487804878049, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI21357415, Length=400, Percent_Identity=25.5, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28574759, Length=376, Percent_Identity=30.5851063829787, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI161085790, Length=376, Percent_Identity=30.5851063829787, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21356575, Length=358, Percent_Identity=26.2569832402235, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 42619; Mature: 42619

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTARPPLPVVATRGARLILEDGRELVDGLASWWTACHGYNHPHIAGALRKQIETMPHVM
CCCCCCCCCEEECCCCEEEHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FGGLAHEPAYRLAKRLARLLPGDLDHVFFAESGSVAVEIAMKMALQYQINRGVGGRTRFL
HCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEE
AFRGGYHGDTLATMTVCDPEEGMHSLFAGVMPAQVIADLPRDPASEAALDALLAARGHEI
EEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHH
AAMLVEPLIQGAGGMLPHPPEVLRTLRRLADKHGVLLIFDEIFTGFGRTGSLFAMQAAGV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCEEEEECCCC
EPDIVTLSKALTGGTLPLSAAVARRHVFEAFWSDDPAAALMHGPTYMANPLACAAANASL
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHCCCHHHHHCCCCC
DLFEDGAWARDVARVSAALAEGLEPCRAGEGVVDVRTLGAIGVVEFEAPVPVSDLCARFA
EECCCCCHHHHHHHHHHHHHHCCCHHHCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHH
ALGVWIRPMGKVVYLTPAFTTPDEDLSRLTSAVRQVVGVD
HHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTARPPLPVVATRGARLILEDGRELVDGLASWWTACHGYNHPHIAGALRKQIETMPHVM
CCCCCCCCCEEECCCCEEEHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FGGLAHEPAYRLAKRLARLLPGDLDHVFFAESGSVAVEIAMKMALQYQINRGVGGRTRFL
HCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEE
AFRGGYHGDTLATMTVCDPEEGMHSLFAGVMPAQVIADLPRDPASEAALDALLAARGHEI
EEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHH
AAMLVEPLIQGAGGMLPHPPEVLRTLRRLADKHGVLLIFDEIFTGFGRTGSLFAMQAAGV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCEEEEECCCC
EPDIVTLSKALTGGTLPLSAAVARRHVFEAFWSDDPAAALMHGPTYMANPLACAAANASL
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHCCCHHHHHCCCCC
DLFEDGAWARDVARVSAALAEGLEPCRAGEGVVDVRTLGAIGVVEFEAPVPVSDLCARFA
EECCCCCHHHHHHHHHHHHHHCCCHHHCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHH
ALGVWIRPMGKVVYLTPAFTTPDEDLSRLTSAVRQVVGVD
HHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8890743 [H]