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The map label for this gene is mrdB [H]

Identifier: 16125794

GI number: 16125794

Start: 1712006

End: 1713163

Strand: Direct

Name: mrdB [H]

Synonym: CC_1547

Alternate gene names: 16125794

Gene position: 1712006-1713163 (Clockwise)

Preceding gene: 16125793

Following gene: 16125795

Centisome position: 42.62

GC content: 65.72

Gene sequence:

>1158_bases
ATGACCCTGAGCGGCGGCCTTTCCCGGCCCGGCGAACGCGACCGGCCGACCATCAAGTTCATGGAGATCGACTGGACCTT
CTGTCTGTTCCTGTGCCTGATCGCCGGCGCGGGCGCGCTGATGCTGTTCTCGATCGCCGGCGCGTCCTGGGAGCCTTGGG
CGGCCAAGCATCTGATCCGCTTTGGCCTCTACTTCATCATGATGGTCATTCTGGCCATGTGTGATCTGCGCTGGTGGTTC
ATGGCCGCCTATCCGATCTATGTCGTGGGCCTGTTGCTGCTCATCGCCGTCGAGGTCGCCGGCGATGTCTCGCTGGGCGC
CCAGCGCTGGCTGTCGATCGGCGGGTTCCGCTTCCAGCCTTCGGAAATCATGAAGATCGGCCTCGTCCTGGCCCTGGCGC
GCTACTATCACGGCCTGTCGGCCGACAGCGCCCGGATGTCCTGGCGGTTGCTGATCCCGGCGGGGATGATCGCGGCGCCC
GTCCTCCTGGTGGCGCACCAGCCCGACCTCGGCACCGCCCTGCTGATCGCGGCGACCGGCCTGTCGATCGTCGTCCTGGC
GGGGCTGTCCTGGCGGATCATCTTCGCGGGCATCGCCGCGTTCGTGGCCGCGATCCCGCCCTTTGTGATGTTCGTTCTGC
ACGACTATCAGCGCCACCGGGTCATGACCTTCCTGAACCCCGAGGCCGACCCGTCGGGCAAGGGCTATCAGATCGTCCAG
TCCAAGATCGCGCTGGGCTCAGGTGGCCTGCTGGGCAAGGGCTTTGGCCTGGGCTCGCAGAGCCAGCTGAACTTCCTGCC
GGAAAAGCAGACCGACTTCATCTTCGCCACCCTGGCCGAGGAGTTCGGCTTCGTCGGCTGCTTCGCCGTGCTGTTCCTCT
ATGGCGCGGTGATCTTCATGGCGCTGCGGATCGCCTCGATCAGCCACAGCCACTTTGGACGCCTGGCCGCCGGCGGCACC
ATCTCGACCTTTGCGGTCTATGTGCTGATCAACGGCGCGATGGTGATGGGCATGGCGCCGGTCGTGGGCGTGCCCATGCC
GATGCTGTCGTACGGCGGCACCGTCATGCTGACGGTGATGATCGGCTTTGGCCTGATCCAGGCCGTCCGCGTGCACCGCT
ACACCGAAGTGACCAGCGGCAAGGGCTCGCTGGTCTGA

Upstream 100 bases:

>100_bases
CGGTTCCCGAGGCCGACATCGAAGGCGCCGCGCCGGAAGATCCGGTCGAAGCGCCGCCGCCCGCGCCCGAAGCGCCCACA
ACTCCGCAGGGAGGCCAGAC

Downstream 100 bases:

>100_bases
TGGGCGATGACGGGGAGGAGTTGCTTCCCGTCGTCGTTACGCCGCGACTTCGGCTCCGCTGTTGGCGGCCGAGCGACGCG
CCGGCTCTGTCGGCCAACAT

Product: rod shape-determining protein RodA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTLSGGLSRPGERDRPTIKFMEIDWTFCLFLCLIAGAGALMLFSIAGASWEPWAAKHLIRFGLYFIMMVILAMCDLRWWF
MAAYPIYVVGLLLLIAVEVAGDVSLGAQRWLSIGGFRFQPSEIMKIGLVLALARYYHGLSADSARMSWRLLIPAGMIAAP
VLLVAHQPDLGTALLIAATGLSIVVLAGLSWRIIFAGIAAFVAAIPPFVMFVLHDYQRHRVMTFLNPEADPSGKGYQIVQ
SKIALGSGGLLGKGFGLGSQSQLNFLPEKQTDFIFATLAEEFGFVGCFAVLFLYGAVIFMALRIASISHSHFGRLAAGGT
ISTFAVYVLINGAMVMGMAPVVGVPMPMLSYGGTVMLTVMIGFGLIQAVRVHRYTEVTSGKGSLV

Sequences:

>Translated_385_residues
MTLSGGLSRPGERDRPTIKFMEIDWTFCLFLCLIAGAGALMLFSIAGASWEPWAAKHLIRFGLYFIMMVILAMCDLRWWF
MAAYPIYVVGLLLLIAVEVAGDVSLGAQRWLSIGGFRFQPSEIMKIGLVLALARYYHGLSADSARMSWRLLIPAGMIAAP
VLLVAHQPDLGTALLIAATGLSIVVLAGLSWRIIFAGIAAFVAAIPPFVMFVLHDYQRHRVMTFLNPEADPSGKGYQIVQ
SKIALGSGGLLGKGFGLGSQSQLNFLPEKQTDFIFATLAEEFGFVGCFAVLFLYGAVIFMALRIASISHSHFGRLAAGGT
ISTFAVYVLINGAMVMGMAPVVGVPMPMLSYGGTVMLTVMIGFGLIQAVRVHRYTEVTSGKGSLV
>Mature_384_residues
TLSGGLSRPGERDRPTIKFMEIDWTFCLFLCLIAGAGALMLFSIAGASWEPWAAKHLIRFGLYFIMMVILAMCDLRWWFM
AAYPIYVVGLLLLIAVEVAGDVSLGAQRWLSIGGFRFQPSEIMKIGLVLALARYYHGLSADSARMSWRLLIPAGMIAAPV
LLVAHQPDLGTALLIAATGLSIVVLAGLSWRIIFAGIAAFVAAIPPFVMFVLHDYQRHRVMTFLNPEADPSGKGYQIVQS
KIALGSGGLLGKGFGLGSQSQLNFLPEKQTDFIFATLAEEFGFVGCFAVLFLYGAVIFMALRIASISHSHFGRLAAGGTI
STFAVYVLINGAMVMGMAPVVGVPMPMLSYGGTVMLTVMIGFGLIQAVRVHRYTEVTSGKGSLV

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=310, Percent_Identity=48.0645161290323, Blast_Score=260, Evalue=9e-71,
Organism=Escherichia coli, GI1786277, Length=335, Percent_Identity=34.9253731343284, Blast_Score=157, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 41547; Mature: 41416

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSGGLSRPGERDRPTIKFMEIDWTFCLFLCLIAGAGALMLFSIAGASWEPWAAKHLIR
CCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHH
FGLYFIMMVILAMCDLRWWFMAAYPIYVVGLLLLIAVEVAGDVSLGAQRWLSIGGFRFQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEECH
SEIMKIGLVLALARYYHGLSADSARMSWRLLIPAGMIAAPVLLVAHQPDLGTALLIAATG
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHEEEECCCCCCHHHHHHHCC
LSIVVLAGLSWRIIFAGIAAFVAAIPPFVMFVLHDYQRHRVMTFLNPEADPSGKGYQIVQ
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHH
SKIALGSGGLLGKGFGLGSQSQLNFLPEKQTDFIFATLAEEFGFVGCFAVLFLYGAVIFM
HHHHCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
ALRIASISHSHFGRLAAGGTISTFAVYVLINGAMVMGMAPVVGVPMPMLSYGGTVMLTVM
HHHHHHHCHHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHCCCHHHHHHH
IGFGLIQAVRVHRYTEVTSGKGSLV
HHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TLSGGLSRPGERDRPTIKFMEIDWTFCLFLCLIAGAGALMLFSIAGASWEPWAAKHLIR
CCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHH
FGLYFIMMVILAMCDLRWWFMAAYPIYVVGLLLLIAVEVAGDVSLGAQRWLSIGGFRFQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEECH
SEIMKIGLVLALARYYHGLSADSARMSWRLLIPAGMIAAPVLLVAHQPDLGTALLIAATG
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHEEEECCCCCCHHHHHHHCC
LSIVVLAGLSWRIIFAGIAAFVAAIPPFVMFVLHDYQRHRVMTFLNPEADPSGKGYQIVQ
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHH
SKIALGSGGLLGKGFGLGSQSQLNFLPEKQTDFIFATLAEEFGFVGCFAVLFLYGAVIFM
HHHHCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
ALRIASISHSHFGRLAAGGTISTFAVYVLINGAMVMGMAPVVGVPMPMLSYGGTVMLTVM
HHHHHHHCHHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHCCCHHHHHHH
IGFGLIQAVRVHRYTEVTSGKGSLV
HHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]