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The map label for this gene is ilvD [H]

Identifier: 16125670

GI number: 16125670

Start: 1568837

End: 1570639

Strand: Direct

Name: ilvD [H]

Synonym: CC_1421

Alternate gene names: 16125670

Gene position: 1568837-1570639 (Clockwise)

Preceding gene: 16125669

Following gene: 16125671

Centisome position: 39.06

GC content: 64.95

Gene sequence:

>1803_bases
ATGAGCGTCCCTAACGTCCCCCGCCGCGCGCTCCGTTCGCGGGCCTGGTTCGACAATCCGGACAATATCGACATGACGGC
GCTTTATCTGGAGCGCTACCTGAACTTCGGCCTGACCCTTGAGGAGCTGCAGTCGGGCAAGCCGATCATCGGTATCGCCC
AGACGGGCTCTGATCTCTCGCCGTGCAACCGGCATCACCTGGTGCTGGCCGAGCGCGTGCGCGAGGGGATCCGCAGCGCC
GGCGGCATCGCGCTGGAGTTTCCGGTTCACCCCATCCAGGAGACCGGCAAGCGGCCCACGGCGGGCCTTGATCGCAACCT
GTCGTATCTGGGCCTTGTCGAGCTGTTGTACGGCTATCCGCTGGATGGCGTGGTGCTGACCATCGGCTGCGACAAGACCA
CGCCCGCCTGCCTGATGGCGGCGGCGACGGTCAACATTCCCGCGATTGCGCTGTCGGTCGGTCCAATGCTGAACGGCTGG
CACAAGGGCAAGCGCACCGGGTCGGGGACGATCGTCTGGAAGGCGCGCGAGATGCTGGCCGCCGGCGAGATCGACAACGC
CGGTTTCATCAAGCTCGTGGCCAGTTCCGCGCCCTCGACCGGCTATTGCAACACTATGGGCACGGCCACGACGATGAACT
CGTTGACGGAGGCTCTCGGCATGTCGCTGCCCGGCTCCGCCGCGATCCCGGCGCCGTATCGCGACCGCCAGGAGAACGCC
TACCGCACCGGTCTTCGGATCGTCGAAATGGTGGCCGAAGACCTCAAGCCCTCGGACATCCTGACCCGCGAGGCGTTCTT
GAACGCCATCGTCGTCAACTCCGCGATCGGCGGCTCGACCAACGCGCCGATCCACCTCAACGCGCTCGCCCGCCACATGG
ACGTGGACCTGACGCTCGAGGACTGGGAGACGGCGGGCAAGGACGTGCCGCTGCTGGTCAATCTTCAGCCCGCCGGCGAG
TATCTCGGCGAAGACTACTATCGCGCCGGCGGCGTTCCGGCCGTGTTCGGGCAGTTGATCGAACAGGGCCTCATCCACCA
AGACGCCCGTGCGGTCTCCGGTCAGAGCATCGGCGAGCAGTATCGCGGCGCCGTCATCGAGGATGAAGACGTCATCCGTC
CGTTTGCGCGCCCGCTCGTTGAACACGCCGGTTTCGCGATCATGCGGGGCAATCTCTTCAACTCCGCGATCATGAAGACC
AGCGTGATCAGCGAAGAGTTTCGCGCGCGCTACCTTTCGAACCCCGACGATCCCGACGCTTTCGAGGGGAATGCGATCGT
TTTCGATGGGCCCGAGGACTACCATCACCGGATCGATGACCCGGCGCTCGGGATCACGGCGTACTCGATCCTGTTCATGC
GTGGCGCGGGTCCGATCGGCTATCCAGGCTCGGCCGAGGTCGTGAACATGCGTGCGCCGAACTACTTGATCAAACAGGGG
ATTCATCAGCTTCCCTGTATCGGCGACGGGCGTCAGTCGGGCACGTCTGGATCACCATCGATCCTCAACGCCTCGCCGGA
AGCGGCGGCGGGCGGCGGCCTGGCGCTGCTTAAAACTGGCGACCGCGTTCGCTTTGATCTGCGCAAGTCCCGGGTGGACG
TCCTGGTCTCCGCCTCAGAAGTCGTCGAGCGTCGCAGGGCCTTGGAAGCTGCAGGCGGCTATGCGTATCCCGAAAGCCAG
ACGCCTTGGCAGGAAATCCAGCGCGCTGTCGTCGGCCAGATGGATACGGGCGCCGTGCTTGAACCGGCGGTGAAGTACCA
GCGCATCGCTCAGACCAAGGGCCTGCCGCGCGACAACCACTAG

Upstream 100 bases:

>100_bases
GTCAGACAAATGCGATAAGCGAGGCGGTGGTGAGCCGACGCGGCCATGCCGGGTCCTTCTCCGGCGCGCGACCGCCGGTT
TCTGCTCCTCAAGGGTTGTC

Downstream 100 bases:

>100_bases
GTCATCGCGGGCTCCTGTTGTCGGCGAACGGCGATCTGGAAACTATATTGTCGGACAAATAGGCGCCTGCTATGGCTTCC
TCAACGACGTATCGTTGATT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 600; Mature: 599

Protein sequence:

>600_residues
MSVPNVPRRALRSRAWFDNPDNIDMTALYLERYLNFGLTLEELQSGKPIIGIAQTGSDLSPCNRHHLVLAERVREGIRSA
GGIALEFPVHPIQETGKRPTAGLDRNLSYLGLVELLYGYPLDGVVLTIGCDKTTPACLMAAATVNIPAIALSVGPMLNGW
HKGKRTGSGTIVWKAREMLAAGEIDNAGFIKLVASSAPSTGYCNTMGTATTMNSLTEALGMSLPGSAAIPAPYRDRQENA
YRTGLRIVEMVAEDLKPSDILTREAFLNAIVVNSAIGGSTNAPIHLNALARHMDVDLTLEDWETAGKDVPLLVNLQPAGE
YLGEDYYRAGGVPAVFGQLIEQGLIHQDARAVSGQSIGEQYRGAVIEDEDVIRPFARPLVEHAGFAIMRGNLFNSAIMKT
SVISEEFRARYLSNPDDPDAFEGNAIVFDGPEDYHHRIDDPALGITAYSILFMRGAGPIGYPGSAEVVNMRAPNYLIKQG
IHQLPCIGDGRQSGTSGSPSILNASPEAAAGGGLALLKTGDRVRFDLRKSRVDVLVSASEVVERRRALEAAGGYAYPESQ
TPWQEIQRAVVGQMDTGAVLEPAVKYQRIAQTKGLPRDNH

Sequences:

>Translated_600_residues
MSVPNVPRRALRSRAWFDNPDNIDMTALYLERYLNFGLTLEELQSGKPIIGIAQTGSDLSPCNRHHLVLAERVREGIRSA
GGIALEFPVHPIQETGKRPTAGLDRNLSYLGLVELLYGYPLDGVVLTIGCDKTTPACLMAAATVNIPAIALSVGPMLNGW
HKGKRTGSGTIVWKAREMLAAGEIDNAGFIKLVASSAPSTGYCNTMGTATTMNSLTEALGMSLPGSAAIPAPYRDRQENA
YRTGLRIVEMVAEDLKPSDILTREAFLNAIVVNSAIGGSTNAPIHLNALARHMDVDLTLEDWETAGKDVPLLVNLQPAGE
YLGEDYYRAGGVPAVFGQLIEQGLIHQDARAVSGQSIGEQYRGAVIEDEDVIRPFARPLVEHAGFAIMRGNLFNSAIMKT
SVISEEFRARYLSNPDDPDAFEGNAIVFDGPEDYHHRIDDPALGITAYSILFMRGAGPIGYPGSAEVVNMRAPNYLIKQG
IHQLPCIGDGRQSGTSGSPSILNASPEAAAGGGLALLKTGDRVRFDLRKSRVDVLVSASEVVERRRALEAAGGYAYPESQ
TPWQEIQRAVVGQMDTGAVLEPAVKYQRIAQTKGLPRDNH
>Mature_599_residues
SVPNVPRRALRSRAWFDNPDNIDMTALYLERYLNFGLTLEELQSGKPIIGIAQTGSDLSPCNRHHLVLAERVREGIRSAG
GIALEFPVHPIQETGKRPTAGLDRNLSYLGLVELLYGYPLDGVVLTIGCDKTTPACLMAAATVNIPAIALSVGPMLNGWH
KGKRTGSGTIVWKAREMLAAGEIDNAGFIKLVASSAPSTGYCNTMGTATTMNSLTEALGMSLPGSAAIPAPYRDRQENAY
RTGLRIVEMVAEDLKPSDILTREAFLNAIVVNSAIGGSTNAPIHLNALARHMDVDLTLEDWETAGKDVPLLVNLQPAGEY
LGEDYYRAGGVPAVFGQLIEQGLIHQDARAVSGQSIGEQYRGAVIEDEDVIRPFARPLVEHAGFAIMRGNLFNSAIMKTS
VISEEFRARYLSNPDDPDAFEGNAIVFDGPEDYHHRIDDPALGITAYSILFMRGAGPIGYPGSAEVVNMRAPNYLIKQGI
HQLPCIGDGRQSGTSGSPSILNASPEAAAGGGLALLKTGDRVRFDLRKSRVDVLVSASEVVERRRALEAAGGYAYPESQT
PWQEIQRAVVGQMDTGAVLEPAVKYQRIAQTKGLPRDNH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=565, Percent_Identity=29.7345132743363, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1788157, Length=443, Percent_Identity=28.6681715575621, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI2367371, Length=460, Percent_Identity=28.0434782608696, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1786464, Length=464, Percent_Identity=28.2327586206897, Blast_Score=109, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6322476, Length=529, Percent_Identity=27.4102079395085, Blast_Score=191, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 64651; Mature: 64520

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPNVPRRALRSRAWFDNPDNIDMTALYLERYLNFGLTLEELQSGKPIIGIAQTGSDLS
CCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCC
PCNRHHLVLAERVREGIRSAGGIALEFPVHPIQETGKRPTAGLDRNLSYLGLVELLYGYP
CCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHCCC
LDGVVLTIGCDKTTPACLMAAATVNIPAIALSVGPMLNGWHKGKRTGSGTIVWKAREMLA
CCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCHHCCHHCCCCCCCCEEEEEHHHHHH
AGEIDNAGFIKLVASSAPSTGYCNTMGTATTMNSLTEALGMSLPGSAAIPAPYRDRQENA
HCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
YRTGLRIVEMVAEDLKPSDILTREAFLNAIVVNSAIGGSTNAPIHLNALARHMDVDLTLE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHCCCEEEEH
DWETAGKDVPLLVNLQPAGEYLGEDYYRAGGVPAVFGQLIEQGLIHQDARAVSGQSIGEQ
HHHCCCCCCCEEEEECCHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
YRGAVIEDEDVIRPFARPLVEHAGFAIMRGNLFNSAIMKTSVISEEFRARYLSNPDDPDA
HCCCCCCCHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FEGNAIVFDGPEDYHHRIDDPALGITAYSILFMRGAGPIGYPGSAEVVNMRAPNYLIKQG
CCCCEEEECCCHHHHHCCCCCCHHHHHHHHHHEECCCCCCCCCCCCEEEECCCHHHHHHC
IHQLPCIGDGRQSGTSGSPSILNASPEAAAGGGLALLKTGDRVRFDLRKSRVDVLVSASE
HHHCCCCCCCCCCCCCCCCCEECCCCCCCCCCCEEEEECCCCEEEHHHHHHHHHEECHHH
VVERRRALEAAGGYAYPESQTPWQEIQRAVVGQMDTGAVLEPAVKYQRIAQTKGLPRDNH
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SVPNVPRRALRSRAWFDNPDNIDMTALYLERYLNFGLTLEELQSGKPIIGIAQTGSDLS
CCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCC
PCNRHHLVLAERVREGIRSAGGIALEFPVHPIQETGKRPTAGLDRNLSYLGLVELLYGYP
CCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHCCC
LDGVVLTIGCDKTTPACLMAAATVNIPAIALSVGPMLNGWHKGKRTGSGTIVWKAREMLA
CCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCHHCCHHCCCCCCCCEEEEEHHHHHH
AGEIDNAGFIKLVASSAPSTGYCNTMGTATTMNSLTEALGMSLPGSAAIPAPYRDRQENA
HCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
YRTGLRIVEMVAEDLKPSDILTREAFLNAIVVNSAIGGSTNAPIHLNALARHMDVDLTLE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHCCCEEEEH
DWETAGKDVPLLVNLQPAGEYLGEDYYRAGGVPAVFGQLIEQGLIHQDARAVSGQSIGEQ
HHHCCCCCCCEEEEECCHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
YRGAVIEDEDVIRPFARPLVEHAGFAIMRGNLFNSAIMKTSVISEEFRARYLSNPDDPDA
HCCCCCCCHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FEGNAIVFDGPEDYHHRIDDPALGITAYSILFMRGAGPIGYPGSAEVVNMRAPNYLIKQG
CCCCEEEECCCHHHHHCCCCCCHHHHHHHHHHEECCCCCCCCCCCCEEEECCCHHHHHHC
IHQLPCIGDGRQSGTSGSPSILNASPEAAAGGGLALLKTGDRVRFDLRKSRVDVLVSASE
HHHCCCCCCCCCCCCCCCCCEECCCCCCCCCCCEEEEECCCCEEEHHHHHHHHHEECHHH
VVERRRALEAAGGYAYPESQTPWQEIQRAVVGQMDTGAVLEPAVKYQRIAQTKGLPRDNH
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]