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The map label for this gene is dapA

Identifier: 16125446

GI number: 16125446

Start: 1355558

End: 1356442

Strand: Direct

Name: dapA

Synonym: CC_1195

Alternate gene names: 16125446

Gene position: 1355558-1356442 (Clockwise)

Preceding gene: 16125444

Following gene: 16125447

Centisome position: 33.75

GC content: 65.76

Gene sequence:

>885_bases
ATGGTCCAGTCTCACTTCAAGGGCGTCATTCCGGCCCTCGTCACGCCGTTCCGGGACGGTGAGGTGGACGAAAAAGCGTT
CGTGGCGCTGGTCGAGCGCCAGATCGCCGGCGGTGTGCATGGTCTAGTCCCCGTCGGTACGACGGGCGAGACCTCGACCC
TGTCGCACGAGGAGCACCGCCGCGTCGTCGAGTTGTGCGTGAAGACCACGGCGGGCCGCGTCCCAGTGATCGCGGGCGCG
GGCAGCAATTCGACCGATGAAGCCATCGAACTGGCCCGTCACGCCAAGACCGTCGGCGCCGACGCCTGTCTGGTGGTGAC
GCCGTATTACAACCGCCCCAGCCAGGAGGGCATGTATCAGCACTACAAGGCGATCAACGACGCCGTGGAGCTGCCGATCT
TTGTTTATAACGTGCCGGGTCGGACCGGCGTCGACATCAGCAACGACACCCTTGAGCGTCTCGCCAAGCTGCCGAACATC
GTCGGGATCAAGGACGCCACGGGCGACCTGACCCGCATCAGCTTCCAGCGCCTGATGTGCGGCCCCGAATGGGTGATGCT
GTCGGGCGATGATCCGACCGCGCTCGGCTACATGGCTCATGGCGGCCACGGTGTGATCTCGGTGACGTCCAACGTCGCGC
CAGACGCCTGCTCGGCCTTCATGAACGCCTGCATGCAGGGCGAATGGGAGAAGGGTCTCTACTGGCAGGACCGCCTGGTG
CGCCTGCACAAGGCCCTGTTCCTGGATTCCTCGCCCGCCCCGACCAAGTTCGCCATGGCGCAACTGGGCCTGTGCACGGA
AGATGTGCGCCTGCCGATCACGGCCTGCGCCGAAGGGGTGCGCCCCGCGATCCTTGAGGCCATGCGCGAGGCTGGTCTGC
GCTGA

Upstream 100 bases:

>100_bases
CCGAGAGCCGGTTGCGGGACGACGGGGCAGGGACATATTGTCCGCCCCCATCGTCCCGCCGCAACACATGCGGCTTCATC
TTCACGGCAATTTGCAAGTC

Downstream 100 bases:

>100_bases
TGTCCAAGCCGATCGCGGAAAATCGGCGCGCGCGCTTCGACTACTTCATCGAGGAGACGTTCGAGGCCGGCATCATGCTG
ACCGGCACCGAGGTGAAGAG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MVQSHFKGVIPALVTPFRDGEVDEKAFVALVERQIAGGVHGLVPVGTTGETSTLSHEEHRRVVELCVKTTAGRVPVIAGA
GSNSTDEAIELARHAKTVGADACLVVTPYYNRPSQEGMYQHYKAINDAVELPIFVYNVPGRTGVDISNDTLERLAKLPNI
VGIKDATGDLTRISFQRLMCGPEWVMLSGDDPTALGYMAHGGHGVISVTSNVAPDACSAFMNACMQGEWEKGLYWQDRLV
RLHKALFLDSSPAPTKFAMAQLGLCTEDVRLPITACAEGVRPAILEAMREAGLR

Sequences:

>Translated_294_residues
MVQSHFKGVIPALVTPFRDGEVDEKAFVALVERQIAGGVHGLVPVGTTGETSTLSHEEHRRVVELCVKTTAGRVPVIAGA
GSNSTDEAIELARHAKTVGADACLVVTPYYNRPSQEGMYQHYKAINDAVELPIFVYNVPGRTGVDISNDTLERLAKLPNI
VGIKDATGDLTRISFQRLMCGPEWVMLSGDDPTALGYMAHGGHGVISVTSNVAPDACSAFMNACMQGEWEKGLYWQDRLV
RLHKALFLDSSPAPTKFAMAQLGLCTEDVRLPITACAEGVRPAILEAMREAGLR
>Mature_294_residues
MVQSHFKGVIPALVTPFRDGEVDEKAFVALVERQIAGGVHGLVPVGTTGETSTLSHEEHRRVVELCVKTTAGRVPVIAGA
GSNSTDEAIELARHAKTVGADACLVVTPYYNRPSQEGMYQHYKAINDAVELPIFVYNVPGRTGVDISNDTLERLAKLPNI
VGIKDATGDLTRISFQRLMCGPEWVMLSGDDPTALGYMAHGGHGVISVTSNVAPDACSAFMNACMQGEWEKGLYWQDRLV
RLHKALFLDSSPAPTKFAMAQLGLCTEDVRLPITACAEGVRPAILEAMREAGLR

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=286, Percent_Identity=29.3706293706294, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI13540533, Length=246, Percent_Identity=27.6422764227642, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788823, Length=290, Percent_Identity=45.5172413793103, Blast_Score=258, Evalue=3e-70,
Organism=Escherichia coli, GI87082415, Length=293, Percent_Identity=34.8122866894198, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1786463, Length=250, Percent_Identity=32.4, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789620, Length=229, Percent_Identity=32.7510917030568, Blast_Score=117, Evalue=9e-28,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_CAUCR (Q9A900)

Other databases:

- EMBL:   AE005673
- PIR:   F87397
- RefSeq:   NP_420010.1
- ProteinModelPortal:   Q9A900
- SMR:   Q9A900
- GeneID:   941636
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_1195
- NMPDR:   fig|190650.1.peg.1190
- TIGR:   CC_1195
- HOGENOM:   HBG358848
- OMA:   HFETIAS
- ProtClustDB:   PRK03170
- BRENDA:   4.2.1.52
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31701; Mature: 31701

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 164-164 BINDING 109-109

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQSHFKGVIPALVTPFRDGEVDEKAFVALVERQIAGGVHGLVPVGTTGETSTLSHEEHR
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHH
RVVELCVKTTAGRVPVIAGAGSNSTDEAIELARHAKTVGADACLVVTPYYNRPSQEGMYQ
HHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHH
HYKAINDAVELPIFVYNVPGRTGVDISNDTLERLAKLPNIVGIKDATGDLTRISFQRLMC
HHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHC
GPEWVMLSGDDPTALGYMAHGGHGVISVTSNVAPDACSAFMNACMQGEWEKGLYWQDRLV
CCCEEEEECCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
RLHKALFLDSSPAPTKFAMAQLGLCTEDVRLPITACAEGVRPAILEAMREAGLR
HHHHHHHCCCCCCCHHHHHHHHCCCHHHCCCCHHHHHCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MVQSHFKGVIPALVTPFRDGEVDEKAFVALVERQIAGGVHGLVPVGTTGETSTLSHEEHR
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHH
RVVELCVKTTAGRVPVIAGAGSNSTDEAIELARHAKTVGADACLVVTPYYNRPSQEGMYQ
HHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHH
HYKAINDAVELPIFVYNVPGRTGVDISNDTLERLAKLPNIVGIKDATGDLTRISFQRLMC
HHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHC
GPEWVMLSGDDPTALGYMAHGGHGVISVTSNVAPDACSAFMNACMQGEWEKGLYWQDRLV
CCCEEEEECCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
RLHKALFLDSSPAPTKFAMAQLGLCTEDVRLPITACAEGVRPAILEAMREAGLR
HHHHHHHCCCCCCCHHHHHHHHCCCHHHCCCCHHHHHCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647