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The map label for this gene is cysG [H]

Identifier: 16125370

GI number: 16125370

Start: 1268736

End: 1269659

Strand: Direct

Name: cysG [H]

Synonym: CC_1118

Alternate gene names: 16125370

Gene position: 1268736-1269659 (Clockwise)

Preceding gene: 16125367

Following gene: 16125371

Centisome position: 31.58

GC content: 72.4

Gene sequence:

>924_bases
ATGGCCCGCCAGCCAGTCCGAAATCGCCCGCCGGGACTTGTCGTCGTGGGCGGAAAGCGCGCGGGTCGCGCGCTCGGCGT
TGTCTGGCTGGTCGGGGCCGGTCCGGGGGACCCGGACCTGCTGACATTCCGGGCGTTCAACGCCCTGCGGGCCGCCGATG
TCGTGGTGCACGACGGGCTGGTGTCCGAAGAGATTCTCGACCTCGCTCCCAGCCGCGCCCGGCGGATCAACGTCGCCAAG
CGCAAGTCGCGCCACACGCTGCCGCAGGACGACATCAACCAGCTGCTGGTCGCCCTGGCGCAGGAGGGGCTGACCGTCGT
CCGGCTGAAGGGCGGCGATCCTTTCCTGTTCGGTCGGGGCGGCGAGGAGCTGGCCGCGTGCCGCGAGGCGGGCGTCGAAT
GCCATGTAGTGCCCGGCGTCACGGCGGCCCTGGCCGCGAGCGCCGGCGCTGGCGCGCCGCTGACCCATCGGGGTGCGGCC
CAAGCGGTGACCTTCGTCACCGGTCACGCGGCCCATGGCGAGCCCGACCTCGACTGGGTCGCCCTGGCGCGCCCCAACCA
GACGGTCGTCGTCTACATGGGCGTTTCGACCGCCGCCCTGATCGCTGAGCGCTTGGTCGCGGCCGGCCGCGCGGCGTCGA
CGCGGGCCCTGATCGTCGAGAATGCGAGCCGCGCGGACGAGCGTCGGATCCTGACGACCTTGTCCGGGTTGGCCGAAGCC
GCCGCCTCGGTGCGCGGCCCCGCGCTGCTGATGGTGGGCGAGGCCATGGCGATGGCGGAAATTCAATCTCCTCCCCCGTT
GACGGGGGAGGGGCACCGCGAAGCGGTGGAGGGGGCGCTCGCCGCAAAGCGCGCCCCCTCCGTCATCTCGCCCCTGGGCG
AGCTGACACCTCCCCCGCTTCGCTGGGGAGGAGAGTTCAAATGA

Upstream 100 bases:

>100_bases
CCTTTTCGTCGACGCGTGCGAGCGGGGTTGGTCCTTAGGGGCGACCCCGCCTTGCTTTCCACCGCTTTATTCCGAGCGGC
TTGATAGAGGTTCTAAACCC

Downstream 100 bases:

>100_bases
AAGCCGTAGTCGCCAATCGCCTGATCGACGGCGAGGTCGTGTTCTGGAAGTCCGGGCAGTGGGTGGAGCGCTTCGGCGAC
GCCGAGCTGTTCGACGCCGA

Product: siroheme synthase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MARQPVRNRPPGLVVVGGKRAGRALGVVWLVGAGPGDPDLLTFRAFNALRAADVVVHDGLVSEEILDLAPSRARRINVAK
RKSRHTLPQDDINQLLVALAQEGLTVVRLKGGDPFLFGRGGEELAACREAGVECHVVPGVTAALAASAGAGAPLTHRGAA
QAVTFVTGHAAHGEPDLDWVALARPNQTVVVYMGVSTAALIAERLVAAGRAASTRALIVENASRADERRILTTLSGLAEA
AASVRGPALLMVGEAMAMAEIQSPPPLTGEGHREAVEGALAAKRAPSVISPLGELTPPPLRWGGEFK

Sequences:

>Translated_307_residues
MARQPVRNRPPGLVVVGGKRAGRALGVVWLVGAGPGDPDLLTFRAFNALRAADVVVHDGLVSEEILDLAPSRARRINVAK
RKSRHTLPQDDINQLLVALAQEGLTVVRLKGGDPFLFGRGGEELAACREAGVECHVVPGVTAALAASAGAGAPLTHRGAA
QAVTFVTGHAAHGEPDLDWVALARPNQTVVVYMGVSTAALIAERLVAAGRAASTRALIVENASRADERRILTTLSGLAEA
AASVRGPALLMVGEAMAMAEIQSPPPLTGEGHREAVEGALAAKRAPSVISPLGELTPPPLRWGGEFK
>Mature_306_residues
ARQPVRNRPPGLVVVGGKRAGRALGVVWLVGAGPGDPDLLTFRAFNALRAADVVVHDGLVSEEILDLAPSRARRINVAKR
KSRHTLPQDDINQLLVALAQEGLTVVRLKGGDPFLFGRGGEELAACREAGVECHVVPGVTAALAASAGAGAPLTHRGAAQ
AVTFVTGHAAHGEPDLDWVALARPNQTVVVYMGVSTAALIAERLVAAGRAASTRALIVENASRADERRILTTLSGLAEAA
ASVRGPALLMVGEAMAMAEIQSPPPLTGEGHREAVEGALAAKRAPSVISPLGELTPPPLRWGGEFK

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=235, Percent_Identity=47.2340425531915, Blast_Score=207, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6322922, Length=236, Percent_Identity=33.0508474576271, Blast_Score=113, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 31807; Mature: 31676

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARQPVRNRPPGLVVVGGKRAGRALGVVWLVGAGPGDPDLLTFRAFNALRAADVVVHDGL
CCCCCCCCCCCCEEEECCCCCCCEEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHCCCC
VSEEILDLAPSRARRINVAKRKSRHTLPQDDINQLLVALAQEGLTVVRLKGGDPFLFGRG
HHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEECCCEEEECCC
GEELAACREAGVECHVVPGVTAALAASAGAGAPLTHRGAAQAVTFVTGHAAHGEPDLDWV
CHHHHHHHHCCCEEEECCCCHHHHHHCCCCCCCCCCCCCHHEEEEEECCCCCCCCCCCEE
ALARPNQTVVVYMGVSTAALIAERLVAAGRAASTRALIVENASRADERRILTTLSGLAEA
EEECCCCEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
AASVRGPALLMVGEAMAMAEIQSPPPLTGEGHREAVEGALAAKRAPSVISPLGELTPPPL
HHHCCCCEEEEECHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCC
RWGGEFK
CCCCCCC
>Mature Secondary Structure 
ARQPVRNRPPGLVVVGGKRAGRALGVVWLVGAGPGDPDLLTFRAFNALRAADVVVHDGL
CCCCCCCCCCCEEEECCCCCCCEEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHCCCC
VSEEILDLAPSRARRINVAKRKSRHTLPQDDINQLLVALAQEGLTVVRLKGGDPFLFGRG
HHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEECCCEEEECCC
GEELAACREAGVECHVVPGVTAALAASAGAGAPLTHRGAAQAVTFVTGHAAHGEPDLDWV
CHHHHHHHHCCCEEEECCCCHHHHHHCCCCCCCCCCCCCHHEEEEEECCCCCCCCCCCEE
ALARPNQTVVVYMGVSTAALIAERLVAAGRAASTRALIVENASRADERRILTTLSGLAEA
EEECCCCEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
AASVRGPALLMVGEAMAMAEIQSPPPLTGEGHREAVEGALAAKRAPSVISPLGELTPPPL
HHHCCCCEEEEECHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCC
RWGGEFK
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]