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The map label for this gene is sir2 [H]

Identifier: 16125371

GI number: 16125371

Start: 1270022

End: 1271680

Strand: Direct

Name: sir2 [H]

Synonym: CC_1119

Alternate gene names: 16125371

Gene position: 1270022-1271680 (Clockwise)

Preceding gene: 16125370

Following gene: 16125372

Centisome position: 31.62

GC content: 66.0

Gene sequence:

>1659_bases
ATGTATCAGTACGATCTCATCGACAAGGAATTCCTGGCCGACCGCTCGGCCGAGTTCCGGGGGCAGGTCGCCCGCCGTCT
CTCCGGCGAGTTGACCGAGGACCAGTTCAAGCCGCTGCGGCTGATGAACGGCCTCTATCTGCAACTGCACGCCTACATGC
TGCGGGTGGCGATCCCGTACGGCTCGCTGAACTCGACCCAGGCCCGCCGCCTCGCGCAGATCGCCCGCGACTTCGACAAG
GGCTATGGCCACTTCACCACGCGCCAGAACATCCAGTTCAACTGGATCAAGCTGAAGGACGCGCCGGAGATCCTCGACAA
GCTGGCCGAGGTTGATCTCCACGCCATCCAGACCAGCGGCAACTGCATCCGCAACACCACGTCCGACCCTTACGCCGGCG
CGACGGCCGAGGAGGTCGATGATCCGCGCGTGTGGTCCGAGGTGATCCGTCAGTGGTCGACCCTGCACCCGGAATTCTCG
TTCCTGCCGCGCAAGTTCAAGATCGCCATCACCGCCTCGGCCAAGGACCGCACGGCGGCCAAGGTGCACGACATCGGTCT
GATGCTGCGCAAGGGGCGTGACGGGACGCTCGGCTTTGAGGTGATCGTCGGCGGCGGGCAGGGGCGCACGCCCTATGTCG
GCCCGACCATCAACGAGTTCCTGCCGACCGACCGCCTGCTGAGCTATCTGGAAGCGGTGCTGCGCGTCTACAACCGCCAC
GGTCGGCGCGACAATATCTACAAGGCCCGGATCAAGATCCTGGTCGCCGCCCTCGGCGCCGAAGAGTTCGCCCGCCAGGT
CGACGAAGAGTGGGCCAAGATCGACGCCGCCCGCGCCGACCTGCCGACCGCAGAACTGGCCCGCATCCGCGCCGCCTTCG
CCAAGACCCCGTTCGAGACCTTGCCGGCGCGCTCTGACGCCTTTGAAACCGCCAAGGCCAATGACGCGGCCTTCGCGCGG
TTTGTGCGCAACAACGTCAAGCCGCACAAGCAGCCGGGCTACGCGATCGTCGAGGTCTCGCTGAAGGCTCAGGAGCAGAC
GCCGGGCGACGCTTCGGCGCAGCAGCTCGAAGTGGTCGCCGATCTCGCCGAACGGTTCAGCCTGAACGACCTGCGGGTCA
CCCATGCGCAGAACCTCGTCCTGCCGCACGTGAAGCTGGACGACCTGCCGACGGTGTTCGCGACGCTGCAGGCGTCCAAT
CTCGCAACGCCGAACATCGACCTCGTCAGCGACATCATCGCCTGCCCGGGCCTGGACTATTGCGCCCTGGCCAACGCCCG
GGCGATCCCGGTCGCGCAGGACATCGCGCGGCAGTTCGCGGACCTGGATCGCGCCGAAAAGGTCGGCGAGCTGAAGATCA
AGATCAGCGGCTGCATCAACGCCTGCGGCCACCACCACGTGGCCCACATCGGCATCCTGGGCGTCGATAAGAAGGGCGAG
GAGTTCTACCAGCTGTCGCTGGGCGGCTCGGGCGCCGAAGACGCCTCAATCGGCAAGATCCTGGGCCCGGCCTTGCCGGC
CGACAAGGTCGCCACGGCGGTCGATCAGCTGGTCGGCGCCTATCTCAACGTTCGAAACGACGGCGAGCGTTTCCTCGACA
CCTATCGCCGGGTCGGCCTCGAGCCCTTCAAGGAGGCGGTCTATGCCCAAGCTGATTGA

Upstream 100 bases:

>100_bases
GCAGGCCGAGGGCGGCGACGTTATCCAGGCGCTGCGTCACGCTGCGGGCGCGGCGCGCTCGACCGGTCGCGTTGACCTGA
TCCGCAGGAAGTAGGGCGGC

Downstream 100 bases:

>100_bases
GCTCGTTGACGGTGAGGCCCGCTGGGCCGAGGACACCTTCACCGCCCTGACCGACGAGGACGCGATCCCGCCCAGCGGCG
ACGTGATCCTGTCCCTGGCC

Product: sulfite reductase (NADPH) hemoprotein beta-component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MYQYDLIDKEFLADRSAEFRGQVARRLSGELTEDQFKPLRLMNGLYLQLHAYMLRVAIPYGSLNSTQARRLAQIARDFDK
GYGHFTTRQNIQFNWIKLKDAPEILDKLAEVDLHAIQTSGNCIRNTTSDPYAGATAEEVDDPRVWSEVIRQWSTLHPEFS
FLPRKFKIAITASAKDRTAAKVHDIGLMLRKGRDGTLGFEVIVGGGQGRTPYVGPTINEFLPTDRLLSYLEAVLRVYNRH
GRRDNIYKARIKILVAALGAEEFARQVDEEWAKIDAARADLPTAELARIRAAFAKTPFETLPARSDAFETAKANDAAFAR
FVRNNVKPHKQPGYAIVEVSLKAQEQTPGDASAQQLEVVADLAERFSLNDLRVTHAQNLVLPHVKLDDLPTVFATLQASN
LATPNIDLVSDIIACPGLDYCALANARAIPVAQDIARQFADLDRAEKVGELKIKISGCINACGHHHVAHIGILGVDKKGE
EFYQLSLGGSGAEDASIGKILGPALPADKVATAVDQLVGAYLNVRNDGERFLDTYRRVGLEPFKEAVYAQAD

Sequences:

>Translated_552_residues
MYQYDLIDKEFLADRSAEFRGQVARRLSGELTEDQFKPLRLMNGLYLQLHAYMLRVAIPYGSLNSTQARRLAQIARDFDK
GYGHFTTRQNIQFNWIKLKDAPEILDKLAEVDLHAIQTSGNCIRNTTSDPYAGATAEEVDDPRVWSEVIRQWSTLHPEFS
FLPRKFKIAITASAKDRTAAKVHDIGLMLRKGRDGTLGFEVIVGGGQGRTPYVGPTINEFLPTDRLLSYLEAVLRVYNRH
GRRDNIYKARIKILVAALGAEEFARQVDEEWAKIDAARADLPTAELARIRAAFAKTPFETLPARSDAFETAKANDAAFAR
FVRNNVKPHKQPGYAIVEVSLKAQEQTPGDASAQQLEVVADLAERFSLNDLRVTHAQNLVLPHVKLDDLPTVFATLQASN
LATPNIDLVSDIIACPGLDYCALANARAIPVAQDIARQFADLDRAEKVGELKIKISGCINACGHHHVAHIGILGVDKKGE
EFYQLSLGGSGAEDASIGKILGPALPADKVATAVDQLVGAYLNVRNDGERFLDTYRRVGLEPFKEAVYAQAD
>Mature_552_residues
MYQYDLIDKEFLADRSAEFRGQVARRLSGELTEDQFKPLRLMNGLYLQLHAYMLRVAIPYGSLNSTQARRLAQIARDFDK
GYGHFTTRQNIQFNWIKLKDAPEILDKLAEVDLHAIQTSGNCIRNTTSDPYAGATAEEVDDPRVWSEVIRQWSTLHPEFS
FLPRKFKIAITASAKDRTAAKVHDIGLMLRKGRDGTLGFEVIVGGGQGRTPYVGPTINEFLPTDRLLSYLEAVLRVYNRH
GRRDNIYKARIKILVAALGAEEFARQVDEEWAKIDAARADLPTAELARIRAAFAKTPFETLPARSDAFETAKANDAAFAR
FVRNNVKPHKQPGYAIVEVSLKAQEQTPGDASAQQLEVVADLAERFSLNDLRVTHAQNLVLPHVKLDDLPTVFATLQASN
LATPNIDLVSDIIACPGLDYCALANARAIPVAQDIARQFADLDRAEKVGELKIKISGCINACGHHHVAHIGILGVDKKGE
EFYQLSLGGSGAEDASIGKILGPALPADKVATAVDQLVGAYLNVRNDGERFLDTYRRVGLEPFKEAVYAQAD

Specific function: This Enzyme Catalyzes The 6-Electron Reduction Of Sulfite To Sulfide. This Is One Of Several Activities Required For The Biosynthesis Of L-Cysteine From Sulfate. [C]

COG id: COG0155

COG function: function code P; Sulfite reductase, beta subunit (hemoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family [H]

Homologues:

Organism=Escherichia coli, GI1789122, Length=586, Percent_Identity=23.037542662116, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005117
- InterPro:   IPR006067
- InterPro:   IPR006066 [H]

Pfam domain/function: PF01077 NIR_SIR; PF03460 NIR_SIR_ferr [H]

EC number: =1.8.7.1 [H]

Molecular weight: Translated: 61062; Mature: 61062

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQYDLIDKEFLADRSAEFRGQVARRLSGELTEDQFKPLRLMNGLYLQLHAYMLRVAIPY
CCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GSLNSTQARRLAQIARDFDKGYGHFTTRQNIQFNWIKLKDAPEILDKLAEVDLHAIQTSG
CCCCHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEEECCCHHHHHHHHHHHHHHEECCC
NCIRNTTSDPYAGATAEEVDDPRVWSEVIRQWSTLHPEFSFLPRKFKIAITASAKDRTAA
CEECCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCHHCCCCEEEEEEEECCCCCHHH
KVHDIGLMLRKGRDGTLGFEVIVGGGQGRTPYVGPTINEFLPTDRLLSYLEAVLRVYNRH
HHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHC
GRRDNIYKARIKILVAALGAEEFARQVDEEWAKIDAARADLPTAELARIRAAFAKTPFET
CCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHH
LPARSDAFETAKANDAAFARFVRNNVKPHKQPGYAIVEVSLKAQEQTPGDASAQQLEVVA
CCCCCCHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHH
DLAERFSLNDLRVTHAQNLVLPHVKLDDLPTVFATLQASNLATPNIDLVSDIIACPGLDY
HHHHHCCCCCEEEECCCCEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCH
CALANARAIPVAQDIARQFADLDRAEKVGELKIKISGCINACGHHHVAHIGILGVDKKGE
HHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHCCCCCEEEEEEEECCCCCC
EFYQLSLGGSGAEDASIGKILGPALPADKVATAVDQLVGAYLNVRNDGERFLDTYRRVGL
EEEEEECCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
EPFKEAVYAQAD
CHHHHHHHCCCC
>Mature Secondary Structure
MYQYDLIDKEFLADRSAEFRGQVARRLSGELTEDQFKPLRLMNGLYLQLHAYMLRVAIPY
CCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GSLNSTQARRLAQIARDFDKGYGHFTTRQNIQFNWIKLKDAPEILDKLAEVDLHAIQTSG
CCCCHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEEECCCHHHHHHHHHHHHHHEECCC
NCIRNTTSDPYAGATAEEVDDPRVWSEVIRQWSTLHPEFSFLPRKFKIAITASAKDRTAA
CEECCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCHHCCCCEEEEEEEECCCCCHHH
KVHDIGLMLRKGRDGTLGFEVIVGGGQGRTPYVGPTINEFLPTDRLLSYLEAVLRVYNRH
HHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHC
GRRDNIYKARIKILVAALGAEEFARQVDEEWAKIDAARADLPTAELARIRAAFAKTPFET
CCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHH
LPARSDAFETAKANDAAFARFVRNNVKPHKQPGYAIVEVSLKAQEQTPGDASAQQLEVVA
CCCCCCHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHH
DLAERFSLNDLRVTHAQNLVLPHVKLDDLPTVFATLQASNLATPNIDLVSDIIACPGLDY
HHHHHCCCCCEEEECCCCEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCH
CALANARAIPVAQDIARQFADLDRAEKVGELKIKISGCINACGHHHVAHIGILGVDKKGE
HHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHCCCCCEEEEEEEECCCCCC
EFYQLSLGGSGAEDASIGKILGPALPADKVATAVDQLVGAYLNVRNDGERFLDTYRRVGL
EEEEEECCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
EPFKEAVYAQAD
CHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA