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The map label for this gene is panE [C]

Identifier: 16124516

GI number: 16124516

Start: 274921

End: 275793

Strand: Direct

Name: panE [C]

Synonym: CC_0261

Alternate gene names: 16124516

Gene position: 274921-275793 (Clockwise)

Preceding gene: 16124515

Following gene: 16124519

Centisome position: 6.84

GC content: 72.51

Gene sequence:

>873_bases
ATGACCAGTATCGCCGTGATCGGCCCGGGCGCCGTCGGTGGAACGCTCGCCGCCTGGCTGGCCCAGAAGCCTGACCACGT
GGTGACCGTCTGCGTCCGCACGCCGTTCGAGGCCCTGGCGGTCGAGACGCCGGAGGGGGCCATTAGCGCCACCCCGCGCG
TAGCGACCTCGCCGGAGAGCCTCGCGCCCGTCGACTGGGTGCTGGTGACGACCAAGACCTACGACACCGACGCGACCTGG
ACCTGGCTGGACGCTCTGGTTGGGCCGCAGACCCGCGTGGCCATCCTGCGCAACGGCGTCGAGCACGTCGCGCCGTTCGT
GGGCAAGATCGCCGCCGAGCGGCTGGTTCCGGCGGTGGTCGACATCCCGGCCGAGCGCTCGGCGCCGGGGCGGATGCTGC
AGCGGCGCAACGGCTGGATCAAGGTTCCCGTTGGGCCGGCCGGTGAGGCCTTTGCAGCGCTGTTCGCCCACACGCCCATA
GAGTTGCACGTCGTCGAAGACTTCGTCACCGAGGCCTGGAAGAAGCTGGCCCTCAACTGCGCCGGGGCGGTCAACGCCCT
GGTGCTCAAGCCCGCCGGGATCGCCCATGACGAGGGCGCGGCCCAGGTCATGCGGTCGCTGGTGCGCGAGTGCGTGGCCG
TGGGCCGGGCCGAGGGCGCCGATCTCTCCGACGATCTGCCCGATCAGGTCATCGCCGGCTATCGCGCCGCCGATCCGGGC
TCGGTCAACTCGCTGCACGCCGACCGCGCGGCGGGCCGGGCCATGGAGCTGGACGCCCGCAACGGCGTCATCGTCCGCCG
GGGCGCCGCGCACGGGATCGCCACGCCCGCCAACGCCATGGTGGTGGCGCTGCTGAACGCGGCGGCGCTCTGA

Upstream 100 bases:

>100_bases
GTTTCCCGGCGTCGCCCGCGCGACCCCTCACCCGGCCCGGCGAGGGCCGGGCCACCCTCTCCCGCAAGGGGAGAGGGTTT
TGTTTTGAGCGGAGCATCCC

Downstream 100 bases:

>100_bases
GGCGCGCGCGCCGCCGAGGCCTTACGGCCGGTGCTTCTTCGGCAGGGCCTGAACCTCTTCCGGCGTCAGCTTGGTGATGG
TCTTGGCGCGGATCGGCAGG

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MTSIAVIGPGAVGGTLAAWLAQKPDHVVTVCVRTPFEALAVETPEGAISATPRVATSPESLAPVDWVLVTTKTYDTDATW
TWLDALVGPQTRVAILRNGVEHVAPFVGKIAAERLVPAVVDIPAERSAPGRMLQRRNGWIKVPVGPAGEAFAALFAHTPI
ELHVVEDFVTEAWKKLALNCAGAVNALVLKPAGIAHDEGAAQVMRSLVRECVAVGRAEGADLSDDLPDQVIAGYRAADPG
SVNSLHADRAAGRAMELDARNGVIVRRGAAHGIATPANAMVVALLNAAAL

Sequences:

>Translated_290_residues
MTSIAVIGPGAVGGTLAAWLAQKPDHVVTVCVRTPFEALAVETPEGAISATPRVATSPESLAPVDWVLVTTKTYDTDATW
TWLDALVGPQTRVAILRNGVEHVAPFVGKIAAERLVPAVVDIPAERSAPGRMLQRRNGWIKVPVGPAGEAFAALFAHTPI
ELHVVEDFVTEAWKKLALNCAGAVNALVLKPAGIAHDEGAAQVMRSLVRECVAVGRAEGADLSDDLPDQVIAGYRAADPG
SVNSLHADRAAGRAMELDARNGVIVRRGAAHGIATPANAMVVALLNAAAL
>Mature_289_residues
TSIAVIGPGAVGGTLAAWLAQKPDHVVTVCVRTPFEALAVETPEGAISATPRVATSPESLAPVDWVLVTTKTYDTDATWT
WLDALVGPQTRVAILRNGVEHVAPFVGKIAAERLVPAVVDIPAERSAPGRMLQRRNGWIKVPVGPAGEAFAALFAHTPIE
LHVVEDFVTEAWKKLALNCAGAVNALVLKPAGIAHDEGAAQVMRSLVRECVAVGRAEGADLSDDLPDQVIAGYRAADPGS
VNSLHADRAAGRAMELDARNGVIVRRGAAHGIATPANAMVVALLNAAAL

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANE_CAUCR (Q9ABG6)

Other databases:

- EMBL:   AE005673
- PIR:   D87281
- RefSeq:   NP_419080.1
- ProteinModelPortal:   Q9ABG6
- SMR:   Q9ABG6
- GeneID:   942395
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_0261
- NMPDR:   fig|190650.1.peg.260
- TIGR:   CC_0261
- HOGENOM:   HBG668370
- OMA:   VCALQNG
- ProtClustDB:   PRK06522
- BRENDA:   1.1.1.169
- GO:   GO:0005737
- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21708:SF21
- TIGRFAMs:   TIGR00745

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.169

Molecular weight: Translated: 30189; Mature: 30058

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: ACT_SITE 175-175 BINDING 98-98 BINDING 98-98 BINDING 179-179 BINDING 244-244 BINDING 256-256

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSIAVIGPGAVGGTLAAWLAQKPDHVVTVCVRTPFEALAVETPEGAISATPRVATSPES
CCEEEEEECCCHHHHHHHHHHCCCCCEEEEEEECCHHHHEEECCCCCCCCCCCCCCCCCC
LAPVDWVLVTTKTYDTDATWTWLDALVGPQTRVAILRNGVEHVAPFVGKIAAERLVPAVV
CCCCEEEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
DIPAERSAPGRMLQRRNGWIKVPVGPAGEAFAALFAHTPIELHVVEDFVTEAWKKLALNC
CCCCCCCCCHHHHHHCCCEEEECCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHH
AGAVNALVLKPAGIAHDEGAAQVMRSLVRECVAVGRAEGADLSDDLPDQVIAGYRAADPG
HHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCC
SVNSLHADRAAGRAMELDARNGVIVRRGAAHGIATPANAMVVALLNAAAL
CCCCHHHHHHCCCEEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSIAVIGPGAVGGTLAAWLAQKPDHVVTVCVRTPFEALAVETPEGAISATPRVATSPES
CEEEEEECCCHHHHHHHHHHCCCCCEEEEEEECCHHHHEEECCCCCCCCCCCCCCCCCC
LAPVDWVLVTTKTYDTDATWTWLDALVGPQTRVAILRNGVEHVAPFVGKIAAERLVPAVV
CCCCEEEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
DIPAERSAPGRMLQRRNGWIKVPVGPAGEAFAALFAHTPIELHVVEDFVTEAWKKLALNC
CCCCCCCCCHHHHHHCCCEEEECCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHH
AGAVNALVLKPAGIAHDEGAAQVMRSLVRECVAVGRAEGADLSDDLPDQVIAGYRAADPG
HHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCC
SVNSLHADRAAGRAMELDARNGVIVRRGAAHGIATPANAMVVALLNAAAL
CCCCHHHHHHCCCEEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647