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The map label for this gene is rncS [H]

Identifier: 161621443

GI number: 161621443

Start: 6428368

End: 6429081

Strand: Direct

Name: rncS [H]

Synonym: mlr7765

Alternate gene names: 161621443

Gene position: 6428368-6429081 (Clockwise)

Preceding gene: 13476441

Following gene: 13476443

Centisome position: 91.36

GC content: 66.95

Gene sequence:

>714_bases
ATGGCGGCAACAAAGCGGTTGACCGCCGATGCGCTCGCCGAAGCGCTGGTGGAACGGACGGGCCATGCCTTTGCCGATCG
CCAGCGCCTGCAGCGCGCGCTCACCCATGCCAGCGCCCGCGGCGCCAATGCCGGCACCGATTACGAGCGTTTCGAATTTC
TCGGTGACCGGGTTCTCGGCCTGGTCGTCGCCGACATGCTGCTGGCGGCGTTTCCCGACGCGGCGGAAGGCGAATTGTCG
CTGCGGCTCAATGCGCTGGTCAATGCCGAGGCACTTTCCGAGATCGCCGAACATATCGGGCTGCCGGACCTGATCCGCGC
CGGATCGGATGTGCGCGGGCTCGAGGGGCGCAAGCGCGTCAATCTGCGCGCCGACGCCTTGGAATCGCTGATCGCCGTGC
TCTATCTCGACGGCGGGCTGGAGGCGGCACGCGCCTTCATCCACAAATACTGGCAGCCGCGTTCGCAGGCTTCCGGTGCG
GCGCGCCGCGACGCCAAGACCGAATTGCAGGAATGGGCGCATCAGGCGGCCAGTGCCGTTCCGGCCTACCAGATCGACAG
CCGCGAGGGGCCGGACCACGATCCGTTGTTCACCGTCAGTGTGAGGGTCGGTGCATTTCAGCCGGCGACCGGCAGCGGTC
GTTCTAAACGTGAAGCGGAGCAGGCAGCCGCGGCTGCCCTTCTGCTGCGCGAAGGTGTATGGAACGCGGCATGA

Upstream 100 bases:

>100_bases
GTCTTCTTCTCGATCGCCGGCAAGGCAAGCCCTCTCGAAATCTGGAAATGGCCGTCGCTGATGCGCGTTTCGCGCCTGTT
CCATTTCGTCAATTAGGGTC

Downstream 100 bases:

>100_bases
CCGATATTGAAACTGCAGAAACCCCCGCCACGCATTCCGGCTTCGTCGCGCTGATCGGCGCGCCGAATGCCGGCAAGTCG
ACGCTGGTCAACCAGTTGGT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MAATKRLTADALAEALVERTGHAFADRQRLQRALTHASARGANAGTDYERFEFLGDRVLGLVVADMLLAAFPDAAEGELS
LRLNALVNAEALSEIAEHIGLPDLIRAGSDVRGLEGRKRVNLRADALESLIAVLYLDGGLEAARAFIHKYWQPRSQASGA
ARRDAKTELQEWAHQAASAVPAYQIDSREGPDHDPLFTVSVRVGAFQPATGSGRSKREAEQAAAAALLLREGVWNAA

Sequences:

>Translated_237_residues
MAATKRLTADALAEALVERTGHAFADRQRLQRALTHASARGANAGTDYERFEFLGDRVLGLVVADMLLAAFPDAAEGELS
LRLNALVNAEALSEIAEHIGLPDLIRAGSDVRGLEGRKRVNLRADALESLIAVLYLDGGLEAARAFIHKYWQPRSQASGA
ARRDAKTELQEWAHQAASAVPAYQIDSREGPDHDPLFTVSVRVGAFQPATGSGRSKREAEQAAAAALLLREGVWNAA
>Mature_236_residues
AATKRLTADALAEALVERTGHAFADRQRLQRALTHASARGANAGTDYERFEFLGDRVLGLVVADMLLAAFPDAAEGELSL
RLNALVNAEALSEIAEHIGLPDLIRAGSDVRGLEGRKRVNLRADALESLIAVLYLDGGLEAARAFIHKYWQPRSQASGAA
RRDAKTELQEWAHQAASAVPAYQIDSREGPDHDPLFTVSVRVGAFQPATGSGRSKREAEQAAAAALLLREGVWNAA

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=220, Percent_Identity=31.3636363636364, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI155030236, Length=220, Percent_Identity=31.3636363636364, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI1788920, Length=206, Percent_Identity=33.0097087378641, Blast_Score=108, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193202651, Length=224, Percent_Identity=29.0178571428571, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17506883, Length=224, Percent_Identity=29.0178571428571, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137682, Length=214, Percent_Identity=30.8411214953271, Blast_Score=81, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25459; Mature: 25328

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATKRLTADALAEALVERTGHAFADRQRLQRALTHASARGANAGTDYERFEFLGDRVLG
CCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LVVADMLLAAFPDAAEGELSLRLNALVNAEALSEIAEHIGLPDLIRAGSDVRGLEGRKRV
HHHHHHHHHHCCCCCCCCCEEHHHHHHCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHC
NLRADALESLIAVLYLDGGLEAARAFIHKYWQPRSQASGAARRDAKTELQEWAHQAASAV
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHCC
PAYQIDSREGPDHDPLFTVSVRVGAFQPATGSGRSKREAEQAAAAALLLREGVWNAA
CCEECCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AATKRLTADALAEALVERTGHAFADRQRLQRALTHASARGANAGTDYERFEFLGDRVLG
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LVVADMLLAAFPDAAEGELSLRLNALVNAEALSEIAEHIGLPDLIRAGSDVRGLEGRKRV
HHHHHHHHHHCCCCCCCCCEEHHHHHHCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHC
NLRADALESLIAVLYLDGGLEAARAFIHKYWQPRSQASGAARRDAKTELQEWAHQAASAV
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHCC
PAYQIDSREGPDHDPLFTVSVRVGAFQPATGSGRSKREAEQAAAAALLLREGVWNAA
CCEECCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]