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The map label for this gene is pgsA1 [H]

Identifier: 13476594

GI number: 13476594

Start: 6569498

End: 6570055

Strand: Direct

Name: pgsA1 [H]

Synonym: mlr7964

Alternate gene names: 13476594

Gene position: 6569498-6570055 (Clockwise)

Preceding gene: 13476590

Following gene: 13476595

Centisome position: 93.37

GC content: 61.83

Gene sequence:

>558_bases
TTGACCATCCCCAACCTGATCACCATCCTGCGCCTTCTCCTGGTGCCTGCCGTGGTGCTGGCCATGCTGCAGGCGCGCTG
GGACTGGGCCTTTGCCGGCTTCGTCATTGCCGGCGTGTCGGATGGCGTCGACGGTTTCATCGCCCGCCGTTTCAACCAGC
AGTCCGAACTCGGTGCCTATCTCGATCCGATGGCCGACAAGCTACTGTTGGTTTCGGTGTTCGTCGTCATGGGCTTCATC
GGGCAATTGCCGCTGTGGCTGGTCGTCACCATGGTGTCGCGCGATGCGCTGATCGTCTGCGCGGTTCTGTTGTCCACGGT
TATGGCGCATCCGGTCGAGATAAAGCCCTTCCTGGTGTCGAAGGCCAATACAGCCATCCAGATCGTGCTGGCGGCGGTTG
TGCTGGGCGAGCTTGCCTTTGCCCTGCACCTCGACCCGCTGCGGCCAGCCCTCATATTGCTGTCCGGGGTCTTGACCGTG
GCTTCGGCCGCAGCCTATCTCGTGGCTTGGCTGAGGCATATGAGCGGCTATGGCGAAGGCTCCAATCCGGAAATCTGA

Upstream 100 bases:

>100_bases
TGGCGTCGGGTTTGGCGCTCGCGCCTGGAACGGACTGTCCCTTGTGGCGGCTCTCCATCTCCTTCATCTATCTCGAAACA
GCGCATGGCGGGACAATGCA

Downstream 100 bases:

>100_bases
GGAAGAAGCGGCGGTGATCGAGGCCGCGGCTGCCGATCTTGCCGCGGCCTCCGCGTTCCGCCGGCAGATCTCCTTCTGGG
TGGCCGGCGTCGCAGGACTT

Product: hypothetical protein

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MTIPNLITILRLLLVPAVVLAMLQARWDWAFAGFVIAGVSDGVDGFIARRFNQQSELGAYLDPMADKLLLVSVFVVMGFI
GQLPLWLVVTMVSRDALIVCAVLLSTVMAHPVEIKPFLVSKANTAIQIVLAAVVLGELAFALHLDPLRPALILLSGVLTV
ASAAAYLVAWLRHMSGYGEGSNPEI

Sequences:

>Translated_185_residues
MTIPNLITILRLLLVPAVVLAMLQARWDWAFAGFVIAGVSDGVDGFIARRFNQQSELGAYLDPMADKLLLVSVFVVMGFI
GQLPLWLVVTMVSRDALIVCAVLLSTVMAHPVEIKPFLVSKANTAIQIVLAAVVLGELAFALHLDPLRPALILLSGVLTV
ASAAAYLVAWLRHMSGYGEGSNPEI
>Mature_184_residues
TIPNLITILRLLLVPAVVLAMLQARWDWAFAGFVIAGVSDGVDGFIARRFNQQSELGAYLDPMADKLLLVSVFVVMGFIG
QLPLWLVVTMVSRDALIVCAVLLSTVMAHPVEIKPFLVSKANTAIQIVLAAVVLGELAFALHLDPLRPALILLSGVLTVA
SAAAYLVAWLRHMSGYGEGSNPEI

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=181, Percent_Identity=31.4917127071823, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI10092647, Length=181, Percent_Identity=31.4917127071823, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI1788220, Length=176, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71984834, Length=155, Percent_Identity=34.8387096774194, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71984838, Length=155, Percent_Identity=34.8387096774194, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24650130, Length=191, Percent_Identity=31.9371727748691, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24650126, Length=191, Percent_Identity=31.9371727748691, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24650128, Length=191, Percent_Identity=31.9371727748691, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 19876; Mature: 19745

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPNLITILRLLLVPAVVLAMLQARWDWAFAGFVIAGVSDGVDGFIARRFNQQSELGAY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHH
LDPMADKLLLVSVFVVMGFIGQLPLWLVVTMVSRDALIVCAVLLSTVMAHPVEIKPFLVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KANTAIQIVLAAVVLGELAFALHLDPLRPALILLSGVLTVASAAAYLVAWLRHMSGYGEG
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SNPEI
CCCCC
>Mature Secondary Structure 
TIPNLITILRLLLVPAVVLAMLQARWDWAFAGFVIAGVSDGVDGFIARRFNQQSELGAY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHH
LDPMADKLLLVSVFVVMGFIGQLPLWLVVTMVSRDALIVCAVLLSTVMAHPVEIKPFLVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KANTAIQIVLAAVVLGELAFALHLDPLRPALILLSGVLTVASAAAYLVAWLRHMSGYGEG
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SNPEI
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]