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The map label for this gene is uvrC

Identifier: 13476555

GI number: 13476555

Start: 6535503

End: 6537569

Strand: Direct

Name: uvrC

Synonym: mlr7912

Alternate gene names: 13476555

Gene position: 6535503-6537569 (Clockwise)

Preceding gene: 13476554

Following gene: 13476556

Centisome position: 92.89

GC content: 63.62

Gene sequence:

>2067_bases
ATGAGTCCTTTAGACCAAAAGAACAAGCCGCGTGGCGGGGCCGATGACCTGCCTCCCGAAATCGACCTTGAGGATGAGGC
GCTGGAGGAGATCGTCGAACCGACAGGTCCGGATGTCGCCTTCACGGCCATCGACTGGACGCCGCATGCCGGGGATGCCG
AAGGCATGGTCGGCGCCGAGGTGATCCAGACCTTGGTCAAGCGGCTGCCCAACGCGCCCGGCGTCTACCGCATGATGAAC
GCCGCAGGCGACGTGCTCTATGTCGGCAAGGCGCGCAGCCTGAAGAAGCGCGTCACTAACTACGCGCAAGGCCGGTTCCA
CACCAACCGTATCGGCCGCATGGTGCGCGAGACGTCGACGATGGAATTCGTCGTCACCCGCACCGAGATCGAGGCGCTGC
TGCTCGAAGCCAATCTTATCAAGCGCCTGCGGCCGCGATTCAACGTGCTGATGCGCGACGACAAGTCGTTCCCCTATATC
CTTTTGACTGGCGACCATGTCTCGCCCGGCATCTACAAGCATCGTGGCGCGCGGTCGCGAAAGGGCGATTATTTCGGCCC
CTTTGCCTCGGCCGGCGCCGTCGGCCGCACCATCAATTCGCTGCAGCGCGCCTTCCTGCTGCGCAGCTGCACCAACTCGT
TCTACGAAAACCGCACCCGGCCATGCCTGCTCTATCAGATCAAGCGCTGCGCCGGCCCCTGCACCGGCGAAATCTCGCAT
GAGGGCTATGCCGAACTGGTCGCCGAGGCGAAGGATTTTTTGTCCGGCCGCAGCCAGAAGGTGAAGACCGAGATTTCGGC
CGCCATGCAGCAGGCCTCCGAGGACCTCGATTTCGAACGTGCCGCCATCTATCGCGACCGGCTGGCCGCCCTGTCGCATG
TGCAGAGCCATCAGGGCATCAATCCCGCGACCGTCGACGAGGCCGATGTCTTCGCCATCCATCAGGAAGGCGGCCAGGTC
TGCATCCAGGTGTTCTTCTTCCGCACTGGCCAGAACTGGGGCAACCGCGCCTATTTCCCGAAAGCCGATCCGGCCCTGGA
AGCGGCCGAGGTATTGGGCTCGTTCCTGGCGCAGTTCTACGACGACAAGCCGACGCCGCGGAACATTCTGCTGTCGCGCG
GCGTCGAGGACCAGGAATTGCTGGGCGAGGCGCTGTCCACCCGCGCTGGCCGCAAGGTTACGATCTCTGTGCCGCAGCGC
GGCGAGAAGAAGGACCTGACCGACAATGCCTTGCAGAACGCCCGTGAGGCGTTGGGCCGCAGGCTGGCCGAAACCTCGAC
GCAAGGACGGTTGCTTGCCGGTTTCGCCGAGACCTTCGGCCTGGCCAAGCCACCGGTGCGCATCGAGGTCTACGACAACT
CGCACATCATGGGTACCAATGCCGTCGGCGCCATGGTTGTCGCGGGGCCGGAAGGGTTTGTGAAAAACCAGTACCGGAAA
TTCAACATCCGCTCGACCGAGATCACGCCGGGCGACGATTTCGGCATGATGCGCGAGGTGATGGAGCGGCGCTTTTCGCG
ACTGCTCAAGGAGCATGGCGATGTCGCGCCCAACGACGCGGCCTCGGCGGAAGCGGGTGATGATATCGAAGACGACATCT
CCGGCAGCTTCCCAGCCTGGCCCGACGTCATCTTGATCGATGGCGGCCAGGGCCAGATGACGGCGGTGCGCAAGATTCTC
GCCGATCTCGGCATTGAGGACCGCGTCGTGGCGATCGGCATCGCCAAGGGCCAGGACCGCGATGCCGGCCGCGAGCGCTT
TTTCGTCAAGGGCAGGGATTCTTTTTCGCTGCCGGTGCGCGACCCTGTTCTCTATTTCGTCCAGCGGCTGCGCGACGAGG
TCCATCGCTTCGCCATCGGCTCGCACCGGGCGCGGCGCAAGAAGGAGATGGTCAAGAGCCCGCTCGACGAGATCGCCGGC
ATCGGCCCCGGCCGCAAGCGGGCGCTGCTGCTGGCATTCGGCACCGCCAAGGCCGTCAGCCGTGCCGCGATCGAGGATCT
GAGGAAAGTCGACGGTATTTCCGAACAGGTCGCCAAACTGGTCTACAATCATTTCCACGAAAGTTGA

Upstream 100 bases:

>100_bases
GCTATCTCTGGGATGCGCGCTCGGTCACCGGTCAGATGATCGCGCTCGATGGCGGCCAGCATCTTGCATGGCAGACGCCC
GATGTGACAGGCATGACGGA

Downstream 100 bases:

>100_bases
AAATTCGGCACTTTCCGCTGGTCAGTCGAATCTGGCCTGTTGACCCCCTACATTGGCTTCTGATTTGAGTACGCAGGCAG
AAAGAGTCCACCAGACATGG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 688; Mature: 687

Protein sequence:

>688_residues
MSPLDQKNKPRGGADDLPPEIDLEDEALEEIVEPTGPDVAFTAIDWTPHAGDAEGMVGAEVIQTLVKRLPNAPGVYRMMN
AAGDVLYVGKARSLKKRVTNYAQGRFHTNRIGRMVRETSTMEFVVTRTEIEALLLEANLIKRLRPRFNVLMRDDKSFPYI
LLTGDHVSPGIYKHRGARSRKGDYFGPFASAGAVGRTINSLQRAFLLRSCTNSFYENRTRPCLLYQIKRCAGPCTGEISH
EGYAELVAEAKDFLSGRSQKVKTEISAAMQQASEDLDFERAAIYRDRLAALSHVQSHQGINPATVDEADVFAIHQEGGQV
CIQVFFFRTGQNWGNRAYFPKADPALEAAEVLGSFLAQFYDDKPTPRNILLSRGVEDQELLGEALSTRAGRKVTISVPQR
GEKKDLTDNALQNAREALGRRLAETSTQGRLLAGFAETFGLAKPPVRIEVYDNSHIMGTNAVGAMVVAGPEGFVKNQYRK
FNIRSTEITPGDDFGMMREVMERRFSRLLKEHGDVAPNDAASAEAGDDIEDDISGSFPAWPDVILIDGGQGQMTAVRKIL
ADLGIEDRVVAIGIAKGQDRDAGRERFFVKGRDSFSLPVRDPVLYFVQRLRDEVHRFAIGSHRARRKKEMVKSPLDEIAG
IGPGRKRALLLAFGTAKAVSRAAIEDLRKVDGISEQVAKLVYNHFHES

Sequences:

>Translated_688_residues
MSPLDQKNKPRGGADDLPPEIDLEDEALEEIVEPTGPDVAFTAIDWTPHAGDAEGMVGAEVIQTLVKRLPNAPGVYRMMN
AAGDVLYVGKARSLKKRVTNYAQGRFHTNRIGRMVRETSTMEFVVTRTEIEALLLEANLIKRLRPRFNVLMRDDKSFPYI
LLTGDHVSPGIYKHRGARSRKGDYFGPFASAGAVGRTINSLQRAFLLRSCTNSFYENRTRPCLLYQIKRCAGPCTGEISH
EGYAELVAEAKDFLSGRSQKVKTEISAAMQQASEDLDFERAAIYRDRLAALSHVQSHQGINPATVDEADVFAIHQEGGQV
CIQVFFFRTGQNWGNRAYFPKADPALEAAEVLGSFLAQFYDDKPTPRNILLSRGVEDQELLGEALSTRAGRKVTISVPQR
GEKKDLTDNALQNAREALGRRLAETSTQGRLLAGFAETFGLAKPPVRIEVYDNSHIMGTNAVGAMVVAGPEGFVKNQYRK
FNIRSTEITPGDDFGMMREVMERRFSRLLKEHGDVAPNDAASAEAGDDIEDDISGSFPAWPDVILIDGGQGQMTAVRKIL
ADLGIEDRVVAIGIAKGQDRDAGRERFFVKGRDSFSLPVRDPVLYFVQRLRDEVHRFAIGSHRARRKKEMVKSPLDEIAG
IGPGRKRALLLAFGTAKAVSRAAIEDLRKVDGISEQVAKLVYNHFHES
>Mature_687_residues
SPLDQKNKPRGGADDLPPEIDLEDEALEEIVEPTGPDVAFTAIDWTPHAGDAEGMVGAEVIQTLVKRLPNAPGVYRMMNA
AGDVLYVGKARSLKKRVTNYAQGRFHTNRIGRMVRETSTMEFVVTRTEIEALLLEANLIKRLRPRFNVLMRDDKSFPYIL
LTGDHVSPGIYKHRGARSRKGDYFGPFASAGAVGRTINSLQRAFLLRSCTNSFYENRTRPCLLYQIKRCAGPCTGEISHE
GYAELVAEAKDFLSGRSQKVKTEISAAMQQASEDLDFERAAIYRDRLAALSHVQSHQGINPATVDEADVFAIHQEGGQVC
IQVFFFRTGQNWGNRAYFPKADPALEAAEVLGSFLAQFYDDKPTPRNILLSRGVEDQELLGEALSTRAGRKVTISVPQRG
EKKDLTDNALQNAREALGRRLAETSTQGRLLAGFAETFGLAKPPVRIEVYDNSHIMGTNAVGAMVVAGPEGFVKNQYRKF
NIRSTEITPGDDFGMMREVMERRFSRLLKEHGDVAPNDAASAEAGDDIEDDISGSFPAWPDVILIDGGQGQMTAVRKILA
DLGIEDRVVAIGIAKGQDRDAGRERFFVKGRDSFSLPVRDPVLYFVQRLRDEVHRFAIGSHRARRKKEMVKSPLDEIAGI
GPGRKRALLLAFGTAKAVSRAAIEDLRKVDGISEQVAKLVYNHFHES

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=630, Percent_Identity=39.6825396825397, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1788037, Length=188, Percent_Identity=30.8510638297872, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_RHILO (Q984P3)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_108125.1
- HSSP:   Q9WYA3
- ProteinModelPortal:   Q984P3
- GeneID:   1230777
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr7912
- NMPDR:   fig|266835.1.peg.6224
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 76148; Mature: 76017

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPLDQKNKPRGGADDLPPEIDLEDEALEEIVEPTGPDVAFTAIDWTPHAGDAEGMVGAE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHH
VIQTLVKRLPNAPGVYRMMNAAGDVLYVGKARSLKKRVTNYAQGRFHTNRIGRMVRETST
HHHHHHHHCCCCCCHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
MEFVVTRTEIEALLLEANLIKRLRPRFNVLMRDDKSFPYILLTGDHVSPGIYKHRGARSR
EEEEEEHHHHHHHHHHHHHHHHHCHHHCEEEECCCCCCEEEEECCCCCCCHHHHCCCCCC
KGDYFGPFASAGAVGRTINSLQRAFLLRSCTNSFYENRTRPCLLYQIKRCAGPCTGEISH
CCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC
EGYAELVAEAKDFLSGRSQKVKTEISAAMQQASEDLDFERAAIYRDRLAALSHVQSHQGI
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
NPATVDEADVFAIHQEGGQVCIQVFFFRTGQNWGNRAYFPKADPALEAAEVLGSFLAQFY
CCCCCCCCCEEEEECCCCCEEEHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
DDKPTPRNILLSRGVEDQELLGEALSTRAGRKVTISVPQRGEKKDLTDNALQNAREALGR
CCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
RLAETSTQGRLLAGFAETFGLAKPPVRIEVYDNSHIMGTNAVGAMVVAGPEGFVKNQYRK
HHHHCCCCCCHHHHHHHHCCCCCCCEEEEEECCCEEEECCCCCEEEEECCCHHHHCCCEE
FNIRSTEITPGDDFGMMREVMERRFSRLLKEHGDVAPNDAASAEAGDDIEDDISGSFPAW
ECCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCC
PDVILIDGGQGQMTAVRKILADLGIEDRVVAIGIAKGQDRDAGRERFFVKGRDSFSLPVR
CCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCC
DPVLYFVQRLRDEVHRFAIGSHRARRKKEMVKSPLDEIAGIGPGRKRALLLAFGTAKAVS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCEEEEEEECCHHHHH
RAAIEDLRKVDGISEQVAKLVYNHFHES
HHHHHHHHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SPLDQKNKPRGGADDLPPEIDLEDEALEEIVEPTGPDVAFTAIDWTPHAGDAEGMVGAE
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHH
VIQTLVKRLPNAPGVYRMMNAAGDVLYVGKARSLKKRVTNYAQGRFHTNRIGRMVRETST
HHHHHHHHCCCCCCHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
MEFVVTRTEIEALLLEANLIKRLRPRFNVLMRDDKSFPYILLTGDHVSPGIYKHRGARSR
EEEEEEHHHHHHHHHHHHHHHHHCHHHCEEEECCCCCCEEEEECCCCCCCHHHHCCCCCC
KGDYFGPFASAGAVGRTINSLQRAFLLRSCTNSFYENRTRPCLLYQIKRCAGPCTGEISH
CCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC
EGYAELVAEAKDFLSGRSQKVKTEISAAMQQASEDLDFERAAIYRDRLAALSHVQSHQGI
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
NPATVDEADVFAIHQEGGQVCIQVFFFRTGQNWGNRAYFPKADPALEAAEVLGSFLAQFY
CCCCCCCCCEEEEECCCCCEEEHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
DDKPTPRNILLSRGVEDQELLGEALSTRAGRKVTISVPQRGEKKDLTDNALQNAREALGR
CCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
RLAETSTQGRLLAGFAETFGLAKPPVRIEVYDNSHIMGTNAVGAMVVAGPEGFVKNQYRK
HHHHCCCCCCHHHHHHHHCCCCCCCEEEEEECCCEEEECCCCCEEEEECCCHHHHCCCEE
FNIRSTEITPGDDFGMMREVMERRFSRLLKEHGDVAPNDAASAEAGDDIEDDISGSFPAW
ECCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCC
PDVILIDGGQGQMTAVRKILADLGIEDRVVAIGIAKGQDRDAGRERFFVKGRDSFSLPVR
CCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCC
DPVLYFVQRLRDEVHRFAIGSHRARRKKEMVKSPLDEIAGIGPGRKRALLLAFGTAKAVS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCEEEEEEECCHHHHH
RAAIEDLRKVDGISEQVAKLVYNHFHES
HHHHHHHHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968