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The map label for this gene is alsR [H]

Identifier: 13476479

GI number: 13476479

Start: 6461049

End: 6461939

Strand: Direct

Name: alsR [H]

Synonym: mlr7811

Alternate gene names: 13476479

Gene position: 6461049-6461939 (Clockwise)

Preceding gene: 13476478

Following gene: 13476481

Centisome position: 91.83

GC content: 67.12

Gene sequence:

>891_bases
ATGTTCGACCTGCGCCAGCTCCGCTACTTCATCACGGTCGCCGAAACCGGCAATGTCGGTCGCGCCGCCGAAATCCTGCA
CATTTCGCAATCGCCGCTCAGCCGGCAGATCATGCAGCTCGAGGAGCAGCTGGGCGTCGCCCTGTTCGAGAGGGCAAGGC
AGCGGGTTCATCTCAATGCCGAGGGCCGCGCCTTTCTCACCGAGGCCCGCGCACTGATTGCCAATGCGCGGCGCGTGGAG
GAGTTCGGCCGCAGCCTCGCCAGCGGCGCGGTCGGCCGTCTCGCCATCGGCTATGTCGAGGGCGCCGTGCATGCTGGGTT
GGTCGCCGGCATGCTCGGGCAATTTCGCCGCGAGCGGCCGCAATTGCATCTCAGCCTGATGAGCCTCCGCTCCGCCGCAC
AACTGGAAGGGCTGCACCTGCGCACGCTCGATCTCGGCCTGGTCTATTCACCGCCGCCGGCCGACTATCCTGAAATTGCC
TCGATGCTGGTCCGCCGCGAGCCATTGGTGCTGGCGATACCCGAGGGCGATGCGCTTACGGCTGTCGCCGACATCGGCCC
GCATCACCTCGACGGGCGCCCGTGGGTCACCGTGGTGCGCCAGCCCGCCGACACCAACCGCGGCCAGTTCCTGGCCGCTT
GCATCGAGGCCGGCTTCGTGCCCGACATCGCCTATGAGACCGCCGATCCGTTGACCTCGCTTGGCCTGGTCAGCGCCGGA
TTGGGCCTGGCGACGGTGCAGCAAAGCCTGCGAAGCGCCGCGCCGCCGGGAATAGTCTTCCGCGACCTTCCCTGGTTCAA
GCGCAGCGTGGCGATTTATCTCGCCTGGCGCCGGCAGGATGAGCGCGCGGTGATTGGGGATTTGCGGAAGGCAGTAGGCA
GTAGGCAGTAG

Upstream 100 bases:

>100_bases
CTTTGGTTGGGATGACCGAATATCCCTGAGACTGGTCAGACTGTCCAAGACTGATTAGGATAGAGTTCAGACCTGTAAGG
ACTTGATCGCCAGGGAAAAG

Downstream 100 bases:

>100_bases
GCAAGCCCTATTCCCCACTTCCTATTCCCTACATCTTGTCGATCACCGACTGCACGCCCTCGGTCGGGGCGTCGACGGAA
GAGCCTGCCACCATGATGGC

Product: transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MFDLRQLRYFITVAETGNVGRAAEILHISQSPLSRQIMQLEEQLGVALFERARQRVHLNAEGRAFLTEARALIANARRVE
EFGRSLASGAVGRLAIGYVEGAVHAGLVAGMLGQFRRERPQLHLSLMSLRSAAQLEGLHLRTLDLGLVYSPPPADYPEIA
SMLVRREPLVLAIPEGDALTAVADIGPHHLDGRPWVTVVRQPADTNRGQFLAACIEAGFVPDIAYETADPLTSLGLVSAG
LGLATVQQSLRSAAPPGIVFRDLPWFKRSVAIYLAWRRQDERAVIGDLRKAVGSRQ

Sequences:

>Translated_296_residues
MFDLRQLRYFITVAETGNVGRAAEILHISQSPLSRQIMQLEEQLGVALFERARQRVHLNAEGRAFLTEARALIANARRVE
EFGRSLASGAVGRLAIGYVEGAVHAGLVAGMLGQFRRERPQLHLSLMSLRSAAQLEGLHLRTLDLGLVYSPPPADYPEIA
SMLVRREPLVLAIPEGDALTAVADIGPHHLDGRPWVTVVRQPADTNRGQFLAACIEAGFVPDIAYETADPLTSLGLVSAG
LGLATVQQSLRSAAPPGIVFRDLPWFKRSVAIYLAWRRQDERAVIGDLRKAVGSRQ
>Mature_296_residues
MFDLRQLRYFITVAETGNVGRAAEILHISQSPLSRQIMQLEEQLGVALFERARQRVHLNAEGRAFLTEARALIANARRVE
EFGRSLASGAVGRLAIGYVEGAVHAGLVAGMLGQFRRERPQLHLSLMSLRSAAQLEGLHLRTLDLGLVYSPPPADYPEIA
SMLVRREPLVLAIPEGDALTAVADIGPHHLDGRPWVTVVRQPADTNRGQFLAACIEAGFVPDIAYETADPLTSLGLVSAG
LGLATVQQSLRSAAPPGIVFRDLPWFKRSVAIYLAWRRQDERAVIGDLRKAVGSRQ

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788887, Length=299, Percent_Identity=31.438127090301, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI2367136, Length=267, Percent_Identity=32.9588014981273, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1787879, Length=288, Percent_Identity=30.2083333333333, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787806, Length=293, Percent_Identity=28.6689419795222, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI145693105, Length=251, Percent_Identity=25.8964143426295, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1788297, Length=152, Percent_Identity=27.6315789473684, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI157672245, Length=229, Percent_Identity=28.82096069869, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1790399, Length=288, Percent_Identity=26.0416666666667, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081904, Length=150, Percent_Identity=35.3333333333333, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789204, Length=248, Percent_Identity=24.5967741935484, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788748, Length=250, Percent_Identity=28.4, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790208, Length=154, Percent_Identity=33.1168831168831, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788481, Length=148, Percent_Identity=30.4054054054054, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787601, Length=179, Percent_Identity=25.6983240223464, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32363; Mature: 32363

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDLRQLRYFITVAETGNVGRAAEILHISQSPLSRQIMQLEEQLGVALFERARQRVHLNA
CCCHHHEEEEEEEECCCCCCCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCC
EGRAFLTEARALIANARRVEEFGRSLASGAVGRLAIGYVEGAVHAGLVAGMLGQFRRERP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
QLHLSLMSLRSAAQLEGLHLRTLDLGLVYSPPPADYPEIASMLVRREPLVLAIPEGDALT
HHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCEE
AVADIGPHHLDGRPWVTVVRQPADTNRGQFLAACIEAGFVPDIAYETADPLTSLGLVSAG
EEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHC
LGLATVQQSLRSAAPPGIVFRDLPWFKRSVAIYLAWRRQDERAVIGDLRKAVGSRQ
CHHHHHHHHHHHCCCCCCEECCCCHHHHHEEEEEEECCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFDLRQLRYFITVAETGNVGRAAEILHISQSPLSRQIMQLEEQLGVALFERARQRVHLNA
CCCHHHEEEEEEEECCCCCCCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCC
EGRAFLTEARALIANARRVEEFGRSLASGAVGRLAIGYVEGAVHAGLVAGMLGQFRRERP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
QLHLSLMSLRSAAQLEGLHLRTLDLGLVYSPPPADYPEIASMLVRREPLVLAIPEGDALT
HHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCEE
AVADIGPHHLDGRPWVTVVRQPADTNRGQFLAACIEAGFVPDIAYETADPLTSLGLVSAG
EEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHC
LGLATVQQSLRSAAPPGIVFRDLPWFKRSVAIYLAWRRQDERAVIGDLRKAVGSRQ
CHHHHHHHHHHHCCCCCCEECCCCHHHHHEEEEEEECCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]