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The map label for this gene is yngE [H]

Identifier: 13476416

GI number: 13476416

Start: 6402451

End: 6404064

Strand: Reverse

Name: yngE [H]

Synonym: mll7731

Alternate gene names: 13476416

Gene position: 6404064-6402451 (Counterclockwise)

Preceding gene: 13476417

Following gene: 13476415

Centisome position: 91.02

GC content: 63.44

Gene sequence:

>1614_bases
GTGAGCATGGCCGTCCTAGAGACTCAGATCTCCCCCTCCTCCGACACTTTCCGCGCCAATGCCGAACGCATGCGCGCGCT
GGTCACCGATATCGCCGACAAGGCCGCGACCGTCGAGCGTGGCGGCTCGGAGGAGGCGCGCGAGCGCCATATTTCGCGCG
GCAAGCTGCTGCCGCGCGAACGCCTCGCGCAATTGCTCGACACCGGCTCCCCATTCCTCGAGATCGGCCAGTTCGCTGCG
TGGTCGATGTATGGCGAGGAGATTTGCTCAGCCGGCATGATCGCCGGCGTCGGCCGTGTCGAGGGCACCGAGGTGATGGT
CGTCGTCAACGATGCCACGGTGAAGGGCGGCACCTACTATCCGCTGACGGTGAAAAAGCATTTGCGGGCGCAGGAGATCG
CGCTGCAGAACAATCTGCCCTGCATCTATCTGGTCGATAGTGGCGGCGCCAACCTGCCCAACCAGGACGAGGTGTTTCCC
GACCGCGAGCATTTCGGCCGCATCTTCTACAACCAGGCCAACATGTCGGCTGCCGGCATCCCGCAGATCGCCTGCGTCAT
GGGGTCCTGCACGGCCGGAGGCGCCTATGTGCCGGCAATGTCGGACGAGACGATCATGGTGCGCAACCAGGCGACCATTT
TTCTCGGAGGCCCGCCGCTGGTGAAGGCGGCCACCGGTGAGGATGTCAGCGCCGAGGATCTGGGGGGCGCGGATGTGCAT
ACGCGGCTTTCCGGCGTCGCCGACCATTATGCGATGGACGACGAACATGCGCTTGCCATCTGCCGGCGCATCGTCAAAAA
CCTGAATCGGAACAAGACCGTAAGCCTGAGCTTACAGAGATCGATTCCGCCGCTTCATCCGGCGGATGAACTCTACGGCG
TCGTGCCGACCGATCTGCGCCAGCCCTATGATGTGCGCGAGGTGATCGCGCGCCTCGTCGACGGCTCCGAATTCGACGAG
TTCAAGCAGAACTACGGCACAACGCTGATCACCGGTTTTGCCCACCTCCACGGCATGCCGGTCGGCCTCATCGCCAACAA
TGGTGTGCTGTTTTCCGAAAGCGCGCTGAAGGGCGCGCATTTCATCGAGCTGTGCTGCCAGCGCAGGATCCCGCTGGTCT
TTCTGCAGAACATCACCGGCTTCATGGTCGGCCGGAAATACGAGGCAGGCGGCATCGCCAAGGACGGCGCCAAGCTGGTG
ATGGCGGTTGCCACCGCCAGGGTGCCGAAGGTGACCGTCATCATCGGCGGTTCGTTCGGCGCCGGCAATTACGGCATGTG
CGGCCGCGCCTATTCCCCGCGCTTCCTGTGGATGTGGCCGAACGCCCGCATCTCGGTGATGGGCGGCGAACAGGCGGCAA
CCGTGCTCGCCATGGTCAAGCGCGAAGGCATCGAGCGCAAGGGCGGCGAATGGAGCGCCGAAGAAGAAGCGAAATTCAAG
AAGCCGATCCTGATGAAATACGAGCATGAGGGCCATCCGCTCTACTCGTCCGCCCGCCTCTGGGATGACGGCATCATCGA
TCCGGCGAAGACGCGCGAAGTGCTGGCGCTCAGCCTGTCCGCGTCGCTCAACGCCGAAATCGAGGACACGCGCTTCGGCG
TGTTCAGGATGTGA

Upstream 100 bases:

>100_bases
CCGGTCGGCTGCTGCGCGACGCCAAACTCTACGAGATCGGCGCCGGCACCAGCGAAATCCGGCGCTGGCTGATCGGCCGC
GAGATCATGGCGGAGGGGGT

Downstream 100 bases:

>100_bases
GGTGAGCAAGGCGCTGGACAGGATCCGCATCCACACCGGCGACATCACGAAGCTGGATGTTGACGCCATCGTCAATGCCG
CCAACACCTTGCTTCTCGGC

Product: acetyl/propionyl CoA carboxylase, beta subunit

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MSMAVLETQISPSSDTFRANAERMRALVTDIADKAATVERGGSEEARERHISRGKLLPRERLAQLLDTGSPFLEIGQFAA
WSMYGEEICSAGMIAGVGRVEGTEVMVVVNDATVKGGTYYPLTVKKHLRAQEIALQNNLPCIYLVDSGGANLPNQDEVFP
DREHFGRIFYNQANMSAAGIPQIACVMGSCTAGGAYVPAMSDETIMVRNQATIFLGGPPLVKAATGEDVSAEDLGGADVH
TRLSGVADHYAMDDEHALAICRRIVKNLNRNKTVSLSLQRSIPPLHPADELYGVVPTDLRQPYDVREVIARLVDGSEFDE
FKQNYGTTLITGFAHLHGMPVGLIANNGVLFSESALKGAHFIELCCQRRIPLVFLQNITGFMVGRKYEAGGIAKDGAKLV
MAVATARVPKVTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAATVLAMVKREGIERKGGEWSAEEEAKFK
KPILMKYEHEGHPLYSSARLWDDGIIDPAKTREVLALSLSASLNAEIEDTRFGVFRM

Sequences:

>Translated_537_residues
MSMAVLETQISPSSDTFRANAERMRALVTDIADKAATVERGGSEEARERHISRGKLLPRERLAQLLDTGSPFLEIGQFAA
WSMYGEEICSAGMIAGVGRVEGTEVMVVVNDATVKGGTYYPLTVKKHLRAQEIALQNNLPCIYLVDSGGANLPNQDEVFP
DREHFGRIFYNQANMSAAGIPQIACVMGSCTAGGAYVPAMSDETIMVRNQATIFLGGPPLVKAATGEDVSAEDLGGADVH
TRLSGVADHYAMDDEHALAICRRIVKNLNRNKTVSLSLQRSIPPLHPADELYGVVPTDLRQPYDVREVIARLVDGSEFDE
FKQNYGTTLITGFAHLHGMPVGLIANNGVLFSESALKGAHFIELCCQRRIPLVFLQNITGFMVGRKYEAGGIAKDGAKLV
MAVATARVPKVTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAATVLAMVKREGIERKGGEWSAEEEAKFK
KPILMKYEHEGHPLYSSARLWDDGIIDPAKTREVLALSLSASLNAEIEDTRFGVFRM
>Mature_536_residues
SMAVLETQISPSSDTFRANAERMRALVTDIADKAATVERGGSEEARERHISRGKLLPRERLAQLLDTGSPFLEIGQFAAW
SMYGEEICSAGMIAGVGRVEGTEVMVVVNDATVKGGTYYPLTVKKHLRAQEIALQNNLPCIYLVDSGGANLPNQDEVFPD
REHFGRIFYNQANMSAAGIPQIACVMGSCTAGGAYVPAMSDETIMVRNQATIFLGGPPLVKAATGEDVSAEDLGGADVHT
RLSGVADHYAMDDEHALAICRRIVKNLNRNKTVSLSLQRSIPPLHPADELYGVVPTDLRQPYDVREVIARLVDGSEFDEF
KQNYGTTLITGFAHLHGMPVGLIANNGVLFSESALKGAHFIELCCQRRIPLVFLQNITGFMVGRKYEAGGIAKDGAKLVM
AVATARVPKVTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAATVLAMVKREGIERKGGEWSAEEEAKFKK
PILMKYEHEGHPLYSSARLWDDGIIDPAKTREVLALSLSASLNAEIEDTRFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=537, Percent_Identity=66.1080074487896, Blast_Score=738, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=518, Percent_Identity=33.5907335907336, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI295821216, Length=538, Percent_Identity=32.3420074349442, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI310133460, Length=147, Percent_Identity=55.7823129251701, Blast_Score=156, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17552936, Length=538, Percent_Identity=61.1524163568773, Blast_Score=706, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=493, Percent_Identity=34.0770791075051, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI25147359, Length=493, Percent_Identity=34.0770791075051, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24586065, Length=550, Percent_Identity=64.9090909090909, Blast_Score=734, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 58432; Mature: 58300

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMAVLETQISPSSDTFRANAERMRALVTDIADKAATVERGGSEEARERHISRGKLLPRE
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHH
RLAQLLDTGSPFLEIGQFAAWSMYGEEICSAGMIAGVGRVEGTEVMVVVNDATVKGGTYY
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCEEEEEEECCEECCCEEE
PLTVKKHLRAQEIALQNNLPCIYLVDSGGANLPNQDEVFPDREHFGRIFYNQANMSAAGI
EEEHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHCEEEEECCCCCCCCC
PQIACVMGSCTAGGAYVPAMSDETIMVRNQATIFLGGPPLVKAATGEDVSAEDLGGADVH
CCEEHHHCCCCCCCEEECCCCCCEEEEECCEEEEECCCCEEEECCCCCCCHHHCCCCHHH
TRLSGVADHYAMDDEHALAICRRIVKNLNRNKTVSLSLQRSIPPLHPADELYGVVPTDLR
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHCCCCCHHHC
QPYDVREVIARLVDGSEFDEFKQNYGTTLITGFAHLHGMPVGLIANNGVLFSESALKGAH
CCCCHHHHHHHHHCCCCHHHHHHHCCCEEEEHHHHHCCCEEEEEECCCEEEECHHHCCHH
FIELCCQRRIPLVFLQNITGFMVGRKYEAGGIAKDGAKLVMAVATARVPKVTVIIGGSFG
HHHHHHHCCCCEEEECCCHHHHCCCEECCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCC
AGNYGMCGRAYSPRFLWMWPNARISVMGGEQAATVLAMVKREGIERKGGEWSAEEEAKFK
CCCCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHC
KPILMKYEHEGHPLYSSARLWDDGIIDPAKTREVLALSLSASLNAEIEDTRFGVFRM
CCEEEEEECCCCCCCCCCEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEECC
>Mature Secondary Structure 
SMAVLETQISPSSDTFRANAERMRALVTDIADKAATVERGGSEEARERHISRGKLLPRE
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHH
RLAQLLDTGSPFLEIGQFAAWSMYGEEICSAGMIAGVGRVEGTEVMVVVNDATVKGGTYY
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCEEEEEEECCEECCCEEE
PLTVKKHLRAQEIALQNNLPCIYLVDSGGANLPNQDEVFPDREHFGRIFYNQANMSAAGI
EEEHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHCEEEEECCCCCCCCC
PQIACVMGSCTAGGAYVPAMSDETIMVRNQATIFLGGPPLVKAATGEDVSAEDLGGADVH
CCEEHHHCCCCCCCEEECCCCCCEEEEECCEEEEECCCCEEEECCCCCCCHHHCCCCHHH
TRLSGVADHYAMDDEHALAICRRIVKNLNRNKTVSLSLQRSIPPLHPADELYGVVPTDLR
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHCCCCCHHHC
QPYDVREVIARLVDGSEFDEFKQNYGTTLITGFAHLHGMPVGLIANNGVLFSESALKGAH
CCCCHHHHHHHHHCCCCHHHHHHHCCCEEEEHHHHHCCCEEEEEECCCEEEECHHHCCHH
FIELCCQRRIPLVFLQNITGFMVGRKYEAGGIAKDGAKLVMAVATARVPKVTVIIGGSFG
HHHHHHHCCCCEEEECCCHHHHCCCEECCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCC
AGNYGMCGRAYSPRFLWMWPNARISVMGGEQAATVLAMVKREGIERKGGEWSAEEEAKFK
CCCCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHC
KPILMKYEHEGHPLYSSARLWDDGIIDPAKTREVLALSLSASLNAEIEDTRFGVFRM
CCEEEEEECCCCCCCCCCEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]