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The map label for this gene is panB1 [H]

Identifier: 13476340

GI number: 13476340

Start: 6321608

End: 6322420

Strand: Direct

Name: panB1 [H]

Synonym: mlr7631

Alternate gene names: 13476340

Gene position: 6321608-6322420 (Clockwise)

Preceding gene: 13476339

Following gene: 13476343

Centisome position: 89.85

GC content: 65.44

Gene sequence:

>813_bases
ATGGTCAGCAAAAATACCCGGCCCACCGTCGCCGACATCCGCGCCATGAAGGGCCGCGGACAGAAGTTCTCCATGCTCTA
CGTCACTTCGCTCGAAGAGGCGGCGGCTGCGGACGCGGCCGGCGTCGACATGCTTTCGATCGAGGGCCGCTTCTTCTCGC
CCGAGATGCGCGAGGCTGCCGGCCGCTGCTTCGTACAGGTCGGGCTTCCCTACGGCCCCGCCGGCAATCTGGTTACGGCG
GAGGACTATCTGAAGACCGCCTACCACTTCATGCGCATCGGCGGCGACTGCTTCTACTGCGCCGCCTCGCTCGATATCCA
GAAGACGCTGTGCGACAACGCCGTGCCGGTCGTCGCCCATGTCGGCCTGATCCCTTCGCAATGCACCTGGACCGGCGGTT
TCAAGGCCGTCGGCAGGACGGCCGAGAGCGCGCGTGCGGTGTGGGACCACGTCAAGCGCCTTGAAACCATCGGCTGCTTC
GGCGCCGAGCTGGAAGTGGTGCCGGACCGGATCGCCGAACTGATCACCAGAAGCACGCCGATGATCATGCTTGGCATGGG
CGCCGGACCGCATGCCGATGCGCAGTATTTATTCAGCGAGGACGTACTCGGCCACACCTCAGGCCACAAGCCACGCCACG
CCAAGACCTACCGCAACTTCGCCGCCGAGCTTGAGCGACTGCAGCGCGAGCGCATCGCCGCCTATCGCGAGTTCATCTCC
GACGTGAAGACCGGCACCTATCCCGAGCCGCAGCACGTCGTCTCGATCGCCGACGAAGAGCTCGCGGCCTTCAGGGCCCC
GCTTGGCCTCTGA

Upstream 100 bases:

>100_bases
GGGCTACCGCGGGCCGGTGGGCATGGAGGCGTTCGCCTCCGGCGATCCTGAGGCCGCCCTGCAAGCCTTCCGCGAAGCTT
TCACCATCTGAGGGAACAAA

Downstream 100 bases:

>100_bases
CGGATCCCGCCCCCGAAATCGTTCTAGGCTGCGGGCACCGACAGGCGTGGCAGGAGCGACGGCTGTCCGCCGCTCTTCGA
CAAACTCAGAAGATCGCGTT

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase 1; KPHMT 1 [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MVSKNTRPTVADIRAMKGRGQKFSMLYVTSLEEAAAADAAGVDMLSIEGRFFSPEMREAAGRCFVQVGLPYGPAGNLVTA
EDYLKTAYHFMRIGGDCFYCAASLDIQKTLCDNAVPVVAHVGLIPSQCTWTGGFKAVGRTAESARAVWDHVKRLETIGCF
GAELEVVPDRIAELITRSTPMIMLGMGAGPHADAQYLFSEDVLGHTSGHKPRHAKTYRNFAAELERLQRERIAAYREFIS
DVKTGTYPEPQHVVSIADEELAAFRAPLGL

Sequences:

>Translated_270_residues
MVSKNTRPTVADIRAMKGRGQKFSMLYVTSLEEAAAADAAGVDMLSIEGRFFSPEMREAAGRCFVQVGLPYGPAGNLVTA
EDYLKTAYHFMRIGGDCFYCAASLDIQKTLCDNAVPVVAHVGLIPSQCTWTGGFKAVGRTAESARAVWDHVKRLETIGCF
GAELEVVPDRIAELITRSTPMIMLGMGAGPHADAQYLFSEDVLGHTSGHKPRHAKTYRNFAAELERLQRERIAAYREFIS
DVKTGTYPEPQHVVSIADEELAAFRAPLGL
>Mature_270_residues
MVSKNTRPTVADIRAMKGRGQKFSMLYVTSLEEAAAADAAGVDMLSIEGRFFSPEMREAAGRCFVQVGLPYGPAGNLVTA
EDYLKTAYHFMRIGGDCFYCAASLDIQKTLCDNAVPVVAHVGLIPSQCTWTGGFKAVGRTAESARAVWDHVKRLETIGCF
GAELEVVPDRIAELITRSTPMIMLGMGAGPHADAQYLFSEDVLGHTSGHKPRHAKTYRNFAAELERLQRERIAAYREFIS
DVKTGTYPEPQHVVSIADEELAAFRAPLGL

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=205, Percent_Identity=30.7317073170732, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319653, Length=272, Percent_Identity=23.5294117647059, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 29490; Mature: 29490

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSKNTRPTVADIRAMKGRGQKFSMLYVTSLEEAAAADAAGVDMLSIEGRFFSPEMREAA
CCCCCCCCHHHHHHHHHCCCCEEEEEEEECHHHHHHCCCCCCEEEEECCCCCCHHHHHHH
GRCFVQVGLPYGPAGNLVTAEDYLKTAYHFMRIGGDCFYCAASLDIQKTLCDNAVPVVAH
CCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHCCCCHHHHH
VGLIPSQCTWTGGFKAVGRTAESARAVWDHVKRLETIGCFGAELEVVPDRIAELITRSTP
HCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
MIMLGMGAGPHADAQYLFSEDVLGHTSGHKPRHAKTYRNFAAELERLQRERIAAYREFIS
EEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVKTGTYPEPQHVVSIADEELAAFRAPLGL
HHCCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVSKNTRPTVADIRAMKGRGQKFSMLYVTSLEEAAAADAAGVDMLSIEGRFFSPEMREAA
CCCCCCCCHHHHHHHHHCCCCEEEEEEEECHHHHHHCCCCCCEEEEECCCCCCHHHHHHH
GRCFVQVGLPYGPAGNLVTAEDYLKTAYHFMRIGGDCFYCAASLDIQKTLCDNAVPVVAH
CCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHCCCCHHHHH
VGLIPSQCTWTGGFKAVGRTAESARAVWDHVKRLETIGCFGAELEVVPDRIAELITRSTP
HCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
MIMLGMGAGPHADAQYLFSEDVLGHTSGHKPRHAKTYRNFAAELERLQRERIAAYREFIS
EEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVKTGTYPEPQHVVSIADEELAAFRAPLGL
HHCCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA