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The map label for this gene is mutB [H]

Identifier: 13476330

GI number: 13476330

Start: 6309533

End: 6311584

Strand: Reverse

Name: mutB [H]

Synonym: mll7619

Alternate gene names: 13476330

Gene position: 6311584-6309533 (Counterclockwise)

Preceding gene: 13476331

Following gene: 13476328

Centisome position: 89.7

GC content: 63.5

Gene sequence:

>2052_bases
GTGACGCCGGAAGGGCTTATCGTCAAGCATCTGTACAATCAGGGCGACCTCAAGGGCCTGCCGCATCTCGACACCTATCC
GGGCCTGCCGCCCTTCGTGCGCGGCCCCTACCCGACCATGTATGTCCAGCAGCCCTGGACGATCCGGCAATATGCCGGCT
TCTCCACGGCCGAAGAATCCAACGCCTTTTACCGGCGCAATCTTGCCGCCGGCCAGAAAGGCCTGTCGGTCGCCTTCGAT
CTCGCCACGCATCGTGGCTATGACAGCGACCACCCACGTGTTGCCGGCGATGTCGGCATGGCGGGCGTCGCCATCGATTC
CATCCTCGACATGCGGCAATTGTTCGACGGCATTCCGCTCGGCGACATGACGGTGTCGATGACGATGAACGGGGCGGTGC
TGCCGATCATGGCGCTCTACATCGTCGCAGCGGAAGAGCAGGGCGTCGCGCAGAAGGATCTGGCCGGAACCATTCAGAAC
GACATTCTGAAGGAGTTCATGGTCCGCAACACCTACATCTACCCGCCAAAACCCTCGATGCGGATCGTGTCGGACATCTT
CTCCTATACGTCGAAGAACATGCCGAAGTTCAATTCGATATCGATCTCCGGCTACCACATGCAGGAAGCCGGTGCGACGG
CCGACCTGGAACTCGCCTATACGATCGCCGACGGCATCGAATATGCCCGCGCCGGCGTTGCGGCGGGCCTCGACATCGAC
CGCTTCGCGCCACGCCTGTCCTTCTTTTGGGCGATCGGCATGAACTTCTTCATGGAAGTGGCCAAGCTCAGGGCCGCGCG
CCTGCTGTGGGCGACGCTGATGAAGAAGAATTTTGCGCCCAAGGACGAACGTTCGCTGTCGCTGCGCACCCATTGCCAGA
CGTCCGGCTGGTCGCTGACGGCGCAGGACCCGTACAACAACATTATCCGCACCATGATCGAGGCGATGGCCGCGACCCAA
GGGCATACCCAGTCGCTGCATACCAATTCCTTCGACGAGGCGATGGCGCTGCCGACCGACCATTCGGCGCGCATCGCCCG
CAACACACAGCTCATCCTGCAGAAGGAATCCGGCACCACGCGCATCATCGACCCGTGGGGTGGCTCGGCCTATCTCGAAC
GGCTGACCCATGATCTCGCCGCGCGCGCGCTCGCCCACATCGAGGAGGTCGAGGCTCTCGGTGGCATGGCCGCCGCGACC
GAACAAGGCATTCCGAAGCTGCGCATCGAGGAAGCGGCGGCGCGCACGCAGGCGCGCATCGATTCCGGCGAGCAGATGCT
GGTCGGCGTCAACGCGCATCGCCCCGAGAACGACATCGAGGTCGACGTGCTGAAGATCGACAATGCCGAGGTCAGGGCCC
GGCAATTGTCCAAGCTGCAACGGCTGAAGGGCACGCGCGATGTCGCTGCCGTCGAAAGCGCGCTCGATGCGCTTACCCGC
GCCGCGCAGGGCAATGAGAACCTTTTGGAGTTCGCCGTCCGCGCCGCGCGCGCCAATGCGACAGTCGGCGAGATCTCGTT
TGCGCTGGAGCGGGCCTTTGGCCGCCACGTCGCTACGGTGCAGACCATTTCCGGCGTCTACCGCAAGGCGCTTGGCGACA
GTCCCGTGGTCGACGGGCTGCAGGACAAGCTCGCAGCTTTCGAGAGGAAAAACGGCGGCAAGCCGCGCATCCTCGTTGCC
AAGATGGGACAGGATGGCCACGACCGTGGGCAGAAGGTGATCGCCACCGCTTTCGCCGATCTCGGCTTCGACGTTACTGT
CGGCGCGATGTTCCAGACACCGGAAGAGATCGCGAAACTGGCGGTCCAGCATGACGTCCATATCATCGGCGCCTCATCAC
TGGCGGCGGGACACCTGACGCTGATCCCCGAATTGCGCGACGCGCTGAAAAAGCTCGGCCGCGGTGATATGCTGATCGTG
GCCGGCGGCGTCATCCCGCCGCAGGACTACGAGGCGGTGCTGCAAGCCGGCGCGGCGGAAATCTTCCCGCCGGGCACGGT
TATTCCGGAAGCGGCGGATCGGCTAATGGATCGACTGCTGGCAGCCAACTAG

Upstream 100 bases:

>100_bases
GCATCGACCAATCGATCGAGGCTGCCTCTTGATCCCGGATTTCAGTCAGGTCGGCTGGGCGCCGCCGCGCCGCGCGCCGG
TCGAGGTCAAGGGCCAGCGG

Downstream 100 bases:

>100_bases
GCTATGCCGCTCTAACTATCCGAGAGCTTGACGATTTCCCATTCCTTGCCGTTGACCGCGGCCACGTCGCCGACCTTCTT
GCCGAACAGGGCGACGGCCA

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 683; Mature: 682

Protein sequence:

>683_residues
MTPEGLIVKHLYNQGDLKGLPHLDTYPGLPPFVRGPYPTMYVQQPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFD
LATHRGYDSDHPRVAGDVGMAGVAIDSILDMRQLFDGIPLGDMTVSMTMNGAVLPIMALYIVAAEEQGVAQKDLAGTIQN
DILKEFMVRNTYIYPPKPSMRIVSDIFSYTSKNMPKFNSISISGYHMQEAGATADLELAYTIADGIEYARAGVAAGLDID
RFAPRLSFFWAIGMNFFMEVAKLRAARLLWATLMKKNFAPKDERSLSLRTHCQTSGWSLTAQDPYNNIIRTMIEAMAATQ
GHTQSLHTNSFDEAMALPTDHSARIARNTQLILQKESGTTRIIDPWGGSAYLERLTHDLAARALAHIEEVEALGGMAAAT
EQGIPKLRIEEAAARTQARIDSGEQMLVGVNAHRPENDIEVDVLKIDNAEVRARQLSKLQRLKGTRDVAAVESALDALTR
AAQGNENLLEFAVRAARANATVGEISFALERAFGRHVATVQTISGVYRKALGDSPVVDGLQDKLAAFERKNGGKPRILVA
KMGQDGHDRGQKVIATAFADLGFDVTVGAMFQTPEEIAKLAVQHDVHIIGASSLAAGHLTLIPELRDALKKLGRGDMLIV
AGGVIPPQDYEAVLQAGAAEIFPPGTVIPEAADRLMDRLLAAN

Sequences:

>Translated_683_residues
MTPEGLIVKHLYNQGDLKGLPHLDTYPGLPPFVRGPYPTMYVQQPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFD
LATHRGYDSDHPRVAGDVGMAGVAIDSILDMRQLFDGIPLGDMTVSMTMNGAVLPIMALYIVAAEEQGVAQKDLAGTIQN
DILKEFMVRNTYIYPPKPSMRIVSDIFSYTSKNMPKFNSISISGYHMQEAGATADLELAYTIADGIEYARAGVAAGLDID
RFAPRLSFFWAIGMNFFMEVAKLRAARLLWATLMKKNFAPKDERSLSLRTHCQTSGWSLTAQDPYNNIIRTMIEAMAATQ
GHTQSLHTNSFDEAMALPTDHSARIARNTQLILQKESGTTRIIDPWGGSAYLERLTHDLAARALAHIEEVEALGGMAAAT
EQGIPKLRIEEAAARTQARIDSGEQMLVGVNAHRPENDIEVDVLKIDNAEVRARQLSKLQRLKGTRDVAAVESALDALTR
AAQGNENLLEFAVRAARANATVGEISFALERAFGRHVATVQTISGVYRKALGDSPVVDGLQDKLAAFERKNGGKPRILVA
KMGQDGHDRGQKVIATAFADLGFDVTVGAMFQTPEEIAKLAVQHDVHIIGASSLAAGHLTLIPELRDALKKLGRGDMLIV
AGGVIPPQDYEAVLQAGAAEIFPPGTVIPEAADRLMDRLLAAN
>Mature_682_residues
TPEGLIVKHLYNQGDLKGLPHLDTYPGLPPFVRGPYPTMYVQQPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDL
ATHRGYDSDHPRVAGDVGMAGVAIDSILDMRQLFDGIPLGDMTVSMTMNGAVLPIMALYIVAAEEQGVAQKDLAGTIQND
ILKEFMVRNTYIYPPKPSMRIVSDIFSYTSKNMPKFNSISISGYHMQEAGATADLELAYTIADGIEYARAGVAAGLDIDR
FAPRLSFFWAIGMNFFMEVAKLRAARLLWATLMKKNFAPKDERSLSLRTHCQTSGWSLTAQDPYNNIIRTMIEAMAATQG
HTQSLHTNSFDEAMALPTDHSARIARNTQLILQKESGTTRIIDPWGGSAYLERLTHDLAARALAHIEEVEALGGMAAATE
QGIPKLRIEEAAARTQARIDSGEQMLVGVNAHRPENDIEVDVLKIDNAEVRARQLSKLQRLKGTRDVAAVESALDALTRA
AQGNENLLEFAVRAARANATVGEISFALERAFGRHVATVQTISGVYRKALGDSPVVDGLQDKLAAFERKNGGKPRILVAK
MGQDGHDRGQKVIATAFADLGFDVTVGAMFQTPEEIAKLAVQHDVHIIGASSLAAGHLTLIPELRDALKKLGRGDMLIVA
GGVIPPQDYEAVLQAGAAEIFPPGTVIPEAADRLMDRLLAAN

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=677, Percent_Identity=63.6632200886263, Blast_Score=904, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=669, Percent_Identity=63.5276532137519, Blast_Score=852, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=681, Percent_Identity=64.4640234948605, Blast_Score=922, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 74243; Mature: 74112

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPEGLIVKHLYNQGDLKGLPHLDTYPGLPPFVRGPYPTMYVQQPWTIRQYAGFSTAEES
CCCCCEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHCCCCCCHHC
NAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVAGDVGMAGVAIDSILDMRQLFDGIPL
CHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
GDMTVSMTMNGAVLPIMALYIVAAEEQGVAQKDLAGTIQNDILKEFMVRNTYIYPPKPSM
CCEEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCHH
RIVSDIFSYTSKNMPKFNSISISGYHMQEAGATADLELAYTIADGIEYARAGVAAGLDID
HHHHHHHHHHCCCCCCCCEEEEECEEECCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCHH
RFAPRLSFFWAIGMNFFMEVAKLRAARLLWATLMKKNFAPKDERSLSLRTHCQTSGWSLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHEECCCCCCEEE
AQDPYNNIIRTMIEAMAATQGHTQSLHTNSFDEAMALPTDHSARIARNTQLILQKESGTT
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCHHHHCCCEEEEEECCCCE
RIIDPWGGSAYLERLTHDLAARALAHIEEVEALGGMAAATEQGIPKLRIEEAAARTQARI
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHC
DSGEQMLVGVNAHRPENDIEVDVLKIDNAEVRARQLSKLQRLKGTRDVAAVESALDALTR
CCCCEEEEEECCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AAQGNENLLEFAVRAARANATVGEISFALERAFGRHVATVQTISGVYRKALGDSPVVDGL
HHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
QDKLAAFERKNGGKPRILVAKMGQDGHDRGQKVIATAFADLGFDVTVGAMFQTPEEIAKL
HHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEHHHHCCHHHHHHH
AVQHDVHIIGASSLAAGHLTLIPELRDALKKLGRGDMLIVAGGVIPPQDYEAVLQAGAAE
HHHHCEEEEECCCCCCCCEEECHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCC
IFPPGTVIPEAADRLMDRLLAAN
CCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPEGLIVKHLYNQGDLKGLPHLDTYPGLPPFVRGPYPTMYVQQPWTIRQYAGFSTAEES
CCCCEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHCCCCCCHHC
NAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVAGDVGMAGVAIDSILDMRQLFDGIPL
CHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
GDMTVSMTMNGAVLPIMALYIVAAEEQGVAQKDLAGTIQNDILKEFMVRNTYIYPPKPSM
CCEEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCHH
RIVSDIFSYTSKNMPKFNSISISGYHMQEAGATADLELAYTIADGIEYARAGVAAGLDID
HHHHHHHHHHCCCCCCCCEEEEECEEECCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCHH
RFAPRLSFFWAIGMNFFMEVAKLRAARLLWATLMKKNFAPKDERSLSLRTHCQTSGWSLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHEECCCCCCEEE
AQDPYNNIIRTMIEAMAATQGHTQSLHTNSFDEAMALPTDHSARIARNTQLILQKESGTT
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCHHHHCCCEEEEEECCCCE
RIIDPWGGSAYLERLTHDLAARALAHIEEVEALGGMAAATEQGIPKLRIEEAAARTQARI
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHC
DSGEQMLVGVNAHRPENDIEVDVLKIDNAEVRARQLSKLQRLKGTRDVAAVESALDALTR
CCCCEEEEEECCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AAQGNENLLEFAVRAARANATVGEISFALERAFGRHVATVQTISGVYRKALGDSPVVDGL
HHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
QDKLAAFERKNGGKPRILVAKMGQDGHDRGQKVIATAFADLGFDVTVGAMFQTPEEIAKL
HHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEHHHHCCHHHHHHH
AVQHDVHIIGASSLAAGHLTLIPELRDALKKLGRGDMLIVAGGVIPPQDYEAVLQAGAAE
HHHHCEEEEECCCCCCCCEEECHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCC
IFPPGTVIPEAADRLMDRLLAAN
CCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]