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The map label for this gene is yfhQ [H]

Identifier: 13476250

GI number: 13476250

Start: 6208224

End: 6209414

Strand: Reverse

Name: yfhQ [H]

Synonym: mll7523

Alternate gene names: 13476250

Gene position: 6209414-6208224 (Counterclockwise)

Preceding gene: 13476254

Following gene: 13476249

Centisome position: 88.25

GC content: 65.74

Gene sequence:

>1191_bases
ATGTACGTTCTCCAGCCACGACCCCAGCAGATTACCGGCCAGGCCAACACACGATCAATGGCACCAGCAGACCAGACCCG
CAAGGCCCAGACACGCAAGGCCCAGACACTTAAGGCAATGCCGGACGACACCGCGTCGCGCCTGCTCGCCTGGTACGACG
TGCATCATCGCGAGTTGCCGTGGCGGGTGAGCCCGCGCGAGCATGCACGCGGCGTGCGGCCCGACCCCTATCGCATCTGG
CTGTCCGAAGTCATGCTGCAGCAGACCACGGTCGAGGCGGTGAAATCCTACTTTCGCGCCTTTGTCGAGAAATGGCCCGA
TGTCGAGGCGCTGGCCGCGGCGCCGACCGAGGACGTCATGAAGGCCTGGGCGGGGCTCGGCTATTACTCCCGCGCCCGCA
ACCTCAAGGCCTGCGCCGATCTGGTGGCGGCGCGTGGTGGCCGGTTTCCCGATACCGAGGCCGATTTGAGAGACCTGCCC
GGCATCGGCGCCTACACTTCGGCGGCGATCACGGCGATCGCCTTCGACCGCCCCGCCGCCGTGGTTGATGGCAATGTCGA
ACGCGTCATATCGAGGCTGTTTTCGATCAGGACGCCACTCAACGAAGCCAAGACCGAGATACGAGCCCTTGTCGAGGCCA
TGGTGCCGGCGGCAAGGCCGGGCGATTTCGCCCAGGCCATGATGGATCTCGGCGCCACGATCTGCACCCCGCGCCGGCCG
CGCTGCATGCTGTGCCCGCTGCGCGAGAACTGCAGCGCCGTCGTTTCAGGCGATCCCGAAAACTTCCCGGTGCGGCTGCC
CAAAGCCGACAAACCGCAGCGGCGCGGCGCTGCTTTCGTCGCCATCCGTGAGGATGGGGCCATGCTTCTGCGCAAACGGC
CGGAAAAAGGTCTGCTCGGCGGCATGACCGAGGTGCCGACAACGGCTTGGACGGCGCGGGTGGACGGAGCCACCACGCAG
GCGGCGGCGCCCTTTCCCGGCGAATGGCGGCGCGCCGGGACAATCACGCATGTCTTCACCCATTTCGCGCTCGAGCTCGA
AGTCTTTCACGCCCACATCAAAGGGGATGCGCCGGCAGGGCATTTCTGGTCGCACGCCCACGAGATTTCCGGAGAGGCCC
TGCCCACTGTCATGAAAAAGGCAATCGAGGCTGCGATACCCGGCGCGACGAAAAAGCAACGCCCGCATTGA

Upstream 100 bases:

>100_bases
ACCAATCGAAATGCCTGCCCGTTTGCGCAGCACAGGGTCGAGGATTTTGGTGGCAAGATCGCTCACCGGGACGGGATTGC
CGTAGGGCGTTCTCCCTGCC

Downstream 100 bases:

>100_bases
AGAGGCTTCATGACCGAGATCCGCCACATCGTTTTCGACATCGGCCGCGTGCTGATCCACTACGATCCCAATATTCCGTT
CAGCCGCCTCATCCCCGATG

Product: adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MYVLQPRPQQITGQANTRSMAPADQTRKAQTRKAQTLKAMPDDTASRLLAWYDVHHRELPWRVSPREHARGVRPDPYRIW
LSEVMLQQTTVEAVKSYFRAFVEKWPDVEALAAAPTEDVMKAWAGLGYYSRARNLKACADLVAARGGRFPDTEADLRDLP
GIGAYTSAAITAIAFDRPAAVVDGNVERVISRLFSIRTPLNEAKTEIRALVEAMVPAARPGDFAQAMMDLGATICTPRRP
RCMLCPLRENCSAVVSGDPENFPVRLPKADKPQRRGAAFVAIREDGAMLLRKRPEKGLLGGMTEVPTTAWTARVDGATTQ
AAAPFPGEWRRAGTITHVFTHFALELEVFHAHIKGDAPAGHFWSHAHEISGEALPTVMKKAIEAAIPGATKKQRPH

Sequences:

>Translated_396_residues
MYVLQPRPQQITGQANTRSMAPADQTRKAQTRKAQTLKAMPDDTASRLLAWYDVHHRELPWRVSPREHARGVRPDPYRIW
LSEVMLQQTTVEAVKSYFRAFVEKWPDVEALAAAPTEDVMKAWAGLGYYSRARNLKACADLVAARGGRFPDTEADLRDLP
GIGAYTSAAITAIAFDRPAAVVDGNVERVISRLFSIRTPLNEAKTEIRALVEAMVPAARPGDFAQAMMDLGATICTPRRP
RCMLCPLRENCSAVVSGDPENFPVRLPKADKPQRRGAAFVAIREDGAMLLRKRPEKGLLGGMTEVPTTAWTARVDGATTQ
AAAPFPGEWRRAGTITHVFTHFALELEVFHAHIKGDAPAGHFWSHAHEISGEALPTVMKKAIEAAIPGATKKQRPH
>Mature_396_residues
MYVLQPRPQQITGQANTRSMAPADQTRKAQTRKAQTLKAMPDDTASRLLAWYDVHHRELPWRVSPREHARGVRPDPYRIW
LSEVMLQQTTVEAVKSYFRAFVEKWPDVEALAAAPTEDVMKAWAGLGYYSRARNLKACADLVAARGGRFPDTEADLRDLP
GIGAYTSAAITAIAFDRPAAVVDGNVERVISRLFSIRTPLNEAKTEIRALVEAMVPAARPGDFAQAMMDLGATICTPRRP
RCMLCPLRENCSAVVSGDPENFPVRLPKADKPQRRGAAFVAIREDGAMLLRKRPEKGLLGGMTEVPTTAWTARVDGATTQ
AAAPFPGEWRRAGTITHVFTHFALELEVFHAHIKGDAPAGHFWSHAHEISGEALPTVMKKAIEAAIPGATKKQRPH

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=425, Percent_Identity=33.6470588235294, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI115298650, Length=397, Percent_Identity=34.7607052896725, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI6912520, Length=425, Percent_Identity=33.6470588235294, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI115298654, Length=397, Percent_Identity=34.7607052896725, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI115298652, Length=397, Percent_Identity=34.7607052896725, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI190358497, Length=425, Percent_Identity=33.6470588235294, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI1789331, Length=308, Percent_Identity=37.987012987013, Blast_Score=206, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 43650; Mature: 43650

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVLQPRPQQITGQANTRSMAPADQTRKAQTRKAQTLKAMPDDTASRLLAWYDVHHRELP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
WRVSPREHARGVRPDPYRIWLSEVMLQQTTVEAVKSYFRAFVEKWPDVEALAAAPTEDVM
CCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHH
KAWAGLGYYSRARNLKACADLVAARGGRFPDTEADLRDLPGIGAYTSAAITAIAFDRPAA
HHHHCCCHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCC
VVDGNVERVISRLFSIRTPLNEAKTEIRALVEAMVPAARPGDFAQAMMDLGATICTPRRP
EECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCC
RCMLCPLRENCSAVVSGDPENFPVRLPKADKPQRRGAAFVAIREDGAMLLRKRPEKGLLG
CEEECCCCCCCCEEECCCCCCCCEECCCCCCCCCCCCEEEEECCCCHHHHHCCCCCCCCC
GMTEVPTTAWTARVDGATTQAAAPFPGEWRRAGTITHVFTHFALELEVFHAHIKGDAPAG
CCHHCCCCCEEEECCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
HFWSHAHEISGEALPTVMKKAIEAAIPGATKKQRPH
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MYVLQPRPQQITGQANTRSMAPADQTRKAQTRKAQTLKAMPDDTASRLLAWYDVHHRELP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
WRVSPREHARGVRPDPYRIWLSEVMLQQTTVEAVKSYFRAFVEKWPDVEALAAAPTEDVM
CCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHH
KAWAGLGYYSRARNLKACADLVAARGGRFPDTEADLRDLPGIGAYTSAAITAIAFDRPAA
HHHHCCCHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCC
VVDGNVERVISRLFSIRTPLNEAKTEIRALVEAMVPAARPGDFAQAMMDLGATICTPRRP
EECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCC
RCMLCPLRENCSAVVSGDPENFPVRLPKADKPQRRGAAFVAIREDGAMLLRKRPEKGLLG
CEEECCCCCCCCEEECCCCCCCCEECCCCCCCCCCCCEEEEECCCCHHHHHCCCCCCCCC
GMTEVPTTAWTARVDGATTQAAAPFPGEWRRAGTITHVFTHFALELEVFHAHIKGDAPAG
CCHHCCCCCEEEECCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
HFWSHAHEISGEALPTVMKKAIEAAIPGATKKQRPH
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]