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The map label for this gene is thrB

Identifier: 13476235

GI number: 13476235

Start: 6193543

End: 6194505

Strand: Direct

Name: thrB

Synonym: mlr7503

Alternate gene names: 13476235

Gene position: 6193543-6194505 (Clockwise)

Preceding gene: 13476234

Following gene: 13476236

Centisome position: 88.03

GC content: 63.24

Gene sequence:

>963_bases
ATGGCGGTCTATACCGACGTTGCGGAGGGCGAACTTGGCGCTTTCCTGAAACACTACCCCGTCGGCGATCTCCTGTCCTA
CAAGGGCATCGCCGAAGGCACCGAGAATTCGAACTTCCTGCTGCACACCTCCAGCGGCTCCTACATATTGACGCTCTATG
AAAAGCGGGTCGAGAAGGCGGATCTGCCGTTTTTCCTCGGGCTGATGGGCCATCTCGCCAACAAGGGCGTGTCCTGCCCG
CTGCCGGTGACCGCGCATGACGGCAGCGTCATCGGCACGCTGGCCGGCCGGCCGGCCGTCATCATCACCTTTCTCGAAGG
CCTCTCACTGCGGCGGCCGACGGCGACGCACTGCGCCGAGGTCGGCAAGGCGCTGGCCGCCTTGCACCTGGCCGGCGCCG
ATTTTCCGATGACCCGCCCGAATGCGCTCGCCATCGACGGTTGGCGCAAGCTGTGGAACGCGGCCCGCGACCGGGCCGAC
GAGGTCGAACCGGGCCTGGCGGCCGAGGTCGACGCCGACTTCGCCGATTTCGAGCGGAACTGGCCGAGGGGCCTTCCTGC
AGGCATCATCCATGCCGATCTGTTTCCGGACAACGTCTTCTTCCTGGGCGAAAAGCTGTCCGGCCTGATCGATTTCTATT
TCGCCTGTGACGACCTCTACGCCTACGATGTCGCCACCTGCCTCAACGCCTGGTGTTTCGAGAAGGATTTCTCCTTCAAC
CTCACCAAGGGCAAGGCACTGCTCGCCGGCTATCAGAGCGTGCGCCCGCTGAGCGGAGAGGAAAAGGCGGCATTGCCCAT
GCTGTCGCGCGGTTCGGCGCTGCGTTTCATGCTGACCCGGCTCTACGACTGGCTGACCGTTTCCGATGGCGGCCTGGTCA
TGAAACGCGACCCGACCGAATATATCAGGCGGATGCGGTTCCATCGGGCGATCAAATCGGCTTCGGAATATGGATTGGCC
TGA

Upstream 100 bases:

>100_bases
CGGCCACTGAAACAGAGGATTTTCCGGTCATGCGGGTACTGCGCGATGTCGAACTGACGCCGGCCGACATGGCCTTCGTC
AATGGGGCCGCGTAAGGCAG

Downstream 100 bases:

>100_bases
TATGGGTATCATGAGCAAACAGGTTGAAATCTTCACCGACGGCGCCTGTTCGGGCAATCCCGGCCCTGGCGGCTGGGGTG
CCATCCTGCGCTTCAACGGG

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MAVYTDVAEGELGAFLKHYPVGDLLSYKGIAEGTENSNFLLHTSSGSYILTLYEKRVEKADLPFFLGLMGHLANKGVSCP
LPVTAHDGSVIGTLAGRPAVIITFLEGLSLRRPTATHCAEVGKALAALHLAGADFPMTRPNALAIDGWRKLWNAARDRAD
EVEPGLAAEVDADFADFERNWPRGLPAGIIHADLFPDNVFFLGEKLSGLIDFYFACDDLYAYDVATCLNAWCFEKDFSFN
LTKGKALLAGYQSVRPLSGEEKAALPMLSRGSALRFMLTRLYDWLTVSDGGLVMKRDPTEYIRRMRFHRAIKSASEYGLA

Sequences:

>Translated_320_residues
MAVYTDVAEGELGAFLKHYPVGDLLSYKGIAEGTENSNFLLHTSSGSYILTLYEKRVEKADLPFFLGLMGHLANKGVSCP
LPVTAHDGSVIGTLAGRPAVIITFLEGLSLRRPTATHCAEVGKALAALHLAGADFPMTRPNALAIDGWRKLWNAARDRAD
EVEPGLAAEVDADFADFERNWPRGLPAGIIHADLFPDNVFFLGEKLSGLIDFYFACDDLYAYDVATCLNAWCFEKDFSFN
LTKGKALLAGYQSVRPLSGEEKAALPMLSRGSALRFMLTRLYDWLTVSDGGLVMKRDPTEYIRRMRFHRAIKSASEYGLA
>Mature_319_residues
AVYTDVAEGELGAFLKHYPVGDLLSYKGIAEGTENSNFLLHTSSGSYILTLYEKRVEKADLPFFLGLMGHLANKGVSCPL
PVTAHDGSVIGTLAGRPAVIITFLEGLSLRRPTATHCAEVGKALAALHLAGADFPMTRPNALAIDGWRKLWNAARDRADE
VEPGLAAEVDADFADFERNWPRGLPAGIIHADLFPDNVFFLGEKLSGLIDFYFACDDLYAYDVATCLNAWCFEKDFSFNL
TKGKALLAGYQSVRPLSGEEKAALPMLSRGSALRFMLTRLYDWLTVSDGGLVMKRDPTEYIRRMRFHRAIKSASEYGLA

Specific function: Unknown

COG id: COG2334

COG function: function code R; Putative homoserine kinase type II (protein kinase fold)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pseudomonas-type thrB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_RHILO (Q985W2)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107805.1
- ProteinModelPortal:   Q985W2
- SMR:   Q985W2
- GeneID:   1230460
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr7503
- NMPDR:   fig|266835.1.peg.5906
- HOGENOM:   HBG309377
- OMA:   ADLFRDN
- ProtClustDB:   PRK05231
- BRENDA:   2.7.1.39
- HAMAP:   MF_00301
- InterPro:   IPR002575
- InterPro:   IPR005280
- InterPro:   IPR011009
- TIGRFAMs:   TIGR00938

Pfam domain/function: PF01636 APH; SSF56112 Kinase_like

EC number: =2.7.1.39

Molecular weight: Translated: 35153; Mature: 35021

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVYTDVAEGELGAFLKHYPVGDLLSYKGIAEGTENSNFLLHTSSGSYILTLYEKRVEKA
CCEECCCCCCHHHHHHHHCCCHHHHHHCCCCCCCCCCCEEEEECCCCEEEEEEHHHHHHC
DLPFFLGLMGHLANKGVSCPLPVTAHDGSVIGTLAGRPAVIITFLEGLSLRRPTATHCAE
CCCHHHHHHHHHHCCCCCCCCCEEECCCCEEEECCCCCEEEEEEHHCCCCCCCCHHHHHH
VGKALAALHLAGADFPMTRPNALAIDGWRKLWNAARDRADEVEPGLAAEVDADFADFERN
HHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHCC
WPRGLPAGIIHADLFPDNVFFLGEKLSGLIDFYFACDDLYAYDVATCLNAWCFEKDFSFN
CCCCCCCCEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LTKGKALLAGYQSVRPLSGEEKAALPMLSRGSALRFMLTRLYDWLTVSDGGLVMKRDPTE
ECCCHHHHHHHHHCCCCCCCCHHHCCHHCCCHHHHHHHHHHHHHEEECCCCEEEECCHHH
YIRRMRFHRAIKSASEYGLA
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AVYTDVAEGELGAFLKHYPVGDLLSYKGIAEGTENSNFLLHTSSGSYILTLYEKRVEKA
CEECCCCCCHHHHHHHHCCCHHHHHHCCCCCCCCCCCEEEEECCCCEEEEEEHHHHHHC
DLPFFLGLMGHLANKGVSCPLPVTAHDGSVIGTLAGRPAVIITFLEGLSLRRPTATHCAE
CCCHHHHHHHHHHCCCCCCCCCEEECCCCEEEECCCCCEEEEEEHHCCCCCCCCHHHHHH
VGKALAALHLAGADFPMTRPNALAIDGWRKLWNAARDRADEVEPGLAAEVDADFADFERN
HHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHCC
WPRGLPAGIIHADLFPDNVFFLGEKLSGLIDFYFACDDLYAYDVATCLNAWCFEKDFSFN
CCCCCCCCEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LTKGKALLAGYQSVRPLSGEEKAALPMLSRGSALRFMLTRLYDWLTVSDGGLVMKRDPTE
ECCCHHHHHHHHHCCCCCCCCHHHCCHHCCCHHHHHHHHHHHHHEEECCCCEEEECCHHH
YIRRMRFHRAIKSASEYGLA
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968