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The map label for this gene is rnhA

Identifier: 13476236

GI number: 13476236

Start: 6194516

End: 6195049

Strand: Direct

Name: rnhA

Synonym: mlr7504

Alternate gene names: 13476236

Gene position: 6194516-6195049 (Clockwise)

Preceding gene: 13476235

Following gene: 13476237

Centisome position: 88.04

GC content: 61.61

Gene sequence:

>534_bases
ATGAGCAAACAGGTTGAAATCTTCACCGACGGCGCCTGTTCGGGCAATCCCGGCCCTGGCGGCTGGGGTGCCATCCTGCG
CTTCAACGGGACCACCAAGGAGCTTTCCGGTGGCGAGGCCGAAACGACCAACAACCGCATGGAGTTGCTGGCCGCCATCT
CGGCGCTGAATGCGCTGAAGGAGCCTTGCACTGTCGAGCTTCACACCGACAGCAAATACGTCATGGACGGCATTTCCAAG
TGGATCCATGGCTGGAAGAAGAACGGCTGGAAGACCGCCGACAAGAAGCCGGTCAAGAACGGCGAACTGTGGCAGGCGCT
GGACGAAGCCAACCGGCGTCACAAAGTCACTTGGAACTGGGTCAAGGGGCATGCCGGCCACACCGAGAACGAACGCGCCG
ACGAGTTGGCCAGGGAAGGCATGGCGCCGTTCAAGAAGGGCTCGTTCAAGCCGGCGGCATCGGCGCCGAAGCCGGATGCC
CAGCTGAAGCAGCCGGTAGCCACGAAAGCGCGTCGTTCGACTCAGAGCTATTGA

Upstream 100 bases:

>100_bases
CTGGTCATGAAACGCGACCCGACCGAATATATCAGGCGGATGCGGTTCCATCGGGCGATCAAATCGGCTTCGGAATATGG
ATTGGCCTGATATGGGTATC

Downstream 100 bases:

>100_bases
GTTTCGGCGGCCGGTCCGCTTTCAGGCAGGAACCTCGATCATGCCGATCCTCTACTATGTCACGCATCCCCAGGTTCAGA
TCGACGCCGCCATTCCCGTG

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MSKQVEIFTDGACSGNPGPGGWGAILRFNGTTKELSGGEAETTNNRMELLAAISALNALKEPCTVELHTDSKYVMDGISK
WIHGWKKNGWKTADKKPVKNGELWQALDEANRRHKVTWNWVKGHAGHTENERADELAREGMAPFKKGSFKPAASAPKPDA
QLKQPVATKARRSTQSY

Sequences:

>Translated_177_residues
MSKQVEIFTDGACSGNPGPGGWGAILRFNGTTKELSGGEAETTNNRMELLAAISALNALKEPCTVELHTDSKYVMDGISK
WIHGWKKNGWKTADKKPVKNGELWQALDEANRRHKVTWNWVKGHAGHTENERADELAREGMAPFKKGSFKPAASAPKPDA
QLKQPVATKARRSTQSY
>Mature_176_residues
SKQVEIFTDGACSGNPGPGGWGAILRFNGTTKELSGGEAETTNNRMELLAAISALNALKEPCTVELHTDSKYVMDGISKW
IHGWKKNGWKTADKKPVKNGELWQALDEANRRHKVTWNWVKGHAGHTENERADELAREGMAPFKKGSFKPAASAPKPDAQ
LKQPVATKARRSTQSY

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=145, Percent_Identity=38.6206896551724, Blast_Score=91, Evalue=8e-19,
Organism=Escherichia coli, GI1786408, Length=138, Percent_Identity=70.2898550724638, Blast_Score=205, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI115532542, Length=147, Percent_Identity=38.0952380952381, Blast_Score=93, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17505482, Length=132, Percent_Identity=34.0909090909091, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45552509, Length=152, Percent_Identity=34.8684210526316, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137476, Length=152, Percent_Identity=34.8684210526316, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_RHILO (Q985W1)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107806.1
- ProteinModelPortal:   Q985W1
- SMR:   Q985W1
- GeneID:   1230461
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr7504
- NMPDR:   fig|266835.1.peg.5907
- HOGENOM:   HBG742437
- OMA:   NGWRTAD
- ProtClustDB:   PRK00203
- BRENDA:   3.1.26.4
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 19458; Mature: 19327

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQVEIFTDGACSGNPGPGGWGAILRFNGTTKELSGGEAETTNNRMELLAAISALNALK
CCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
EPCTVELHTDSKYVMDGISKWIHGWKKNGWKTADKKPVKNGELWQALDEANRRHKVTWNW
CCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEE
VKGHAGHTENERADELAREGMAPFKKGSFKPAASAPKPDAQLKQPVATKARRSTQSY
ECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKQVEIFTDGACSGNPGPGGWGAILRFNGTTKELSGGEAETTNNRMELLAAISALNALK
CCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
EPCTVELHTDSKYVMDGISKWIHGWKKNGWKTADKKPVKNGELWQALDEANRRHKVTWNW
CCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEE
VKGHAGHTENERADELAREGMAPFKKGSFKPAASAPKPDAQLKQPVATKARRSTQSY
ECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968