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The map label for this gene is dgoD [H]

Identifier: 13476139

GI number: 13476139

Start: 6102809

End: 6104011

Strand: Reverse

Name: dgoD [H]

Synonym: mll7377

Alternate gene names: 13476139

Gene position: 6104011-6102809 (Counterclockwise)

Preceding gene: 13476140

Following gene: 13476138

Centisome position: 86.75

GC content: 62.26

Gene sequence:

>1203_bases
ATGAAAATCCACTCGCTTGAGACCATTCGTATCGAAGAGCGGCCCAATCTGCTCTGGATCGAGGTGCATACCGACGAGGG
CATCACCGGCCTTGGCGAAACCTTTTTCTTGGCCCGAACGGTCGAGGAATATGTCCATGAATATGTCGCGCCACGCGTGA
TCGGCCGCGATCCACTGCAGATCGATCTGCTTTCCGCGGATCTGGTCGGCTATCTCGGTTTCCGCTCAAGCGGGGTCGAA
GTCCGCGGCAATTCGGCTTTCGACATCGCGCTCTGGGATATTTTCGGCAAGGCCATGAACCAGCCGATCGCGCAGCTCCT
GGGAGGCTTTTCGCGGCAGTCCATCCGTACCTACAACACATGCGCGGGCACCGAATACATCAAGGACGGCAAGGGACAGA
CCACCGCGAATTATGGTCTCGGCACAAGGCAAGGCTACGATGACCTGAACGGGTTTCTCCACCGCGCCGACGAATTGGCG
GCGGAGCTGCTCGAGGACGGCATCACGGCCATGAAGATCTGGCCTTTCGACCATGCCGCCGAGAAAAGCCGGGGGCAAGA
CATCACCGCCGGCGACCTCAAAGCCGCGCTGCAACCCTTCGAAAAGATCCGCAAAGCTGTCGGCGACAAGATCGACATCA
TGGTCGAGTTCCACTCCATGTGGCAGCTCTTGCCCGCGATCAAGATCGCCAAGGCGCTCGGGCCTTATGGCACGTACTGG
CATGAGGATCCCATCCGCATGGACAGTCTCGCCGATCTCAAGCGCTATGAGGCCGCGAGCCCGGCACCGATCTCGGCGTC
GGAAACCTTGGGCAGCCGCTGGGCATTCCGCGACCTTCTGGAGACCGGCGCCGCGGGCATCGTCATGCTGGACATTTCCT
GGTGCGGCGGGCTTTCCGAAGCACGCAAGATCGCCGCGATGGCGGAGGCCTGGCATTTGCCGGTCGCGCCGCACGACTGC
ACCGGGCCGGTGGTCCTGGCGGCGTCCACGCATTTGTCGCTCAACGCGCCCAACGCACTCGTCCAGGAGAGTGTGCGGGC
ATTTTACAGGACCTGGTACCGCGACCTGGTGACCGCGCTACCGGAAGTCAGGGACGGCATGATCACCGTGCCGCCCGGCC
CAGGCCTCGGGCTGCAACTCAATCCCGACCTCGGTCGGGCCTACACCGTCCATCGCCGCGTCTCCGACAAGACGGACATC
TGA

Upstream 100 bases:

>100_bases
TTGCTCGGGCGATCATCGCGGGGAACCCGCAACTTGCCGCCGAACATATGGCGGCGCATTTCGATAAAAGCGTCAAGGCA
TTGATCGACGCGGGGATCGC

Downstream 100 bases:

>100_bases
AGCACACTCAACGGGAGGAATAGAAATGAAACGACTGACTGCAACGCTTTTGCTCGCCACGACGCTGCTTGCCGGGCCTT
CCGTCGCCAGCGCCGACGGG

Product: 2-oxo-3-deoxygalactonate 6-phosphate aldolase and galactonate dehydratase

Products: NA

Alternate protein names: GalD [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MKIHSLETIRIEERPNLLWIEVHTDEGITGLGETFFLARTVEEYVHEYVAPRVIGRDPLQIDLLSADLVGYLGFRSSGVE
VRGNSAFDIALWDIFGKAMNQPIAQLLGGFSRQSIRTYNTCAGTEYIKDGKGQTTANYGLGTRQGYDDLNGFLHRADELA
AELLEDGITAMKIWPFDHAAEKSRGQDITAGDLKAALQPFEKIRKAVGDKIDIMVEFHSMWQLLPAIKIAKALGPYGTYW
HEDPIRMDSLADLKRYEAASPAPISASETLGSRWAFRDLLETGAAGIVMLDISWCGGLSEARKIAAMAEAWHLPVAPHDC
TGPVVLAASTHLSLNAPNALVQESVRAFYRTWYRDLVTALPEVRDGMITVPPGPGLGLQLNPDLGRAYTVHRRVSDKTDI

Sequences:

>Translated_400_residues
MKIHSLETIRIEERPNLLWIEVHTDEGITGLGETFFLARTVEEYVHEYVAPRVIGRDPLQIDLLSADLVGYLGFRSSGVE
VRGNSAFDIALWDIFGKAMNQPIAQLLGGFSRQSIRTYNTCAGTEYIKDGKGQTTANYGLGTRQGYDDLNGFLHRADELA
AELLEDGITAMKIWPFDHAAEKSRGQDITAGDLKAALQPFEKIRKAVGDKIDIMVEFHSMWQLLPAIKIAKALGPYGTYW
HEDPIRMDSLADLKRYEAASPAPISASETLGSRWAFRDLLETGAAGIVMLDISWCGGLSEARKIAAMAEAWHLPVAPHDC
TGPVVLAASTHLSLNAPNALVQESVRAFYRTWYRDLVTALPEVRDGMITVPPGPGLGLQLNPDLGRAYTVHRRVSDKTDI
>Mature_400_residues
MKIHSLETIRIEERPNLLWIEVHTDEGITGLGETFFLARTVEEYVHEYVAPRVIGRDPLQIDLLSADLVGYLGFRSSGVE
VRGNSAFDIALWDIFGKAMNQPIAQLLGGFSRQSIRTYNTCAGTEYIKDGKGQTTANYGLGTRQGYDDLNGFLHRADELA
AELLEDGITAMKIWPFDHAAEKSRGQDITAGDLKAALQPFEKIRKAVGDKIDIMVEFHSMWQLLPAIKIAKALGPYGTYW
HEDPIRMDSLADLKRYEAASPAPISASETLGSRWAFRDLLETGAAGIVMLDISWCGGLSEARKIAAMAEAWHLPVAPHDC
TGPVVLAASTHLSLNAPNALVQESVRAFYRTWYRDLVTALPEVRDGMITVPPGPGLGLQLNPDLGRAYTVHRRVSDKTDI

Specific function: Catalyzes the dehydration of D-galactonate to 2-keto-3- deoxy-D-galactonate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily [H]

Homologues:

Organism=Homo sapiens, GI42544119, Length=337, Percent_Identity=22.8486646884273, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI48994953, Length=388, Percent_Identity=29.639175257732, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI1787864, Length=410, Percent_Identity=25.3658536585366, Blast_Score=120, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018110
- InterPro:   IPR013342
- InterPro:   IPR013341
- InterPro:   IPR001354 [H]

Pfam domain/function: PF01188 MR_MLE; PF02746 MR_MLE_N [H]

EC number: =4.2.1.6 [H]

Molecular weight: Translated: 44132; Mature: 44132

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHSLETIRIEERPNLLWIEVHTDEGITGLGETFFLARTVEEYVHEYVAPRVIGRDPLQ
CCCCCEEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCCCE
IDLLSADLVGYLGFRSSGVEVRGNSAFDIALWDIFGKAMNQPIAQLLGGFSRQSIRTYNT
EEEEHHHHHHHHCCCCCCCEEECCCEEEEHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHH
CAGTEYIKDGKGQTTANYGLGTRQGYDDLNGFLHRADELAAELLEDGITAMKIWPFDHAA
HCCCHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHH
EKSRGQDITAGDLKAALQPFEKIRKAVGDKIDIMVEFHSMWQLLPAIKIAKALGPYGTYW
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCC
HEDPIRMDSLADLKRYEAASPAPISASETLGSRWAFRDLLETGAAGIVMLDISWCGGLSE
CCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCHHH
ARKIAAMAEAWHLPVAPHDCTGPVVLAASTHLSLNAPNALVQESVRAFYRTWYRDLVTAL
HHHHHHHHHHHCCCCCCCCCCCCEEEEEECEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
PEVRDGMITVPPGPGLGLQLNPDLGRAYTVHRRVSDKTDI
HHHHCCEEEECCCCCCCEEECCCCCCEEEEEHHCCCCCCC
>Mature Secondary Structure
MKIHSLETIRIEERPNLLWIEVHTDEGITGLGETFFLARTVEEYVHEYVAPRVIGRDPLQ
CCCCCEEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCCCE
IDLLSADLVGYLGFRSSGVEVRGNSAFDIALWDIFGKAMNQPIAQLLGGFSRQSIRTYNT
EEEEHHHHHHHHCCCCCCCEEECCCEEEEHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHH
CAGTEYIKDGKGQTTANYGLGTRQGYDDLNGFLHRADELAAELLEDGITAMKIWPFDHAA
HCCCHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHH
EKSRGQDITAGDLKAALQPFEKIRKAVGDKIDIMVEFHSMWQLLPAIKIAKALGPYGTYW
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCC
HEDPIRMDSLADLKRYEAASPAPISASETLGSRWAFRDLLETGAAGIVMLDISWCGGLSE
CCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCHHH
ARKIAAMAEAWHLPVAPHDCTGPVVLAASTHLSLNAPNALVQESVRAFYRTWYRDLVTAL
HHHHHHHHHHHCCCCCCCCCCCCEEEEEECEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
PEVRDGMITVPPGPGLGLQLNPDLGRAYTVHRRVSDKTDI
HHHHCCEEEECCCCCCCEEECCCCCCEEEEEHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]